EP2015863B1 - Système de récipients avec un récipient doté d'une paroi flexible - Google Patents

Système de récipients avec un récipient doté d'une paroi flexible Download PDF

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Publication number
EP2015863B1
EP2015863B1 EP07724176A EP07724176A EP2015863B1 EP 2015863 B1 EP2015863 B1 EP 2015863B1 EP 07724176 A EP07724176 A EP 07724176A EP 07724176 A EP07724176 A EP 07724176A EP 2015863 B1 EP2015863 B1 EP 2015863B1
Authority
EP
European Patent Office
Prior art keywords
container
baffles
support
arrangement according
wall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP07724176A
Other languages
German (de)
English (en)
Other versions
EP2015863A1 (fr
Inventor
Oscar-Werner Reif
Reinhard Baumfalk
Gerhard Greller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sartorius Stedim Biotech GmbH
Original Assignee
Sartorius Stedim Biotech GmbH
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Filing date
Publication date
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Publication of EP2015863A1 publication Critical patent/EP2015863A1/fr
Application granted granted Critical
Publication of EP2015863B1 publication Critical patent/EP2015863B1/fr
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50—Mixing receptacles
    • B01F35/513—Flexible receptacles, e.g. bags supported by rigid containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50—Mixing receptacles
    • B01F35/53—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components
    • B01F35/531—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components with baffles, plates or bars on the wall or the bottom
    • B01F35/5312—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components with baffles, plates or bars on the wall or the bottom with vertical baffles mounted on the walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/42—Mixers with shaking, oscillating, or vibrating mechanisms with pendulum stirrers, i.e. with stirrers suspended so as to oscillate about fixed points or axes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers

Definitions

  • the invention relates to a container arrangement with a support container and a container with a flexible wall, in particular disposable container, which can be inserted into the supporting its lateral container wall support container and in the introduced liquid medium is Wegmischbar.
  • Containers with flexible walls are increasingly being used in particular as a flexible disposable container or mixing bags in the pharmaceutical / biotechnological industry, in many applications sterile liquids must not only be transfilled, transported and stored, but also manipulated.
  • a container with a flexible wall which is designed as a flexible disposable container and has a mixing device for liquids located in flexible disposable containers.
  • the disposable container is used for ease of manipulation in a supporting its lateral container wall support container.
  • a disadvantage of the known containers with flexible wall is that they have to support the mixing process no so-called baffles, as they are of containers with rigid walls, for example from the DE 692 33 170 T2 or the WO 03/012027 A1 , are known.
  • GB 2 274 404 A describes a drum-shaped mixing device rotatable about a horizontal axis, in particular for the mixing of cement, in which a flexible, bag-shaped lining is supported by a strut-formed cage.
  • the bag-shaped lining is fastened by bolts on a bottom plate and on a bottom plate opposite collar, so that during rotation of the drum parts of the lining filled with cement as Aussackung between the struts are pulled by gravity down and so mixing is achieved ,
  • EP 0 360 456 A2 discloses a temperature control cabinet, in particular for fluids from food technology, which contains a plurality of parallel box-shaped receptacles for fluid-filled, flexible bags. A mixing of the fluids in the bags can be done through above the bag arranged hydraulic punch can be achieved.
  • Each of the box-shaped receiving devices has two elevations with circular cross-section on the lateral inner wall of the receiving device, which promote the mixing in the bag.
  • EP 1 214 142 B1 discloses a mixing device, in particular for paints and pasty foods, in which a displaceable punch with a cylindrical cavity and with a cavity downwardly bounding, annular head plate in the vertical direction in a container is displaceable.
  • Media-filled bags can be inserted into the device, whereby a mixing of the bag contents is achieved by moving the stamp up and down along the vertical.
  • the cylindrical cavity of the punch is closed by lateral walls which have inward bulges towards the bag. In the bulges pneumatic cylinder for vertical drive of the punch are positioned.
  • a disadvantage of the embodiments in the three aforementioned documents is that the mixing-enhancing struts, elevations or bulges improve the mixing of the reactor contents, but are not interchangeable, whereby the flexible and cost-effective adjustment of a support container is difficult to different disposable containers with variable mixing devices.
  • the object of the present invention is therefore to provide a container arrangement into which variable disposable containers with variable mixing devices can be inserted with high flexibility and in which improved mixing can be achieved.
  • the arrangement of interchangeable baffles on the inner support surface of the support container of the container is provided with flexible wall easily and inexpensively with the mixing process supporting baffles. While the disposable container does not have to be provided with a chicane at high cost, the support container having the baffles can be used again and again.
  • a plurality of baffles are arranged on the inner support surface.
  • the baffles are vertical, ie aligned parallel to the container longitudinal axis. This has the advantage that the container is relatively easy to insert into the support container and also removable.
  • the baffles are tilted relative to the support container longitudinal axis by an angle.
  • the tilting about the support longitudinal axis leads to a slightly helical formation of baffles, whereby the flow pattern in the mixing process and also a possible gas exchange can be further positively influenced.
  • the chicane has a contact surface in the upper region in the vertical direction. Accordingly, an outlet surface may be provided in the lower region.
  • the run-up or outflow surfaces prevent damage to the container with a flexible wall and on the other hand facilitate the introduction or removal of the container in or out of the support container.
  • the baffles are integrally formed on the inner support surface of the support container.
  • the baffles can be formed, for example, as a kind of beads in the wall of the support container.
  • the baffles are fixed interchangeably on the inner support surface of the support container.
  • the support containers can be used with different baffles. Also, they can be used without harassment if necessary.
  • the support container can be easily adapted to different disposable containers with different mixing devices with interchangeable baffles. It is also possible, for example, to arrange baffles in different directions in the vertical direction, which may be advantageous in particular for mixers having mixing elements in different levels.
  • the baffles adhere magnetically to the inner support surface of the support container.
  • the baffles are formed from a ferromagnetic material or have permanent magnets, with which they can be fastened to the support surface.
  • the chicanes can also be made of metal and held by a in the wall of the support container or externally opposable permanent magnet.
  • the baffles can be plastic coated.
  • Magnetic baffles are particularly easy to replace and on the other hand they can be used without any problems be attached to different locations of the inner support surface. But the baffles can also be fixed mechanically, for example by screws.
  • the baffles have a rounded cross-sectional shape transversely to their longitudinal axis.
  • the web-shaped baffles are convex toward the container longitudinal axis.
  • the chicane may have a cross section which is formed as elliptical or parabolic or circular section. At the transition to the support surface of the container, the chicane may also be rounded. As a result, sharp corners are avoided even in the area of the bullying ground.
  • a container 1 with a flexible wall 2 has a mixer 3 and is located at least for a mixing process in a support container 4.
  • the container 1 has a container interior 5, in which the mixer 3 is arranged.
  • a mixing element 7 is arranged at one end of a mixer shaft 6, a mixing element 7 is arranged.
  • the mixing element 7 may be part of a rotary mixer, a pendulum mixer, a magnetic stirrer or a vibration mixer.
  • the medium to be mixed 8 is further filled. Connections for media to be supplied or deducted are not shown.
  • the drive 9 for the mixer 3 is arranged outside of the container 1.
  • the container 1 is inserted into the support container 4.
  • the container 1 is with its lateral container wall 10 on an inner support surface 11 of a lateral support container wall 12 at.
  • the container bottom 13 of the container 1 rests on the support container bottom 14 of the support container 4.
  • On the inner support surface 11 four web-shaped baffles 15 are arranged in the embodiment.
  • the baffles 15 are secured with permanent magnets 16 on the inner support surface 11 of the lateral Stütz aserwandung.
  • the baffles 15 are formed as elongated webs, which are aligned in the vertical direction, ie parallel to the support container longitudinal axis 17.
  • the cross section 18 of the chicane 15 is convex, ie rounded, to the support container longitudinal axis 17.
  • the baffles 15 have a contact surface 20 in the upper direction 19 in the vertical direction. In the lower region 21 in the vertical direction, the baffles 15 have an outlet surface 22.
  • the baffles 15 are coated with plastic.
  • the baffles 15 ' may have a cross-section 18' which is rounded convexly toward the longitudinal axis of the support container 17 and concavely rounded laterally towards the inner support surface 11.
  • the baffles 15 are designed to be longer in the vertical direction than in the exemplary embodiment FIG. 1 and the stop surfaces 20 "and outlet surfaces 22" are flatter.
  • the chicanes 15 "'on the lateral container wall 12"' formed.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
  • Tubes (AREA)

Claims (11)

  1. Système de récipients, comportant un récipient de support (4) et un récipient (1) à paroi flexible, en particulier un récipient à usage unique, qui peut être inséré dans le récipient de support (4) supportant la paroi latérale (10) du récipient et dans lequel peut être mélangé un fluide liquide (8) introduit, sachant que ledit récipient de support (4), sur sa face de support (11) intérieure entourant la paroi latérale (10), comporte des chicanes (15, 15', 15", 15"') imprimant la forme de la paroi latérale (10) du récipient et favorisant le processus de mélange, caractérisé en ce que les chicanes (15, 15', 15", 15"') sont fixées de manière amovible sur la face de support (11) intérieure du récipient de support (4).
  2. Système de récipients selon la revendication 1, caractérisé en ce que les chicanes (15, 15', 15", 15"') sont orientées verticalement.
  3. Système de récipients selon la revendication 1 ou 2, caractérisé en ce que les chicanes (15, 15', 15", 15"') sont inclinées selon un angle par rapport à l'axe longitudinal (17) du récipient de support.
  4. Système de récipients selon l'une quelconque des revendications 1 à 3, caractérisé en ce que la chicane (15, 15") comporte une surface d'entrée (20, 20") dans la zone supérieure (19) par référence à la direction verticale.
  5. Système de récipients selon l'une quelconque des revendications 1 à 4, caractérisé en ce que la chicane (15, 15") comporte une surface de sortie (22, 22") dans la zone inférieure (21) par référence à la direction verticale.
  6. Système de récipients selon l'une quelconque des revendications 1 à 5, caractérisé en ce que les chicanes (15, 15', 15") adhèrent magnétiquement à la face de support (11) intérieure.
  7. Système de récipients selon la revendication 6, caractérisé en ce que les chicanes (15, 15', 15") sont réalisées dans un matériau ferromagnétique.
  8. Système de récipients selon la revendication 6, caractérisé en ce que les chicanes (15, 15', 15") sont réalisées en métal et sont fixées par un aimant agencé dans la zone de paroi du récipient de support (4) ou pouvant être agencé de l'extérieur.
  9. Système de récipients selon l'une quelconque des revendications 1 à 5, caractérisé en ce que les chicanes (15, 15', 15") sont fixées mécaniquement contre la face de support (11) intérieure du récipient de support (4).
  10. Système de récipients selon l'une quelconque des revendications 1 à 9, caractérisé en ce que les chicanes (15, 15', 15") sont revêtues de matière plastique.
  11. Système de récipients selon l'une quelconque des revendications 1 à 10, caractérisé en ce que les chicanes (15, 15', 15", 15"') ont une section à forme arrondie transversalement à leur axe longitudinal.
EP07724176A 2006-05-03 2007-04-12 Système de récipients avec un récipient doté d'une paroi flexible Active EP2015863B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006020813A DE102006020813B3 (de) 2006-05-03 2006-05-03 Behälteranordnung mit einem Behälter mit flexibler Wandung
PCT/EP2007/003235 WO2007124847A1 (fr) 2006-05-03 2007-04-12 Système de récipients avec un récipient doté d'une paroi flexible

Publications (2)

Publication Number Publication Date
EP2015863A1 EP2015863A1 (fr) 2009-01-21
EP2015863B1 true EP2015863B1 (fr) 2010-06-23

Family

ID=38198329

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07724176A Active EP2015863B1 (fr) 2006-05-03 2007-04-12 Système de récipients avec un récipient doté d'une paroi flexible

Country Status (5)

Country Link
US (1) US10322388B2 (fr)
EP (1) EP2015863B1 (fr)
AT (1) ATE471756T1 (fr)
DE (2) DE102006020813B3 (fr)
WO (1) WO2007124847A1 (fr)

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DE102006020461B3 (de) * 2006-04-28 2007-10-04 Sartorius Biotech Gmbh Behälter mit flexiblen Wänden
DE102007060291B4 (de) 2007-12-12 2011-04-28 Sartorius Stedim Biotech Gmbh Behälteranordnung mit einem Behälter mit flexibler Wandung
DE102007061664B4 (de) 2007-12-18 2009-11-19 Sartorius Stedim Biotech Gmbh Behälter mit flexibler Wandung
EP2598234B1 (fr) * 2010-07-30 2016-01-06 EMD Millipore Corporation Dispositif de mélange jetable
US10427121B2 (en) * 2013-02-01 2019-10-01 Asociacion Centro De Investigacion Cooperativa En Biomateriales (Cic Biomagune) Non intrusive agitation system
EP2853584B1 (fr) 2013-09-30 2021-03-10 Eppendorf Ag Bioréacteur à usage unique avec déflecteurs et procédé de fabrication et d'utilisation de ce dernier
US9314756B2 (en) 2014-03-18 2016-04-19 Kw Container Plastic container with internal mixing ribs
EP2944372A1 (fr) * 2014-05-17 2015-11-18 Miltenyi Biotec GmbH Procédé et dispositif pour la suspension de cellules
US10092888B2 (en) * 2014-11-07 2018-10-09 Genesis Technologies, Llc Linear reciprocating actuator
DE102014117658B4 (de) 2014-12-02 2023-02-16 Sartorius Stedim Biotech Gmbh Mischvorrichtung mit Strömungsbrecher
JP2018065594A (ja) * 2016-10-19 2018-04-26 富士フイルム株式会社 撹拌タンク及びその製造方法
US11766807B2 (en) 2017-01-15 2023-09-26 Michael George BUTLER Apparatuses and systems for and methods of generating and placing zero-slump-pumpable concrete
US20190382944A1 (en) * 2017-07-11 2019-12-19 Robert Shewchuck Magnetic pickup for clothing machines
CN107897498A (zh) * 2017-12-29 2018-04-13 宁夏万辉生物环保科技有限公司 富含花青素的蚯蚓蛋白粉的制备方法

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Also Published As

Publication number Publication date
DE502007004194D1 (de) 2010-08-05
DE102006020813B3 (de) 2007-10-04
EP2015863A1 (fr) 2009-01-21
ATE471756T1 (de) 2010-07-15
US20090314666A1 (en) 2009-12-24
US10322388B2 (en) 2019-06-18
WO2007124847A1 (fr) 2007-11-08

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