EP1993924B1 - Anordnung zur aufnahme und ausgabe einer fluessigkeit - Google Patents

Anordnung zur aufnahme und ausgabe einer fluessigkeit Download PDF

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Publication number
EP1993924B1
EP1993924B1 EP07731026A EP07731026A EP1993924B1 EP 1993924 B1 EP1993924 B1 EP 1993924B1 EP 07731026 A EP07731026 A EP 07731026A EP 07731026 A EP07731026 A EP 07731026A EP 1993924 B1 EP1993924 B1 EP 1993924B1
Authority
EP
European Patent Office
Prior art keywords
liquid
cap
spout
assembly according
air
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP07731026A
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English (en)
French (fr)
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EP1993924A2 (de
Inventor
Guillaume Grevin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rexam Pharma SAS
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Rexam Pharma SAS
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Filing date
Publication date
Application filed by Rexam Pharma SAS filed Critical Rexam Pharma SAS
Publication of EP1993924A2 publication Critical patent/EP1993924A2/de
Application granted granted Critical
Publication of EP1993924B1 publication Critical patent/EP1993924B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
    • B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers

Definitions

  • the present invention relates to a set of packaging and dispensing liquid
  • Such a set of packages is known from JP 200-263 166 A .
  • the invention applies in particular, but not exclusively, to the packages for packaging and dispensing eye drops in the form of an aqueous solution, the sterility of which must be guaranteed.
  • the filtration means prevent the penetration of contaminating agents inside the container upstream of the membrane.
  • An object of the invention is to provide a set of conditioning and liquid distribution to limit the risk of distribution of contaminated liquid.
  • the set 2 of packaging and distribution shown on the figure 1 comprises a container 4 for receiving eye drops in the form of an aqueous solution, a device 6 for dispensing eye drops, and a device 8 for closing the container 4.
  • the container 4 is in the example illustrated a plastic bottle containing the eye drops which has not been shown in the figures.
  • the container 4 comprises a hollow body 10 extended by an upper neck 12 which extends along a longitudinal axis L vertical to an outlet 13.
  • the walls of the body 10 are elastically deformable under the action of a transverse force to cause a decrease in the internal volume of the body 10, and thus allow the expulsion of the eye drops through the neck 12.
  • the closure device 8 comprises a plug 14 and a tamperproof ring 16 made of material.
  • the neck 12 is provided with external reliefs such as threads, allowing the connection to the plug 14, provided with a complementary thread, and the tamperproof ring 16 is translationally connected along the axis L to a relief collar 12, for example a rib 18.
  • the dispensing device 6 comprises a nozzle 20 for liquid outlet and air inlet, received in part in the neck 12 through the orifice 13.
  • upstream and downstream refer to the direction of flow of the eye drops through the neck 12 and the tip 20 of the inside of the body 10 towards the outside, as illustrated by an arrow A on the figure 1 .
  • the tip 20 comprises two parts 22 and 24 superimposed along the axis L and defining a passage 26 for circulation of eye drops and air, passing through the nozzle 20 from side to side along the axis L, an orifice 26a opening into the body 10 to an opening 26b opening outwardly.
  • the lower portion 24 is sealingly connected to the orifice 13.
  • the device 6 comprises a microporous membrane 28 for filtering liquid and air extending across the passage 26.
  • the membrane 28 is mounted in the tip 20 being blocked between the portion 22 and the portion 24.
  • the membrane 28 comprises liquophilic regions and liquophobic regions.
  • the portion 22 is arranged to prevent the formation of a jet of liquid for a drip distribution of the eye drops.
  • the section 29 of the passage 26, located downstream of the membrane 28 and defined in the part 22, comprises from downstream upstream a restriction 30 followed by a diverging 31 flaring up to the orifice 26b located at a free end 34 of a pin 35 of the portion 22 projecting along the axis L from a disk-shaped base 36 of the portion 22, connected to the portion 24 .
  • the portion 24 comprises a tubular sleeve 37 partly sealed in the neck 12, and a circumferentially continuous annular elastic lip 38 integral with the sleeve 37, and extending radially outwardly from the sleeve 37, outside the collar 12.
  • the device 6 comprises a block 39 of open-cell porous material, for example a compressible foam, allowing the passage of liquid and having liquophobic properties, in contact with an upstream face 28a of the membrane 28.
  • the block 39 extends over the entire section of passage 26.
  • the cap 14 is screwed onto the neck 12 to close the container 4.
  • the user unscrews the cap 14.
  • the user unscrews the cap 14 which breaks the connection between cap 14 and the ring 16 because it is retained by the rib 18. This rupture indicates to the user that the bottle has not been used previously.
  • the connection between the plug 14 and the ring 16 is already broken; and the plug 14 is unscrewed more easily.
  • the user disposes the container 4 upside down, and presses the walls of the body 10 to expel the eye drops through the neck 12 and the device 6 forcing its passage through the block 39 and the membrane 28.
  • the user releases the walls of the body 10, which are returned to their original shape by elasticity. This causes a depression in the body 10 relative to the outside, tending to suck through the membrane 28 a residual amount of liquid in the section 29 and the outside air.
  • the suction of the residual amount of liquid section 29 avoids the stagnation of this liquid in the section 29 between two uses.
  • the external air intake makes it possible to replace the volume of distributed eye drops.
  • the aspirated liquid preferably passes through the liquophilic regions of the membrane 28 while being filtered, and the sucked air preferably passes through the liquophobic regions of the membrane 28 while being filtered.
  • the membrane 28 Due to the small passage surface offered by the membrane 28 to air and eyedrops, the membrane 28 is a brake to the re-aspiration of the amount of residual eye drops and the suction of air.
  • the elasticity of the walls of the body 10 is generally not sufficient to ensure the complete re-aspiration of the residual amount of eye drops in the section 29 before the complete closure of the stopper 14.
  • the lip 38 and the block 39 make it possible to limit these risks by increasing the entry of air and the re-aspiration of the quantity of eye drops trapped after dispensing.
  • the lip 38 comes into sealed contact at its free end with an internal cylindrical sealing surface 41 of axis L of the plug 14.
  • the lip 38 thus seals a space 42 located between the endpiece 20 and the bottom 40 of the cap 14 partially closed.
  • the lip 38 slides along the bearing surface 41 of the plug 14 which moves along the axis L with respect to the lip 38, and the volume of the space 42 decreases progressively. It follows the appearance of an overpressure in the space 42 and in the section 29 with respect to the pressure prevailing upstream of the membrane 28.
  • the lip 38 is inclined relative to the axis L and extends axially down the bottom 40. This results in effective sealing because the overpressure in the space 42 tends to press the lip 38 against the scope 41.
  • the block 39 prevents the formation of a film of eye drops, retained by capillarity on the upstream face 28a of the membrane 28. Such a film would prevent the aspiration of air and also the re-aspiration of part of the quantity entrapped eye drops by clogging the pores of the membrane 28.
  • Block 39 because it is porous and liquophobic, causes the pooling or coalescence of the eye drops retained on the membrane 28 into drops forming in the porosities of the block 39.
  • the block 39 thus promotes the re-aspiration of the eye drops on the upstream side. the membrane 28, as well as the air inlet inside the body 10 by releasing air circulation channels between the drops of eye drops, inside the block 39.
  • Block 39 is made for example of an open-cell foam made of polyurethane (PUR), PTFE, PVC, polyester, polyether, polyethylene or polypropylene.
  • Block 39 has for example a porosity of 10 to 100 PPI ("pores per inch" in English, pores per inch in French).
  • the assembly 2 thus makes it possible to promote the re-aspiration of eye drops and the suction of air into the container 4 before it is closed.
  • the assembly 2 thus makes it possible to limit the amount of eye drops trapped downstream of the membrane, and consequently to limit the risk of contamination.
  • the suction of the amount of trapped eye drops and the suction of air are particularly effective because the force exerted by the user is used to close the cap 14 to force the entry of eye drops and the entrance of the eye. air through the membrane 28.
  • the block 39 and the lip 38 can be used independently of one another while maintaining their respective advantages, to promote the aspiration of eye drops and / or air into the container.
  • the invention thus generally relates to a liquid conditioning and dispensing assembly, of the type comprising a container for containing the liquid, a liquid dispensing device, comprising a liquid outlet and air inlet nozzle. , and means for filtering liquid and air circulating in the nozzle, and a closure cap of the container, the assembly further comprising means sealing means capable of sealingly closing a space between the nozzle and the partially closed cap, the volume of which is reduced when the plug is being closed, so as to cause the appearance of an overpressure in the container. nozzle downstream of the filtration means, because of the closure of the cap.
  • the invention also generally relates to a liquid conditioning and dispensing assembly, of the type comprising a container for containing the liquid, a liquid dispensing device, comprising a liquid outlet and air inlet nozzle. , and means for filtering liquid and air circulating in the nozzle, and a closure cap of the container, the assembly further comprising a layer of porous liquophobic material, in contact with an upstream face of the membrane.
  • the invention applies to packages for the packaging and dispensing of eye drops, and more generally to liquid conditioning and dispensing assemblies whose sterility must be preserved.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)

Claims (10)

  1. Vorrichtung zur Verpackung und Abgabe von Flüssigkeit von der Art, bestehend aus
    - einem Behälter (4), der zur Aufnahme der Flüssigkeit bestimmt ist,
    - einer Flüssigkeitsabgabevorrichtung (6), umfassend:
    - einen Stopfen (20) für den Flüssigkeitsaustritt und den Lufteintritt, und
    - Mittel (28) zum Filtrieren der Flüssigkeit und der Luft, die im Stopfen (20) zirkulieren, und
    - einer Kappe (14) zum Verschließen des Behälters (4), und
    - Mitteln (38, 41, 39) zur Erhöhung des Luftzuflusses und/oder einer Rückkehr einer verbleibenden Flüssigkeitsmenge, die im Stopfen (20) der Flüssigkeit nach Abgabe von Flüssigkeit eingeschlossen bleibt, durch die Filtriermittel (28) in den Behälter (4), dadurch gekennzeichnet, dass die Mittel zur Erhöhung des Luftzuflusses und/oder einer Rückkehr einer verbleibenden Flüssigkeitsmenge Abdichtungsmittel (38, 41) umfassen, die geeignet sind, einen Raum (42) zwischen dem Stopfen (20) und der teilweise geschlossenen Kappe (14) dicht abzuschließen, dessen Volumen sich beim weiteren Verschließen der Kappe (14) verringert, derart dass durch das Schließen der Kappe (14) das Auftreten eines Überdruckes im Stopfen (20) auf der Abflussseite der Filtriermittel (28) bewirkt wird.
  2. Vorrichtung nach Patentanspruch 1, dadurch gekennzeichnet, dass die Abdichtungsmittel eine Dichtungslippe (38) umfassen, die mit dem Stopfen (20) fest verbunden ist und beim Verschließen der Kappe (14) mit einer inneren Dichtungsfläche (41) der Kappe (14) in Berührung gelangt.
  3. Vorrichtung nach Patentanspruch 2, dadurch gekennzeichnet, dass die Lippe (38) einstückig mit einem Teil (24) des rohrförmigen Stopfens (20) ausgebildet ist, das eine Längsachse (L) aufweist.
  4. Vorrichtung nach Patentanspruch 3, dadurch gekennzeichnet, dass die Lippe (38) relativ zur Längsachse (L) vom Teil (24) absteht, radial auswärts und axial in Richtung eines Bodens (40) der Kappe (14) geneigt.
  5. Vorrichtung nach irgendeinem der vorangehenden Patentansprüche, dadurch gekennzeichnet, dass die Kappe (14) einen Boden (40) aufweist, der mit einer Austrittsöffnung (26b) des Stopfens (20) beim vollständigen Verschließen der Kappe (14) abdichtend in Berührung kommt.
  6. Vorrichtung nach irgendeinem der vorangehenden Patentansprüche, dadurch gekennzeichnet, dass die Filtriermittel mindestens eine mikroporöse Filtermembran (28) umfassen, die sich quer über einen Durchgang (26) zur Flüssigkeits- und Luftzirkulation durch den Stopfen (20) erstreckt.
  7. Vorrichtung nach Patentanspruch 6, dadurch gekennzeichnet, dass die mikroporöse Filtermembran (28) mindestens einen liquophilen Bereich und mindestens einen liquophoben Bereich aufweist.
  8. Vorrichtung nach Patentanspruch 6 oder 7, dadurch gekennzeichnet, dass die Membran (28) zwischen zwei Teilen (22, 24) des Stopfens (20) eingeklemmt ist, die relativ zueinander befestigt sind.
  9. Vorrichtung nach irgendeinem der Patentansprüche 6 bis 8, dadurch gekennzeichnet, dass die Mittel zur Erhöhung des Luftzutritts und/oder einer Rückkehr einer verbleibenden Flüssigkeitsmenge eine Schicht (39) aus liquophobem, porösem Werkstoff, der geeignet ist, von einer Flüssigkeit durchquert zu werden, in Berührung mit einer Anströmseite (28a) der Membran (28) aufweisen.
  10. Vorrichtung nach irgendeinem der Patentansprüche 6 bis 9, dadurch gekennzeichnet, dass die Filtriermittel eine einzige mikroporöse Filtermembran (28) umfassen.
EP07731026A 2006-02-23 2007-02-22 Anordnung zur aufnahme und ausgabe einer fluessigkeit Active EP1993924B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0601607A FR2897599B1 (fr) 2006-02-23 2006-02-23 Ensemble de conditionnement et de distribution de liquide.
PCT/FR2007/000320 WO2007096526A2 (fr) 2006-02-23 2007-02-22 Ensemble de conditionnement et de distribution de liquide.

Publications (2)

Publication Number Publication Date
EP1993924A2 EP1993924A2 (de) 2008-11-26
EP1993924B1 true EP1993924B1 (de) 2013-04-03

Family

ID=37067582

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07731026A Active EP1993924B1 (de) 2006-02-23 2007-02-22 Anordnung zur aufnahme und ausgabe einer fluessigkeit

Country Status (5)

Country Link
US (1) US8056766B2 (de)
EP (1) EP1993924B1 (de)
JP (1) JP5020981B2 (de)
FR (1) FR2897599B1 (de)
WO (1) WO2007096526A2 (de)

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JP5317498B2 (ja) * 2008-03-03 2013-10-16 ニプロ株式会社 滴下容器
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JP5224915B2 (ja) * 2008-06-03 2013-07-03 大成化工株式会社 フィルター付き吐出容器
FR2934572A1 (fr) * 2008-07-31 2010-02-05 Thea Lab Embout pour flacon de conditionnement de liquide a distribuer goutte a goutte.
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FR2937019B1 (fr) * 2008-10-15 2012-06-08 Rexam Pharma La Verpilliere Dispositif de distribution de liquide muni d'un organe d'etancheite ayant une partie elastomere
JP2011201577A (ja) * 2010-03-26 2011-10-13 Murazumi Kk 吐出部構造
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US11679028B2 (en) 2019-03-06 2023-06-20 Novartis Ag Multi-dose ocular fluid delivery system
US12097145B2 (en) 2019-03-06 2024-09-24 Bausch + Lomb Ireland Limited Vented multi-dose ocular fluid delivery system
US10723526B1 (en) 2019-03-29 2020-07-28 Chubby Gorilla, Inc. Bottle and cap arrangement
CN111330517B (zh) * 2020-03-18 2022-04-29 山东凯泰科技股份有限公司 一种催化剂添加及过滤的自动控制系统
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WO2021212038A1 (en) 2020-04-17 2021-10-21 Kedalion Therapeutics, Inc. Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir

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Also Published As

Publication number Publication date
JP5020981B2 (ja) 2012-09-05
WO2007096526A2 (fr) 2007-08-30
WO2007096526A3 (fr) 2008-01-24
US20090152302A1 (en) 2009-06-18
US8056766B2 (en) 2011-11-15
EP1993924A2 (de) 2008-11-26
FR2897599A1 (fr) 2007-08-24
FR2897599B1 (fr) 2010-08-27
JP2009527421A (ja) 2009-07-30

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