EP1962669A2 - Dispositif de determination de variables physiologiques - Google Patents

Dispositif de determination de variables physiologiques

Info

Publication number
EP1962669A2
EP1962669A2 EP06828507A EP06828507A EP1962669A2 EP 1962669 A2 EP1962669 A2 EP 1962669A2 EP 06828507 A EP06828507 A EP 06828507A EP 06828507 A EP06828507 A EP 06828507A EP 1962669 A2 EP1962669 A2 EP 1962669A2
Authority
EP
European Patent Office
Prior art keywords
light
less
saturation
tissue
saco
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06828507A
Other languages
German (de)
English (en)
Inventor
Bernd Schöller
Thomas Magin
Klaus Forstner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Loewenstein Medical Technology GmbH and Co KG
Original Assignee
Loewenstein Medical Technology GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Loewenstein Medical Technology GmbH and Co KG filed Critical Loewenstein Medical Technology GmbH and Co KG
Publication of EP1962669A2 publication Critical patent/EP1962669A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14535—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring haematocrit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04—Constructional details of apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04—Constructional details of apparatus
    • A61B2560/0431—Portable apparatus, e.g. comprising a handle or case
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A61B5/7207—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts

Definitions

  • the invention relates to a device for the optical determination of physiological variables in perfused tissue having at least a first and a second light source, which respectively emit light radiation of a first and a second predeterminable wavelength, wherein the light sources are arranged such that the light radiation emanating from them the perfused tissue can penetrate.
  • pulse oximetry allows a non-invasive measurement of the oxygen saturation of the arterial blood.
  • light is guided by two fingers of two different wavelengths, for example 660 nm and 905 nm, which is partially absorbed by the blood pulsating in the tissue.
  • the degree of absorption is determined by analysis of the light component emerging on the other side of the irradiated tissue, which leads directly to the oxygen saturation. movement of the pulsating and thus arterial blood.
  • pulse oximetry In a typical measurement range (80-100% saturation) the pulse oximetry is quite accurate compared to the arterially invasively measured oxygen saturation.
  • the limits of pulse oximetry occur, for example, in the presence of intoxication, e.g. by carbon monoxide, or in a drug-toxic methaemoglobinaemia.
  • the pulse oximetric oxygen saturation is measured incorrectly high, which can have dangerous consequences.
  • pulse oximetry is not suitable for specifying the oxygen content (caO2). To assess the oxygenation of a patient, one also needs information about the hemoglobin concentration.
  • PD photodetector
  • a control unit which supplies control signals to the light sources in such a way that the light sources continuously emit light alternately, whereby one or more darkening lights are emitted in this sequence. phases can be inserted, in which at least one light source does not emit light;
  • the evaluation device for at least one pV to be measured supplies a displayable output signal to an interface connectable to the evaluation device.
  • a device and a method are presented with which a non-invasive determination of several physiological variables (pV) selected from the group temperature, pulse rate, pH, concentration of hemoglobin (cHb), oxyhemoglobin (HbO2), deoxygenated hemoglobin (HbDe ), Carboxyhemoglobin (HbCO), methemoglobin (cMetHb), sulfhemoglobin (HbSuIf), bilirubin, glucose, bile pigments, SaO2, SaCO, SpO2, CaO2, SpCO.
  • physiological variables selected from the group temperature, pulse rate, pH, concentration of hemoglobin (cHb), oxyhemoglobin (HbO2), deoxygenated hemoglobin (HbDe ), Carboxyhemoglobin (HbCO), methemoglobin (cMetHb), sulfhemoglobin (HbSuIf), bilirubin, glucose, bile pigments, SaO2, SaCO, SpO2, CaO2, SpCO
  • the invention relates to a device that non-invasively registers, compensates, processes a physiological variable (pV) to provide an output signal that represents the value of the pV at the time of the measurement.
  • pV physiological variable
  • the device according to the invention is a non-invasive method.
  • one or more light sources are set to a body part. Be distanced from the source one or more analyzing photocells are provided which receive a light attenuation and / or a scattered light component.
  • the source of electromagnetic radiation is designed, for example, as one or more laser diodes and / or one or more white light sources and / or one or more LEDs.
  • the electromagnetic radiation is selected from one or more ranges of 150 nm + 15%, 400nm ⁇ 15%, 460nm ⁇ 15%, 480nm + 15%, 520nm ⁇ 15%, 550nm ⁇ 15%, 560nm + 15 %, 606 nm + 15%, 617 nm + 15%, 620 nm ⁇ 15%, 630 nm ⁇ 15%, 650 nm ⁇ 15%, 660 nm ⁇ 15%, 705 nm ⁇ 15%, 710 nm + 15%, 720 nm ⁇ 15%, 805 nm + 15%, 810 nm + 15%, 880 nm ⁇ 15%, 905 nm ⁇ 15%, 910 nm ⁇ 15%, 950 nm + 15%, 980 nm ⁇ 15%, 980 nm ⁇ 15%, 1050 nm ⁇ 15%, 1200 nm + 15%, 1310 nm ⁇ 15%, 1380 nm ⁇ 15%, 1450 nm
  • the electromagnetic waves are passed through a live and / or dead medium to be examined, preferably animal and / or human tissue.
  • the transmitted and / or the reflected portion of the electromagnetic waves is detected by a receiving system, which is preferably designed as one or more photodetectors.
  • the receiving system is capable of detecting different wavelengths substantially simultaneously.
  • the receiving system is furthermore able to record and / or store and / or pass on the detected electromagnetic waves, for example in the form of at least one of them electrical pulse, preferably as a current and / or voltage signal.
  • the signal is processed by an evaluation unit by signal conditioning. Regardless of the original wavelength, the at least one signal is further processed by active and / or passive electronic components. Preferably, an adaptation according to frequency and amplitude. Particularly preferably, the ratio of the AC to the DC component and / or its level is adjusted by filtering, noise suppression, rectification, amplification, via resistors, capacitors, amplifiers, high-pass filters, logic flip-flops. As a result, the output of the evaluation unit is preferably a processed AC component of the output signal.
  • the processed signal is digitized by an A / D converter with high bit width and resolution.
  • an A / D converter of at least 12 bits is used for this purpose.
  • Digital signals representative of at least two different wavelengths of the originally irradiated electromagnetic radiation are analyzed by at least one CPU.
  • an analyzer is preferably provided in the area of a CPU.
  • a signal processing takes place.
  • at least one readable data memory is provided in the area of the CPU.
  • Extractions are calculated (calculated or read out)
  • the CPU provides data representative of at least one pV of the transmitted medium.
  • the output of the CPU is coupled to a controller.
  • This is coupled to a D / A converter.
  • the controller couples back to the source of electromagnetic waves and controls the intensity of the radiation emanating from the source such that the radiation intensity detected by the receiving system and relayed to the A / D converter is always in a preferred resolution range.
  • the feedback to the source (and the controller) can be completely eliminated.
  • An artifact correction is preferably carried out by means of a CPU which processes the output signal of the evaluation unit in the time domain (for example by polynomial functions) or image domain (for example by Fourier transformation or wavelets).
  • the functions are selected to match the possible artifact properties.
  • the PVs are typically determined to an accuracy of at least 5%, preferably 2%, over the measurement range of the particular pV.
  • the measurement range for the concentration of hemoglobin cHb is typically 5 to 20 g / dl, the norm being 14-18 g / dl (men) and 12-16 g / dl (females).
  • the compensation mechanisms of the body are fully loaded even under normal 02 consumption and under otherwise favorable conditions.
  • the measured value for cHb preferably being present in less than 1 minute, particularly preferably the measured value for cHb is determined in less than 10 seconds.
  • To determine cHb at least four wavelengths from the range of 600 nm to 1500 nm are used according to the invention.
  • the range of values for bilirubin is typically 0.1-5.0 mg / dl. According to the invention, it is therefore proposed to determine bilirubin with an accuracy of 0.1-1.0 mg / dl, preferably to 0.5 mg / dl accurately, non-invasively, the measured value for bilirubin preferably being able to be present in less than 1 minute, particularly preferably, the measured value for cHb is determined in less than 10 seconds.
  • at least two wavelengths, selected from the group 400 nm to 2000 nm, are used according to the invention.
  • the range of values for blood oxygen 02 is typically 40% to 100% saturation, with physiological and / or pathophysiological variations can be quite rapid.
  • the measured value for oxygen can be present in less than 1 minute, particularly preferably the measured value for cHb is determined in less than 5 seconds .
  • the measured value for cHb is determined in less than 5 seconds .
  • the range of values for a carbon monoxide SaCO in the blood is typically 0% to 40% saturation, whereby changes can be quite rapid.
  • the invention it is therefore proposed to determine SaCO with an accuracy of at least 5%, preferably at least 2%, non-invasively, wherein the measured value for a carbon monoxide SaCO in the blood in less than 100 seconds, preferably in less than 20 seconds, more preferably in less than a 5 seconds.
  • the measured value for a carbon monoxide SaCO in the blood in less than 100 seconds, preferably in less than 20 seconds, more preferably in less than a 5 seconds.
  • at least two wavelengths from the range 600 nm to 1000 nm are used according to the invention.
  • the accuracy and speed of the determination of the pV depends on the available electrical energy and time for the calculation of the measuring signals. Especially with portable devices that run on batteries, the available energy is a limiting factor.
  • Errors in the operating characteristic of the device can be complex and a non-linear function of many variables. be riableness.
  • the pV contributes directly to the error, while secondary process variables (affecting the measurement of the primary process variable) indirectly contribute to the error. As the need for accuracy increases, the contributions of the secondary variables become more important.
  • the power consumption of, for example, the CPU of the device is critical because all operating power or power is supplied over the same lines used for communication. Furthermore, some intrinsically safe areas limit the power available to the device. The limited amount of power not only limits the number and complexity of the calculations, but also affects the functionality that can be realized in the device.
  • the senor, the CPU and the signal processing require a lot of energy.
  • Fig. 1 shows a schematic representation of the circuit diagram of the device
  • Fig. 2 shows a schematic representation of the components of the device
  • a device according to the invention according to FIG. 1 has a transmitter unit (1) in which there is at least one light-emitting diode LEDa of a first predetermined nominal wavelength LAMBDAa. Opposite the transmitter unit is a photodetector PD (2). Between the transmitter unit (1) and the photodetector PD (2), a human and / or animal tissue and / or vessel can be arranged such that the light emitted by the transmitter unit (1) after passing through the tissue and / or vessel, the photodetector PD (2) achieved. In this case, the light intensity received from the PD is converted into an electrical quantity and processed analogously in the device, then A / D converted and further processed digitally.
  • the light-emitting diodes LEDa, LEDn are connected to a multiplexer MUX (3).
  • the control unit of the multiplexer MUX (3) controls the LEDs so that in the case of, for example, four LEDs connected, all four LEDs are alternately turned on and off.
  • the multiplexer MUX (3) has a further connection
  • the evaluation device has at least one microcontroller
  • the output current of the photodetector PD (2) is supplied to the input of a current / voltage converting means (4).
  • the current / voltage converting means (4) converts the output current of the photodetector into an output voltage.
  • the analog signal of the PD is digitized by an A / D converter of at least 8 bits and forwarded via an actuator to the evaluation device (7).
  • the evaluation device (7) In connection with the evaluation device (7) are at least one volatile memory, RAM (10) and a non-volatile memory ROM (11).
  • the non-volatile memory (11) is designed, for example, as EEPROM or Flash. In the non-volatile memory (11) an algorithm is stored, which is used to determine the pV.
  • An input device (12) in the form of a keyboard can be connected to the evaluation device (7).
  • various output devices 13, 14, 15, 16
  • a loudspeaker (13) can be used, for example, to generate warning sounds or voice outputs that can inform or guide the user.
  • warning lights and / or status signals can be generated via lights (15).
  • a display (14) shows the pV values.
  • the tissue / vessel is alternately irradiated by the light emitted by the first light-emitting diode LEDa or by the further light-emitting diode LEDn, wherein the light passing through the tissue / vessel from the photodetector PD is received and converted into a photodetector output current.
  • the light-emitting diodes LEDa, LEDn can be driven either binary, in this case emits an LED at any time either no light or light at a predetermined power, alternatively, the LED can be controlled with an analog signal of predetermined amplitude.
  • the timing for the activation of the LED can be effected as a function of the pulse wave phases, for example every 200 ⁇ sec.
  • the activation can be carried out as follows:
  • Wavelength a Wavelength a
  • Wavelength b Wavelength b
  • the evaluation device (7) determines from the voltage signal the progression of the spectral absorption of the tissue / vessel at the wavelengths defined by the LED of the first or further light-emitting diodes LEDa, LEDn and determines from these spectral absorption values by processing and / or further processing and / or or linking the respective pV of interest, for example the absolute or relative hemoglobin concentration Hb, the COHb concentration, the oxygen saturation SaO2, CaO2 or the heart rate.
  • the measured values for the pV for each wavelength are stored in the volatile (10) and / or non-volatile memory (11). Subsequently, the measured values are read out again by the evaluation device (7) with the aid of the microcontroller (8) and analyzed in the CPU (9) with the aid of the algorithm stored in the ROM (11).
  • digitized data representing the attenuation and / or scattering of electromagnetic radiation through a tissue / vessel is processed in a central unit under program control, wherein a control unit receives from a memory the instructions of a program and executes operations by an arithmetic unit according to the program instruction which consists of at least one arithmetic-logical unit.
  • absolute and / or relative measured values for the desired pV are determined.
  • the results of the pV electronically, optically (14, 15) and / or acoustically (13) are output.
  • the data representing the pV are conditioned for an interface and provided at an interface.
  • a protocol is provided via an interface.
  • a voltage and / or current that is substantially proportional to the pV is provided at the interface.
  • a digitized value representing the pV can be made available in a TCP / IP protocol via Ethernet.
  • a SaO2 value may be provided via a proprietary protocol on a UART interface.
  • FIG. 2 Another aspect of the invention, as shown in FIG. 2, relates to a portable, small, and handy device that allows a user to non-invasively determine multiple pVs.
  • the device consists of a housing upper shell (17) made of plastic with a recess for a display (30) and recesses for control buttons.
  • a control panel (18) is inserted with buttons.
  • the control panel has a recess for a display (31) and control buttons (32).
  • the display (19) is available on the control panel (18) and is electrical and mechanical by the main board (20) with the upper housing shell (17) connectable.
  • a separator (21) mechanically separates the motherboard (20) and the power board (22).
  • lower shell (24) and separating device (21) recesses (34) for a fastening device (27) are provided in the region of the motherboard (20).
  • recesses (34) for a fastening device (27) are provided on the back of the housing upper shell (17) are receptacles (33) for the fastening device (27).
  • a socket (23) is adaptable.
  • the socket (23) can be electrically and mechanically connected to the main board (20) and / or power board (22).
  • the socket is for receiving a sensor cable.
  • the socket may be equipped as a receiving module for a radio transmission of sensor signals.
  • a power supply for example accumulators (26).
  • a cover (25) may be slid over the power supply receptacle (28).
  • the dimensions of the device according to the invention are preferably less than 15 cm in length and less than 5 cm in depth and less than 8 cm in width.
  • the volume of the device is preferably less than 600 cc.
  • the device consists of no more than two boards (20, 22) and / or less than 11 Items and / or less than three fasteners (27).
  • the device according to the invention is designed as an original equipment manufacturer (OEM) printed circuit board.
  • OEM original equipment manufacturer
  • the OEM printed circuit board according to the invention can be mounted in the region of the board of patient monitors via at least one plug-in contact, which enables a detachable mechanical and electronic coupling.
  • the functional scope of patient monitors by simply adding the OEM printed circuit board according to the invention, can be extended by the functions implemented on the OEM printed circuit board according to the invention.
  • the device according to the invention is formed in a preferred embodiment as an integrated circuit and - because of the low power consumption - in CMOS technology.
  • the printed circuit board is preferably equipped on both sides.
  • the track width on the PCB is in the range 0.15 mm +/- 0.5 mm.
  • the track spacing is in the range 0.15 mm +/- 0.5 mm.
  • the operating voltage is preferably in the range 3 V to 15 V.
  • the dimensions of the printed circuit board according to the invention are preferably less than 100 mm ⁇ 80 mm, more preferably less than 73 mm ⁇ 39 mm.
  • at least one fastening device is preferably provided in the area of the OEM printed circuit board. This can be configured as a borehole for receiving a screw. According to the invention, the integration of the OEM printed circuit board according to the invention into any patient monitors is possible due to the compact design.
  • the power supply of the OEM printed circuit board according to the invention for example via the motherboard of the patient monitor.
  • Data communication between the OEM printed circuit board according to the invention and the patient monitor takes place via a definable protocol.
  • DE 103 21 338 A1 and DE 102 13 692 A1 are used, for example, to determine the pV.
  • the methods of DE 103 21 338 A1 and DE 102 13 692 A1 are to be understood as part of this application.
  • the device receives electromagnetic waves, in particular light, of at least two different wavelengths and / or of at least two different wavelength bands from at least one source, the source emitting the electromagnetic waves and passing them through a human tissue and / or vessels to be examined and the transmitted and / or reflected portion of the electromagnetic waves are detected by a receiving system, wherein the receiving system is adapted to detect the light signals of different wavelengths in a time interval of less than one second, in current and / or voltage Ie,
  • the at least one measured value is processed by an evaluation unit by a signal conditioning and a measured value independent of the original wavelength by active and / or passive electronic components is further processed to be displayed via an interface, for example on a display.
  • an analog or digital signal is generated from the pV which is made available to internal and / or external signal receivers via an interface, the measured value of at least one pV being available within a defined time, for example in the region of 10 seconds. evaluated and made available via the interface for display.
  • a SaO2 and / or a CaO2 and / or the cHb is determined.
  • Data representing the SaO2 and / or CaO2 and / or cHb at the time of measurement is determined and processed such that data representing the current measurements is delayed by less than 30 seconds, preferably less than 15 seconds, and most preferably less than 5 seconds, starting from the time of transmission of a first wavelength to the time of presentation, are available to a user and / or transmission via an interface.
  • the first time it becomes possible for the first time to non-invasively determine physiological variables, such as oxygen supply parameters in the periphery of the body, by providing a device and to provide information such that, depending on the measured values determined, the oxygen supply is direct and / or indirect in the time domain of less than 5 minutes, preferably less than 2 minutes, more preferably less than 30 seconds, can be represented.
  • physiological variables such as SaCO, SaO2, cHb, CaO2, bilirubin by a device and to provide information such that at least two of the pV are spaced at less than one minute, preferably less than 10 seconds, as information can be provided.
  • the first time to non-invasively determine physiological variables such as SaCO, SaO2, cHb, CaO2 or bilirubin by a device and to provide information such that at least two of the pV simultaneously display information as information on a display, for example can be provided.
  • physiological variables such as SaCO, SaO2, cHb, CaO2 or bilirubin

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

L'invention concerne un dispositif servant à la détermination optique de variables physiologiques dans des tissus perfusés. Le dispositif présente une première et une seconde sources lumineuses émettant respectivement un faisceau lumineux d'une première ou d'une seconde longueurs d'ondes prédéterminées. Les sources lumineuses sont disposées de telle façon que le faisceau lumineux provenant de ces sources puisse pénétrer dans le tissu perforé. On utilise au moins un photodétecteur disposé de manière à détecter la lumière émise par les sources lumineuses et rétrodiffusée par le tissu perfusé ou traversant ce dernier. Le dispositif présente en outre une unité de commande fournissant des signaux de commande aux sources lumineuses de façon que lesdites sources émettent une lumière en continu, alternativement les unes par rapport aux autres, cependant que dans ce processus, une ou plusieurs phases obscures peuvent être introduites, phases dans lesquelles au moins une source lumineuse n'émet aucune lumière. Un dispositif d'évaluation est connecté avec une sortie du photodétecteur et fournit, pour au moins une variable physiologique à mesurer, un signal de sortie décelable à une interface pouvant être liée avec le dispositif d'évaluation.
EP06828507A 2005-11-15 2006-11-02 Dispositif de determination de variables physiologiques Withdrawn EP1962669A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005054838 2005-11-15
PCT/DE2006/001934 WO2007056971A2 (fr) 2005-11-15 2006-11-02 Dispositif de determination de variables physiologiques

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EP1962669A2 true EP1962669A2 (fr) 2008-09-03

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US (1) US20090270699A1 (fr)
EP (1) EP1962669A2 (fr)
DE (1) DE112006003694A5 (fr)
WO (1) WO2007056971A2 (fr)

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WO2007056971A2 (fr) 2007-05-24
WO2007056971A3 (fr) 2007-11-29
DE112006003694A5 (de) 2008-10-23
US20090270699A1 (en) 2009-10-29

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