EP1945606A4 - ALKYLCARBAMOYLNAPHTALENYLOXYOCTENOYLHYDROXYAMIDE DERIVATIVES HAVING HISTONE DEACETYLASE INHIBITORY ACTIVITY AND SYNTHESIS OF THE DERIVATIVES - Google Patents

ALKYLCARBAMOYLNAPHTALENYLOXYOCTENOYLHYDROXYAMIDE DERIVATIVES HAVING HISTONE DEACETYLASE INHIBITORY ACTIVITY AND SYNTHESIS OF THE DERIVATIVES

Info

Publication number
EP1945606A4
EP1945606A4 EP06812321A EP06812321A EP1945606A4 EP 1945606 A4 EP1945606 A4 EP 1945606A4 EP 06812321 A EP06812321 A EP 06812321A EP 06812321 A EP06812321 A EP 06812321A EP 1945606 A4 EP1945606 A4 EP 1945606A4
Authority
EP
European Patent Office
Prior art keywords
octenoylhydroxyamide
derivatives
preparation
inhibitory activity
activity against
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06812321A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1945606A1 (en
Inventor
Cheol Hae Lee
Hee Jung Jung
Jae Hak Kim
Won Jang Jeong
Joong Myung Cho
Seonggu Ro
Young Lan Hyun
Dongkyu Shin
Cheol Soon Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korea Research Institute of Chemical Technology KRICT
CrystalGenomics Inc
Original Assignee
Korea Research Institute of Chemical Technology KRICT
CrystalGenomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Research Institute of Chemical Technology KRICT, CrystalGenomics Inc filed Critical Korea Research Institute of Chemical Technology KRICT
Publication of EP1945606A1 publication Critical patent/EP1945606A1/en
Publication of EP1945606A4 publication Critical patent/EP1945606A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/66—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP06812321A 2005-11-01 2006-10-31 ALKYLCARBAMOYLNAPHTALENYLOXYOCTENOYLHYDROXYAMIDE DERIVATIVES HAVING HISTONE DEACETYLASE INHIBITORY ACTIVITY AND SYNTHESIS OF THE DERIVATIVES Withdrawn EP1945606A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020050103693A KR100696139B1 (ko) 2005-11-01 2005-11-01 히스톤 디아세틸라제 저해활성을 갖는 알킬카바모일나프탈렌일옥시 옥테노일 하이드록시아마이드 유도체 및그의 제조방법
PCT/KR2006/004482 WO2007052938A1 (en) 2005-11-01 2006-10-31 Alkylcarbamoyl naphthalenyloxy- octenoylhydroxyamide derivatives having inhibitory activity against histone deacetylase and preparation thereof

Publications (2)

Publication Number Publication Date
EP1945606A1 EP1945606A1 (en) 2008-07-23
EP1945606A4 true EP1945606A4 (en) 2010-05-05

Family

ID=38006052

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06812321A Withdrawn EP1945606A4 (en) 2005-11-01 2006-10-31 ALKYLCARBAMOYLNAPHTALENYLOXYOCTENOYLHYDROXYAMIDE DERIVATIVES HAVING HISTONE DEACETYLASE INHIBITORY ACTIVITY AND SYNTHESIS OF THE DERIVATIVES

Country Status (7)

Country Link
EP (1) EP1945606A4 (pt)
JP (1) JP2009513697A (pt)
KR (1) KR100696139B1 (pt)
CN (1) CN101300226B (pt)
BR (1) BRPI0618131A2 (pt)
CA (1) CA2628040A1 (pt)
WO (1) WO2007052938A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100814092B1 (ko) 2006-11-03 2008-03-14 한국화학연구원 히스톤 디아세틸라제 저해활성을 갖는 알킬카바모일나프탈렌일옥시 옥테노일 하이드록시아마이드 유도체, 이의제조방법 및 이를 유효성분으로 하는 항암제용 약학조성물
US8053435B2 (en) 2006-11-03 2011-11-08 Korea Research Institute Of Chemical Technology Naphthalenyloxypropenyl derivatives having inhibitory activity against histone deacetylase and pharmaceutical composition comprising the same
US8450525B2 (en) * 2007-10-22 2013-05-28 Orchid Chemicals & Pharmaceuticals Limited Histone deacetylase inhibitors
EP2112152A1 (en) 2008-04-22 2009-10-28 GPC Biotech AG Dihydropteridinones as Plk Inhibitors
WO2010067980A2 (ko) * 2008-12-11 2010-06-17 대한민국(관리부서 질병관리본부장) 잠복성 ｈｉｖ 감염 세포에서 ｈｉｖ-1 프로바이러스를 재활성화시키는 히스톤 디아세틸라제 억제제
KR101978364B1 (ko) * 2017-06-15 2019-05-14 크리스탈지노믹스(주) 알킬카바모일 나프탈렌일옥시 옥테노일 하이드록시아마이드 또는 그 유도체의 약학적으로 허용 가능한 염 및 그 제조방법
KR20190113639A (ko) * 2018-03-28 2019-10-08 크리스탈지노믹스(주) 섬유화증 예방 또는 치료용 약학 조성물
KR102678356B1 (ko) * 2018-10-29 2024-06-26 씨지인바이츠 주식회사 알킬카바모일 나프탈렌일옥시 옥테노일 하이드록시아마이드 인산염, 타르타르산염 또는 이들의 조합을 포함하는 약제학적 조성물 및 그 제조방법
CN110105213B (zh) * 2019-06-06 2022-03-25 唐山师范学院 一种(e)-2-(萘基-1-氧甲基)-2-二辛烯酸-8-酯的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020115826A1 (en) * 2000-03-24 2002-08-22 Daniel Delorme Inhibitors of histone deacetylase

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020059393A (ko) * 1999-09-08 2002-07-12 제임스 에스. 쿼크 새로운 부류의 세포분화제 및 히스톤 데아세틸라아제, 및이의 사용 방법
EA007272B1 (ru) * 2002-03-13 2006-08-25 Янссен Фармацевтика Н. В. Новые ингибиторы гистондеацетилазы
EP1485348B1 (en) * 2002-03-13 2008-06-11 Janssen Pharmaceutica N.V. Carbonylamino-derivatives as novel inhibitors of histone deacetylase
WO2003087066A1 (en) * 2002-04-11 2003-10-23 Sk Chemicals, Co., Ltd. α,β-UNSATURATED HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS
ITMI20030025A1 (it) * 2003-01-10 2004-07-11 Italfarmaco Spa Derivati dell'acido idrossammico ad attivita' antinfiammatoria.
US7465719B2 (en) * 2003-01-17 2008-12-16 Topotarget Uk Limited Carbamic acid compounds comprising an ester or ketone linkage as HDAC inhibitors
WO2004076386A2 (en) * 2003-02-25 2004-09-10 Topotarget Uk Limited Carbamic acid compounds comprising a bicyclic heteroaryl group as hdac inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020115826A1 (en) * 2000-03-24 2002-08-22 Daniel Delorme Inhibitors of histone deacetylase

Also Published As

Publication number Publication date
CA2628040A1 (en) 2007-05-10
EP1945606A1 (en) 2008-07-23
CN101300226B (zh) 2012-05-30
BRPI0618131A2 (pt) 2011-08-16
KR100696139B1 (ko) 2007-03-20
WO2007052938A1 (en) 2007-05-10
CN101300226A (zh) 2008-11-05
JP2009513697A (ja) 2009-04-02

Similar Documents

Publication Publication Date Title
EP2089354A4 (en) NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING HISTONE DEACETYLASE INHIBITORY ACTIVITY AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
EP1945606A4 (en) ALKYLCARBAMOYLNAPHTALENYLOXYOCTENOYLHYDROXYAMIDE DERIVATIVES HAVING HISTONE DEACETYLASE INHIBITORY ACTIVITY AND SYNTHESIS OF THE DERIVATIVES
IL188692A0 (en) Histone deacetylase inhibitors
EP1945617A4 (en) HISTONDEACETYLASEINHIBITORS WITH ARYLPYRAZOLYL MOTIVES
ZA200902632B (en) Haloalkylsufonanilide derivative or salt thereof, herbicide comprising the derivative as active ingredient, and use of the herbicide
EP1940805A4 (en) BENZODIAZEPIN AND BENZOPIPERAZINANALOGA AS INHIBITORS OF HISTONDEACETYLASE
EP1771167A4 (en) INHIBITORS OF HISTONE DEACETYLASE
EP1991247A4 (en) BIFUNCTIONAL HISTONE DEACETYLASE INHIBITORS
IL190292A (en) History of pyridopyrimidinone and their pharmaceutical preparations
EP1735319A4 (en) Histone deacetylase INHIBITORS
EP1755601A4 (en) HISTONE DEACETYLASE INHIBITORS
EP1789381A4 (en) Histone deacetylase INHIBITORS
EP2170339A4 (en) PYRIDYL AND PYRIMIDINYL DERIVATIVES AS HISTONDEACETYLASE INHIBITORS
IL195675A0 (en) Human binding molecules having killing activity against staphylococci and uses thereof
EP1816915A4 (en) CURCUMINOID COMPOSITIONS HAVING A SYNERGISTIC INHIBITION OF THE EXPRESSION AND / OR ACTIVITY OF CYCLOOXYGENASE-2
EP1909780A4 (en) AGAINST TUBERCULOSIS, COMPOSITIONS AND PROCEDURES
IL196113A0 (en) N-(aminoheteroaryl)-1h-indole-2-carboxamide derivatives, preparation thereof and therapeutic use thereof
IL198263A0 (en) Hydroxamates as inhibitors of histone deacetylase
IL193458A0 (en) Histone deacetylase inhibitors
AP2009004747A0 (en) Compounds having a potentiating effect on the activity of ethoionamide and uses thereof
ZA200708749B (en) Hydroxamates as histone deacetylase inhibitors and pharmaceutical formulations containing them
IL196136A (en) Its aminoindane or salt derivative, the pharmaceutical composition containing them and their uses
EP1784386A4 (en) HISTONE DEACETYLASE INHIBITORS
EP2208721A4 (en) HISTONE DEACETYLASE INHIBITOR, COMPOSITION AND USE THEREOF
EP2045253A4 (en) alpha-amino acid derivative and pharmaceutical agent containing it as an active ingredient

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20080529

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Owner name: CRYSTALGENOMICS, INC.

RIN1 Information on inventor provided before grant (corrected)

Inventor name: JUNG, HEE JUNG

Inventor name: LEE, CHEOL SOON6F, 2ND BUILDING OF ASAN INSTITUTE

Inventor name: JEONG, WON JANG

Inventor name: CHO, JOONG MYUNG

Inventor name: RO, SEONGGU

Inventor name: SHIN, DONGKYU

Inventor name: HYUN, YOUNG LAN

Inventor name: LEE, CHEOL HAE

Inventor name: KIM, JAE HAK

RIN1 Information on inventor provided before grant (corrected)

Inventor name: KIM, JAE HAK

Inventor name: RO, SEONGGU

Inventor name: HYUN, YOUNG LAN

Inventor name: SHIN, DONGKYU

Inventor name: LEE, CHEOL HAE

Inventor name: JUNG, HEE JUNG

Inventor name: JEONG, WON JANG

Inventor name: CHO, JOONG MYUNG

Inventor name: LEE, CHEOL SOON6F, 2ND BUILDING OF ASAN INSTITUTE

A4 Supplementary search report drawn up and despatched

Effective date: 20100408

RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 295/13 20060101ALI20100331BHEP

Ipc: C07D 207/14 20060101ALI20100331BHEP

Ipc: A61K 31/495 20060101ALI20100331BHEP

Ipc: A61K 31/40 20060101ALI20100331BHEP

Ipc: C07C 237/32 20060101AFI20070628BHEP

Ipc: C07D 211/58 20060101ALI20100331BHEP

Ipc: A61P 35/00 20060101ALI20100331BHEP

Ipc: A61K 31/165 20060101ALI20100331BHEP

Ipc: A61K 31/175 20060101ALI20100331BHEP

Ipc: A61K 31/445 20060101ALI20100331BHEP

Ipc: C07C 259/06 20060101ALI20100331BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20100708

18RA Request filed for re-establishment of rights before grant

Effective date: 20110413