EP1937224A2 - Produits pour le soin de la peau - Google Patents

Produits pour le soin de la peau

Info

Publication number
EP1937224A2
EP1937224A2 EP06777902A EP06777902A EP1937224A2 EP 1937224 A2 EP1937224 A2 EP 1937224A2 EP 06777902 A EP06777902 A EP 06777902A EP 06777902 A EP06777902 A EP 06777902A EP 1937224 A2 EP1937224 A2 EP 1937224A2
Authority
EP
European Patent Office
Prior art keywords
formulation according
weight
emulsion
urea
hyaluronic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06777902A
Other languages
German (de)
English (en)
Inventor
Thomas Neubourg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neubourg Skin Care GmbH and Co KG
Original Assignee
Neubourg Skin Care GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neubourg Skin Care GmbH and Co KG filed Critical Neubourg Skin Care GmbH and Co KG
Priority to EP10004152A priority Critical patent/EP2238977A3/fr
Publication of EP1937224A2 publication Critical patent/EP1937224A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/046—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A61K8/556—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/122—Foams; Dry foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin

Definitions

  • the invention relates to skin care products, in particular for the treatment and care of dry skin conditions and chronic dermatoses.
  • the skin care products are useful in dermatoses including atopic dermatitis, allergic contact dermatitis, irritant contact dermatitis, psoriasis, and are particularly useful for treating dry skin and its concomitants such as inflammation, ulcers, etc. that occur in diabetes mellitus, diabetic foot syndrome.
  • DFS diabetic foot syndrome
  • dermatoses such as atopic dermatitis, allergic contact dermatitis, irritant contact dermatitis, psoriasis and especially dry skin and their Concomitants such as inflammation, ulcers, etc., which occur in diabetes mellitus, the diabetic foot syndrome, as well as for profilaxe suitable.
  • the invention relates in one aspect to formulations comprising an aqueous emulsion and propellant gas for a foam skin cream, characterized in that the emulsion comprises urea and hyaluronic acid, at least one free fatty acid and at least two emulsifiers, the hyaluronic acid having a molecular weight of at least 1 x 10 5 As has.
  • the invention relates to formulations comprising an aqueous emulsion and propellant gas for a foam skin cream, characterized in that the emulsion comprises urea and a carbohydrate mixture obtained from naturally occurring carbohydrates, at least one free fatty acid and at least two emulsifiers.
  • the invention relates to formulations comprising an aqueous emulsion and propellant for a foam skin cream, characterized in that the emulsion comprises at least one free fatty acid and at least two emulsifiers and with the aid of potassium hydroxide to a pH of 5.5 to 8 is set.
  • the invention further relates to a day and night skin care kit comprising a day skin care composition and a night skin care composition, wherein the day skin care composition is a foam skin cream comprising at least one free fatty acid and at least two emulsifiers, wherein the night skin care composition comprises an additional active ingredient or a higher% by weight.
  • the day skin care composition is a foam skin cream comprising at least one free fatty acid and at least two emulsifiers
  • the night skin care composition comprises an additional active ingredient or a higher% by weight.
  • Content of active ingredient or an active substance other than the day skin care composition wherein the Active ingredient selected from the group of lipid substances and hydrating substances or mixtures thereof.
  • a night skin care composition according to the invention is applied to the skin to be treated.
  • the dermatoses are e.g. dry skin conditions, chronic dermatoses, atopic dermatitis, allergic contact dermatitis, irritant contact dermatitis, psoriasis and diabetic foot syndrome.
  • Foam creams are aerosols which are formed from an emulsion by means of propellant gas by spraying from a suitable container / dosage form.
  • the foam skin cream of the present invention is produced by spraying a formulation containing an aqueous emulsion and propellant gas from a pressurized container.
  • propellant all pharmaceutically acceptable propellant gases can be used, which are suitable for the production of cream foams.
  • the aqueous emulsion contains all constituents of the formulation except the propellant gas.
  • urea causes an increase in the water binding capacity of the horny layer both inter- and intracellularly. Its low molecular weight and the resulting strong osmotic properties as well as its polarity and the resulting hygroscopic properties give the urea its effectiveness. In native form, urea is present as a bipolar molecule, at the positive or negative pole preferably water molecules over
  • Hyaluronic acid is a natural, endogenous polymer of carbohydrates and highly hygroscopic. Due to its physicochemical structure, hyaluronic acid forms a network of polysaccharides capable of binding water and improving the elasticity of the epidermis. In particular, the high molecular weight hyaluronic acid is able to form such networks and act through their physical properties within the foam cream of the invention. In particular, it has been found in the context of this invention that the hyaluronic acid has a stabilizing effect on the foam structure and thus provides for the formation of the network structure on the skin and the associated protective function.
  • the emulsion also contains unsaturated and / or polyunsaturated fatty acids, such as omega-6 Fatty acids, as known, for example, from evening primrose oil and borage oil. It is possible, for example, to use synthetic omega-6 fatty acids or also those derived from plants.
  • the emulsion contains evening primrose oil.
  • Suitable further moisurizers are propylene glycol and / or polyhydric alcohols, in particular glycerol. Moisturizers may be added in amounts of 1-10% by weight, preferably 2.5-8.5% by weight. Preferably, glycerol and propylene glycol are added.
  • purslane is used in one aspect of the invention.
  • Purslane can be used in amounts of from 0.01 to 2% by weight, preferably about 0.1% by weight.
  • the formulations according to the invention also have a skin-compatible pH, such as from 7.0 to 8.0, 5.5 to 8 or 6.5 to 7.5.
  • a skin-compatible pH such as from 7.0 to 8.0, 5.5 to 8 or 6.5 to 7.5.
  • AMP 2-amino-2-methyl-l-propanol
  • potassium hydroxide is used as described above.
  • a foam skin cream is used, which may for example be one of the formulations described above. Especially the foam formulation offers an increased ease of use and a good protective function, which correspond to the daily application.
  • a night skin care composition is also a foam skin cream in question, but also greasy ointments and lotions can be used here.
  • the active ingredients contained, such as lipid substances and hydrating substances of the day skin care composition and the night skin care composition are coordinated.
  • both skin care compositions may contain the same active ingredient or the same active ingredient combination, wherein the
  • the day skin care composition is a formulation containing urea and hyaluronic acid as described above and the night skin care composition is a formulation containing urea, hyaluronic acid and the carbohydrate mixture.
  • a formulation which contains 11% urea, 0.2% hyaluronic acid and is adjusted to a pH of about 7 by adding KOH as the base is suitable here for the day cream skin foam.
  • a night skin care comprising a formulation containing 11% by weight of urea, 0.2% by weight of hyaluronic acid, and 0.6 and 1.25% by weight of the carbohydrate mixture in the form of pentavidin® and with KOH with a pH of about 7, combined.
  • the day skin care is a formulation containing urea, preferably 5 to 17% urea or 5 to 15% urea
  • the night skin care is a formulation comprising a carbohydrate mixture and optionally hyaluronic acid as described in this application, contains, or vice versa.
  • day cream care is a formulation containing 16.5% urea and 1% evening primrose oil, which may also be adjusted to about pH 7 with KOH. As night skin care becomes the
  • an ointment having the exemplary composition shown below is used.
  • the day and night skin care kit according to the present invention and as described above comprising a day skin care composition and a night skin care composition is suitable for many applications.
  • a day skin care composition for the treatment and care of dry skin conditions and chronic Dermatoses.
  • stressed skin areas such as hands and feet of athletes, can be treated and (further) skin damage can be prevented.
  • Example 1 The foam creams are produced in a heatable and coolable closed apparatus with a self-discharging homogenizer and a heatable metering funnel.
  • Phase I is produced in a heatable metering funnel by melting a mixture containing 2% by weight of glyceryl stearate, 4% by weight.
  • Day Care Composition Foam cream formulation with an emulsion containing 16.5% urea and 1% evening primrose oil
  • Nourishing composition in the form of an ointment having the following composition:
  • IPM Isopropyl myristate
  • Prunus dulcis (almond oil) 16,00
  • the formulations are stored for two weeks at about 11 ° C or at about 35 ° C and then sprayed on a smooth surface.
  • the stability of the sprayed foams is assessed visually and evaluated on the basis of a rating scale of 1-4, where 1 represents the worst stability and 4 the best stability.
  • Examples 1 (ae) are based on the composition of Example 2 (5.5% urea), Examples 2 (ae) are based on the composition of Example 3 (11% urea) and Examples 3 (ae) on the composition of Example 2 or 3, containing 16.5% urea.
  • the base and the amount of hyaluronic acid were changed and the stability after storage was tested.
  • the KOH examples are more stable than the AMP or NaOH examples. It can also be seen that the use of hyaluronic acid causes an increase in stability and a further increase in stability is caused by the use of 0.2% by weight instead of 0.1% by weight. The best results are achieved using KOH as the base and 0.2% hyaluronic acid.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne une formulation comprenant une émulsion aqueuse et un gaz propulseur, cette formulation étant destinée à une crème moussante pour la peau. L'invention se caractérise en ce que l'émulsion contient de l'urée et de l'acide hyaluronique, au moins un acide gras libre et au moins deux émulsifiants, l'acide hyaluronique présentant un poids moléculaire d'au moins 1 x 10<SUP>5</SUP> Da.
EP06777902A 2005-09-28 2006-07-21 Produits pour le soin de la peau Withdrawn EP1937224A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10004152A EP2238977A3 (fr) 2005-09-28 2006-07-21 Produits pour le soin de la peau

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72117005P 2005-09-28 2005-09-28
DE202005015309 2005-09-28
US78539106P 2006-03-23 2006-03-23
DE202006004676U DE202006004676U1 (de) 2005-09-28 2006-03-23 Hautpflegeprodukte
PCT/EP2006/064533 WO2007036376A2 (fr) 2005-09-28 2006-07-21 Produits pour le soin de la peau

Publications (1)

Publication Number Publication Date
EP1937224A2 true EP1937224A2 (fr) 2008-07-02

Family

ID=37763493

Family Applications (2)

Application Number Title Priority Date Filing Date
EP06777902A Withdrawn EP1937224A2 (fr) 2005-09-28 2006-07-21 Produits pour le soin de la peau
EP10004152A Withdrawn EP2238977A3 (fr) 2005-09-28 2006-07-21 Produits pour le soin de la peau

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP10004152A Withdrawn EP2238977A3 (fr) 2005-09-28 2006-07-21 Produits pour le soin de la peau

Country Status (5)

Country Link
US (2) US20080241079A1 (fr)
EP (2) EP1937224A2 (fr)
CA (1) CA2624356A1 (fr)
DE (2) DE202006004676U1 (fr)
WO (1) WO2007036376A2 (fr)

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US20070098647A1 (en) 2007-05-03
US20080241079A1 (en) 2008-10-02
EP2238977A3 (fr) 2010-12-22
WO2007036376A3 (fr) 2007-09-20
EP2238977A2 (fr) 2010-10-13
DE202006014258U1 (de) 2006-11-16
WO2007036376A2 (fr) 2007-04-05
DE202006004676U1 (de) 2007-02-08

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