EP1909973A4 - Polymer coatings containing drug powder of controlled morphology - Google Patents

Polymer coatings containing drug powder of controlled morphology

Info

Publication number
EP1909973A4
EP1909973A4 EP20060787258 EP06787258A EP1909973A4 EP 1909973 A4 EP1909973 A4 EP 1909973A4 EP 20060787258 EP20060787258 EP 20060787258 EP 06787258 A EP06787258 A EP 06787258A EP 1909973 A4 EP1909973 A4 EP 1909973A4
Authority
EP
European Patent Office
Prior art keywords
polymer coatings
drug powder
containing drug
coatings containing
controlled morphology
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP20060787258
Other languages
German (de)
French (fr)
Other versions
EP1909973B1 (en
EP1909973A2 (en
Inventor
Doug Taylor
Jim Mcclain
Clint Smoke
Mike Cole
James Deyoung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MiCell Technologies Inc
Original Assignee
MiCell Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37669385&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP1909973(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by MiCell Technologies Inc filed Critical MiCell Technologies Inc
Priority to PL06787258T priority Critical patent/PL1909973T3/en
Publication of EP1909973A2 publication Critical patent/EP1909973A2/en
Publication of EP1909973A4 publication Critical patent/EP1909973A4/en
Application granted granted Critical
Publication of EP1909973B1 publication Critical patent/EP1909973B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0076—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof multilayered, e.g. laminated structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/426—Immunomodulating agents, i.e. cytokines, interleukins, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/63—Crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/08—Coatings comprising two or more layers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/26—Web or sheet containing structurally defined element or component, the element or component having a specified physical dimension
    • Y10T428/263—Coating layer not in excess of 5 mils thick or equivalent
    • Y10T428/264—Up to 3 mils
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/26—Web or sheet containing structurally defined element or component, the element or component having a specified physical dimension
    • Y10T428/263—Coating layer not in excess of 5 mils thick or equivalent
    • Y10T428/264—Up to 3 mils
    • Y10T428/265—1 mil or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31507—Of polycarbonate
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/3154—Of fluorinated addition polymer from unsaturated monomers
    • Y10T428/31544—Addition polymer is perhalogenated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31551—Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31652—Of asbestos
    • Y10T428/31663—As siloxane, silicone or silane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31786—Of polyester [e.g., alkyd, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31855—Of addition polymer from unsaturated monomers
    • Y10T428/31935—Ester, halide or nitrile of addition polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31855—Of addition polymer from unsaturated monomers
    • Y10T428/31938—Polymer of monoethylenically unsaturated hydrocarbon

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
EP06787258.0A 2005-07-15 2006-07-14 Polymer coatings containing drug powder of controlled morphology Active EP1909973B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL06787258T PL1909973T3 (en) 2005-07-15 2006-07-14 Polymer coatings containing drug powder of controlled morphology

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US69965005P 2005-07-15 2005-07-15
US75233805P 2005-12-20 2005-12-20
US77106606P 2006-02-07 2006-02-07
US77172506P 2006-02-08 2006-02-08
US74573306P 2006-04-26 2006-04-26
US74573106P 2006-04-26 2006-04-26
PCT/US2006/027321 WO2007011707A2 (en) 2005-07-15 2006-07-14 Polymer coatings containing drug powder of controlled morphology

Publications (3)

Publication Number Publication Date
EP1909973A2 EP1909973A2 (en) 2008-04-16
EP1909973A4 true EP1909973A4 (en) 2012-03-07
EP1909973B1 EP1909973B1 (en) 2018-08-22

Family

ID=37669385

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06787258.0A Active EP1909973B1 (en) 2005-07-15 2006-07-14 Polymer coatings containing drug powder of controlled morphology

Country Status (11)

Country Link
US (6) US8298565B2 (en)
EP (1) EP1909973B1 (en)
JP (3) JP5756588B2 (en)
KR (1) KR101406415B1 (en)
CN (2) CN105233349B (en)
AU (1) AU2006270221B2 (en)
CA (1) CA2615452C (en)
ES (1) ES2691646T3 (en)
HK (2) HK1217662A1 (en)
PL (1) PL1909973T3 (en)
WO (1) WO2007011707A2 (en)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8458879B2 (en) * 2001-07-03 2013-06-11 Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. Method of fabricating an implantable medical device
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US7702764B1 (en) * 2004-01-30 2010-04-20 Cisco Technology, Inc. System and method for testing network protocols
US20070009564A1 (en) * 2005-06-22 2007-01-11 Mcclain James B Drug/polymer composite materials and methods of making the same
CN105233349B (en) 2005-07-15 2019-06-18 胶束技术股份有限公司 The polymer coating of drug powder comprising controlled morphology
US20090062909A1 (en) 2005-07-15 2009-03-05 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
US7842312B2 (en) 2005-12-29 2010-11-30 Cordis Corporation Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same
CA2650590C (en) 2006-04-26 2018-04-03 Micell Technologies, Inc. Coatings containing multiple drugs
US20080234810A1 (en) * 2006-06-28 2008-09-25 Abbott Cardiovascular Systems Inc. Amorphous Glass-Coated Drug Delivery Medical Device
WO2008042909A2 (en) 2006-10-02 2008-04-10 Micell Technologies Inc. Surgical sutures having increased strength
CA2667228C (en) 2006-10-23 2015-07-14 Micell Technologies, Inc. Holder for electrically charging a substrate during coating
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
CN101711137B (en) 2007-01-08 2014-10-22 米歇尔技术公司 Stents having biodegradable layers
EP2491962A1 (en) 2007-01-21 2012-08-29 Hemoteq AG Medical product for treating closures of bodily passages and preventing reclosures
BRPI0810370A2 (en) * 2007-04-17 2014-10-29 Micell Technologies Inc STENT COATED, AND METHOD FOR PREPARING A STENT
JP2010527746A (en) * 2007-05-25 2010-08-19 ミセル テクノロジーズ、インコーポレイテッド Polymer film for medical device coating
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
EP2018864A1 (en) * 2007-07-23 2009-01-28 Biomet Deutschland GmbH Pharmaceutical composition, substrate comprising a pharmaceutical composition, and use of a pharmaceutical composition
US20100298928A1 (en) * 2007-10-19 2010-11-25 Micell Technologies, Inc. Drug Coated Stents
US20090228097A1 (en) * 2008-03-07 2009-09-10 Abbott Cardiovascular Systems Inc. A1 Adenosine Receptor Antagonist-Coated Implantable Medical Device
CN102083397B (en) 2008-04-17 2013-12-25 米歇尔技术公司 Stents having bioabsorbable layers
KR101104901B1 (en) 2008-05-23 2012-01-12 김영곤 manufacturing method of thermo-rod for active drug release the thermo-rod
AU2009253739B2 (en) 2008-05-27 2014-02-06 Otolanum Ag Methods of treating mammals with eustachian tube dysfunctions
WO2010009335A1 (en) 2008-07-17 2010-01-21 Micell Technologies, Inc. Drug delivery medical device
CN102238946B (en) * 2008-11-07 2014-11-26 株式会社三养生物制药 Pharmaceutical composition for the controlled release of methylphenidate
US8834913B2 (en) 2008-12-26 2014-09-16 Battelle Memorial Institute Medical implants and methods of making medical implants
US20120231037A1 (en) * 2009-02-02 2012-09-13 Yissum Research Development Companyof the Hebrew U Crystalline drug-containing coatings
US9636255B2 (en) 2009-02-13 2017-05-02 Dose Medical Corporation Uveoscleral drug delivery implant and methods for implanting the same
WO2010111238A2 (en) * 2009-03-23 2010-09-30 Micell Technologies, Inc. Improved biodegradable polymers
US20100241220A1 (en) * 2009-03-23 2010-09-23 Mcclain James B Peripheral Stents Having Layers
EP2411083A4 (en) * 2009-03-23 2013-11-13 Micell Technologies Inc Drug delivery medical device
WO2010120552A2 (en) 2009-04-01 2010-10-21 Micell Technologies, Inc. Coated stents
EP3366326A1 (en) 2009-04-17 2018-08-29 Micell Technologies, Inc. Stents having controlled elution
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
WO2012071476A2 (en) 2010-11-24 2012-05-31 David Haffner Drug eluting ocular implant
US8888840B2 (en) * 2009-05-20 2014-11-18 Boston Scientific Scimed, Inc. Drug eluting medical implant
US9265633B2 (en) 2009-05-20 2016-02-23 480 Biomedical, Inc. Drug-eluting medical implants
ES2550634T3 (en) 2009-07-10 2015-11-11 Boston Scientific Scimed, Inc. Use of nanocrystals for a drug delivery balloon
EP2453834A4 (en) 2009-07-16 2014-04-16 Micell Technologies Inc Drug delivery medical device
US10080821B2 (en) 2009-07-17 2018-09-25 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
CA2774034C (en) * 2009-10-13 2017-05-09 Sebastian Schmidt Method for deactivating undesired contaminations in leech extracts
WO2011097103A1 (en) 2010-02-02 2011-08-11 Micell Technologies, Inc. Stent and stent delivery system with improved deliverability
US8795762B2 (en) 2010-03-26 2014-08-05 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
CA2794704C (en) * 2010-04-16 2019-09-17 Micell Technologies, Inc. Stents having controlled elution
CA2797110C (en) 2010-04-22 2020-07-21 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
CA2805631C (en) 2010-07-16 2018-07-31 Micell Technologies, Inc. Drug delivery medical device
US8889211B2 (en) 2010-09-02 2014-11-18 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
US9636309B2 (en) 2010-09-09 2017-05-02 Micell Technologies, Inc. Macrolide dosage forms
WO2012083594A1 (en) * 2010-12-24 2012-06-28 Dongguan Tiantianxiangshang Medical Technology Co., Ltd Biodegradable drug eluting stent and methodsｏf making the same.
US10464100B2 (en) 2011-05-31 2019-11-05 Micell Technologies, Inc. System and process for formation of a time-released, drug-eluting transferable coating
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
US10117972B2 (en) 2011-07-15 2018-11-06 Micell Technologies, Inc. Drug delivery medical device
WO2013022458A1 (en) 2011-08-05 2013-02-14 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
US20140257465A1 (en) * 2011-08-12 2014-09-11 Micell Technologies, Inc. Stents having controlled elution
WO2013028208A1 (en) 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
AU2012326010B2 (en) * 2011-10-18 2017-05-11 Micell Technologies, Inc. Drug delivery medical device
JP5933234B2 (en) * 2011-11-24 2016-06-08 国立大学法人東北大学 Fine particle production equipment
FR2987266B1 (en) * 2012-02-28 2014-12-19 Debregeas Et Associes Pharma PROCESS FOR OBTAINING A PHARMACEUTICAL COMPOSITION BASED ON MODAFINIL, PHARMACEUTICAL COMPOSITION THUS OBTAINED AND ITS APPLICATION
MX2015006002A (en) * 2012-11-14 2016-02-05 Orthopaedic Innovation Ct Inc Antimicrobial articles produced by additive manufacturing.
KR20150143476A (en) 2013-03-12 2015-12-23 미셀 테크놀로지즈, 인코포레이티드 Bioabsorbable biomedical implants
US10517759B2 (en) 2013-03-15 2019-12-31 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
WO2014186532A1 (en) * 2013-05-15 2014-11-20 Micell Technologies, Inc. Bioabsorbable biomedical implants
CN103566414B (en) * 2013-08-13 2016-01-13 重庆大学 A kind of nucleocapsid structure receives particulate coatings intravascular stent and preparation method thereof
DE102013110294B4 (en) * 2013-09-18 2016-07-07 Innora Gmbh Limus depot formulation on balloon catheters
GB201317756D0 (en) * 2013-10-08 2013-11-20 Critical Pharmaceuticals Ltd New process
WO2015181826A1 (en) 2014-05-27 2015-12-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Crystalline coating and release of bioactive agents
EP3148491B1 (en) 2014-05-29 2020-07-01 Glaukos Corporation Implants with controlled drug delivery features and manufacturing method for said implants
DE102014014771A1 (en) * 2014-10-10 2016-04-14 Alexander Rübben Gefäßendoprothesenbeschichtung
US10086116B2 (en) * 2015-08-31 2018-10-02 Ethicon Llc Adjunct material to provide controlled drug release
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
US20170065521A1 (en) 2015-09-09 2017-03-09 Micell Technologies, Inc. Biopharma application of micell technology
GB201516683D0 (en) * 2015-09-21 2015-11-04 Univ Bolton Vascular graft
WO2017053885A1 (en) 2015-09-25 2017-03-30 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
US10365229B2 (en) * 2015-12-31 2019-07-30 Kaiser Optical Systems, Inc. Real-time characterization of pharmaceutical tablet coatings using Raman spectroscopy
EP3442479A1 (en) 2016-04-20 2019-02-20 Harold Alexander Heitzmann Bioresorbable ocular drug delivery device
RU2619836C1 (en) * 2016-07-26 2017-05-18 Акционерное общество "Медсил" Antimicrobial composition based on siloxane rubber
US20180085498A1 (en) 2016-09-23 2018-03-29 Micell Technologies, Inc. Prolonged drug-eluting products
CN106512084B (en) * 2016-11-02 2019-04-09 中山大学附属口腔医院 Titanium implant surface bioactive film with implantation mechanical damage resistance and adjustable mechanical property and preparation method and application thereof
JP6235749B1 (en) * 2017-07-07 2017-11-22 長瀬産業株式会社 COATING GUN, COATING DEVICE, AND COATING METHOD
WO2019143687A1 (en) 2018-01-17 2019-07-25 Micell Technologies Transfer ring
CN108283626B (en) * 2018-02-06 2021-02-26 江苏长泰药业有限公司 Film for blocking drug release and preparation thereof
WO2019222856A1 (en) 2018-05-24 2019-11-28 Nureva Inc. Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones
WO2019226519A1 (en) 2018-05-24 2019-11-28 Celanese EVA Performance Polymers Corporation Implantable device for sustained release of a macromolecular drug compound
SG11202005947RA (en) 2018-05-24 2020-07-29 Celanese Eva Performance Polymers Corp Implantable device for sustained release of a macromolecular drug compound
US11998654B2 (en) 2018-07-12 2024-06-04 Bard Shannon Limited Securing implants and medical devices
CN110856692B (en) * 2018-08-22 2024-08-09 深圳善康医药科技股份有限公司 Automatic coating device and coating process for implant
CN109663142B (en) * 2018-09-30 2021-06-22 温州医科大学 Drug-loaded degradable surgical sewing thread and preparation method thereof
KR20200107009A (en) * 2019-03-05 2020-09-16 (주)시지바이오 Drug eluting stent and manufacturing method of the same
AU2020101017A4 (en) * 2019-06-17 2020-07-23 David Decorte Gas Treatment System and Method
KR102054346B1 (en) * 2019-06-20 2019-12-10 한국지질자원연구원 A controlled-release composition comprising a complex of a clay mineral and alpha adrenergic blocking agent for administration
DE102020101197A1 (en) * 2020-01-20 2021-07-22 Charité - Universitätsmedizin Berlin Medical device for drug delivery with enhanced effect
WO2021188178A1 (en) * 2020-03-20 2021-09-23 The Regents Of The University Of California Implantable drug delivery devices for localized drug delivery
CN113577383B (en) * 2021-07-21 2022-10-14 西南交通大学 Metal-organic/inorganic hybrid coating for promoting bone regeneration and regulating corrosion on degradable metal surface and preparation method thereof
CN117771451B (en) * 2024-02-28 2024-05-17 柔脉医疗(深圳)有限公司 Artificial vascular stent and preparation method and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030222017A1 (en) * 2002-05-28 2003-12-04 Battelle Memorial Institute Electrostatic deposition of particles generated from rapid expansion of supercritical fluid solutions

Family Cites Families (621)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123077A (en) 1964-03-03 Surgical suture
US3087860A (en) 1958-12-19 1963-04-30 Abbott Lab Method of prolonging release of drug from a precompressed solid carrier
US3087660A (en) 1962-07-24 1963-04-30 Yankee Plasties Inc Two-step garment hanger
US3457280A (en) 1967-06-12 1969-07-22 American Cyanamid Co Alpha-glycolide and methods for the isolation thereof
US3597449A (en) 1967-11-16 1971-08-03 American Cyanamid Co Stable glycolide and lactide composition
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
DE2010115A1 (en) 1970-03-04 1971-09-16 Farbenfabriken Bayer Ag, 5090 Leverkusen Process for the production of micro-granules
ZA737247B (en) * 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation
US4000137A (en) 1975-06-10 1976-12-28 American Home Products Corporation Antitumor derivatives of periodate-oxidized nucleosides
US4188373A (en) 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4285987A (en) 1978-10-23 1981-08-25 Alza Corporation Process for manufacturing device with dispersion zone
JPS5668674A (en) 1979-11-08 1981-06-09 Shionogi & Co Ltd 5-fluorouracil derivative
US4326532A (en) 1980-10-06 1982-04-27 Minnesota Mining And Manufacturing Company Antithrombogenic articles
US4389330A (en) 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4675189A (en) 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US4474572A (en) 1981-09-29 1984-10-02 Syntex (U.S.A.) Inc. Implanting device and implant magazine
SE445884B (en) 1982-04-30 1986-07-28 Medinvent Sa DEVICE FOR IMPLANTATION OF A RODFORM PROTECTION
US4530840A (en) 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
SE435444B (en) 1983-02-25 1984-10-01 Hakan Johansson Fishing gear with a fishing line made by a light guide
US4606347A (en) 1983-03-25 1986-08-19 Thomas J. Fogarty Inverted balloon catheter having sealed through lumen
US4478822A (en) 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US4582731A (en) 1983-09-01 1986-04-15 Battelle Memorial Institute Supercritical fluid molecular spray film deposition and powder formation
US4734227A (en) 1983-09-01 1988-03-29 Battelle Memorial Institute Method of making supercritical fluid molecular spray films, powder and fibers
US4734451A (en) 1983-09-01 1988-03-29 Battelle Memorial Institute Supercritical fluid molecular spray thin films and fine powders
US6309669B1 (en) 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
US5102417A (en) 1985-11-07 1992-04-07 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4985625A (en) 1986-03-06 1991-01-15 Finnigan Corporation Transfer line for mass spectrometer apparatus
US4762593A (en) 1986-06-13 1988-08-09 Youngner Philip G Distilling apparatus
US4758435A (en) 1986-08-11 1988-07-19 American Cyanamid Company Estradiol implant composition and method for preparation
JPH068902Y2 (en) 1988-04-19 1994-03-09 マツダ株式会社 Starting safety device for vehicle
US5106650A (en) 1988-07-14 1992-04-21 Union Carbide Chemicals & Plastics Technology Corporation Electrostatic liquid spray application of coating with supercritical fluids as diluents and spraying from an orifice
US4950239A (en) 1988-08-09 1990-08-21 Worldwide Medical Plastics Inc. Angioplasty balloons and balloon catheters
AU4191989A (en) 1988-08-24 1990-03-23 Marvin J. Slepian Biodegradable polymeric endoluminal sealing
US4931037A (en) 1988-10-13 1990-06-05 International Medical, Inc. In-dwelling ureteral stent and injection stent assembly, and method of using same
US5272012A (en) 1989-06-23 1993-12-21 C. R. Bard, Inc. Medical apparatus having protective, lubricious coating
US4958625A (en) 1989-07-18 1990-09-25 Boston Scientific Corporation Biopsy needle instrument
ES2043289T3 (en) 1989-09-25 1993-12-16 Schneider Usa Inc THE EXTRUSION OF MULTIPLE LAYERS AS A PROCEDURE FOR MAKING ANGIOPLASTY BALLS.
IE73670B1 (en) 1989-10-02 1997-07-02 Medtronic Inc Articulated stent
US5000519A (en) 1989-11-24 1991-03-19 John Moore Towed vehicle emergency brake control system
US5674192A (en) 1990-12-28 1997-10-07 Boston Scientific Corporation Drug delivery
JP2641781B2 (en) 1990-02-23 1997-08-20 シャープ株式会社 Method of forming semiconductor element isolation region
US5545208A (en) 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5360403A (en) 1990-05-16 1994-11-01 Lake Region Manufacturing Co., Inc. Balloon catheter with lumen occluder
WO1991017724A1 (en) 1990-05-17 1991-11-28 Harbor Medical Devices, Inc. Medical device polymer
US5320634A (en) 1990-07-03 1994-06-14 Interventional Technologies, Inc. Balloon catheter with seated cutting edges
US5090419A (en) 1990-08-23 1992-02-25 Aubrey Palestrant Apparatus for acquiring soft tissue biopsy specimens
US6248129B1 (en) 1990-09-14 2001-06-19 Quanam Medical Corporation Expandable polymeric stent with memory and delivery apparatus and method
US6524698B1 (en) 1990-09-27 2003-02-25 Helmuth Schmoock Fluid impermeable foil
CA2060635A1 (en) 1991-02-12 1992-08-13 Keith D'alessio Bioabsorbable medical implants
GB2253164B (en) 1991-02-22 1994-10-05 Hoechst Uk Ltd Improvements in or relating to electrostatic coating of substrates of medicinal products
US5158986A (en) 1991-04-05 1992-10-27 Massachusetts Institute Of Technology Microcellular thermoplastic foamed with supercritical fluid
US5195969A (en) 1991-04-26 1993-03-23 Boston Scientific Corporation Co-extruded medical balloons and catheter using such balloons
US5372676A (en) 1991-05-15 1994-12-13 Lowe; Michael Method for producing replicated paving stone
US5185776A (en) 1991-08-05 1993-02-09 Townsend Boyd E Cover for an x-ray cassette
US5356433A (en) 1991-08-13 1994-10-18 Cordis Corporation Biocompatible metal surfaces
US5243023A (en) 1991-08-28 1993-09-07 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Polyimides containing amide and perfluoroisopropylidene connecting groups
US5366504A (en) 1992-05-20 1994-11-22 Boston Scientific Corporation Tubular medical prosthesis
JPH0698902A (en) 1991-11-22 1994-04-12 Janome Sewing Mach Co Ltd Production of bone implant
US5125570A (en) 1991-12-30 1992-06-30 Robert Jones Delivery box signal device
US5697882A (en) 1992-01-07 1997-12-16 Arthrocare Corporation System and method for electrosurgical cutting and ablation
US5876452A (en) 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
WO1993019803A1 (en) 1992-03-31 1993-10-14 Boston Scientific Corporation Medical wire
US5288711A (en) 1992-04-28 1994-02-22 American Home Products Corporation Method of treating hyperproliferative vascular disease
US5514379A (en) 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
US5342621A (en) 1992-09-15 1994-08-30 Advanced Cardiovascular Systems, Inc. Antithrombogenic surface
US5500180A (en) 1992-09-30 1996-03-19 C. R. Bard, Inc. Method of making a distensible dilatation balloon using a block copolymer
GB9221220D0 (en) 1992-10-09 1992-11-25 Sandoz Ag Organic componds
US5387313A (en) 1992-11-09 1995-02-07 Bmc Industries, Inc. Etchant control system
US5385776A (en) 1992-11-16 1995-01-31 Alliedsignal Inc. Nanocomposites of gamma phase polymers containing inorganic particulate material
EP0604022A1 (en) 1992-12-22 1994-06-29 Advanced Cardiovascular Systems, Inc. Multilayered biodegradable stent and method for its manufacture
US5324049A (en) 1992-12-23 1994-06-28 Xerox Corporation Mandrel with flared, dish shaped disk and process for using mandrel
KR0147482B1 (en) 1993-01-19 1998-08-01 알렌 제이. 스피겔 Clad composite stent
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5340614A (en) 1993-02-11 1994-08-23 Minnesota Mining And Manufacturing Company Methods of polymer impregnation
US6228879B1 (en) 1997-10-16 2001-05-08 The Children's Medical Center Methods and compositions for inhibition of angiogenesis
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
ES2113094T3 (en) 1993-03-09 1998-04-16 Epic Therapeutics Inc THE MACROMOLECULAR MICROPARTICLES AND METHODS OF OBTAINING.
JPH08507715A (en) 1993-03-18 1996-08-20 シーダーズ サイナイ メディカル センター Drug-inducing and releasable polymeric coatings for bioartificial components
US20020055710A1 (en) 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation
US5403347A (en) 1993-05-27 1995-04-04 United States Surgical Corporation Absorbable block copolymers and surgical articles fabricated therefrom
US5350627A (en) 1993-06-11 1994-09-27 Camelot Technologies, Inc. Coated webs
US5380299A (en) 1993-08-30 1995-01-10 Med Institute, Inc. Thrombolytic treated intravascular medical device
DE4336209C2 (en) 1993-09-10 1995-09-21 Michael Dr Simon Method for producing a vascular prosthesis coated with antithrombotic agents
US5632772A (en) 1993-10-21 1997-05-27 Corvita Corporation Expandable supportive branched endoluminal grafts
US5350361A (en) 1993-11-10 1994-09-27 Medtronic, Inc. Tri-fold balloon for dilatation catheter and related method
US5494620A (en) 1993-11-24 1996-02-27 United States Surgical Corporation Method of manufacturing a monofilament suture
US5626611A (en) 1994-02-10 1997-05-06 United States Surgical Corporation Composite bioabsorbable materials and surgical articles made therefrom
US5556383A (en) 1994-03-02 1996-09-17 Scimed Lifesystems, Inc. Block copolymer elastomer catheter balloons
US6146356A (en) 1994-03-02 2000-11-14 Scimed Life Systems, Inc. Block copolymer elastomer catheter balloons
US5733303A (en) 1994-03-17 1998-03-31 Medinol Ltd. Flexible expandable stent
US5843120A (en) 1994-03-17 1998-12-01 Medinol Ltd. Flexible-expandable stent
US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
JPH10503179A (en) 1994-06-24 1998-03-24 イミュネックス・コーポレーション Controlled release polypeptide composition and method of treating inflammatory bowel disease
CZ297271B6 (en) 1994-07-12 2006-10-11 Bpsi Holdings, Inc. Dry moisture barrier film coating composition, method, and coated form
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
NL9401690A (en) 1994-10-13 1996-05-01 Industrial Res Bv Body-implantable stent.
JPH10510450A (en) 1994-12-02 1998-10-13 サイエンス インコーポレイテッド Drug dispensing device
ATE252894T1 (en) 1995-01-05 2003-11-15 Univ Michigan SURFACE-MODIFIED NANOPARTICLES AND METHODS FOR THEIR PRODUCTION AND USE
US5599576A (en) 1995-02-06 1997-02-04 Surface Solutions Laboratories, Inc. Medical apparatus with scratch-resistant coating and method of making same
US6231600B1 (en) 1995-02-22 2001-05-15 Scimed Life Systems, Inc. Stents with hybrid coating for medical devices
US5605696A (en) 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
US6120536A (en) 1995-04-19 2000-09-19 Schneider (Usa) Inc. Medical devices with long term non-thrombogenic coatings
US20020091433A1 (en) 1995-04-19 2002-07-11 Ni Ding Drug release coated stent
US5837313A (en) 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
DE29624503U1 (en) 1995-04-19 2004-09-16 Boston Scientific Scimed, Inc. Drug-releasing coated stent
US5570537A (en) 1995-04-27 1996-11-05 Black; Douglas A. Electronic insecticidal cable
CA2219995C (en) 1995-05-01 2004-04-13 Sam Yang Co., Ltd. Implantable bioresorbable membrane and method for the preparation thereof
US6602281B1 (en) 1995-06-05 2003-08-05 Avantec Vascular Corporation Radially expansible vessel scaffold having beams and expansion joints
US5714007A (en) 1995-06-06 1998-02-03 David Sarnoff Research Center, Inc. Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate
US5674242A (en) 1995-06-06 1997-10-07 Quanam Medical Corporation Endoprosthetic device with therapeutic compound
CA2178541C (en) 1995-06-07 2009-11-24 Neal E. Fearnot Implantable medical device
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
US6774278B1 (en) 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
DK0833828T3 (en) 1995-06-09 2003-03-17 Novartis Ag rapamycin derivatives
US6256529B1 (en) 1995-07-26 2001-07-03 Burdette Medical Systems, Inc. Virtual reality 3D visualization for surgical procedures
JP3476604B2 (en) 1995-08-22 2003-12-10 鐘淵化学工業株式会社 Method for manufacturing stent with drug attached / coated
EP0764675B1 (en) 1995-09-19 1998-05-13 Mitsubishi Gas Chemical Company, Inc. Biodegrable water-soluble polymer
US5607442A (en) 1995-11-13 1997-03-04 Isostent, Inc. Stent with improved radiopacity and appearance characteristics
CA2192520A1 (en) 1996-03-05 1997-09-05 Ian M. Penn Expandable stent and method for delivery of same
US6461644B1 (en) 1996-03-25 2002-10-08 Richard R. Jackson Anesthetizing plastics, drug delivery plastics, and related medical products, systems and methods
NZ331269A (en) 1996-04-10 2000-01-28 Advanced Cardiovascular System Expandable stent, its structural strength varying along its length
US5669932A (en) 1996-05-29 1997-09-23 Isostent, Inc. Means for accurately positioning an expandable stent
WO1997045502A1 (en) 1996-05-31 1997-12-04 Toto Ltd. Antifouling member and antifouling coating composition
US6143037A (en) 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
US5876426A (en) 1996-06-13 1999-03-02 Scimed Life Systems, Inc. System and method of providing a blood-free interface for intravascular light delivery
FR2750897B1 (en) 1996-07-10 1998-09-18 Sames Sa TRIBOELECTRIC PROJECTOR, COATING PRODUCT PROJECTION INSTALLATION AND METHOD FOR CONTROLLING SUCH A PROJECTOR
EP0937082A2 (en) 1996-07-12 1999-08-25 Ariad Pharmaceuticals, Inc. Materials and method for treating or preventing pathogenic fungal infection
JPH1029524A (en) 1996-07-15 1998-02-03 Toyota Motor Corp Wheel slip controller
US5871436A (en) 1996-07-19 1999-02-16 Advanced Cardiovascular Systems, Inc. Radiation therapy method and device
CA2211249C (en) 1996-07-24 2007-07-17 Cordis Corporation Balloon catheter and methods of use
US6013855A (en) 1996-08-06 2000-01-11 United States Surgical Grafting of biocompatible hydrophilic polymers onto inorganic and metal surfaces
DE19633901A1 (en) 1996-08-22 1998-02-26 Thomas Prof Dr Med Ischinger Vascular support in the form of a tube section-like support structure
US6884377B1 (en) 1996-08-27 2005-04-26 Trexel, Inc. Method and apparatus for microcellular polymer extrusion
US5807404A (en) 1996-09-19 1998-09-15 Medinol Ltd. Stent with variable features to optimize support and method of making such stent
US6193963B1 (en) 1996-10-17 2001-02-27 The Regents Of The University Of California Method of treating tumor-bearing patients with human plasma hyaluronidase
US6387121B1 (en) 1996-10-21 2002-05-14 Inflow Dynamics Inc. Vascular and endoluminal stents with improved coatings
US6530951B1 (en) 1996-10-24 2003-03-11 Cook Incorporated Silver implantable medical device
GB9623634D0 (en) 1996-11-13 1997-01-08 Bpsi Holdings Inc Method and apparatus for the coating of substrates for pharmaceutical use
US6251980B1 (en) 1996-12-06 2001-06-26 Amcol International Corporation Nanocomposites formed by onium ion-intercalated clay and rigid anhydride-cured epoxy resins
US5871437A (en) 1996-12-10 1999-02-16 Inflow Dynamics, Inc. Radioactive stent for treating blood vessels to prevent restenosis
US6517860B1 (en) 1996-12-31 2003-02-11 Quadrant Holdings Cambridge, Ltd. Methods and compositions for improved bioavailability of bioactive agents for mucosal delivery
FR2758253B1 (en) 1997-01-10 1999-04-02 Nycomed Lab Sa IMPLANTABLE DEVICE FOR THE TREATMENT OF A BODY DUCT
US6884823B1 (en) 1997-01-16 2005-04-26 Trexel, Inc. Injection molding of polymeric material
DE29702671U1 (en) 1997-02-17 1997-04-10 Jomed Implantate GmbH, 72414 Rangendingen Stent
JP2001521503A (en) * 1997-03-31 2001-11-06 ネオルックス コーポレイション Therapeutic inhibitors of vascular smooth muscle cells
US6240616B1 (en) 1997-04-15 2001-06-05 Advanced Cardiovascular Systems, Inc. Method of manufacturing a medicated porous metal prosthesis
US8172897B2 (en) 1997-04-15 2012-05-08 Advanced Cardiovascular Systems, Inc. Polymer and metal composite implantable medical devices
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
IT1292295B1 (en) 1997-04-29 1999-01-29 Sorin Biomedica Cardio Spa ANGIOPLASTIC STENT
FR2762777B1 (en) 1997-05-05 1999-10-22 Patrick Sabaria VASCULAR AND CORONARY EXTENDERS, USUALLY DESIGNATED UNDER THE NAME OF "STENT"
GB9800936D0 (en) 1997-05-10 1998-03-11 Univ Nottingham Biofunctional polymers
US6344055B1 (en) 1997-05-14 2002-02-05 Novo Rps Ulc Method for production of an expandable stent
DE19720115C2 (en) 1997-05-14 1999-05-20 Jomed Implantate Gmbh Stent graft
DE29708689U1 (en) 1997-05-15 1997-07-17 Jomed Implantate GmbH, 72414 Rangendingen Coronary stent
US5913895A (en) 1997-06-02 1999-06-22 Isostent, Inc. Intravascular stent with enhanced rigidity strut members
US6416779B1 (en) 1997-06-11 2002-07-09 Umd, Inc. Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections
US6433154B1 (en) 1997-06-12 2002-08-13 Bristol-Myers Squibb Company Functional receptor/kinase chimera in yeast cells
US6245103B1 (en) 1997-08-01 2001-06-12 Schneider (Usa) Inc Bioabsorbable self-expanding stent
US6077880A (en) 1997-08-08 2000-06-20 Cordis Corporation Highly radiopaque polyolefins and method for making the same
WO1999008729A1 (en) 1997-08-13 1999-02-25 Boston Scientific Limited Loading and release of water-insoluble drugs
ATE307584T1 (en) 1997-08-28 2005-11-15 Nissan Chemical Ind Ltd AGENT FOR PROMOTING AND ENHANCEMENT NEOVASCULARIZATION
DE29716476U1 (en) 1997-09-13 1997-12-18 Convent, Gerd, 47829 Krefeld Stenosis treatment stent
DE29716467U1 (en) 1997-09-15 1998-02-26 Rittal-Werk Rudolf Loh Gmbh & Co Kg, 35745 Herborn Housing structure for electrical or electronic installations
US8257725B2 (en) 1997-09-26 2012-09-04 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
TW557297B (en) 1997-09-26 2003-10-11 Abbott Lab Rapamycin analogs having immunomodulatory activity, and pharmaceutical compositions containing same
US7378105B2 (en) 1997-09-26 2008-05-27 Abbott Laboratories Drug delivery systems, kits, and methods for administering zotarolimus and paclitaxel to blood vessel lumens
US6042606A (en) 1997-09-29 2000-03-28 Cook Incorporated Radially expandable non-axially contracting surgical stent
US6071308A (en) 1997-10-01 2000-06-06 Boston Scientific Corporation Flexible metal wire stent
US6127000A (en) 1997-10-10 2000-10-03 North Carolina State University Method and compositions for protecting civil infrastructure
DE29880158U1 (en) 1997-11-07 2000-11-30 Salviac Ltd Embolic protection device
DE59808721D1 (en) 1997-11-24 2003-07-17 Efmt Entwicklungs Und Forschun METHOD FOR IMMOBILIZING MEDIATOR MOLECULES ON INORGANIC AND METAL IMPLANT MATERIALS
US5957975A (en) 1997-12-15 1999-09-28 The Cleveland Clinic Foundation Stent having a programmed pattern of in vivo degradation
JP2002500065A (en) 1998-01-06 2002-01-08 バイオアミド・インコーポレイテッド Bioabsorbable fibers and reinforced composites made therefrom
US6129755A (en) 1998-01-09 2000-10-10 Nitinol Development Corporation Intravascular stent having an improved strut configuration
US6221425B1 (en) 1998-01-30 2001-04-24 Advanced Cardiovascular Systems, Inc. Lubricious hydrophilic coating for an intracorporeal medical device
CA2322134C (en) 1998-03-04 2009-04-07 Scimed Life Systems, Inc. Improved stent cell configurations
US7208010B2 (en) 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
SE9801288D0 (en) 1998-04-14 1998-04-14 Astra Ab Vaccine delivery system and method of production
US8029561B1 (en) 2000-05-12 2011-10-04 Cordis Corporation Drug combination useful for prevention of restenosis
GB9808052D0 (en) 1998-04-17 1998-06-17 Secr Defence Implants for administering substances and methods of producing implants
US6206914B1 (en) 1998-04-30 2001-03-27 Medtronic, Inc. Implantable system with drug-eluting cells for on-demand local drug delivery
US6190699B1 (en) 1998-05-08 2001-02-20 Nzl Corporation Method of incorporating proteins or peptides into a matrix and administration thereof through mucosa
DE19822157B4 (en) 1998-05-16 2013-01-10 Abbott Laboratories Vascular Enterprises Ltd. Radially expandable stent for implantation in a body vessel
FR2780057B1 (en) 1998-06-18 2002-09-13 Sanofi Sa PHENOXYPROPANOLAMINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US6939569B1 (en) 1998-06-19 2005-09-06 Oxibio, Inc. Medical device having anti-infective and contraceptive properties
US6153252A (en) 1998-06-30 2000-11-28 Ethicon, Inc. Process for coating stents
US6541033B1 (en) 1998-06-30 2003-04-01 Amgen Inc. Thermosensitive biodegradable hydrogels for sustained delivery of leptin
US7004962B2 (en) 1998-07-27 2006-02-28 Schneider (Usa), Inc. Neuroaneurysm occlusion and delivery device and method of using same
US8070796B2 (en) 1998-07-27 2011-12-06 Icon Interventional Systems, Inc. Thrombosis inhibiting graft
US7967855B2 (en) 1998-07-27 2011-06-28 Icon Interventional Systems, Inc. Coated medical device
US6461380B1 (en) 1998-07-28 2002-10-08 Advanced Cardiovascular Systems, Inc. Stent configuration
US6248127B1 (en) 1998-08-21 2001-06-19 Medtronic Ave, Inc. Thromboresistant coated medical device
US6193744B1 (en) 1998-09-10 2001-02-27 Scimed Life Systems, Inc. Stent configurations
US6342062B1 (en) 1998-09-24 2002-01-29 Scimed Life Systems, Inc. Retrieval devices for vena cava filter
US6363104B1 (en) 1998-10-02 2002-03-26 Ericsson Inc. Method and apparatus for interference cancellation in a rake receiver
US6245104B1 (en) 1999-02-28 2001-06-12 Inflow Dynamics Inc. Method of fabricating a biocompatible stent
US6042597A (en) 1998-10-23 2000-03-28 Scimed Life Systems, Inc. Helical stent design
US6143314A (en) 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
FR2785174A1 (en) 1998-11-03 2000-05-05 Jacques Seguin BODY CONDUIT EXTENSIONER, ESPECIALLY VASCULAR
US6355691B1 (en) 1998-11-12 2002-03-12 Tobias M. Goodman Urushiol therapy of transitional cell carcinoma of the bladder
EP1131114B1 (en) 1998-11-20 2004-06-16 The University of Connecticut Apparatus and method for control of tissue/implant interactions
EP1135165A1 (en) 1998-12-03 2001-09-26 Boston Scientific Limited Stent having drug crystals thereon
US6372246B1 (en) 1998-12-16 2002-04-16 Ortho-Mcneil Pharmaceutical, Inc. Polyethylene glycol coating for electrostatic dry deposition of pharmaceuticals
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6147135A (en) 1998-12-31 2000-11-14 Ethicon, Inc. Fabrication of biocompatible polymeric composites
US6638727B1 (en) 1999-01-26 2003-10-28 Cytyc Health Corporation Methods for identifying treating or monitoring asymptomatic patients for risk reduction or therapeutic treatment of breast cancer
US6706283B1 (en) 1999-02-10 2004-03-16 Pfizer Inc Controlled release by extrusion of solid amorphous dispersions of drugs
SE9900519D0 (en) 1999-02-17 1999-02-17 Lars Lidgren A method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof
US6171327B1 (en) 1999-02-24 2001-01-09 Scimed Life Systems, Inc. Intravascular filter and method
US6620192B1 (en) 1999-03-16 2003-09-16 Advanced Cardiovascular Systems, Inc. Multilayer stent
US6364903B2 (en) 1999-03-19 2002-04-02 Meadox Medicals, Inc. Polymer coated stent
SE9901002D0 (en) 1999-03-19 1999-03-19 Electrolux Ab Apparatus for cleaning textile articles with a densified liquid processing gas
US6368658B1 (en) * 1999-04-19 2002-04-09 Scimed Life Systems, Inc. Coating medical devices using air suspension
US6923979B2 (en) 1999-04-27 2005-08-02 Microdose Technologies, Inc. Method for depositing particles onto a substrate using an alternating electric field
US8016873B1 (en) 1999-05-03 2011-09-13 Drasler William J Intravascular hinge stent
US6673053B2 (en) 1999-05-07 2004-01-06 Scimed Life Systems, Inc. Hydrophilic lubricity coating for medical devices comprising an antiblock agent
JP2000316981A (en) 1999-05-14 2000-11-21 Kawasumi Lab Inc Stent
US6726712B1 (en) 1999-05-14 2004-04-27 Boston Scientific Scimed Prosthesis deployment device with translucent distal end
US6610035B2 (en) 1999-05-21 2003-08-26 Scimed Life Systems, Inc. Hydrophilic lubricity coating for medical devices comprising a hybrid top coat
US6815218B1 (en) 1999-06-09 2004-11-09 Massachusetts Institute Of Technology Methods for manufacturing bioelectronic devices
EP1196163B1 (en) 1999-07-06 2009-11-11 Endorecherche Inc. Pharmaceutical compositions for the treatment of insulin resistance
ES2219388T3 (en) 1999-08-24 2004-12-01 Ariad Gene Therapeutics, Inc. 28-EPI-RAPALOGOS.
US6146404A (en) 1999-09-03 2000-11-14 Scimed Life Systems, Inc. Removable thrombus filter
US20070032853A1 (en) * 2002-03-27 2007-02-08 Hossainy Syed F 40-O-(2-hydroxy)ethyl-rapamycin coated stent
US6358557B1 (en) 1999-09-10 2002-03-19 Sts Biopolymers, Inc. Graft polymerization of substrate surfaces
US6610013B1 (en) 1999-10-01 2003-08-26 Life Imaging Systems, Inc. 3D ultrasound-guided intraoperative prostate brachytherapy
US6755871B2 (en) 1999-10-15 2004-06-29 R.R. Street & Co. Inc. Cleaning system utilizing an organic cleaning solvent and a pressurized fluid solvent
US6458387B1 (en) 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
US6605696B1 (en) 1999-10-22 2003-08-12 Pfizer, Inc. Lawsonia intracellularis proteins, and related methods and materials
US7537785B2 (en) 1999-10-29 2009-05-26 Nitromed, Inc. Composition for treating vascular diseases characterized by nitric oxide insufficiency
US6537310B1 (en) 1999-11-19 2003-03-25 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal implantable devices and method of making same
US6908624B2 (en) 1999-12-23 2005-06-21 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
US6572813B1 (en) 2000-01-13 2003-06-03 Advanced Cardiovascular Systems, Inc. Balloon forming process
TWI284048B (en) 2000-01-27 2007-07-21 Zentaris Ag Compressed microparticles for dry injection
IL151287A0 (en) 2000-02-24 2003-04-10 Xcyte Therapies Inc A method for stimulation and concentrating cells
EP1132058A1 (en) 2000-03-06 2001-09-12 Advanced Laser Applications Holding S.A. Intravascular prothesis
EP1145719A3 (en) 2000-03-10 2001-11-14 Pfizer Products Inc. Use a ferrous salt for inhibiting oxidative degradation of pharmaceutical formulations
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
CN2423899Y (en) 2000-05-08 2001-03-21 微创医疗器械(上海)有限公司 Coronary artery stand
EP1280565A2 (en) 2000-05-12 2003-02-05 Advanced Bio Prothestic Surfaces, Ltd. Self-supporting laminated films, structural materials and medical devices
ATE317709T1 (en) 2000-05-16 2006-03-15 Ortho Mcneil Pharm Inc METHOD FOR COATING MEDICAL DEVICES USING SUPERCRITICAL CARBON DIOXIDE
US7217770B2 (en) 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof
US20030077200A1 (en) 2000-07-07 2003-04-24 Craig Charles H. Enhanced radiopaque alloy stent
US20020144757A1 (en) 2000-07-07 2002-10-10 Craig Charles Horace Stainless steel alloy with improved radiopaque characteristics
US7332242B2 (en) 2000-09-01 2008-02-19 Itochu Corporation Lithium-based battery having extensible, ion-impermeable polymer covering on the battery container
EP1317304B1 (en) 2000-09-01 2011-04-27 Palmaya Pty Ltd. Slow release pharmaceutical preparation and method of administering same
US6362718B1 (en) 2000-09-06 2002-03-26 Stephen L. Patrick Motionless electromagnetic generator
US6521258B1 (en) 2000-09-08 2003-02-18 Ferro Corporation Polymer matrices prepared by supercritical fluid processing techniques
US6506213B1 (en) 2000-09-08 2003-01-14 Ferro Corporation Manufacturing orthopedic parts using supercritical fluid processing techniques
US6953560B1 (en) 2000-09-28 2005-10-11 Advanced Cardiovascular Systems, Inc. Barriers for polymer-coated implantable medical devices and methods for making the same
US20060222756A1 (en) 2000-09-29 2006-10-05 Cordis Corporation Medical devices, drug coatings and methods of maintaining the drug coatings thereon
US20020111590A1 (en) 2000-09-29 2002-08-15 Davila Luis A. Medical devices, drug coatings and methods for maintaining the drug coatings thereon
IL155479A0 (en) 2000-11-03 2003-11-23 Control Delivery Sys Inc Improved device and method for treating conditions of a joint
US20050084514A1 (en) 2000-11-06 2005-04-21 Afmedica, Inc. Combination drug therapy for reducing scar tissue formation
US20040018228A1 (en) 2000-11-06 2004-01-29 Afmedica, Inc. Compositions and methods for reducing scar tissue formation
WO2002040702A2 (en) 2000-11-09 2002-05-23 Vanderbilt University Methods for the treatment of cancer and other diseases and methods of developing the same
US6682757B1 (en) 2000-11-16 2004-01-27 Euro-Celtique, S.A. Titratable dosage transdermal delivery system
KR20020076265A (en) * 2000-11-30 2002-10-09 가부시키가이샤 이가키 이료 세케이 Stent for blood vessel and material for stent for blood vessel
US20020082679A1 (en) 2000-12-22 2002-06-27 Avantec Vascular Corporation Delivery or therapeutic capable agents
US6913617B1 (en) 2000-12-27 2005-07-05 Advanced Cardiovascular Systems, Inc. Method for creating a textured surface on an implantable medical device
GB0100760D0 (en) * 2001-01-11 2001-02-21 Biocompatibles Ltd Drug delivery from stents
GB0100761D0 (en) 2001-01-11 2001-02-21 Biocompatibles Ltd Drug delivery from stents
TWI246524B (en) 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
US6660176B2 (en) 2001-01-24 2003-12-09 Virginia Commonwealth University Molecular imprinting of small particles, and production of small particles from solid state reactants
ATE380022T1 (en) 2001-01-31 2007-12-15 Evonik Roehm Gmbh MULTIPARTICULAR MEDICINAL FORM CONTAINING AT LEAST TWO DIFFERENTLY COATED PELLET FORMS
US20040220660A1 (en) 2001-02-05 2004-11-04 Shanley John F. Bioresorbable stent with beneficial agent reservoirs
DE10106810A1 (en) 2001-02-14 2002-09-05 Siemens Ag Off-grid power supply unit
US6905555B2 (en) 2001-02-15 2005-06-14 Micell Technologies, Inc. Methods for transferring supercritical fluids in microelectronic and other industrial processes
US6720003B2 (en) 2001-02-16 2004-04-13 Andrx Corporation Serotonin reuptake inhibitor formulations
US6811549B2 (en) 2001-02-16 2004-11-02 William H. Fleming Administration of therapeutic or diagnostic agents using interlabial pad
JP2002239013A (en) 2001-02-21 2002-08-27 Terumo Corp Stent and method of manufacturing for the same
US6949251B2 (en) 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
US7771468B2 (en) 2001-03-16 2010-08-10 Angiotech Biocoatings Corp. Medicated stent having multi-layer polymer coating
EP1399094A4 (en) 2001-03-16 2004-07-28 Sts Biopolymers Inc Medicated stent having multi-layer polymer coating
WO2002085188A2 (en) 2001-04-24 2002-10-31 Kaplan Edward J Deflectable implantation device and method for use
US20040022853A1 (en) 2001-04-26 2004-02-05 Control Delivery Systems, Inc. Polymer-based, sustained release drug delivery system
US8182527B2 (en) 2001-05-07 2012-05-22 Cordis Corporation Heparin barrier coating for controlled drug release
US7247338B2 (en) 2001-05-16 2007-07-24 Regents Of The University Of Minnesota Coating medical devices
US6973718B2 (en) 2001-05-30 2005-12-13 Microchips, Inc. Methods for conformal coating and sealing microchip reservoir devices
US7201940B1 (en) 2001-06-12 2007-04-10 Advanced Cardiovascular Systems, Inc. Method and apparatus for thermal spray processing of medical devices
US20030044514A1 (en) * 2001-06-13 2003-03-06 Richard Robert E. Using supercritical fluids to infuse therapeutic on a medical device
US7485113B2 (en) 2001-06-22 2009-02-03 Johns Hopkins University Method for drug delivery through the vitreous humor
US7501157B2 (en) 2001-06-26 2009-03-10 Accelr8 Technology Corporation Hydroxyl functional surface coating
US7015875B2 (en) 2001-06-29 2006-03-21 Novus Partners Llc Dynamic device for billboard advertising
US6585755B2 (en) 2001-06-29 2003-07-01 Advanced Cardiovascular Polymeric stent suitable for imaging by MRI and fluoroscopy
US6967234B2 (en) 2002-12-18 2005-11-22 Ethicon, Inc. Alkyd-lactone copolymers for medical applications
US6743505B2 (en) 2001-07-27 2004-06-01 Ethicon, Inc. Bioabsorbable multifilament yarn and methods of manufacture
US6723913B1 (en) 2001-08-23 2004-04-20 Anthony T. Barbetta Fan cooling of active speakers
US6669980B2 (en) * 2001-09-18 2003-12-30 Scimed Life Systems, Inc. Method for spray-coating medical devices
DE50213462D1 (en) 2001-10-15 2009-05-28 Hemoteq Ag COATING OF STENTS TO PREVENT RESTENOSIS
US20030088307A1 (en) 2001-11-05 2003-05-08 Shulze John E. Potent coatings for stents
US6939376B2 (en) 2001-11-05 2005-09-06 Sun Biomedical, Ltd. Drug-delivery endovascular stent and method for treating restenosis
MXPA04003866A (en) 2001-11-09 2004-07-08 Pharmacia Ab Anti-muscarinic agent and estrogen-agonist for treating unstable or overactive bladder.
US6517889B1 (en) 2001-11-26 2003-02-11 Swaminathan Jayaraman Process for coating a surface of a stent
US7488313B2 (en) 2001-11-29 2009-02-10 Boston Scientific Scimed, Inc. Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment
US6868123B2 (en) * 2001-12-07 2005-03-15 Motorola, Inc. Programmable motion estimation module with vector array unit
TW497494U (en) 2001-12-28 2002-08-01 Metal Ind Redearch & Amp Dev C Fluid driven stirring device for compressing gas cleaning system
DE10200388A1 (en) 2002-01-08 2003-07-24 Translumina Gmbh coating system
TW200306826A (en) 2002-01-10 2003-12-01 Novartis Ag Drug delivery systems for the prevention and treatment of vascular diseases
US20030135256A1 (en) 2002-01-14 2003-07-17 Gallagher Brendan P. Stent delivery system
KR20040097126A (en) 2002-02-15 2004-11-17 씨브이 쎄러퓨틱스, 인코포레이티드 Polymer coating for medical devices
US20060093771A1 (en) 2002-02-15 2006-05-04 Frantisek Rypacek Polymer coating for medical devices
KR20040093058A (en) 2002-02-28 2004-11-04 노파르티스 아게 N-(5-(4-(4-methyl-piperazino-methyl)-benzoylamido)-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine-amine coated stents
WO2003074992A2 (en) 2002-03-01 2003-09-12 Mds Proteomics Inc. Phosphorylated proteins and uses related thereto
GB0205868D0 (en) 2002-03-13 2002-04-24 Univ Nottingham Polymer composite with internally distributed deposition matter
US7919075B1 (en) 2002-03-20 2011-04-05 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices
AU2008205550B2 (en) 2002-03-22 2012-11-01 Cardinal Health 529, Llc Rapid-exchange balloon catheter shaft and method
US6743463B2 (en) * 2002-03-28 2004-06-01 Scimed Life Systems, Inc. Method for spray-coating a medical device having a tubular wall such as a stent
US7470281B2 (en) 2002-04-26 2008-12-30 Medtronic Vascular, Inc. Coated stent with crimpable coating
US7270675B2 (en) 2002-05-10 2007-09-18 Cordis Corporation Method of forming a tubular membrane on a structural frame
US6669785B2 (en) 2002-05-15 2003-12-30 Micell Technologies, Inc. Methods and compositions for etch cleaning microelectronic substrates in carbon dioxide
US6749902B2 (en) 2002-05-28 2004-06-15 Battelle Memorial Institute Methods for producing films using supercritical fluid
US6756084B2 (en) 2002-05-28 2004-06-29 Battelle Memorial Institute Electrostatic deposition of particles generated from rapid expansion of supercritical fluid solutions
DE60331731D1 (en) 2002-05-28 2010-04-29 Battelle Memorial Institute ELECTROSTATIC DIVISION OF PARTICLES RECEIVED BY QUICK RELAXATION OF SUPERCRITICAL SOLUTIONS (RESS)
US7229837B2 (en) 2002-05-30 2007-06-12 Uchicago Argonne, Llc Enhanced photophysics of conjugated polymers
TW200403065A (en) 2002-05-30 2004-03-01 Akzo Nobel Nv New etonogestrel esters
WO2003106543A1 (en) 2002-06-13 2003-12-24 Kappler, Inc. Microporous membrane with adsorbent multi-functional filler
US6794902B2 (en) 2002-06-14 2004-09-21 Sun Microsystems, Inc. Virtual ground circuit
US7217426B1 (en) 2002-06-21 2007-05-15 Advanced Cardiovascular Systems, Inc. Coatings containing polycationic peptides for cardiovascular therapy
US7033602B1 (en) 2002-06-21 2006-04-25 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of coating implantable medical devices
US6839913B2 (en) 2002-06-25 2005-01-11 Noble Ideas, Inc. Adjustable garment waistband and method of manufacture
CN100471469C (en) 2002-06-27 2009-03-25 微创医疗器械(上海)有限公司 Drug-eluting stent (DES) with multicoating
WO2004002367A1 (en) 2002-06-27 2004-01-08 Microport Medical (Shanghai) Co., Ltd. Drug eluting stent
US7491233B1 (en) * 2002-07-19 2009-02-17 Advanced Cardiovascular Systems Inc. Purified polymers for coatings of implantable medical devices
US20040013792A1 (en) 2002-07-19 2004-01-22 Samuel Epstein Stent coating holders
JP2004058431A (en) 2002-07-29 2004-02-26 Nitto Denko Corp Pressure-sensitive adhesive tape or sheet
GB2391439B (en) 2002-07-30 2006-06-21 Wolfson Ltd Bass compressor
US20050019747A1 (en) 2002-08-07 2005-01-27 Anderson Daniel G. Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
US7029495B2 (en) 2002-08-28 2006-04-18 Scimed Life Systems, Inc. Medical devices and methods of making the same
US7060051B2 (en) 2002-09-24 2006-06-13 Scimed Life Systems, Inc. Multi-balloon catheter with hydrogel coating
JP2006500996A (en) 2002-09-26 2006-01-12 エンドバスキュラー デバイセス インコーポレイテッド Apparatus and method for delivering mitomycin via an eluting biocompatible implantable medical device
US6702850B1 (en) 2002-09-30 2004-03-09 Mediplex Corporation Korea Multi-coated drug-eluting stent for antithrombosis and antirestenosis
US6770729B2 (en) 2002-09-30 2004-08-03 Medtronic Minimed, Inc. Polymer compositions containing bioactive agents and methods for their use
CA2501617C (en) 2002-10-11 2012-04-24 Ronald A. Sahatjian Expandable polymeric endoprosthesis with shape memory
US6800663B2 (en) 2002-10-18 2004-10-05 Alkermes Controlled Therapeutics Inc. Ii, Crosslinked hydrogel copolymers
KR100511030B1 (en) 2002-10-21 2005-08-31 한국과학기술연구원 Blood compatible metallic materials and preparation thereof
CA2504953C (en) 2002-11-07 2013-08-20 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services A new target for angiogenesis and anti-angiogenesis therapy
US20060121080A1 (en) 2002-11-13 2006-06-08 Lye Whye K Medical devices having nanoporous layers and methods for making the same
US20050070989A1 (en) 2002-11-13 2005-03-31 Whye-Kei Lye Medical devices having porous layers and methods for making the same
US20040098106A1 (en) 2002-11-14 2004-05-20 Williams Michael S. Intraluminal prostheses and carbon dioxide-assisted methods of impregnating same with pharmacological agents
CA2503388C (en) * 2002-11-15 2012-05-15 Synecor, Llc Improved endoprostheses and methods of manufacture
WO2004045549A2 (en) 2002-11-18 2004-06-03 Polymerix Corporation Medical devices employing novel polymers
JP4371653B2 (en) 2002-11-25 2009-11-25 テルモ株式会社 Implantable medical device
US20050095267A1 (en) 2002-12-04 2005-05-05 Todd Campbell Nanoparticle-based controlled release polymer coatings for medical implants
US6790483B2 (en) 2002-12-06 2004-09-14 Eastman Kodak Company Method for producing patterned deposition from compressed fluid
US7094256B1 (en) 2002-12-16 2006-08-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical device containing polycationic peptides
WO2004060059A2 (en) 2002-12-23 2004-07-22 Vical Incorporated Method for freeze-drying nucleic acid/block copolymer/cationic surfactant complexes
US7152452B2 (en) 2002-12-26 2006-12-26 Advanced Cardiovascular Systems, Inc. Assembly for crimping an intraluminal device and method of use
US20040143317A1 (en) 2003-01-17 2004-07-22 Stinson Jonathan S. Medical devices
US7309349B2 (en) 2003-01-23 2007-12-18 Cordis Corporation Friction reducing lubricant for stent loading and stent delivery systems
JP2004225126A (en) 2003-01-24 2004-08-12 Pioneer Electronic Corp Film deposition mask, and method for manufacturing the same
US20050079199A1 (en) 2003-02-18 2005-04-14 Medtronic, Inc. Porous coatings for drug release from medical devices
US20080051866A1 (en) 2003-02-26 2008-02-28 Chao Chin Chen Drug delivery devices and methods
US20040170685A1 (en) 2003-02-26 2004-09-02 Medivas, Llc Bioactive stents and methods for use thereof
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
US20040193262A1 (en) 2003-03-29 2004-09-30 Shadduck John H. Implants for treating ocular hypertension, methods of use and methods of fabrication
US7527632B2 (en) 2003-03-31 2009-05-05 Cordis Corporation Modified delivery device for coated medical devices
US7326734B2 (en) 2003-04-01 2008-02-05 The Regents Of The University Of California Treatment of bladder and urinary tract cancers
US20060102871A1 (en) 2003-04-08 2006-05-18 Xingwu Wang Novel composition
US20050216075A1 (en) 2003-04-08 2005-09-29 Xingwu Wang Materials and devices of enhanced electromagnetic transparency
WO2004091571A2 (en) 2003-04-08 2004-10-28 New Jersey Institute Of Technology (Njit) Polymer coating/encapsulation of nanoparticles using a supercritical antisolvent process
US20050208102A1 (en) 2003-04-09 2005-09-22 Schultz Clyde L Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases
US20050038498A1 (en) 2003-04-17 2005-02-17 Nanosys, Inc. Medical device applications of nanostructured surfaces
US8246974B2 (en) 2003-05-02 2012-08-21 Surmodics, Inc. Medical devices and methods for producing the same
GB0310300D0 (en) 2003-05-06 2003-06-11 Univ Belfast Nanocomposite drug delivery composition
US7279174B2 (en) 2003-05-08 2007-10-09 Advanced Cardiovascular Systems, Inc. Stent coatings comprising hydrophilic additives
US7429378B2 (en) 2003-05-13 2008-09-30 Depuy Spine, Inc. Transdiscal administration of high affinity anti-MMP inhibitors
US7553827B2 (en) 2003-08-13 2009-06-30 Depuy Spine, Inc. Transdiscal administration of cycline compounds
JP2007504920A (en) 2003-05-16 2007-03-08 ブルー メンブレーンス ゲーエムベーハー Biocompatible coated medical implant
US7524527B2 (en) 2003-05-19 2009-04-28 Boston Scientific Scimed, Inc. Electrostatic coating of a device
US20040236416A1 (en) 2003-05-20 2004-11-25 Robert Falotico Increased biocompatibility of implantable medical devices
US7662864B2 (en) 2003-06-04 2010-02-16 Rutgers, The State University Of New Jersey Solution polymerization processes to prepare a polymer that degrades to release a physiologically active agent
WO2004108274A1 (en) 2003-06-06 2004-12-16 Mitsubishi Chemical Corporation Water-absorbent articles and process for the production thereof
WO2004113429A2 (en) 2003-06-23 2004-12-29 The University Of Chicago Polyolefin nanocomposites
US8399013B2 (en) 2003-06-26 2013-03-19 Poly-Med, Inc. Partially absorbable fiber-reinforced composites for controlled drug delivery
US20040267345A1 (en) 2003-06-30 2004-12-30 Lorenzo Juan A. Balloon catheter with self-centering tip
US7318945B2 (en) 2003-07-09 2008-01-15 Medtronic Vascular, Inc. Laminated drug-polymer coated stent having dipped layers
US8025637B2 (en) 2003-07-18 2011-09-27 Boston Scientific Scimed, Inc. Medical balloons and processes for preparing same
US7128277B2 (en) 2003-07-29 2006-10-31 Illinois Tool Works Inc. Powder bell with secondary charging electrode
US7169404B2 (en) 2003-07-30 2007-01-30 Advanced Cardiovasular Systems, Inc. Biologically absorbable coatings for implantable devices and methods for fabricating the same
US7056591B1 (en) 2003-07-30 2006-06-06 Advanced Cardiovascular Systems, Inc. Hydrophobic biologically absorbable coatings for drug delivery devices and methods for fabricating the same
US20050033417A1 (en) 2003-07-31 2005-02-10 John Borges Coating for controlled release of a therapeutic agent
KR20060052722A (en) 2003-08-05 2006-05-19 가부시키가이샤 가네카 Stent to be placed in vivo
US7318944B2 (en) 2003-08-07 2008-01-15 Medtronic Vascular, Inc. Extrusion process for coating stents
ES2336913T3 (en) 2003-08-08 2010-04-19 Biovail Laboratories International Srl COMPRESSED OF MODIFIED RELEASE OF BUPROPION HYDROCHLORIDE.
CA2535345A1 (en) 2003-08-13 2005-03-03 Medtronic, Inc. Active agent delivery systems including a miscible polymer blend, medical devices, and methods
US7204560B2 (en) 2003-08-15 2007-04-17 Sandvik Intellectual Property Ab Rotary cutting bit with material-deflecting ledge
US20050055078A1 (en) 2003-09-04 2005-03-10 Medtronic Vascular, Inc. Stent with outer slough coating
US7544381B2 (en) 2003-09-09 2009-06-09 Boston Scientific Scimed, Inc. Lubricious coatings for medical device
AU2004273998A1 (en) 2003-09-18 2005-03-31 Advanced Bio Prosthetic Surfaces, Ltd. Medical device having mems functionality and methods of making same
US7785653B2 (en) 2003-09-22 2010-08-31 Innovational Holdings Llc Method and apparatus for loading a beneficial agent into an expandable medical device
US8801692B2 (en) 2003-09-24 2014-08-12 Medtronic Vascular, Inc. Gradient coated stent and method of fabrication
US20050070990A1 (en) 2003-09-26 2005-03-31 Stinson Jonathan S. Medical devices and methods of making same
US7198675B2 (en) 2003-09-30 2007-04-03 Advanced Cardiovascular Systems Stent mandrel fixture and method for selectively coating surfaces of a stent
US7618647B2 (en) 2003-10-03 2009-11-17 Boston Scientific Scimed, Inc. Using bucky paper as a therapeutic aid in medical applications
US6984411B2 (en) 2003-10-14 2006-01-10 Boston Scientific Scimed, Inc. Method for roll coating multiple stents
US7329383B2 (en) 2003-10-22 2008-02-12 Boston Scientific Scimed, Inc. Alloy compositions and devices including the compositions
EP1675890A1 (en) 2003-10-23 2006-07-05 The University Of Nottingham Preparing active polymer extrudates
US7220755B2 (en) 2003-11-12 2007-05-22 Biosensors International Group, Ltd. 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same
JP4618997B2 (en) 2003-12-09 2011-01-26 テルモ株式会社 Stent and manufacturing method thereof
ES2293368T3 (en) 2003-12-16 2008-03-16 Cytec Surface Specialties, S.A. PROCESS FOR APPLYING A COATING TO A WINDED METAL BAND.
US20050131513A1 (en) 2003-12-16 2005-06-16 Cook Incorporated Stent catheter with a permanently affixed conductor
AU2004308654B2 (en) 2003-12-24 2008-11-20 Novartis Ag Pharmaceutical Compositions
US20050147734A1 (en) 2004-01-07 2005-07-07 Jan Seppala Method and system for coating tubular medical devices
US20050268573A1 (en) 2004-01-20 2005-12-08 Avantec Vascular Corporation Package of sensitive articles
US7534495B2 (en) 2004-01-29 2009-05-19 Boston Scientific Scimed, Inc. Lubricious composition
US7306677B2 (en) 2004-01-30 2007-12-11 Boston Scientific Corporation Clamping fixture for coating stents, system using the fixture, and method of using the fixture
GB2411078B (en) 2004-02-10 2009-02-04 Samsung Electronics Co Ltd Mobile communications
US7241344B2 (en) 2004-02-10 2007-07-10 Boston Scientific Scimed, Inc. Apparatus and method for electrostatic spray coating of medical devices
US7695731B2 (en) * 2004-03-22 2010-04-13 Cordis Corporation Local vascular delivery of etoposide in combination with rapamycin to prevent restenosis following vascular injury
US8551512B2 (en) 2004-03-22 2013-10-08 Advanced Cardiovascular Systems, Inc. Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS
EP2329852A1 (en) 2004-03-26 2011-06-08 SurModics, Inc. Composition and method for preparing biocompatible surfaces
US7541048B2 (en) 2004-04-06 2009-06-02 Surmodics, Inc. Coating compositions for bioactive agents
US7371424B2 (en) 2004-04-14 2008-05-13 Boston Scientific Scimed, Inc. Method and apparatus for coating a medical device using a coating head
US7335264B2 (en) 2004-04-22 2008-02-26 Boston Scientific Scimed, Inc. Differentially coated medical devices, system for differentially coating medical devices, and coating method
US7820732B2 (en) 2004-04-30 2010-10-26 Advanced Cardiovascular Systems, Inc. Methods for modulating thermal and mechanical properties of coatings on implantable devices
US20050288481A1 (en) 2004-04-30 2005-12-29 Desnoyer Jessica R Design of poly(ester amides) for the control of agent-release from polymeric compositions
WO2005117942A2 (en) 2004-05-14 2005-12-15 The Regents Of The University Of Michigan Methods for encapsulation of biomacromolecules in polymers
JP5042820B2 (en) 2004-05-14 2012-10-03 ベクトン・ディキンソン・アンド・カンパニー Articles with bioactive surfaces and methods for their solvent-free preparation
US7682656B2 (en) 2004-06-14 2010-03-23 Agruim Inc. Process and apparatus for producing a coated product
US7976557B2 (en) 2004-06-23 2011-07-12 Boston Scientific Scimed, Inc. Cutting balloon and process
US20060001011A1 (en) 2004-07-02 2006-01-05 Wilson Neil R Surface conditioner for powder coating systems
CA2573720A1 (en) 2004-07-14 2006-02-23 University Of Utah Research Foundation Netrin-related compositions and uses
US8597716B2 (en) 2009-06-23 2013-12-03 Abbott Cardiovascular Systems Inc. Methods to increase fracture resistance of a drug-eluting medical device
US20060020325A1 (en) 2004-07-26 2006-01-26 Robert Burgermeister Material for high strength, controlled recoil stent
US8541078B2 (en) 2004-08-06 2013-09-24 Societe Bic Fuel supplies for fuel cells
WO2006023530A2 (en) 2004-08-16 2006-03-02 Massachusetts Institute Of Technology Compositions and methods for enhancing structural and functional nervous system reorganization and recovery
US7425368B2 (en) 2004-08-20 2008-09-16 Massachusetts Institute Of Technology Filler-enhanced polymeric fibers with improved mechanical properties and method for making
US8119153B2 (en) 2004-08-26 2012-02-21 Boston Scientific Scimed, Inc. Stents with drug eluting coatings
US20080077232A1 (en) 2004-09-08 2008-03-27 Kaneka Corporation Stent for Placement in Body
EP1792582B1 (en) 2004-09-08 2018-04-04 Kaneka Corporation Indwelling stent
US20090011116A1 (en) 2004-09-28 2009-01-08 Atrium Medical Corporation Reducing template with coating receptacle containing a medical device to be coated
US8263102B2 (en) 2004-09-28 2012-09-11 Atrium Medical Corporation Drug delivery coating for use with a stent
MX2007003731A (en) 2004-09-29 2007-08-14 Johnson & Johnson Pharmaceutical dosage forms of stable amorphous rapamycin like compounds.
US8313763B2 (en) 2004-10-04 2012-11-20 Tolmar Therapeutics, Inc. Sustained delivery formulations of rapamycin compounds
US20060093643A1 (en) 2004-11-04 2006-05-04 Stenzel Eric B Medical device for delivering therapeutic agents over different time periods
US7455658B2 (en) 2004-11-10 2008-11-25 Samw Hong Jen Wang Fluid dispensing or feeding device
US7455688B2 (en) 2004-11-12 2008-11-25 Con Interventional Systems, Inc. Ostial stent
WO2006063021A2 (en) 2004-12-07 2006-06-15 Surmodics, Inc. Coatngs with crystallized active agents (s)
US20070059350A1 (en) 2004-12-13 2007-03-15 Kennedy John P Agents for controlling biological fluids and methods of use thereof
US7632307B2 (en) 2004-12-16 2009-12-15 Advanced Cardiovascular Systems, Inc. Abluminal, multilayer coating constructs for drug-delivery stents
EP1830900A1 (en) 2004-12-16 2007-09-12 Miv Therapeutics Inc. Multi-layer drug delivery device and method of manufacturing same
US8292944B2 (en) 2004-12-17 2012-10-23 Reva Medical, Inc. Slide-and-lock stent
US20060198868A1 (en) 2005-01-05 2006-09-07 Dewitt David M Biodegradable coating compositions comprising blends
US7727273B2 (en) 2005-01-13 2010-06-01 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
US7772352B2 (en) 2005-01-28 2010-08-10 Bezwada Biomedical Llc Bioabsorbable and biocompatible polyurethanes and polyamides for medical devices
WO2006110197A2 (en) 2005-03-03 2006-10-19 Icon Medical Corp. Polymer biodegradable medical device
US7837726B2 (en) 2005-03-14 2010-11-23 Abbott Laboratories Visible endoprosthesis
KR20070116821A (en) 2005-03-14 2007-12-11 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Biocompatible polymer compounds for medicinal formulations
EP1868576A2 (en) 2005-03-17 2007-12-26 Elan Pharma International Limited Injectable compositions of nanoparticulate immunosuppressive compounds
EP1868663B1 (en) 2005-03-23 2011-11-16 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US8628565B2 (en) 2005-04-13 2014-01-14 Abbott Cardiovascular Systems Inc. Intravascular stent
US20110118827A1 (en) 2005-06-06 2011-05-19 Dr. Tim Wu Biodegradable stent formed with polymer-bioceramic nanoparticle composite and method of making the same
US20070009564A1 (en) 2005-06-22 2007-01-11 Mcclain James B Drug/polymer composite materials and methods of making the same
US20090062909A1 (en) 2005-07-15 2009-03-05 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
CN105233349B (en) 2005-07-15 2019-06-18 胶束技术股份有限公司 The polymer coating of drug powder comprising controlled morphology
US20070026042A1 (en) 2005-07-29 2007-02-01 Narayanan Pallasssana V System for treating aneurysmal disease
EP1912614A4 (en) 2005-08-03 2009-08-05 Univ Western Ontario Direct coating solid dosage forms using powdered materials
EP1911214B1 (en) 2005-08-05 2008-12-10 Telecom Italia S.p.A. Method of establishing a connection on a communication network
WO2007017707A1 (en) 2005-08-11 2007-02-15 Hilary Nwokeabia The slanting toothbrush
US8343170B2 (en) 2005-08-12 2013-01-01 Massicotte J Mathieu Method and device for extracting objects from the body
US20070043434A1 (en) 2005-08-18 2007-02-22 David Meerkin Biodegradable endovascular stent using stereocomplexation of polymers
EP1764116A1 (en) 2005-09-16 2007-03-21 Debiotech S.A. Porous coating process using colloidal particles
US7935379B2 (en) 2005-11-14 2011-05-03 Boston Scientific Scimed, Inc. Coated and imprinted medical devices and methods of making the same
US20070196423A1 (en) 2005-11-21 2007-08-23 Med Institute, Inc. Implantable medical device coatings with biodegradable elastomer and releasable therapeutic agent
WO2007065722A1 (en) 2005-12-09 2007-06-14 Dsm Ip Assets B.V. Hydrophilic coating comprising a polyelectrolyte
US20070148251A1 (en) 2005-12-22 2007-06-28 Hossainy Syed F A Nanoparticle releasing medical devices
US7842312B2 (en) 2005-12-29 2010-11-30 Cordis Corporation Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same
US8834912B2 (en) 2005-12-30 2014-09-16 Boston Scientific Scimed, Inc. Medical devices having multiple charged layers
US20080286325A1 (en) 2006-01-05 2008-11-20 Med Institute, Inc. Cyclodextrin elution media for medical device coatings comprising a taxane therapeutic agent
US7919108B2 (en) 2006-03-10 2011-04-05 Cook Incorporated Taxane coatings for implantable medical devices
JP5128497B2 (en) 2006-01-23 2013-01-23 スミス アンド ネフュー インコーポレーテッド Patellar component
WO2007092179A2 (en) 2006-01-27 2007-08-16 Med Institute, Inc. Device with nanocomposite coating for controlled drug release
WO2007089259A1 (en) 2006-02-02 2007-08-09 The Johns Hopkins University Therapeutic electrospun fiber compositions
EP1986923A4 (en) 2006-02-23 2012-12-19 Agamatrix Inc Used test strip storage container
US20070200268A1 (en) 2006-02-24 2007-08-30 Vipul Dave Implantable device prepared from solution processing
US20070203569A1 (en) 2006-02-24 2007-08-30 Robert Burgermeister Implantable device formed from polymer blends having modified molecular structures
US8500772B2 (en) 2006-03-20 2013-08-06 Cook Medical Technologies Llc Distal protection device
US20070225795A1 (en) 2006-03-24 2007-09-27 Juan Granada Composite vascular prosthesis
US7879086B2 (en) 2006-04-20 2011-02-01 Boston Scientific Scimed, Inc. Medical device having a coating comprising an adhesion promoter
US7955383B2 (en) 2006-04-25 2011-06-07 Medtronics Vascular, Inc. Laminated implantable medical device having a metallic coating
CA2650590C (en) 2006-04-26 2018-04-03 Micell Technologies, Inc. Coatings containing multiple drugs
US20070254012A1 (en) 2006-04-28 2007-11-01 Ludwig Florian N Controlled degradation and drug release in stents
US7691400B2 (en) 2006-05-05 2010-04-06 Medtronic Vascular, Inc. Medical device having coating with zeolite drug reservoirs
US20080279909A1 (en) 2006-05-12 2008-11-13 Cleek Robert L Immobilized Biologically Active Entities Having A High Degree of Biological Activity Following Sterilization
US7959940B2 (en) 2006-05-30 2011-06-14 Advanced Cardiovascular Systems, Inc. Polymer-bioceramic composite implantable medical devices
US20070281117A1 (en) 2006-06-02 2007-12-06 Xtent, Inc. Use of plasma in formation of biodegradable stent coating
BRPI0603437A2 (en) 2006-06-06 2010-07-06 Luiz Gonzaga Granja Jr extraluminal stent anastomosis prosthesis
US20080124372A1 (en) 2006-06-06 2008-05-29 Hossainy Syed F A Morphology profiles for control of agent release rates from polymer matrices
US8535372B1 (en) 2006-06-16 2013-09-17 Abbott Cardiovascular Systems Inc. Bioabsorbable stent with prohealing layer
WO2008008291A2 (en) 2006-07-13 2008-01-17 Icon Medical Corp. Stent
US7812032B2 (en) 2006-07-25 2010-10-12 Abbott Laboratories Crystalline forms of rapamycin analogs
WO2008033956A2 (en) 2006-09-13 2008-03-20 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
US20080065192A1 (en) 2006-09-13 2008-03-13 Medtronic Vascular, Inc. Compliance Graded Stent
WO2008033603A2 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Medical devices having alloy compositions
ATE530210T1 (en) 2006-09-18 2011-11-15 Boston Scient Ltd ENDOPROSTHESES
WO2008039749A2 (en) 2006-09-25 2008-04-03 Surmodics, Inc. Multi-layered coatings and methods for controlling elution of active agents
WO2008042909A2 (en) 2006-10-02 2008-04-10 Micell Technologies Inc. Surgical sutures having increased strength
EP1916006A1 (en) 2006-10-19 2008-04-30 Albert Schömig Implant coated with a wax or a resin
EP1913960A1 (en) 2006-10-19 2008-04-23 Albert Schömig Coated implant
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
US20080097591A1 (en) 2006-10-20 2008-04-24 Biosensors International Group Drug-delivery endovascular stent and method of use
US20080098178A1 (en) 2006-10-23 2008-04-24 Veazey Judson E Data storage on a switching system coupling multiple processors of a computer system
CA2667228C (en) 2006-10-23 2015-07-14 Micell Technologies, Inc. Holder for electrically charging a substrate during coating
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US8414909B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
EP2101779A1 (en) 2006-12-13 2009-09-23 Angiotech Pharmaceuticals, Inc. Medical implants with a combination of compounds
US9474833B2 (en) 2006-12-18 2016-10-25 Cook Medical Technologies Llc Stent graft with releasable therapeutic agent and soluble coating
US8114466B2 (en) 2007-01-03 2012-02-14 Boston Scientific Scimed, Inc. Methods of applying coating to the inside surface of a stent
CN101711137B (en) 2007-01-08 2014-10-22 米歇尔技术公司 Stents having biodegradable layers
US20130150943A1 (en) 2007-01-19 2013-06-13 Elixir Medical Corporation Biodegradable endoprostheses and methods for their fabrication
US7745566B2 (en) 2007-01-23 2010-06-29 Ferro Corporation Methods for the purification of polymers
US7887830B2 (en) 2007-02-27 2011-02-15 Boston Scientific Scimed, Inc. Medical devices having polymeric regions based on styrene-isobutylene copolymers
WO2008115405A2 (en) 2007-03-16 2008-09-25 Sti Medicals Systems, Llc A method of image quality assessment to procuce standardized imaging data
US7815962B2 (en) 2007-03-22 2010-10-19 Medtronic Vascular, Inc. Coated stent with evenly distributed therapeutic agent
US20080249605A1 (en) 2007-04-04 2008-10-09 Vipul Dave Bioabsorbable Polymer, Non-Bioabsorbable Metal Composite Stents
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
BRPI0810370A2 (en) 2007-04-17 2014-10-29 Micell Technologies Inc STENT COATED, AND METHOD FOR PREPARING A STENT
CA2686736A1 (en) 2007-05-03 2008-11-13 Abraxis Bioscience, Llc Nanoparticle compositions comprising rapamycin for treating pulmonary hypertension
US7952706B2 (en) 2007-05-17 2011-05-31 Prescient Medical, Inc. Multi-channel fiber optic spectroscopy systems employing integrated optics modules
GB0709517D0 (en) 2007-05-17 2007-06-27 Queen Mary & Westfield College An electrostatic spraying device and a method of electrostatic spraying
JP2010527746A (en) 2007-05-25 2010-08-19 ミセル テクノロジーズ、インコーポレイテッド Polymer film for medical device coating
US7922760B2 (en) 2007-05-29 2011-04-12 Abbott Cardiovascular Systems Inc. In situ trapping and delivery of agent by a stent having trans-strut depots
US8109904B1 (en) 2007-06-25 2012-02-07 Abbott Cardiovascular Systems Inc. Drug delivery medical devices
US20090068266A1 (en) 2007-09-11 2009-03-12 Raheja Praveen Sirolimus having specific particle size and pharmaceutical compositions thereof
US20090076446A1 (en) 2007-09-14 2009-03-19 Quest Medical, Inc. Adjustable catheter for dilation in the ear, nose or throat
EP2193127A4 (en) 2007-09-27 2011-09-14 Inst Medical W & E Hall Benzothiazole compounds
US8709071B1 (en) 2007-09-28 2014-04-29 Abbott Cardiovascular Systems Inc. Stent with preferential coating
JP5114788B2 (en) 2007-09-28 2013-01-09 三菱重工業株式会社 Lithium secondary battery
US20090105687A1 (en) 2007-10-05 2009-04-23 Angioscore, Inc. Scoring catheter with drug delivery membrane
DK2214646T3 (en) 2007-10-05 2021-10-04 Univ Wayne State DENDRIMERS FOR SUSTAINED RELEASE OF COMPOUNDS
US20100298928A1 (en) 2007-10-19 2010-11-25 Micell Technologies, Inc. Drug Coated Stents
EP3025685B1 (en) 2007-10-19 2019-07-17 CeloNova Biosciences, Inc. Implantable and lumen-supporting stents
US9987399B2 (en) 2007-10-30 2018-06-05 Nanyang Technological University Non-biodegradable stent comprising a biodegradable coating and method of coating the same
US20090111787A1 (en) 2007-10-31 2009-04-30 Florencia Lim Polymer blends for drug delivery stent matrix with improved thermal stability
US8642062B2 (en) 2007-10-31 2014-02-04 Abbott Cardiovascular Systems Inc. Implantable device having a slow dissolving polymer
CN101161300B (en) 2007-11-27 2011-03-16 北京美中双和医疗器械有限公司 Arsenic trioxide medicament elution bracket and its preparation method
US20090202609A1 (en) 2008-01-06 2009-08-13 Keough Steven J Medical device with coating composition
US20100042206A1 (en) 2008-03-04 2010-02-18 Icon Medical Corp. Bioabsorbable coatings for medical devices
WO2009111716A1 (en) 2008-03-06 2009-09-11 Boston Scientific Scimed, Inc. Balloon catheter devices with sheath covering
JP5667559B2 (en) 2008-03-28 2015-02-12 サーモディクス，インコーポレイティド Insertable medical device having an elastic matrix with microparticles disposed thereon, and drug delivery method
CN102083397B (en) 2008-04-17 2013-12-25 米歇尔技术公司 Stents having bioabsorbable layers
US8557273B2 (en) 2008-04-18 2013-10-15 Medtronic, Inc. Medical devices and methods including polymers having biologically active agents therein
US20110143429A1 (en) 2008-04-30 2011-06-16 Iksoo Chun Tissue engineered blood vessels
US8703302B2 (en) 2008-05-08 2014-04-22 Nippon Steel & Sumikin Chemical Co., Ltd. Indolocarbazole derivative with aromatic phosphne oxide group for organic electroluminescent device and organic electroluminescent device containing same
US8298607B2 (en) 2008-05-15 2012-10-30 Abbott Cardiovascular Systems Inc. Method for electrostatic coating of a medical device
US7865562B2 (en) 2008-05-20 2011-01-04 International Business Machines Corporation Selecting email signatures
EP2131614B1 (en) 2008-05-30 2014-01-01 Alcatel Lucent Method for transmitting broadcast services in a radiocommunication cellular network through a femto base station, as well as corresponding femto base station
US20090297578A1 (en) 2008-06-03 2009-12-03 Trollsas Mikael O Biosoluble coating comprising anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders
US8206635B2 (en) 2008-06-20 2012-06-26 Amaranth Medical Pte. Stent fabrication via tubular casting processes
US7770466B2 (en) 2008-07-02 2010-08-10 Abbott Cardiovascular Systems Inc. Method for measuring stent dislodgement force
JP4557061B2 (en) 2008-07-11 2010-10-06 トヨタ自動車株式会社 Hybrid vehicle and control method thereof
WO2010009335A1 (en) 2008-07-17 2010-01-21 Micell Technologies, Inc. Drug delivery medical device
JP2010052503A (en) 2008-08-27 2010-03-11 Kawano Terukazu Engine for vessel
US20100055145A1 (en) 2008-08-29 2010-03-04 Biosensors International Group Stent coatings for reducing late stent thrombosis
WO2010024898A2 (en) 2008-08-29 2010-03-04 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
US8367090B2 (en) 2008-09-05 2013-02-05 Abbott Cardiovascular Systems Inc. Coating on a balloon comprising a polymer and a drug
WO2010033482A1 (en) 2008-09-19 2010-03-25 Innovative Surface Technologies, Inc. Drug eluting superhydrophobic coatings
CN102137642A (en) 2008-09-29 2011-07-27 斯特灵血管系统股份有限公司 Matrix coated stent
US8535655B2 (en) 2008-10-10 2013-09-17 Polyactiva Pty Ltd. Biodegradable polymer—bioactive moiety conjugates
PT2365802T (en) 2008-11-11 2017-11-14 Univ Texas Microcapsules of rapamycin and use for treating cancer
JP5784500B2 (en) 2008-11-21 2015-09-24 ライフセル コーポレーションＬｉｆｅＣｅｌｌ Ｃｏｒｐｏｒａｔｉｏｎ Enhanced biological material
CA2748273C (en) 2008-12-26 2018-01-09 Battelle Memorial Institute Medical implants and methods of making medical implants
US8834913B2 (en) 2008-12-26 2014-09-16 Battelle Memorial Institute Medical implants and methods of making medical implants
US20120231037A1 (en) 2009-02-02 2012-09-13 Yissum Research Development Companyof the Hebrew U Crystalline drug-containing coatings
US20100198330A1 (en) 2009-02-02 2010-08-05 Hossainy Syed F A Bioabsorbable Stent And Treatment That Elicits Time-Varying Host-Material Response
US9572692B2 (en) 2009-02-02 2017-02-21 Abbott Cardiovascular Systems Inc. Bioabsorbable stent that modulates plaque geometric morphology and chemical composition
EP2411083A4 (en) 2009-03-23 2013-11-13 Micell Technologies Inc Drug delivery medical device
US20100241220A1 (en) 2009-03-23 2010-09-23 Mcclain James B Peripheral Stents Having Layers
WO2010111238A2 (en) 2009-03-23 2010-09-30 Micell Technologies, Inc. Improved biodegradable polymers
WO2010120552A2 (en) 2009-04-01 2010-10-21 Micell Technologies, Inc. Coated stents
US9050176B2 (en) 2009-04-03 2015-06-09 Biomerix Corporation At least partially resorbable reticulated elastomeric matrix elements and methods of making same
US20110301697A1 (en) 2009-04-10 2011-12-08 Hemoteq Ag Manufacture, method and use of drug-eluting medical devices for permanently keeping blood vessels open
US9492587B2 (en) 2009-04-13 2016-11-15 Abbott Cardiovascular Systems Inc. Stent made from an ultra high molecular weight bioabsorbable polymer with high fatigue and fracture resistance
EP3366326A1 (en) 2009-04-17 2018-08-29 Micell Technologies, Inc. Stents having controlled elution
CA2979355C (en) 2009-05-18 2023-02-21 Dose Medical Corporation Drug eluting ocular implant
WO2010136604A1 (en) 2009-05-29 2010-12-02 Dsm Ip Assets B.V. Transfer matrix for transferring a bioactive agent to body tissue
EP2266507B1 (en) 2009-06-22 2015-07-29 Biotronik VI Patent AG Stent having improved stent design
US9327060B2 (en) 2009-07-09 2016-05-03 CARDINAL HEALTH SWITZERLAND 515 GmbH Rapamycin reservoir eluting stent
EP2453834A4 (en) 2009-07-16 2014-04-16 Micell Technologies Inc Drug delivery medical device
US8039147B2 (en) 2009-08-27 2011-10-18 Sb Limotive Co., Ltd. Rechargeable secondary battery having improved safety against puncture and collapse
WO2011044533A2 (en) 2009-10-09 2011-04-14 Specialized Vascular Technologies, Inc. Coating system and method for drug elution management
WO2011097103A1 (en) 2010-02-02 2011-08-11 Micell Technologies, Inc. Stent and stent delivery system with improved deliverability
WO2011119607A2 (en) 2010-03-24 2011-09-29 The Board Of Trustees Of The University Of Illinois Viscoelastic ink for direct writing of hydrogel structures
ES2676314T3 (en) 2010-03-25 2018-07-18 Lutonix, Inc. Coatings that release drugs for medical devices
US8795762B2 (en) 2010-03-26 2014-08-05 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
US10413391B2 (en) 2010-04-01 2019-09-17 Rensselaer Polytechnic Institute Three-dimensinoal scaffolds, methods for fabricating the same, and methods of treating a peripheral nerve or spinal cord injury
CA2794704C (en) 2010-04-16 2019-09-17 Micell Technologies, Inc. Stents having controlled elution
CA2797110C (en) 2010-04-22 2020-07-21 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
US10189773B2 (en) 2010-05-07 2019-01-29 Medicus Biosciences, Llc In-vivo gelling pharmaceutical pre-formulation
CA2805631C (en) 2010-07-16 2018-07-31 Micell Technologies, Inc. Drug delivery medical device
US9636309B2 (en) 2010-09-09 2017-05-02 Micell Technologies, Inc. Macrolide dosage forms
WO2012078955A1 (en) 2010-12-10 2012-06-14 Micropen Technologies Corporation Stents and methods of making stents
US8974622B2 (en) 2010-12-28 2015-03-10 Boston Scientific Scimed, Inc. Composite ePTFE-silicone covering for stent
US20120177742A1 (en) 2010-12-30 2012-07-12 Micell Technologies, Inc. Nanoparticle and surface-modified particulate coatings, coated balloons, and methods therefore
EP2696815B1 (en) 2011-04-13 2019-03-20 Micell Technologies, Inc. Stents having controlled elution
US20120280432A1 (en) 2011-05-06 2012-11-08 Industrial Technology Research Institute Method for manufacturing bioabsorbable stents
US9446172B2 (en) 2011-05-10 2016-09-20 Abbott Cardiovascular Systems Inc. Modification of bioabsorbable stent to reduce thrombogenecity
US10464100B2 (en) 2011-05-31 2019-11-05 Micell Technologies, Inc. System and process for formation of a time-released, drug-eluting transferable coating
US10117972B2 (en) 2011-07-15 2018-11-06 Micell Technologies, Inc. Drug delivery medical device
US20140257465A1 (en) 2011-08-12 2014-09-11 Micell Technologies, Inc. Stents having controlled elution
WO2014063111A1 (en) 2012-10-18 2014-04-24 Micell Technologyies, Inc. Drug delivery medical device
AU2012326010B2 (en) 2011-10-18 2017-05-11 Micell Technologies, Inc. Drug delivery medical device
WO2013177211A1 (en) 2012-05-21 2013-11-28 Micell Technologies, Inc. Safe drug eluting stent with absorbable coating
JP2013153822A (en) 2012-01-27 2013-08-15 Terumo Corp In-vivo indwelling stent and living organ dilator
US9090029B2 (en) 2012-02-06 2015-07-28 Warsaw Orthopedic, Inc. Pultrusion process for preparing composites having low percentage of fibers and articles made from same
US8859088B2 (en) 2012-04-16 2014-10-14 Auburn University Minimal weight composites using open structure
WO2013173657A1 (en) 2012-05-16 2013-11-21 Micell Technologies, Inc. Low burst sustained release lipophilic and biologic agent compositions
US8968387B2 (en) 2012-07-23 2015-03-03 Abbott Cardiovascular Systems Inc. Shape memory bioresorbable polymer peripheral scaffolds
US9744058B2 (en) 2013-02-14 2017-08-29 Abbott Cardiovascular Systems Inc. Methods of treatment directed to neointimal proliferation generated by endothelial shear stress patterns from drug-eluting bioresorbable vascular scaffold implantation
KR20150143476A (en) 2013-03-12 2015-12-23 미셀 테크놀로지즈, 인코포레이티드 Bioabsorbable biomedical implants
WO2014176451A1 (en) 2013-04-24 2014-10-30 Trustees Of Tufts College Bioresorbable biopolymer stent
WO2014186532A1 (en) 2013-05-15 2014-11-20 Micell Technologies, Inc. Bioabsorbable biomedical implants
EP3033053A4 (en) 2013-08-16 2017-04-05 Amaranth Medical PTE Bioresorbable scaffold for treatment of bifurcation lesion
US9510976B2 (en) 2014-04-29 2016-12-06 Abbott Cardiovascular Systems Inc. Devices and methods for treatment of the Eustachian tube and sinus cavity
WO2015181826A1 (en) 2014-05-27 2015-12-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Crystalline coating and release of bioactive agents
US11628077B2 (en) 2016-10-31 2023-04-18 Razmodics Llc Post deployment radial force recovery of biodegradable scaffolds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030222017A1 (en) * 2002-05-28 2003-12-04 Battelle Memorial Institute Electrostatic deposition of particles generated from rapid expansion of supercritical fluid solutions

Also Published As

Publication number Publication date
US8298565B2 (en) 2012-10-30
KR101406415B1 (en) 2014-06-19
PL1909973T3 (en) 2019-01-31
US20240285421A1 (en) 2024-08-29
JP5852027B2 (en) 2016-02-03
JP5851949B2 (en) 2016-02-03
US10898353B2 (en) 2021-01-26
EP1909973B1 (en) 2018-08-22
ES2691646T3 (en) 2018-11-28
WO2007011707A2 (en) 2007-01-25
AU2006270221A1 (en) 2007-01-25
CA2615452C (en) 2015-03-31
US20130006351A1 (en) 2013-01-03
US20180092762A1 (en) 2018-04-05
US8758429B2 (en) 2014-06-24
US11911301B2 (en) 2024-02-27
CN101454086B (en) 2015-08-26
CA2615452A1 (en) 2007-01-25
JP2013099598A (en) 2013-05-23
WO2007011707A3 (en) 2007-12-27
US20210161687A1 (en) 2021-06-03
US9827117B2 (en) 2017-11-28
JP2012183441A (en) 2012-09-27
AU2006270221B2 (en) 2012-01-19
KR20080090380A (en) 2008-10-08
US20150025620A1 (en) 2015-01-22
CN105233349B (en) 2019-06-18
JP2009501566A (en) 2009-01-22
CN101454086A (en) 2009-06-10
HK1217662A1 (en) 2017-01-20
US20090123515A1 (en) 2009-05-14
CN105233349A (en) 2016-01-13
HK1131585A1 (en) 2010-01-29
JP5756588B2 (en) 2015-07-29
EP1909973A2 (en) 2008-04-16

Similar Documents

Publication Publication Date Title
PL1909973T3 (en) Polymer coatings containing drug powder of controlled morphology
HK1203421A1 (en) Flat process of drug coating of stents
PL2019657T3 (en) Coatings containing multiple drugs
EP2500047B8 (en) Drug releasing coatings for medical devices
EP2059626A4 (en) Solid precursor-based delivery of fluid utilizing controlled solids morphology
ZA200600403B (en) Antibiotic coating of implants
EP1761212A4 (en) Porous coatings for biomedical implants
EP2094188A4 (en) Polymer coating for medical devices
IL189103A0 (en) Processes for the manufacture of sterilized pancreation powder
ZA201000437B (en) Pharmaceutical compositions of rifaximin
SI2011486T1 (en) Pharmaceutical compositions of rifaximin
EP2010650A4 (en) Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
EP2089529A4 (en) Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
EP2170985A4 (en) Silicone coatings, methods of making silicone coated articles and coated articles therefrom
EP2049591A4 (en) Biocompatible polymer compositions
ZA200770518B (en) Use of polysllazanes as permanent anti-fingerprint coatings
GB0502085D0 (en) Powder coatings
IL206562A0 (en) Novel catechol derivative, pharmaceutical composition containing the same, use of the catechol derivative, and use of the pharmaceutical composition
EP1940431A4 (en) Polymer coatings containing phytochemical agents and methods for making and using same
EP2173360A4 (en) Heparosan-based biomaterials and coatings and methods of production and use thereof
EP1905455A4 (en) Capsule coating composition
IL206341A0 (en) Coated extended release pharmaceutical compositions of levetiracetam
GB0414911D0 (en) Biocompatible coating of medical devices
GB0425322D0 (en) Biocompatible coating of medical devices
AU2006905740A0 (en) Treatment of polymers

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20080214

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA HR MK RS

A4 Supplementary search report drawn up and despatched

Effective date: 20120206

RIC1 Information provided on ipc code assigned before grant

Ipc: A61L 2/00 20060101ALI20120131BHEP

Ipc: B05D 3/00 20060101AFI20120131BHEP

Ipc: A61L 31/16 20060101ALI20120131BHEP

Ipc: A61L 31/10 20060101ALI20120131BHEP

DAX Request for extension of the european patent (deleted)
17Q First examination report despatched

Effective date: 20130315

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20180309

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602006056160

Country of ref document: DE

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 1031855

Country of ref document: AT

Kind code of ref document: T

Effective date: 20180915

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: NL

Ref legal event code: FP

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2691646

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20181128

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180822

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180822

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181222

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181122

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181123

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 1031855

Country of ref document: AT

Kind code of ref document: T

Effective date: 20180822

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180822

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180822

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180822

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180822

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180822

REG Reference to a national code

Ref country code: DE

Ref legal event code: R026

Ref document number: 602006056160

Country of ref document: DE

PLBI Opposition filed

Free format text: ORIGINAL CODE: 0009260

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180822

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180822

PLAX Notice of opposition and request to file observation + time limit sent

Free format text: ORIGINAL CODE: EPIDOSNOBS2

26 Opposition filed

Opponent name: BIOTRONIK AG

Effective date: 20190523

PLAX Notice of opposition and request to file observation + time limit sent

Free format text: ORIGINAL CODE: EPIDOSNOBS2

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180822

PLBB Reply of patent proprietor to notice(s) of opposition received

Free format text: ORIGINAL CODE: EPIDOSNOBS3

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180822

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20190731

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190714

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190731

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20181222

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190714

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: PL

Payment date: 20200617

Year of fee payment: 15

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20200803

Year of fee payment: 15

Ref country code: TR

Payment date: 20200714

Year of fee payment: 15

PLCK Communication despatched that opposition was rejected

Free format text: ORIGINAL CODE: EPIDOSNREJ1

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20200716

Year of fee payment: 15

Ref country code: SE

Payment date: 20200710

Year of fee payment: 15

APAH Appeal reference modified

Free format text: ORIGINAL CODE: EPIDOSCREFNO

APBM Appeal reference recorded

Free format text: ORIGINAL CODE: EPIDOSNREFNO

APBP Date of receipt of notice of appeal recorded

Free format text: ORIGINAL CODE: EPIDOSNNOA2O

APBQ Date of receipt of statement of grounds of appeal recorded

Free format text: ORIGINAL CODE: EPIDOSNNOA3O

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180822

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20060714

REG Reference to a national code

Ref country code: DE

Ref legal event code: R081

Ref document number: 602006056160

Country of ref document: DE

Owner name: MICELL MEDTECH INC. (N.D. GES. D. STAATES DELA, US

Free format text: FORMER OWNER: MICELL TECHNOLOGIES, INC., RALEIGH, N.C., US

Ref country code: DE

Ref legal event code: R081

Ref document number: 602006056160

Country of ref document: DE

Owner name: MT ACQUISITION HOLDINGS LLC (N.D.GES.D. STAATE, US

Free format text: FORMER OWNER: MICELL TECHNOLOGIES, INC., RALEIGH, N.C., US

REG Reference to a national code

Ref country code: DE

Ref legal event code: R081

Ref document number: 602006056160

Country of ref document: DE

Owner name: MICELL MEDTECH INC. (N.D. GES. D. STAATES DELA, US

Free format text: FORMER OWNERS: MICELL SPV EQUITY LLC (N.D.GES.D. STAATES DELAWARE), PINE PLAINS, NY, US; MICELL SPV I LLC (N.D.GES.D. STAATES DELAWARE), PINE PLAINS, NY, US

Ref country code: DE

Ref legal event code: R081

Ref document number: 602006056160

Country of ref document: DE

Owner name: MT ACQUISITION HOLDINGS LLC (N.D.GES.D. STAATE, US

Free format text: FORMER OWNERS: MICELL SPV EQUITY LLC (N.D.GES.D. STAATES DELAWARE), PINE PLAINS, NY, US; MICELL SPV I LLC (N.D.GES.D. STAATES DELAWARE), PINE PLAINS, NY, US

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

APAH Appeal reference modified

Free format text: ORIGINAL CODE: EPIDOSCREFNO

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210731

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210731

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210715

REG Reference to a national code

Ref country code: NL

Ref legal event code: PD

Owner name: MICELL SPV I LLC; US

Free format text: DETAILS ASSIGNMENT: CHANGE OF OWNER(S), ASSIGNMENT; FORMER OWNER NAME: MICELL TECHNOLOGIES, INC.

Effective date: 20220531

REG Reference to a national code

Ref country code: GB

Ref legal event code: 732E

Free format text: REGISTERED BETWEEN 20220728 AND 20220803

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20220902

REG Reference to a national code

Ref country code: NL

Ref legal event code: PD

Owner name: MICELL SPV I LLC; US

Free format text: DETAILS ASSIGNMENT: CHANGE OF OWNER(S), ASSIGNMENT; FORMER OWNER NAME: MICELL TECHNOLOGIES, INC.

Effective date: 20220927

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210715

REG Reference to a national code

Ref country code: DE

Ref legal event code: R081

Ref document number: 602006056160

Country of ref document: DE

Owner name: MICELL MEDTECH INC. (N.D. GES. D. STAATES DELA, US

Free format text: FORMER OWNER: MT ACQUISITION HOLDINGS LLC (N.D.GES.D. STAATES DELAWARE), PINE PLAINS, NY, US

REG Reference to a national code

Ref country code: GB

Ref legal event code: 732E

Free format text: REGISTERED BETWEEN 20230629 AND 20230705

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20230612

Year of fee payment: 18

REG Reference to a national code

Ref country code: NL

Ref legal event code: PD

Owner name: MICELL SPV I LLC; US

Free format text: DETAILS ASSIGNMENT: CHANGE OF OWNER(S), ASSIGNMENT; FORMER OWNER NAME: MT ACQUISITION HOLDINGS LLC

Effective date: 20231017

APBU Appeal procedure closed

Free format text: ORIGINAL CODE: EPIDOSNNOA9O

PLAY Examination report in opposition despatched + time limit

Free format text: ORIGINAL CODE: EPIDOSNORE2

PLBC Reply to examination report in opposition received

Free format text: ORIGINAL CODE: EPIDOSNORE3

PLAP Information related to despatch of examination report in opposition + time limit deleted

Free format text: ORIGINAL CODE: EPIDOSDORE2

PLAT Information related to reply to examination report in opposition deleted

Free format text: ORIGINAL CODE: EPIDOSDORE3

PLAY Examination report in opposition despatched + time limit

Free format text: ORIGINAL CODE: EPIDOSNORE2

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210714

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210714

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20240722

Year of fee payment: 19

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210714

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20240719

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20240709

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20240705

Year of fee payment: 19