EP1883465A1 - Doppelkammer-mischvorrichtung für visköse pharmazeutische substanzen - Google Patents
Doppelkammer-mischvorrichtung für visköse pharmazeutische substanzenInfo
- Publication number
- EP1883465A1 EP1883465A1 EP06752699A EP06752699A EP1883465A1 EP 1883465 A1 EP1883465 A1 EP 1883465A1 EP 06752699 A EP06752699 A EP 06752699A EP 06752699 A EP06752699 A EP 06752699A EP 1883465 A1 EP1883465 A1 EP 1883465A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- tanks
- mixing
- substances
- mixing element
- vessel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000126 substance Substances 0.000 title claims description 13
- 239000011345 viscous material Substances 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 13
- 230000003068 static effect Effects 0.000 claims description 11
- 238000002347 injection Methods 0.000 claims description 7
- 239000007924 injection Substances 0.000 claims description 7
- 229910001220 stainless steel Inorganic materials 0.000 claims description 6
- 239000010935 stainless steel Substances 0.000 claims description 6
- 230000004913 activation Effects 0.000 claims description 3
- 238000009529 body temperature measurement Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000011261 inert gas Substances 0.000 claims description 3
- 238000005086 pumping Methods 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- 238000005070 sampling Methods 0.000 claims description 2
- 230000003213 activating effect Effects 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 1
- 239000012809 cooling fluid Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
- B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
- B01F25/4512—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture with reciprocating pistons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
- B01F35/7161—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components the containers being connected coaxially before contacting the contents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
- B01F35/7174—Feed mechanisms characterised by the means for feeding the components to the mixer using pistons, plungers or syringes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
- B01F35/71775—Feed mechanisms characterised by the means for feeding the components to the mixer using helical screws
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
- B01F35/71805—Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/75—Discharge mechanisms
- B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
- B01F35/7547—Discharge mechanisms characterised by the means for discharging the components from the mixer using valves, gates, orifices or openings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/90—Heating or cooling systems
- B01F35/92—Heating or cooling systems for heating the outside of the receptacle, e.g. heated jackets or burners
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
Definitions
- the present invention relates to a dual chamber mixing device for obtaining a very good homogeneity in the case of a mixture of viscous substances, particularly in the pharmaceutical field.
- the invention also relates to the method of implementation of the device.
- the present invention aims to provide a solution that makes it possible to overcome the drawbacks of the state of the art.
- the present invention aims to provide a device and a mixing process that allow to obtain a perfectly homogeneous mixture of viscous pharmaceutical substances.
- the invention also aims to provide a device and a fully automated mixing process.
- the invention has the additional object of providing a mixing process whose result is satisfactory in less than 10 to 15 minutes.
- the invention also aims to allow the mixture of heat-sensitive pharmaceutical substances. Finally, the invention aims to provide a mixing device for the complete emptying of the tanks used.
- a first object of the present invention is to propose a device for mixing at least two viscous substances, with a double chamber, comprising: a first and a second cylindrical coaxial tank, each closed at a first end in a sealed manner by a movable piston and provided at its second end with a slightly conical bottom, the two tanks being arranged, preferably vertically, symmetrically in a mirror with respect to a plane perpendicular to their common axis;
- a second object of the present invention is to provide a method of mixing at least two viscous substances, preferably pharmaceutical, by means of the aforementioned device, characterized by the following steps:
- the substances to be mixed are injected into the first tank by withdrawing the piston or by screw injection;
- a predetermined number of successive mixing cycles are carried out by pumping from the first tank to the second tank, passing through the central static mixer, and vice versa; the final mixture is transferred to one of the two tanks which is then emptied.
- Figure 1 shows a sectional view of the mixing device according to a preferred embodiment of the present invention.
- FIG. 2 diagrammatically represents the different steps of the implementation method of the device according to FIG. 1.
- Figure 3 shows schematically the emptying step of the mixing device of the invention, which occurs once achieved the desired homogeneity.
- the present invention relates to a mixing unit which allows the incorporation and the automated and closed-loop mixing of pharmaceutical products for obtaining a mixture. final high viscosity.
- the invented mixing unit generally consists of two communicating tanks, vertical cylindrical, of the same axis and symmetrical with respect to a median horizontal plane (image of the tanks one of the other as in a mirror). These tanks are equipped with sealed pistons whose actuation by a hydraulic system allows the passage in successive cycles of the components to be mixed through a baffle mixing device.
- the assembly is fully automated using a PLC and can be thermostatically controlled for mixtures of heat-sensitive substances that require it.
- the mixing unit consists of the following elements:
- a high pressure hydraulic device for the automatic activation of the lid / piston (not shown);
- connections 4 possibly equipped with valves, for temperature measurement, evacuation or putting in an inert gas, sampling during mixing, injection or removal of substances, etc. ;
- a mixing element 5 also made of stainless steel connecting the two tanks 1, 2 equipped with: a double jacket 3 in which a cooling fluid or heating can circulate;
- a stainless steel element provided with baffles (static mixer) allowing the creation of a turbulent flow of mixture at the level of the components to be mixed;
- FIG. 2 is carried out by pumping, in the form of successive cycles, components to be mixed from the upper tank 1 to the lower tank 2 through the static mixer 5 and vice versa.
- the number of cycles required is set by the type and viscosity of the components to be mixed.
- this process is carried out between 5 and 10 cycles of about 30 seconds, which corresponds to a total process time of between 2 minutes and 5 minutes. According to the state of the art, a typical mixing time is 60 minutes.
- the components of the mixture are introduced into the upper tank 1 before starting the mixing process by removing the cover 12 or are injected into the system being mixed using a sealed worm gear (not shown in the figures) which can be positioned indifferently on the upper tank 1 or on the central mixing element 5.
- a sealed worm gear not shown in the figures
- the system allows complete emptying of the latter as shown in FIG. 3.
- the mixture is transferred for this purpose completely into the upper tank 1 or lower 2 and then drained outwards.
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Accessories For Mixers (AREA)
- Medicines Containing Plant Substances (AREA)
- Nozzles (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL06752699T PL1883465T3 (pl) | 2005-05-24 | 2006-05-23 | Dwukomorowe urządzenie mieszające do lepkich substancji farmaceutycznych oraz sposób |
| SI200630625T SI1883465T1 (sl) | 2005-05-24 | 2006-05-23 | Dvokomorna mešalna naprava za viskozne farmacevtske snovi in postopek |
| CY20101100310T CY1109930T1 (el) | 2005-05-24 | 2010-03-31 | Διαταξη αναμιξης διπλου θαλαμου για πυκνορρευστες φαρμακευτικες ουσιες και μεθοδος |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68433805P | 2005-05-24 | 2005-05-24 | |
| PCT/BE2006/000058 WO2006125284A1 (fr) | 2005-05-24 | 2006-05-23 | Dispositif de melange a double chambre pour substances pharmaceutiques visqueuses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP1883465A1 true EP1883465A1 (de) | 2008-02-06 |
| EP1883465B1 EP1883465B1 (de) | 2010-01-20 |
Family
ID=36747276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP06752699A Active EP1883465B1 (de) | 2005-05-24 | 2006-05-23 | Doppelkammer-mischvorrichtung für visköse pharmazeutische substanzen und verfahren |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7878704B2 (de) |
| EP (1) | EP1883465B1 (de) |
| AT (1) | ATE455588T1 (de) |
| CA (1) | CA2609438C (de) |
| CY (1) | CY1109930T1 (de) |
| DE (1) | DE602006011876D1 (de) |
| DK (1) | DK1883465T3 (de) |
| EA (1) | EA012125B1 (de) |
| ES (1) | ES2339384T3 (de) |
| PL (1) | PL1883465T3 (de) |
| PT (1) | PT1883465E (de) |
| SI (1) | SI1883465T1 (de) |
| WO (1) | WO2006125284A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010027107A1 (ja) * | 2008-09-05 | 2010-03-11 | オンコセラピー・サイエンス株式会社 | エマルジョン製剤を自動調整するための装置及び調整方法 |
| ITMI20090102A1 (it) * | 2009-01-29 | 2010-07-30 | Marina Scremin | Miscelatore |
| GB2513675A (en) * | 2011-04-05 | 2014-11-05 | Edge Therapeutics | Intraventricular drug delivery system for improving outcome after a brain injury affecting cerebral blood flow |
| NL2006787C2 (en) * | 2011-05-16 | 2012-11-19 | Avantium Holding B V | COMPOUNDER AND METHOD FOR MIXING ONE OR MORE VISCOUS FLUIDS. |
| US9604184B2 (en) | 2013-03-06 | 2017-03-28 | Orthovita, Inc. | Mixing system and valve assembly |
| US10596069B2 (en) * | 2015-12-22 | 2020-03-24 | Ethicon, Inc. | Syringes with mixing chamber in a removable cap |
| RU2656319C2 (ru) * | 2016-11-25 | 2018-06-04 | Общество с ограниченной ответственностью "Тунег" | Способ смешения сыпучих материалов и автоматическое устройство для его осуществления |
| RU170178U1 (ru) * | 2016-11-25 | 2017-04-18 | Общество с ограниченной ответственностью "Тунег" | Смеситель для приготовления смесей из сыпучих материалов |
| CN111729532B (zh) * | 2020-08-03 | 2020-12-18 | 山东明福染业有限公司 | 一种天然植物染料混匀装置 |
| CN113230958A (zh) * | 2021-05-10 | 2021-08-10 | 深圳杰明纳微电子科技有限公司 | 一种均匀混合氧化铈泥浆的装置 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2477598A (en) * | 1948-02-16 | 1949-08-02 | George M Hain | Microworker for lubricating greases |
| US2724383A (en) * | 1951-06-28 | 1955-11-22 | Compule Corp | Combined mixing container structure and hypodermic syringe for segregated ingredients of hypodermically injectable preparations |
| US2798488A (en) * | 1954-09-15 | 1957-07-09 | Merck & Co Inc | Syringe unit |
| US3035820A (en) * | 1960-03-23 | 1962-05-22 | Allergy Section Of The Res Fou | Emulsification apparatus |
| US3010705A (en) * | 1960-09-26 | 1961-11-28 | Brown Ethan Allan | Emulsifiers |
| GB1052971A (de) * | 1962-10-25 | |||
| US3190619A (en) * | 1963-05-27 | 1965-06-22 | Union Carbide Corp | Fluid mixing container assembly |
| US3700215A (en) * | 1970-10-21 | 1972-10-24 | Hardman Inc | Mixing and dispensing device |
| CH542699A (de) * | 1972-02-18 | 1973-10-15 | P Huerlimann Hans | Vorrichtung zum Behandeln von Stoffen |
| US4350650A (en) * | 1979-01-09 | 1982-09-21 | Euro-Linea S.N.C. Di Colombo & C. | Method for admixing at least two liquids and feeding them to a shaping mould |
| SU895160A1 (ru) * | 1979-01-16 | 1983-12-23 | Среднеазиатский научно-исследовательский институт природного газа | Устройство дл приготовлени бурового раствора |
| US4463875A (en) * | 1982-06-14 | 1984-08-07 | Robert W. Mann | Method and apparatus for preparing and applying a two-component cement |
| GB8516344D0 (en) * | 1985-06-28 | 1985-07-31 | Brunold C R | Mixing apparatus & processes |
| US5425580A (en) * | 1990-12-28 | 1995-06-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Dosage form for micro-bubble echo contrast agents |
| US6062722A (en) | 1997-10-21 | 2000-05-16 | Micron Communications, Inc. | Fluid mixing and withdrawing methods |
| SE9904539D0 (sv) * | 1999-12-10 | 1999-12-10 | Alphahelix Ab | Method and device for the handling of samples and reagents |
| US6592251B2 (en) * | 2001-01-26 | 2003-07-15 | Howmedica Osteonics Corp. | Cement mixing and dispensing device |
| US6799884B2 (en) * | 2002-12-23 | 2004-10-05 | The Goodyear Tire And Rubber Company | Dual chamber orifice mixer and method of use |
| US7748892B2 (en) * | 2004-06-02 | 2010-07-06 | Mccoy William | Method and apparatus for compounding medications |
-
2006
- 2006-05-23 AT AT06752699T patent/ATE455588T1/de active
- 2006-05-23 CA CA2609438A patent/CA2609438C/en active Active
- 2006-05-23 DK DK06752699.6T patent/DK1883465T3/da active
- 2006-05-23 WO PCT/BE2006/000058 patent/WO2006125284A1/fr not_active Application Discontinuation
- 2006-05-23 DE DE602006011876T patent/DE602006011876D1/de active Active
- 2006-05-23 SI SI200630625T patent/SI1883465T1/sl unknown
- 2006-05-23 EP EP06752699A patent/EP1883465B1/de active Active
- 2006-05-23 PL PL06752699T patent/PL1883465T3/pl unknown
- 2006-05-23 EA EA200702272A patent/EA012125B1/ru unknown
- 2006-05-23 PT PT06752699T patent/PT1883465E/pt unknown
- 2006-05-23 ES ES06752699T patent/ES2339384T3/es active Active
- 2006-05-23 US US11/915,118 patent/US7878704B2/en active Active
-
2010
- 2010-03-31 CY CY20101100310T patent/CY1109930T1/el unknown
Non-Patent Citations (1)
| Title |
|---|
| See references of WO2006125284A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006125284A1 (fr) | 2006-11-30 |
| EP1883465B1 (de) | 2010-01-20 |
| CA2609438A1 (en) | 2006-11-30 |
| CY1109930T1 (el) | 2014-04-09 |
| ES2339384T3 (es) | 2010-05-19 |
| DK1883465T3 (da) | 2010-05-17 |
| PT1883465E (pt) | 2010-04-14 |
| US7878704B2 (en) | 2011-02-01 |
| SI1883465T1 (sl) | 2010-05-31 |
| CA2609438C (en) | 2014-07-08 |
| US20080212399A1 (en) | 2008-09-04 |
| ATE455588T1 (de) | 2010-02-15 |
| EA200702272A1 (ru) | 2008-04-28 |
| DE602006011876D1 (de) | 2010-03-11 |
| EA012125B1 (ru) | 2009-08-28 |
| PL1883465T3 (pl) | 2010-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2006125284A1 (fr) | Dispositif de melange a double chambre pour substances pharmaceutiques visqueuses | |
| US5934803A (en) | Apparatus and method for mixing multi-part reaction materials under vacuum | |
| LU82470A1 (fr) | Installation pour preparer un melange liquide ou pateux destine a etre moule, et procede de mise en oeuvre de cette installation | |
| FR2865457A1 (fr) | Procede d'assemblage d'un capuchon avec recipient de reception, capuchon realise pour ce procede ainsi que recipient de reception et installation de reception forme a partir de ceux-ci | |
| JP7384988B2 (ja) | 混合のための装置 | |
| US9993783B2 (en) | Post/pedestal-mounted IBC mixing/blending machine | |
| JP2007511424A (ja) | 多成分材料用容器 | |
| JPH0735176B2 (ja) | ペ−スト状ないしは液状物質を適量づつ取出すための装置 | |
| CA2533912C (fr) | Dispositif melangeur pour dechets solides divises | |
| EP2215426B1 (de) | Verfahren zum giessen eines explosiven materials und gussvorrichtung unter verwendung dieses verfahrens | |
| FR2524265A1 (fr) | Cuve de transformation notamment cuve a fromage, cuve de melange, cuve de sterilisation ou cuve de maturation | |
| FR2616322A1 (fr) | Dispositif aseptique de mise en solution de composants reactifs | |
| EP0472138A1 (de) | Bodenventil | |
| WO2000040503A1 (fr) | Procede de refoulement dans une machine de remplissage et machine de remplissage pour la mise en oeuvre d'un tel procede | |
| FR2700495A1 (fr) | Procédé et dispositif pour la préparation de fûts métalliques usagés en vue de faciliter leur manutention et leur recyclage. | |
| FR2583903A1 (fr) | Procede et dispositif pour maintenir le volume variable d'une masse liquide entre deux valeurs limites predeterminees | |
| EP1348364A1 (de) | Gerät und Verfahren zum automatischen Herstellen und Verteilen von löslichen Getränken | |
| WO2022258914A1 (fr) | Dispositif d'alimentation d'un récipient pour installation de traitement thermique de déchets | |
| EP3616865A1 (de) | Vorrichtung und verfahren zum 3d-drucken in gel | |
| FR2771383A1 (fr) | Dispositif pour le melange extemporane de deux produits | |
| CH640428A5 (en) | Process for mixing and dispersing products in pulverulent and liquid and/or pasty form and plant for its use | |
| FR2872682A1 (fr) | Dispositif de melange en continu d'une pate alimentaire comprenant un outil de melange centrifuge et une evacuation laterale | |
| EP1897608B1 (de) | Mischvorrichtung zur Mischung eines Flüssigprodukts mit mindestens einem Inhaltsstoff | |
| EP3363023B1 (de) | Vorrichtung zum mischen von stoffen in einem behälter | |
| FR2616686A1 (fr) | Installation de traitement des corps creux |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20070908 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR |
|
| DAX | Request for extension of the european patent (deleted) | ||
| RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: UTERON PHARMA S.A. |
|
| RTI1 | Title (correction) |
Free format text: DOUBLE-CHAMBER MIXING DEVICE FOR VISCOUS PHARMACEUTICAL SUBSTANCES AND METHOD |
|
| GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
| GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
| GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
| AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR |
|
| REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D Free format text: NOT ENGLISH |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP |
|
| REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D |
|
| REF | Corresponds to: |
Ref document number: 602006011876 Country of ref document: DE Date of ref document: 20100311 Kind code of ref document: P |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: NV Representative=s name: CRONIN INTELLECTUAL PROPERTY |
|
| REG | Reference to a national code |
Ref country code: NL Ref legal event code: T3 Ref country code: PT Ref legal event code: SC4A Free format text: AVAILABILITY OF NATIONAL TRANSLATION Effective date: 20100406 |
|
| REG | Reference to a national code |
Ref country code: SE Ref legal event code: TRGR Ref country code: RO Ref legal event code: EPE |
|
| REG | Reference to a national code |
Ref country code: GR Ref legal event code: EP Ref document number: 20100400731 Country of ref document: GR |
|
| REG | Reference to a national code |
Ref country code: DK Ref legal event code: T3 |
|
| REG | Reference to a national code |
Ref country code: ES Ref legal event code: FG2A Ref document number: 2339384 Country of ref document: ES Kind code of ref document: T3 |
|
| REG | Reference to a national code |
Ref country code: SK Ref legal event code: T3 Ref document number: E 7117 Country of ref document: SK |
|
| REG | Reference to a national code |
Ref country code: HU Ref legal event code: AG4A Ref document number: E007989 Country of ref document: HU |
|
| PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
| 26N | No opposition filed |
Effective date: 20101021 |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R082 Ref document number: 602006011876 Country of ref document: DE Representative=s name: PATENTANWALTSKANZLEI VIEL & WIESKE, DE |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: PUE Owner name: ODYSSEA PHARMA S.A. Free format text: UTERON PHARMA S.A.#RUE SAINT-GEORGES 5#4000 LIEGE (BE) -TRANSFER TO- ODYSSEA PHARMA S.A.#RUE DU TRAVAIL 16#4460 GRACE-HOLLOGNE (BE) |
|
| REG | Reference to a national code |
Ref country code: HU Ref legal event code: GB9C Owner name: ODYSSEA PHARMA S.A., BE Free format text: FORMER OWNER(S): UTERON PHARMA S.A., BE Ref country code: HU Ref legal event code: FH1C Free format text: FORMER REPRESENTATIVE(S): SIPOS JOZSEF, DANUBIA SZABADALMI ES JOGI IRODA KFT., HU Representative=s name: DANUBIA SZABADALMI ES JOGI IRODA KFT., HU |
|
| BECH | Be: change of holder |
Owner name: ODYSSEA PHARMA S.A. Effective date: 20111214 |
|
| BECN | Be: change of holder's name |
Owner name: ODYSSEA PHARMA S.A. Effective date: 20111214 |
|
| REG | Reference to a national code |
Ref country code: NL Ref legal event code: SD Effective date: 20111228 |
|
| REG | Reference to a national code |
Ref country code: PT Ref legal event code: PC4A Owner name: ODYSSEA PHARMA S.A., BE Effective date: 20111230 |
|
| REG | Reference to a national code |
Ref country code: SI Ref legal event code: SP73 Owner name: ODYSSEA PHARMA S.A.; BE Effective date: 20111229 |
|
| REG | Reference to a national code |
Ref country code: GB Ref legal event code: 732E Free format text: REGISTERED BETWEEN 20120105 AND 20120111 |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R082 Ref document number: 602006011876 Country of ref document: DE Representative=s name: PATENTANWALTSKANZLEI VIEL UND WIESKE PARTGMBB, DE Effective date: 20111213 Ref country code: DE Ref legal event code: R082 Ref document number: 602006011876 Country of ref document: DE Representative=s name: PATENTANWALTSKANZLEI VIEL & WIESKE, DE Effective date: 20111213 Ref country code: DE Ref legal event code: R081 Ref document number: 602006011876 Country of ref document: DE Owner name: ODYSSEA PHARMA S.P.R.L., BE Free format text: FORMER OWNER: UTERON PHARMA S.A., LIEGE, BE Effective date: 20111213 Ref country code: DE Ref legal event code: R081 Ref document number: 602006011876 Country of ref document: DE Owner name: ODYSSEA PHARMA S.A., BE Free format text: FORMER OWNER: UTERON PHARMA S.A., LIEGE, BE Effective date: 20111213 |
|
| REG | Reference to a national code |
Ref country code: EE Ref legal event code: GB1A Ref document number: E004164 Country of ref document: EE |
|
| REG | Reference to a national code |
Ref country code: ES Ref legal event code: PC2A Owner name: ODYSSEA PHARMA S.A. Effective date: 20120227 |
|
| REG | Reference to a national code |
Ref country code: SK Ref legal event code: TC4A Ref document number: E 7117 Country of ref document: SK Owner name: UTERON PHARMA TECHNOLOGIES S.A., GRACE-HOLLOGN, BE Effective date: 20120313 Ref country code: SK Ref legal event code: PC4A Ref document number: E 7117 Country of ref document: SK Owner name: ODYSSEA PHARMA S.A., GRACE-HOLLOGNE, BE Free format text: FORMER OWNER: UTERON PHARMA TECHNOLOGIES S.A., GRACE-HOLLOGNE, BE Effective date: 20111107 |
|
| REG | Reference to a national code |
Ref country code: AT Ref legal event code: PC Ref document number: 455588 Country of ref document: AT Kind code of ref document: T Owner name: ODYSSEA PHARMA S.A., BE Effective date: 20120402 |
|
| REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 10 |
|
| REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 11 |
|
| REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 11 |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R082 Ref document number: 602006011876 Country of ref document: DE Representative=s name: PATENTANWALTSKANZLEI VIEL UND WIESKE PARTGMBB, DE Ref country code: DE Ref legal event code: R081 Ref document number: 602006011876 Country of ref document: DE Owner name: ODYSSEA PHARMA S.P.R.L., BE Free format text: FORMER OWNER: ODYSSEA PHARMA S.A., GRACE-HOLLOGNE, BE |
|
| REG | Reference to a national code |
Ref country code: FR Ref legal event code: RM Effective date: 20170227 Ref country code: FR Ref legal event code: CJ Effective date: 20170227 |
|
| REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 12 |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: PFA Owner name: ODYSSEA PHARMA S.P.R.L., BE Free format text: FORMER OWNER: ODYSSEA PHARMA S.A., BE |
|
| REG | Reference to a national code |
Ref country code: EE Ref legal event code: HC1A Ref document number: E004164 Country of ref document: EE |
|
| REG | Reference to a national code |
Ref country code: HU Ref legal event code: GB9C Owner name: ODYSSEA PHARMA S.P.R.L., BE Free format text: FORMER OWNER(S): UTERON PHARMA S.A., BE; ODYSSEA PHARMA S.A., BE Ref country code: HU Ref legal event code: FH1C Free format text: FORMER REPRESENTATIVE(S): SIPOS JOZSEF, DANUBIA SZABADALMI ES JOGI IRODA KFT., HU Representative=s name: DANUBIA SZABADALMI ES JOGI IRODA KFT., HU |
|
| REG | Reference to a national code |
Ref country code: ES Ref legal event code: PC2A Owner name: ODYSSEA PHARMA S.P.R.L. Effective date: 20171010 |
|
| REG | Reference to a national code |
Ref country code: SI Ref legal event code: SP73 Owner name: ODYSSEA PHARMA S.P.R.L.; BE Effective date: 20170920 |
|
| REG | Reference to a national code |
Ref country code: NL Ref legal event code: PD Owner name: ODYSSEA PHARMA SPRL; BE Free format text: DETAILS ASSIGNMENT: CHANGE OF OWNER(S), CHANGE OF LEGAL ENTITY; FORMER OWNER NAME: ODYSSEA PHARMA S.A. Effective date: 20170926 |
|
| REG | Reference to a national code |
Ref country code: SK Ref legal event code: TC4A Ref document number: E 7117 Country of ref document: SK Owner name: ODYSSEA PHARMA S.P.R.L., GRACE-HOLLOGNE, BE Effective date: 20171019 |
|
| REG | Reference to a national code |
Ref country code: AT Ref legal event code: PC Ref document number: 455588 Country of ref document: AT Kind code of ref document: T Owner name: ODYSSEA PHARMA S.P.R.L., BE Effective date: 20171220 |
|
| REG | Reference to a national code |
Ref country code: CH Ref legal event code: PCAR Free format text: NEW ADDRESS: CHEMIN DE LA VUARPILLIERE 29, 1260 NYON (CH) |
|
| REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 13 |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R079 Ref document number: 602006011876 Country of ref document: DE Free format text: PREVIOUS MAIN CLASS: B01F0005060000 Ipc: B01F0025400000 |
|
| REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 18 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: SE Payment date: 20230315 Year of fee payment: 18 |
|
| P01 | Opt-out of the competence of the unified patent court (upc) registered |
Effective date: 20230331 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: RO Payment date: 20230426 Year of fee payment: 18 Ref country code: PT Payment date: 20230426 Year of fee payment: 18 Ref country code: LT Payment date: 20230509 Year of fee payment: 18 Ref country code: IT Payment date: 20230510 Year of fee payment: 18 Ref country code: IE Payment date: 20230425 Year of fee payment: 18 Ref country code: FR Payment date: 20230412 Year of fee payment: 18 Ref country code: ES Payment date: 20230608 Year of fee payment: 18 Ref country code: EE Payment date: 20230413 Year of fee payment: 18 Ref country code: DK Payment date: 20230426 Year of fee payment: 18 Ref country code: DE Payment date: 20230412 Year of fee payment: 18 Ref country code: CZ Payment date: 20230419 Year of fee payment: 18 Ref country code: CY Payment date: 20230413 Year of fee payment: 18 Ref country code: CH Payment date: 20230602 Year of fee payment: 18 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: TR Payment date: 20230517 Year of fee payment: 18 Ref country code: SK Payment date: 20230425 Year of fee payment: 18 Ref country code: SI Payment date: 20230419 Year of fee payment: 18 Ref country code: LV Payment date: 20230413 Year of fee payment: 18 Ref country code: IS Payment date: 20230412 Year of fee payment: 18 Ref country code: HU Payment date: 20230421 Year of fee payment: 18 Ref country code: GR Payment date: 20230425 Year of fee payment: 18 Ref country code: FI Payment date: 20230426 Year of fee payment: 18 Ref country code: AT Payment date: 20230425 Year of fee payment: 18 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: BE Payment date: 20230413 Year of fee payment: 18 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: GB Payment date: 20230412 Year of fee payment: 18 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: MC Payment date: 20240329 Year of fee payment: 19 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: BG Payment date: 20240321 Year of fee payment: 19 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: LU Payment date: 20240415 Year of fee payment: 19 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: NL Payment date: 20240415 Year of fee payment: 19 |
|
| PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: PL Payment date: 20240319 Year of fee payment: 19 |