EP1857121A3 - Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same - Google Patents

Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same Download PDF

Info

Publication number
EP1857121A3
EP1857121A3 EP07017679A EP07017679A EP1857121A3 EP 1857121 A3 EP1857121 A3 EP 1857121A3 EP 07017679 A EP07017679 A EP 07017679A EP 07017679 A EP07017679 A EP 07017679A EP 1857121 A3 EP1857121 A3 EP 1857121A3
Authority
EP
European Patent Office
Prior art keywords
hapten
drug
methods
preparation
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07017679A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1857121A2 (en
Inventor
Philip A. Swain
Julia L. Greenstein
Mark A. Exley
Barbara S. Fox
Stephen P. Powers
Malcolm L. Gefter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xenova Research Ltd
Original Assignee
Xenova Research Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24894184&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP1857121(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Xenova Research Ltd filed Critical Xenova Research Ltd
Publication of EP1857121A2 publication Critical patent/EP1857121A2/en
Publication of EP1857121A3 publication Critical patent/EP1857121A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0013—Therapeutic immunisation against small organic molecules, e.g. cocaine, nicotine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Addiction (AREA)
  • Neurology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP07017679A 1996-09-30 1997-09-30 Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same Withdrawn EP1857121A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/720,487 US5876727A (en) 1995-03-31 1996-09-30 Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
EP97949331A EP1024834B1 (en) 1996-09-30 1997-09-30 Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP97949331A Division EP1024834B1 (en) 1996-09-30 1997-09-30 Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
EP97949331.9 Division 1998-04-09

Publications (2)

Publication Number Publication Date
EP1857121A2 EP1857121A2 (en) 2007-11-21
EP1857121A3 true EP1857121A3 (en) 2011-03-09

Family

ID=24894184

Family Applications (2)

Application Number Title Priority Date Filing Date
EP07017679A Withdrawn EP1857121A3 (en) 1996-09-30 1997-09-30 Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
EP97949331A Revoked EP1024834B1 (en) 1996-09-30 1997-09-30 Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP97949331A Revoked EP1024834B1 (en) 1996-09-30 1997-09-30 Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same

Country Status (13)

Country Link
US (1) US5876727A (https=)
EP (2) EP1857121A3 (https=)
JP (2) JP2001501933A (https=)
CN (3) CN1235640C (https=)
AT (1) ATE372786T1 (https=)
AU (1) AU733980B2 (https=)
BR (1) BR9711580A (https=)
CA (2) CA2574049A1 (https=)
DE (1) DE69738140T2 (https=)
DK (1) DK1024834T3 (https=)
ES (1) ES2293664T3 (https=)
PT (1) PT1024834E (https=)
WO (1) WO1998014216A2 (https=)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5876727A (en) * 1995-03-31 1999-03-02 Immulogic Pharmaceutical Corporation Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
US20020032316A1 (en) * 1995-03-31 2002-03-14 Cantab Pharmaceuticals Research Limited Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
US5840307A (en) * 1995-03-31 1998-11-24 Immulogic Pharmacuetical Corp. Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation
AU719289B2 (en) 1995-12-14 2000-05-04 Scripps Research Institute, The Anti-cocaine vaccine
US5817770A (en) 1997-03-21 1998-10-06 Drug Abuse Sciences, Inc. Cocaethylene immunogens and antibodies
JP2001516567A (ja) * 1997-09-19 2001-10-02 セレックス， インコーポレイテッド 抗原の免疫原性および抗体の特異性を改善する方法
SE9801923D0 (sv) * 1998-05-29 1998-05-29 Independent Pharmaceutical Ab Nicotine vaccine
US6541669B1 (en) * 1998-06-08 2003-04-01 Theravance, Inc. β2-adrenergic receptor agonists
US6858211B1 (en) * 1998-07-20 2005-02-22 The United States Of America As Represented By The Department Of Health And Human Services Vaccines against Escherichia coli O157 infection
US6232082B1 (en) 1998-12-01 2001-05-15 Nabi Hapten-carrier conjugates for treating and preventing nicotine addiction
GB2361473C (en) * 2000-03-08 2005-06-28 Microgenics Corp Ecstasy-class analogs and use of same in detection of ecstasy-class compounds
GB0031079D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Vaccine
WO2002058635A2 (en) * 2001-01-26 2002-08-01 The Scripps Research Institute Nicotine immunogens and antibodies and uses thereof
NZ511705A (en) * 2001-05-14 2004-03-26 Horticulture & Food Res Inst Methods and rapid immunoassay device for detecting progesterone and other steroids
ES2283589T3 (es) * 2001-06-15 2007-11-01 Vicuron Pharmaceuticals, Inc. Compuestos biciclicos de pirrolidina.
BR0213117A (pt) 2001-10-05 2004-09-21 Cytos Biotechnology Ag Conjugados peptìdeo angiotensina-veìculo e seus usos
US7115266B2 (en) * 2001-10-05 2006-10-03 Cytos Biotechnology Ag Angiotensin peptide-carrier conjugates and uses thereof
US20050089524A1 (en) * 2002-03-01 2005-04-28 Sanderson Sam D. Compositions and compounds for use as molecular adjuvant for a nicotine vaccine
NZ537003A (en) * 2002-07-18 2008-03-28 Cytos Biotechnology Ag Hapten-carrier conjugates comprising virus like particles and uses thereof
WO2005058920A1 (en) * 2003-11-17 2005-06-30 North Carolina State University Regiospecific synthesis of nicotine derivatives
US7279340B2 (en) * 2004-04-07 2007-10-09 Dade Behring Inc. Synthesis and application of procainamide analogs for use in an immunoassay
MXPA04006617A (es) 2004-07-07 2006-01-12 Inst Nac De Psiquiatria Ramon Proceso para la preparacion y uso de una vacuna bivalente contra la adiccion a la morfina-heroina.
US9492400B2 (en) * 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
FR2877668B1 (fr) * 2004-11-10 2007-07-06 Gemac Sa Procede de couplage de molecules non immunogenes, compose intermediaire, produit final obtenu et utilisations
US9267937B2 (en) 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
ES2776100T3 (es) * 2006-03-31 2020-07-29 Massachusetts Inst Technology Sistema para el suministro dirigido de agentes terapéuticos
US8367113B2 (en) 2006-05-15 2013-02-05 Massachusetts Institute Of Technology Polymers for functional particles
US20110052697A1 (en) * 2006-05-17 2011-03-03 Gwangju Institute Of Science & Technology Aptamer-Directed Drug Delivery
WO2007150030A2 (en) * 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
US20100144845A1 (en) * 2006-08-04 2010-06-10 Massachusetts Institute Of Technology Oligonucleotide systems for targeted intracellular delivery
WO2008147456A2 (en) * 2006-11-20 2008-12-04 Massachusetts Institute Of Technology Drug delivery systems using fc fragments
US9217129B2 (en) 2007-02-09 2015-12-22 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
WO2008124632A1 (en) * 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Amphiphilic compound assisted nanoparticles for targeted delivery
EP2630966B1 (en) 2007-10-12 2017-04-19 Massachusetts Institute of Technology Vaccine nanotechnology
US20110086063A1 (en) * 2008-06-04 2011-04-14 Cornell University Vaccines for prevention and treatment of addiction
US20110182918A1 (en) 2008-06-13 2011-07-28 Nabi Biopharmaceuticals Personalized drug treatment and smoking cessation kit and method
US8591905B2 (en) * 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
JP2012519724A (ja) 2009-03-09 2012-08-30 ヘンルイ ウイルリアム シグナルペプチドを担体として有する細菌毒素とのハプテン‐担体抱合体及び免疫原性組成物としてのその使用
KR20120022984A (ko) * 2009-04-21 2012-03-12 셀렉타 바이오사이언시즈, 인크. Ｔｈ１ 편향 반응을 제공하는 면역나노치료법
US20110064750A1 (en) * 2009-07-31 2011-03-17 Nabi Biopharmaceuticals Method and kit for treating nicotine addiction
EP2477974A2 (en) * 2009-09-14 2012-07-25 The Scripps Research Institute Nicotine haptens, immunoconjugates and their uses
ES2887335T3 (es) 2010-03-17 2021-12-22 Univ Cornell Vacuna contra las drogas de abuso basada en adenovirus alterado
WO2011123042A1 (en) * 2010-04-01 2011-10-06 Independent Pharmaceutica Ab Vaccination procedure and products for use therein
GB201006324D0 (en) 2010-04-15 2010-06-02 Glaxosmithkline Biolog Sa Vaccine
AU2011258165B2 (en) 2010-05-26 2016-11-17 Selecta Biosciences, Inc. Dose selection of adjuvanted synthetic nanocarriers
TWI578997B (zh) * 2010-06-04 2017-04-21 輝瑞疫苗有限責任公司 用於預防或治療菸鹼成癮之共軛體
WO2012061717A1 (en) 2010-11-05 2012-05-10 Selecta Biosciences, Inc. Modified nicotinic compounds and related methods
JP2014521687A (ja) 2011-07-29 2014-08-28 セレクタ バイオサイエンシーズ インコーポレーテッド 体液性および細胞傷害性ｔリンパ球（ｃｔｌ）免疫応答を生成する合成ナノキャリア
EP2568289A3 (en) 2011-09-12 2013-04-03 International AIDS Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
US9402894B2 (en) 2011-10-27 2016-08-02 International Aids Vaccine Initiative Viral particles derived from an enveloped virus
US9347065B2 (en) 2012-03-29 2016-05-24 International Aids Vaccine Initiative Methods to improve vector expression and genetic stability
US10004811B2 (en) 2012-04-13 2018-06-26 Cornell University Development of a highly efficient second generation nicotine-conjugate vaccine to treat nicotine addiction
EP2970319A4 (en) * 2013-03-14 2016-11-09 Alere San Diego Inc 6-ACETYLMORPHINE ANALOGUE AND METHOD FOR THE SYNTHESIS AND USE
US20170107275A1 (en) * 2014-05-19 2017-04-20 The Scripps Research Institute Enantiopure haptens for nicotine vaccine development
CA3041631A1 (en) * 2016-10-24 2018-05-03 The Scripps Research Institute Anti-opioid vaccines
AU2018283973B2 (en) * 2017-06-11 2025-04-24 Molecular Express, Inc. Methods and compositions for substance use disorder vaccine formulations and uses thereof
CN108409749B (zh) * 2018-01-30 2019-09-06 中国农业科学院蜜蜂研究所 钩吻素己半抗原和全抗原及其制备方法与应用
WO2020157381A1 (en) * 2019-01-29 2020-08-06 Teknologian Tutkimuskeskus Vtt Oy Methods for screening polypeptides capable of binding specific target molecules and tools related thereto
CN113999163A (zh) * 2021-11-03 2022-02-01 公安部第三研究所 合成大麻素半抗原化合物及其制备方法和用途
CN115974836A (zh) * 2023-01-16 2023-04-18 浙江安诺和生物医药有限公司 一种s-(-)-6-甲基尼古丁水杨酸盐及其制备方法
WO2024238822A1 (en) * 2023-05-17 2024-11-21 Regents Of The University Of Minnesota Heroin vaccine compositions and methods thereof
CN117865868B (zh) * 2023-05-19 2024-09-06 湖南大学 一种功能化分子、其制备方法及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992003163A1 (de) * 1990-08-22 1992-03-05 Cerny Erich H Impfstoff und immunserum gegen drogen
WO1993023076A1 (en) * 1992-05-20 1993-11-25 The Johns-Hopkins University Alternative receptor therapy

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4375414A (en) * 1971-05-20 1983-03-01 Meir Strahilevitz Immunological methods for removing species from the blood circulatory system and devices therefor
US3766162A (en) * 1971-08-24 1973-10-16 Hoffmann La Roche Barbituric acid antigens and antibodies specific therefor
US4045420A (en) * 1973-05-29 1977-08-30 Syva Company Non-oxo-carbonyl containing benzoyl ecgonine and cocaine compounds polypeptide and derivatives thereof
US4053459A (en) * 1975-09-24 1977-10-11 Hoffmann-La Roche Inc. Antibody specific to methaqualone and its metabolites
SU792869A1 (ru) * 1979-03-30 1982-03-30 Научно-Исследовательский Институт По Биологическим Испытаниям Химических Соединений Способ получени конъюгированных антигенов барбитурова кислота-иммуногенный носитель
SU1123704A1 (ru) * 1983-04-08 1984-11-15 Научно-Исследовательский Институт По Биологическим Испытаниям Химических Соединений Способ получени конъюгированных антигенов
US5229490A (en) * 1987-05-06 1993-07-20 The Rockefeller University Multiple antigen peptide system
DE3884731D1 (de) * 1987-10-09 1993-11-11 Ube Industries Monoklonaler Antikörper gegen Methamphetamin, seine Herstellung, Testverfahren und Testsatz für Methamphetamin.
EP0365646B1 (en) * 1988-03-25 1996-05-08 The Rockefeller University Synthetic peptides from streptococcal m protein and vaccines prepared therefrom
EP0363041A1 (en) * 1988-09-21 1990-04-11 Ube Industries, Ltd. Monoclonal antibody to morphine, preparation of monoclonal antibody, assaying kit and assaying method of morphine
GB8924438D0 (en) * 1989-10-31 1989-12-20 Hoffmann La Roche Vaccine composition
IL96475A0 (en) * 1989-11-29 1991-08-16 Innovative Tech Center Chimeric proteins
US5256066A (en) * 1991-03-14 1993-10-26 Larussa Joseph Hybridized target acquisition trainer
GB9112553D0 (en) * 1991-06-11 1991-07-31 Wellcome Found Fusion proteins
US5283066A (en) * 1992-02-19 1994-02-01 Development Center For Biotechnology Method of stimulating an immune response by using a hapten
GB9310412D0 (en) * 1993-05-20 1993-07-07 Danbiosyst Uk Nasal nicotine system
US5876727A (en) * 1995-03-31 1999-03-02 Immulogic Pharmaceutical Corporation Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
DK1329226T3 (da) * 1995-03-31 2007-09-24 Xenova Res Ltd Haptenbærerkonjugater til anvendelse i behandling af stofmisbrug

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992003163A1 (de) * 1990-08-22 1992-03-05 Cerny Erich H Impfstoff und immunserum gegen drogen
WO1993023076A1 (en) * 1992-05-20 1993-11-25 The Johns-Hopkins University Alternative receptor therapy

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CASTRO A ET AL: "Nicotine antibody production: Comparison of two nicotine conjugates in different animal species", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US LNKD- DOI:10.1016/0006-291X(75)90852-9, vol. 67, no. 2, 17 November 1975 (1975-11-17), pages 583 - 589, XP024844325, ISSN: 0006-291X, [retrieved on 19751117] *
HAINES C F JR ET AL: "Radioimmunoassay of plasma nicotine in habituated and naive smokers.", CLINICAL PHARMACOLOGY AND THERAPEUTICS DEC 1974 LNKD- PUBMED:4473994, vol. 16, no. 6, December 1974 (1974-12-01), pages 1083 - 1089, XP002603747, ISSN: 0009-9236 *
SCHAD V C ET AL: "The potential use of T cell epitopes to alter the immune response", SEMINARS IN IMMUNOLOGY, W.B. SAUNDERS COMPANY, PA, US, vol. 3, no. 4, 1 July 1991 (1991-07-01), pages 217 - 224, XP008085501, ISSN: 1044-5323 *

Also Published As

Publication number Publication date
WO1998014216A2 (en) 1998-04-09
EP1024834B1 (en) 2007-09-12
AU733980B2 (en) 2001-05-31
CN1814301B (zh) 2010-05-26
CN1951502A (zh) 2007-04-25
EP1857121A2 (en) 2007-11-21
ES2293664T3 (es) 2008-03-16
DE69738140D1 (de) 2007-10-25
JP2009280599A (ja) 2009-12-03
CN1814301A (zh) 2006-08-09
WO1998014216A3 (en) 1998-12-10
HK1106140A1 (en) 2008-03-07
AU6483498A (en) 1998-04-24
EP1024834A2 (en) 2000-08-09
BR9711580A (pt) 2004-03-30
CA2574049A1 (en) 1998-04-09
DE69738140T2 (de) 2008-06-12
US5876727A (en) 1999-03-02
DK1024834T3 (da) 2008-01-21
JP2001501933A (ja) 2001-02-13
CN1951502B (zh) 2010-09-15
CN1244130A (zh) 2000-02-09
ATE372786T1 (de) 2007-09-15
HK1027293A1 (en) 2001-01-12
CA2267456A1 (en) 1998-04-09
PT1024834E (pt) 2007-12-18
CN1235640C (zh) 2006-01-11
CA2267456C (en) 2009-03-24

Similar Documents

Publication Publication Date Title
EP1857121A3 (en) Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
EP1782835A3 (en) Hapten-carrier conjugates for use in drug-abuse therapy
CA2216658A1 (en) Hapten-carrier conjugates for use in drug-abuse therapy
IL143474A0 (en) Haptene-carrier conjugates and vaccines containing the same
EP2392345A3 (en) Hapten-carrier conjugates comprising virus like particles and uses thereof
EP2368575A3 (en) Dry formulation for transcutaneous immunization
IL144730A (en) Use of statin drug in the preparation of a medicament and as a medicament for the treatment of diabetic neuropathy
EE200000503A (et) Meetod topiramaadi farmatseutilise kompositsioonivalmistamiseks, farmatseutiline kompositsioon ning topiramaadi kasutamine diabeedi raviks ette nähtud ravimi valmistamiseks
CA2067205A1 (en) Vaccine and immune serum against drugs of abuse
WO1999044608A8 (en) New use
CA2279497A1 (en) The use of levobupivacaine in facial surgery
AU2003271021A1 (en) Immunogen for preparation of therapeutic vaccines or drugs for treatment of hepatitis b and the producing method and use thereof
EP1182455A4 (en) METHOD FOR SCREENING MEDICINAL PREPARATIONS
WO2003061595A3 (en) Antibodies against and compositions containing new amphetamine derivatives
DE3787477D1 (de) Nasal applizierbares Arzneimittel, Verfahren zu seiner Herstellung und seine Verwendung.
WO1997033620A3 (de) Verbindungen zur behandlung von tumoren
AU4073797A (en) Method of enhancing the delivery of growth factors
WO2005042028A3 (en) Il-13 conjugated to an immunogen and uses thereof
RU96111557A (ru) Способ лечения нейросенсорной тугоухости
MD1469G2 (ro) Metodă de tratament al şocului combustional
Dharmshaktu A project model for attempting integration of leprosy services with general health care services after the prevalence of the disease is reduced in the endemic districts on multidrug therapy for over five years
EP1733736A3 (en) Method of producing recombinant antibodies against tumours

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AC Divisional application: reference to earlier application

Ref document number: 1024834

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Extension state: RO

RIN1 Information on inventor provided before grant (corrected)

Inventor name: GEFTER, MALCOLM L.

Inventor name: POWERS, STEPHEN P.

Inventor name: FOX, BARBARA S.

Inventor name: EXLEY, MARK A.

Inventor name: GREENSTEIN, JULIA L.

Inventor name: SWAIN, PHILIP A.

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1110794

Country of ref document: HK

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 39/385 20060101ALI20101008BHEP

Ipc: A61K 47/48 20060101AFI20071003BHEP

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Extension state: RO

AKY No designation fees paid
REG Reference to a national code

Ref country code: DE

Ref legal event code: R108

REG Reference to a national code

Ref country code: DE

Ref legal event code: R108

Effective date: 20111116

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20110910

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1110794

Country of ref document: HK