CN1235640C - 用于药物滥用治疗的半抗原载体轭合物及其制备方法 - Google Patents

用于药物滥用治疗的半抗原载体轭合物及其制备方法 Download PDF

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Publication number
CN1235640C
CN1235640C CNB971993637A CN97199363A CN1235640C CN 1235640 C CN1235640 C CN 1235640C CN B971993637 A CNB971993637 A CN B971993637A CN 97199363 A CN97199363 A CN 97199363A CN 1235640 C CN1235640 C CN 1235640C
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Prior art keywords
side chain
carrier
hapten
conjugates
nicotine
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Expired - Fee Related
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CNB971993637A
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English (en)
Chinese (zh)
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CN1244130A (zh
Inventor
P·A·斯温
J·L·格林斯泰恩
M·A·艾克丝雷
B·S·福克斯
S·P·帕沃斯
M·L·格夫特
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Immulogic Pharmaceutical Corp
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Immulogic Pharmaceutical Corp
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Publication of CN1244130A publication Critical patent/CN1244130A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0013—Therapeutic immunisation against small organic molecules, e.g. cocaine, nicotine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Addiction (AREA)
  • Neurology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CNB971993637A 1996-09-30 1997-09-30 用于药物滥用治疗的半抗原载体轭合物及其制备方法 Expired - Fee Related CN1235640C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/720,487 US5876727A (en) 1995-03-31 1996-09-30 Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
US08/720,487 1996-09-30

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN2005100228305A Division CN1814301B (zh) 1996-09-30 1997-09-30 用于药物滥用治疗的半抗原载体轭合物及其制备方法
CN200610099904XA Division CN1951502B (zh) 1996-09-30 1997-09-30 用于药物滥用治疗的半抗原载体轭合物及其制备方法

Publications (2)

Publication Number Publication Date
CN1244130A CN1244130A (zh) 2000-02-09
CN1235640C true CN1235640C (zh) 2006-01-11

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ID=24894184

Family Applications (3)

Application Number Title Priority Date Filing Date
CNB971993637A Expired - Fee Related CN1235640C (zh) 1996-09-30 1997-09-30 用于药物滥用治疗的半抗原载体轭合物及其制备方法
CN200610099904XA Expired - Fee Related CN1951502B (zh) 1996-09-30 1997-09-30 用于药物滥用治疗的半抗原载体轭合物及其制备方法
CN2005100228305A Expired - Fee Related CN1814301B (zh) 1996-09-30 1997-09-30 用于药物滥用治疗的半抗原载体轭合物及其制备方法

Family Applications After (2)

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CN200610099904XA Expired - Fee Related CN1951502B (zh) 1996-09-30 1997-09-30 用于药物滥用治疗的半抗原载体轭合物及其制备方法
CN2005100228305A Expired - Fee Related CN1814301B (zh) 1996-09-30 1997-09-30 用于药物滥用治疗的半抗原载体轭合物及其制备方法

Country Status (13)

Country Link
US (1) US5876727A (https=)
EP (2) EP1857121A3 (https=)
JP (2) JP2001501933A (https=)
CN (3) CN1235640C (https=)
AT (1) ATE372786T1 (https=)
AU (1) AU733980B2 (https=)
BR (1) BR9711580A (https=)
CA (2) CA2574049A1 (https=)
DE (1) DE69738140T2 (https=)
DK (1) DK1024834T3 (https=)
ES (1) ES2293664T3 (https=)
PT (1) PT1024834E (https=)
WO (1) WO1998014216A2 (https=)

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EP1024834B1 (en) 2007-09-12
AU733980B2 (en) 2001-05-31
CN1814301B (zh) 2010-05-26
CN1951502A (zh) 2007-04-25
EP1857121A2 (en) 2007-11-21
ES2293664T3 (es) 2008-03-16
DE69738140D1 (de) 2007-10-25
JP2009280599A (ja) 2009-12-03
CN1814301A (zh) 2006-08-09
WO1998014216A3 (en) 1998-12-10
HK1106140A1 (en) 2008-03-07
AU6483498A (en) 1998-04-24
EP1857121A3 (en) 2011-03-09
EP1024834A2 (en) 2000-08-09
BR9711580A (pt) 2004-03-30
CA2574049A1 (en) 1998-04-09
DE69738140T2 (de) 2008-06-12
US5876727A (en) 1999-03-02
DK1024834T3 (da) 2008-01-21
JP2001501933A (ja) 2001-02-13
CN1951502B (zh) 2010-09-15
CN1244130A (zh) 2000-02-09
ATE372786T1 (de) 2007-09-15
HK1027293A1 (en) 2001-01-12
CA2267456A1 (en) 1998-04-09
PT1024834E (pt) 2007-12-18
CA2267456C (en) 2009-03-24

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