EP1853269A4 - Amidderivate als ionenkanalliganden und pharmazeutische zusammensetzungen sowie verfahren damit - Google Patents

Amidderivate als ionenkanalliganden und pharmazeutische zusammensetzungen sowie verfahren damit

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Publication number
EP1853269A4
EP1853269A4 EP06736043A EP06736043A EP1853269A4 EP 1853269 A4 EP1853269 A4 EP 1853269A4 EP 06736043 A EP06736043 A EP 06736043A EP 06736043 A EP06736043 A EP 06736043A EP 1853269 A4 EP1853269 A4 EP 1853269A4
Authority
EP
European Patent Office
Prior art keywords
ion
methods
same
pharmaceutical compositions
amide derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06736043A
Other languages
English (en)
French (fr)
Other versions
EP1853269A2 (de
Inventor
Michael Kelly
John Kincaid
Matthew Duncton
Kiran Sahasrabudhe
Satyanarayana Janagani
Ravindra B Upasani
Guoxian Wu
Yunfeng Fang
Zhi-Liang Wei
Carl Kaub
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evotec OAI AG
Original Assignee
Renovis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Renovis Inc filed Critical Renovis Inc
Publication of EP1853269A2 publication Critical patent/EP1853269A2/de
Publication of EP1853269A4 publication Critical patent/EP1853269A4/de
Withdrawn legal-status Critical Current

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    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
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    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
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EP06736043A 2005-02-28 2006-02-24 Amidderivate als ionenkanalliganden und pharmazeutische zusammensetzungen sowie verfahren damit Withdrawn EP1853269A4 (de)

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PCT/US2006/006615 WO2006093832A2 (en) 2005-02-28 2006-02-24 Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
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JP2008531690A (ja) * 2005-02-28 2008-08-14 レノビス， インコーポレイテッド イオンチャネルリガンドとしてのアミド誘導体並びにそれを使用する医薬組成物及び方法
JP2010520292A (ja) 2007-03-07 2010-06-10 アラントス・フアーマシユーテイカルズ・ホールデイング・インコーポレイテツド 複素環式部分を含有するメタロプロテアーゼ阻害剤
US8853392B2 (en) 2007-06-03 2014-10-07 Vanderbilt University Benzamide mGluR5 positive allosteric modulators and methods of making and using same
SG185285A1 (en) * 2007-06-03 2012-11-29 Univ Vanderbilt Benzamide mglur5 positive allosteric modulators and methods of making and using same
JP2011503072A (ja) * 2007-11-13 2011-01-27 レノビス， インコーポレイテッド イオンチャネルのリガンドとしてのアミド誘導体ならびにそれを使用する薬学的組成物および方法
MX356032B (es) * 2007-11-16 2018-04-11 Neuraxon Inc Compuestos indola y métodos para tratar el dolor visceral.
FR2933977B1 (fr) * 2008-07-18 2013-04-26 Centre Nat Rech Scient Derives heterocycliques utiles dans le traitement des maladies neurodegeneratives
WO2011016234A1 (en) * 2009-08-04 2011-02-10 Raqualia Pharma Inc. Picolinamide derivatives as ttx-s blockers
WO2012152741A1 (de) 2011-05-10 2012-11-15 Bayer Intellectual Property Gmbh Bicyclische (thio)carbonylamidine
CN105566219B (zh) * 2011-09-29 2019-03-01 三井化学Agro株式会社 3，4－二氢异喹啉衍生物的制造方法及其制造中间体
MY167697A (en) * 2011-09-29 2018-09-21 Mitsui Chemicals Agro Inc Method for producing 4,4-difluoro-3,4- dihydroisoquinoline derivatives
TW201326180A (zh) 2011-11-30 2013-07-01 Actelion Pharmaceuticals Ltd ３，７－二取代八氫－２Ｈ－吡啶并［４，３－ｅ］［１，３］□嗪－２－酮抗生素
US9562002B2 (en) 2013-01-15 2017-02-07 Board Of Regents, The University Of Texas System STAT3 inhibitor

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WO2005046683A1 (en) * 2003-10-07 2005-05-26 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

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CA2305342A1 (en) * 1997-10-07 1999-04-15 Ortho-Mcneil Pharmaceutical, Inc. Novel heterocyclic derivatives useful in treating central nervous system disorders
US20060035939A1 (en) * 2004-07-14 2006-02-16 Japan Tobacco Inc. 3-Aminobenzamide compounds and inhibitors of vanilloid receptor subtype 1 (VR1) activity
JP2008531690A (ja) * 2005-02-28 2008-08-14 レノビス， インコーポレイテッド イオンチャネルリガンドとしてのアミド誘導体並びにそれを使用する医薬組成物及び方法

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WO2005046683A1 (en) * 2003-10-07 2005-05-26 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

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AP2007004119A0 (en) 2007-08-31
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