EP1836294A4 - Anticorps anti-il-12, epitopes, compositions, procedes et utilisations associes - Google Patents

Anticorps anti-il-12, epitopes, compositions, procedes et utilisations associes

Info

Publication number
EP1836294A4
EP1836294A4 EP05854726A EP05854726A EP1836294A4 EP 1836294 A4 EP1836294 A4 EP 1836294A4 EP 05854726 A EP05854726 A EP 05854726A EP 05854726 A EP05854726 A EP 05854726A EP 1836294 A4 EP1836294 A4 EP 1836294A4
Authority
EP
European Patent Office
Prior art keywords
epitopes
antibodies
compositions
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05854726A
Other languages
German (de)
English (en)
Other versions
EP1836294A2 (fr
Inventor
Jill Giles-Komar
George Heavner
David Knight
Jinquan Luo
David Peritt
Bernard Scallon
David Shealy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Biotech Inc
Original Assignee
Centocor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc filed Critical Centocor Inc
Publication of EP1836294A2 publication Critical patent/EP1836294A2/fr
Publication of EP1836294A4 publication Critical patent/EP1836294A4/fr
Withdrawn legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
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    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61P7/06Antianaemics
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5434IL-12
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Diabetes (AREA)
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  • Hematology (AREA)
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EP05854726A 2004-12-21 2005-12-20 Anticorps anti-il-12, epitopes, compositions, procedes et utilisations associes Withdrawn EP1836294A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63781904P 2004-12-21 2004-12-21
PCT/US2005/046063 WO2006069036A2 (fr) 2004-12-21 2005-12-20 Anticorps anti-il-12, epitopes, compositions, procedes et utilisations associes

Publications (2)

Publication Number Publication Date
EP1836294A2 EP1836294A2 (fr) 2007-09-26
EP1836294A4 true EP1836294A4 (fr) 2009-06-17

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ID=36602254

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05854726A Withdrawn EP1836294A4 (fr) 2004-12-21 2005-12-20 Anticorps anti-il-12, epitopes, compositions, procedes et utilisations associes

Country Status (22)

Country Link
US (8) US8080247B2 (fr)
EP (1) EP1836294A4 (fr)
JP (1) JP2008523842A (fr)
KR (1) KR20070094927A (fr)
CN (1) CN101120087A (fr)
AR (1) AR051805A1 (fr)
AU (1) AU2005319278A1 (fr)
BR (1) BRPI0515858A (fr)
CA (1) CA2591813A1 (fr)
CR (1) CR9265A (fr)
EA (1) EA016022B1 (fr)
IL (1) IL183939A0 (fr)
MY (1) MY157915A (fr)
NI (1) NI200700155A (fr)
NO (1) NO20073778L (fr)
NZ (2) NZ555658A (fr)
PE (1) PE20061115A1 (fr)
SG (1) SG158150A1 (fr)
TW (1) TWI406943B (fr)
UY (1) UY29291A1 (fr)
WO (1) WO2006069036A2 (fr)
ZA (1) ZA200706036B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6706264B1 (en) * 1994-03-14 2004-03-16 Genetics Institute, Llc Use of IL-12 antagonists in the treatment of conditions promoted by an increase in levels of IFN-y
US6914128B1 (en) 1999-03-25 2005-07-05 Abbott Gmbh & Co. Kg Human antibodies that bind human IL-12 and methods for producing
US7883704B2 (en) 1999-03-25 2011-02-08 Abbott Gmbh & Co. Kg Methods for inhibiting the activity of the P40 subunit of human IL-12
PT1839120E (pt) * 2004-12-21 2014-01-03 Janssen Biotech Inc Anticorpo anti-il-12 baseado em vectores, células hospedeiras, e métodos de produção e utilizações
TW201444869A (zh) * 2005-06-30 2014-12-01 Abbvie Inc Il-12/p40結合蛋白
US20080199460A1 (en) 2005-09-01 2008-08-21 Schering Corporation Use of IL-23 and IL-17 antagonists to treat autoimmune ocular inflammatory disease
ES2625798T3 (es) * 2006-10-02 2017-07-20 E. R. Squibb & Sons, L.L.C. Anticuerpos humanos que se unen a CXCR4 y usos de los mismos
EP2684895A1 (fr) 2006-10-27 2014-01-15 AbbVie Biotechnology Ltd Anticorps anti-hTNfalpha cristallins
SG177982A1 (en) 2007-01-16 2012-02-28 Abbott Lab Methods for treating psoriasis
US8168760B2 (en) * 2007-03-29 2012-05-01 Abbott Laboratories Crystalline anti-human IL-12 antibodies
WO2009020654A1 (fr) 2007-08-08 2009-02-12 Abbott Laboratories Compositions et procédés permettant la cristallisation d'anticorps
US20090181027A1 (en) * 2007-09-28 2009-07-16 Paul Dal Monte Anti-IL-12/23p40 Antibodies, Epitopes, Formulations, Compositions, Methods and Uses
CN101970490A (zh) 2007-11-27 2011-02-09 埃博灵克斯股份有限公司 针对异二聚体细胞因子和/或其受体的氨基酸序列以及包括所述氨基酸序列的多肽
EP2274333A4 (fr) 2008-03-18 2011-06-15 Abbott Lab Procédé de traitement de psoriasis
MX2011001409A (es) 2008-08-14 2011-03-29 Cephalon Australia Pty Ltd Anticuerpos anti-il-12/il-23.
RU2012114854A (ru) * 2009-09-14 2013-10-27 Эбботт Лэборетриз Способы лечения псориаза
JO3244B1 (ar) 2009-10-26 2018-03-08 Amgen Inc بروتينات ربط مستضادات il – 23 البشرية
TWI609698B (zh) * 2010-01-20 2018-01-01 Chugai Pharmaceutical Co Ltd 穩定化的含抗體溶液製劑
TW201242976A (en) * 2011-01-07 2012-11-01 Abbott Lab Anti-IL-12/IL-23 antibodies and uses thereof
CN105572380A (zh) * 2014-11-06 2016-05-11 上海市东方医院 Il-12在诊断和治疗非小细胞肺癌远处转移中的应用
EP3268028A4 (fr) * 2015-03-11 2018-09-05 Rush University Medical Center Compositions et méthodes pour le traitement d'un cancer
JOP20170013B1 (ar) 2016-01-22 2021-08-17 Merck Sharp & Dohme أجسام xi مضادة لعامل مضاد للتجلط
PE20190416A1 (es) 2016-06-14 2019-03-19 Merck Sharp & Dohme Anticuerpos antifactor de la coagulacion xi
KR102318480B1 (ko) * 2016-08-25 2021-10-28 제이씨알 파마 가부시키가이샤 항체 융합 단백질의 제조 방법
TW201922780A (zh) * 2017-09-25 2019-06-16 美商健生生物科技公司 以抗il12/il23抗體治療狼瘡之安全且有效之方法
CN109813897A (zh) * 2017-11-18 2019-05-28 镇江亿特生物科技发展有限公司 盐酸可乐定快速时间分辨荧光免疫层析定量检测试纸条
EP3793521A4 (fr) 2018-05-18 2022-02-23 Janssen Biotech, Inc. Méthode sûre et efficace de traitement du lupus avec un anticorps anti-il12/il23
US11253534B2 (en) 2020-03-23 2022-02-22 Sabine Hazan Method of preventing COVID-19 infection
US11744866B2 (en) 2020-03-18 2023-09-05 Sabine Hazan Methods of preventing and treating COVID-19 infection with probiotics
US11278520B2 (en) 2020-03-31 2022-03-22 Sabine Hazan Method of preventing COVID-19 infection
CN111549834B (zh) * 2020-05-17 2021-08-10 福建金鼎建筑发展有限公司 一种基于地表水渗透的基坑开挖模型试验装置及使用方法
WO2023004282A2 (fr) 2021-07-19 2023-01-26 Regeneron Pharmaceuticals, Inc. Agonistes du récepteur de l'il12 et leurs procédés d'utilisation
CN114468015B (zh) * 2022-03-15 2023-10-17 重庆大学 一种高肉粘性的胶原肠衣及其制备方法和用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002097048A2 (fr) * 2001-05-30 2002-12-05 Centocor, Inc. Proteines derivees de l'immunoglobuline anti-p40, compositions, procedes et utilisations
EP1309692A2 (fr) * 2000-08-07 2003-05-14 Centocor, Inc. Anticorps, compositions, procedes anti-il-12 et leur utilisation

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457038A (en) 1988-11-10 1995-10-10 Genetics Institute, Inc. Natural killer stimulatory factor
US5811523A (en) 1988-11-10 1998-09-22 Trinchieri; Giorgio Antibodies to natural killer stimulatory factor
WO1990005147A1 (fr) 1988-11-10 1990-05-17 Genetics Institute, Inc. Facteur stimulateur de cellules cytotoxiques naturelles
US6683046B1 (en) 1989-12-22 2004-01-27 Hoffmann-La Roche Inc. Purification and characterization of cytotoxic lymphocyte maturation factor and monoclonal antibodies thereto
ATE366311T1 (de) 1989-12-22 2007-07-15 Hoffmann La Roche Zytotoxischer lymphozyten-reifefaktor 35kd untereinheit und monoklonale antikörper spezifisch dafür
DE4315127A1 (de) 1993-05-07 1994-11-10 Behringwerke Ag Arzneimittel enthaltend die Untereinheit p40 von Interleukin-12
ZA95960B (en) 1994-03-14 1995-10-10 Genetics Inst Use of interleukin-12 antagonists in the treatment of autoimmune diseases
ATE206163T1 (de) 1994-04-22 2001-10-15 Corixa Corp Verbindungen und methoden für die stimulierungen und die erhöhung von schutzimmunantworten und il- 12 herstellung
US5891680A (en) 1995-02-08 1999-04-06 Whitehead Institute For Biomedical Research Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12
EP1978033A3 (fr) 1995-04-27 2008-12-24 Amgen Fremont Inc. Anticorps humains dérivés à partir de xénosouris immunisée
US5853697A (en) 1995-10-25 1998-12-29 The United States Of America, As Represented By The Department Of Health & Human Services Methods of treating established colitis using antibodies against IL-12
WO1998034635A1 (fr) 1997-02-07 1998-08-13 The Wistar Institute Procedes et compositions pour inhiber la production d'interleukine 12
US6060284A (en) 1997-07-25 2000-05-09 Schering Corporation DNA encoding interleukin-B30
ATE357459T1 (de) 1998-01-23 2007-04-15 Hoffmann La Roche Antikörper gegen mensliches il-12
US6914128B1 (en) 1999-03-25 2005-07-05 Abbott Gmbh & Co. Kg Human antibodies that bind human IL-12 and methods for producing
TR200102715T2 (tr) 1999-03-25 2002-09-23 Knoll Gmbh Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
WO2001019373A2 (fr) 1999-09-17 2001-03-22 Basf Aktiengesellschaft Procedes et compositions permettant de moduler la sensibilite aux corticosteroides
WO2003080672A1 (fr) 2002-03-22 2003-10-02 Aprogen, Inc. Anticorps humanise et procede de preparation correspondant

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1309692A2 (fr) * 2000-08-07 2003-05-14 Centocor, Inc. Anticorps, compositions, procedes anti-il-12 et leur utilisation
WO2002097048A2 (fr) * 2001-05-30 2002-12-05 Centocor, Inc. Proteines derivees de l'immunoglobuline anti-p40, compositions, procedes et utilisations

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
"Abstracts 1230-1630", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, MOSBY - YEARLY BOOK, INC, US, vol. 99, no. 1, 1 January 1997 (1997-01-01), pages S301 - S400, XP022292809, ISSN: 0091-6749 *
D'ANDREA A ET AL: "Production of natural killer cell stimulatory factor ( interleukin 12 ) by peripheral blood mononuclear cells", JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, JP, vol. 176, no. 5, 1 November 1992 (1992-11-01), pages 1387 - 1398, XP002115993, ISSN: 0022-1007 *
DATABASE UniProt [online] 1 April 1993 (1993-04-01), "RecName: Full=Interleukin-12 subunit alpha; Short=IL-12A; AltName: Full=IL-12 subunit p35; AltName: Full=Cytotoxic lymphocyte maturation factor 35 kDa subunit; Short=CLMF p35; AltName: Full=NK cell stimulatory factor chain 1; Short=NKSF1;", XP002520281, retrieved from EBI accession no. UNIPROT:P29459 Database accession no. P29459 *
DATABASE UniProt [online] 1 April 1993 (1993-04-01), "RecName: Full=Interleukin-12 subunit beta; Short=IL-12B; AltName: Full=IL-12 subunit p40; AltName: Full=Cytotoxic lymphocyte maturation factor 40 kDa subunit; Short=CLMF p40; AltName: Full=NK cell stimulatory factor chain 2; Short=NKSF2;", XP002520282, retrieved from EBI accession no. UNIPROT:P29460 Database accession no. P29460 *
KAUFFMAN CATHARINE L ET AL: "A phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis.", THE JOURNAL OF INVESTIGATIVE DERMATOLOGY DEC 2004, vol. 123, no. 6, December 2004 (2004-12-01), pages 1037 - 1044, XP009114202, ISSN: 0022-202X *
LI JIAN ET AL: "ANTI-IL-12 P40 MAB PREVENTS DIABETES ONSET BY INDUCING ACTIVE IMMUNE SUPPRESSION", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD, US, vol. 17, no. 7, 10 May 2003 (2003-05-10), pages C270(ABSTRACT125.4), XP008069228, ISSN: 0892-6638 *
MANNON PETER ET AL: "Anti-interleukin-12 treats active Crohn's disease", GASTROENTEROLOGY, vol. 126, no. 4, Suppl. 2, April 2004 (2004-04-01), & DIGESTIVE DISEASE WEEK/105TH ANNUAL MEETING OF THE AMERICAN-GASTROENTEROLOGICAL-ASSOCIATION; NEW ORLEANS, LA, USA; MAY 16 20, 2004, pages A22 - A23, XP009114205, ISSN: 0016-5085 *

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