EP1786570A1 - Dispositif de dosage comprenant une amenee d'air capillaire - Google Patents

Dispositif de dosage comprenant une amenee d'air capillaire

Info

Publication number
EP1786570A1
EP1786570A1 EP05776351A EP05776351A EP1786570A1 EP 1786570 A1 EP1786570 A1 EP 1786570A1 EP 05776351 A EP05776351 A EP 05776351A EP 05776351 A EP05776351 A EP 05776351A EP 1786570 A1 EP1786570 A1 EP 1786570A1
Authority
EP
European Patent Office
Prior art keywords
capillary channel
medium
section
metering device
capillary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05776351A
Other languages
German (de)
English (en)
Inventor
Stefan Ritsche
Ralf Fichtner
Günter NADLER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aptar Radolfzell GmbH
Original Assignee
Erich Pfeiffer GmbH
Ing Erich Pfeiffer GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erich Pfeiffer GmbH, Ing Erich Pfeiffer GmbH filed Critical Erich Pfeiffer GmbH
Publication of EP1786570A1 publication Critical patent/EP1786570A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
    • B05B11/00444—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means with provision for filtering or cleaning the air flow drawn into the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means

Definitions

  • the invention relates to a metering device for at least one medium with a pumping device, which is in operative connection for a medium discharge with a medium storage, as well as with a medium storage device associated with the ventilation device.
  • a metering device with a ventilation device serves for discharging a medium from a medium reservoir by means of a pumping device in a plurality of discharge strokes which are separated in time or directly successive.
  • the pump device is connected to the medium storage device in a communicating operative connection, which allows medium to be discharged from the medium reservoir and discharged into an environment of the metering device.
  • Suitable medium are liquid and solid substances and mixtures thereof, which can be administered in particular as medicaments.
  • low to high demands are placed on the dosage of the amount of medium to be discharged by the pump device and the concentration of optionally medically active ingredients contained therein.
  • the pumping device can be designed, for example, for a nebulised medium discharge or for individual jets of the medium.
  • the ventilation device provided on the metering device serves to equalize the pressure between an internal pressure of a volume enclosed in the medium reservoir and an external pressure which prevails in the surroundings of the medium reservoir.
  • a pressure difference can result from the discharge of medium from the medium reservoir or else from thermally induced expansion or shrinkage processes of the medium (s) enclosed in the medium reservoir.
  • pressure differences are usually undesirable in such dosing devices, since they have a can have a negative influence on the dosing accuracy of the medi ⁇ ums to be discharged.
  • a ventilation device in which a nozzle-like tapered pressure equalization opening is provided for a pressure equalization between the medium reservoir and the environment. Due to the extremely small opening diameter of the pressure equalization opening of the aeration device, undesired evaporation of medium from the medium reservoir should be avoided.
  • the metering device according to EP 1 295 644 A1 can be provided with a filter device which is provided as a barrier for contaminating components of the outside air with respect to the medium enclosed in the medium reservoir. Such a filter device should be able to dispense with preserving the medium, since the air entering the medium reservoir when the pressure is equalized between the environment and the medium reservoir should be free of contaminating constituents. This is of particular importance in medical substances.
  • the object underlying the invention is to provide a metering device which has a reduced evaporation rate compared to known metering devices.
  • a metering device of the type mentioned initially in which the ventilation device has a capillary channel which forms a ventilation path between the medium reservoir and the environment and whose channel length is many times greater as its effective channel diameter.
  • the effective capillary channel diameter is that diameter of a circular cross-section whose surface is identical to the area of the cross-section of the capillary channel which, if in doubt, is arbitrarily shaped.
  • the capillary channel may, in particular, have a round, rectangular, polygonal, circular segment-shaped, circular-annular cross-section or combinations thereof.
  • the length of the channel refers to its extended length from a front end facing the medium reservoir to a front end of the channel facing the surrounding space.
  • an undesired outflow of evaporated medium constituents can advantageously be reduced or prevented.
  • An evaporation of medium constituents occurs in particular when heat is applied to the metering device. Due to the evaporation, as a function of the vapor pressure of the medium enclosed in the medium reservoir, an overpressure in the medium reservoir is formed, which can lead to an outflow of the evaporated medium constituents from the medium reservoir via the aeration device into the environment. Due to the narrow cross-section of the capillary channel, there is a high flow resistance for the ventilation device, which prevents rapid escape of evaporated medium components.
  • the capillary channel it is achieved by the capillary channel that the evaporated medium constituents, which escape from the medium reservoir due to the vapor pressure, are at least largely retained in the ventilation path and mix only slightly with the ambient air.
  • the evaporated medium constituents which escape from the medium reservoir due to the vapor pressure, are at least largely retained in the ventilation path and mix only slightly with the ambient air.
  • formed in the capillary channel due to the narrow cross-section and the contrast large length of the capillary channel advantageously a microclimate, which has a higher concentration of evaporated medium components compared to the environment.
  • the narrow cross-section in conjunction with the large length of the capillary channel, substantially prevents volatilization of the evaporated medium constituents.
  • the vaporized medium components are available again for a suction process into the medium reservoir, as can occur during cooling of the medium reservoir or after a discharge stroke of the metering device.
  • condensation of these medium constituents may take place.
  • a lower evaporation of the medium enclosed in the medium reservoir is ensured on the whole, so that the metering device according to the invention has a lower diffusion rate compared to known metering devices.
  • the solution according to the invention is particularly suitable for the dosing of pharmaceutical, but also of cosmetic media.
  • the capillary channel at least in sections, has a ratio between an effective capillary channel diameter and a capillary channel length which is less than 1/4.
  • the capillary channel has a cross section with a ratio of effective capillary channel diameter and capillary channel length smaller than 1/4, at least in the region of an end remote from the ventilation opening of the medium reservoir.
  • the capillary channel length is the length on which the capillary channel has a substantially constant effective channel cross-section.
  • the capillary channel it is also conceivable for the capillary channel to have a constant cross section over its length or to have a plurality of sections with different cross sections, which are optionally delimited from one another by aperture-like cross-sectional constrictions.
  • the ratio of effective Kapillarka ⁇ nal to micr and Kapillarkanalin less than 1/4 a Strömungs ⁇ resistance for particular gaseous medium components is generated, which leads to a reduced gas exchange with the environment, even if a high concentration difference between the contained in the capillary channel, evaporated medium components and the Environment vor ⁇ lies. While in known aeration devices, the evaporated medium constituents mix with the environment, this mixing only takes place to a much lesser extent in the case of a metering device with capillary channel because of the increased flow resistance and the small interaction cross section. In a preferred embodiment of the invention, the ratio of effective capillary channel diameter and capillary channel length less than 1/10.
  • the ratio of effective capillary channel diameter and capillary channel length is less than 1/15.
  • Such capillary channel sections can in particular be produced by material-removing methods, such as laser drilling. It is thus possible in a simple manner to introduce corresponding capillary channel sections, in particular in thin layers which are provided, for example, in the plastic injection molding method for limiting the capillary channel.
  • Such an effective capillary channel diameter and a corresponding capillary channel length can be produced in a simple manner by means of the plastic injection molding method, without subsequent processing of the manufactured components being necessary.
  • a particularly kos ⁇ ten redesigne ventilation device can be provided.
  • a dimensioning of the capillary channel is preferably realized by material-removing methods, such as laser boring. Although this requires a subsequent processing of the component or the components of the medium reservoir and / or the pumping device usually produced in the plastic injection molding process, the accuracy of the cross section of the capillary channel can be ensured particularly advantageously here. In addition, only a very slight mixing of the evaporated medium components with the environment occurs due to the particularly small interaction cross-section.
  • a filter arrangement is integrated into the ventilation path.
  • the filter arrangement can be provided at any position in the ventilation device.
  • the filter arrangement is attached adjacent to the ventilation opening of the medium storage or even closes it, or the filter arrangement is provided at an end of the ventilation device facing away from the medium storage and thus forms a contamination barrier the entire capillary channel.
  • the capillary channel is aligned coaxially or axially parallel to a filter passage axis.
  • the capillary channel is formed integrally on the medium reservoir and / or on the pumping device.
  • This allows a particularly advantageous production of the capillary channel, for example in plastic injection molding or by material-removing process.
  • this allows a particularly narrow dimensional and / or shape tolerance for the capillary channel to be maintained, so that a flow behavior of the evaporated medium constituents and of the gas possibly aspirated from the surroundings can also be predetermined with a narrow tolerance.
  • the capillary channel is designed as a passage with a closed hollow cross-section.
  • the capillary channel has an integrated in the component, open to an adjacent component, the first hollow cross-section.
  • the capillary channel is accordingly formed by the interaction of the adjacent components, wherein the hollow cross section can be introduced in particular as a groove with or without undercuts into the component.
  • Flat surface contact or a small spacing between the component provided with the open hollow cross section and the component arranged opposite create the capillary channel during assembly of the two components.
  • the adjacent component has a corresponding, second open hollow cross section, which forms a capillary channel together with the first hollow cross section.
  • the capillary channel is at least partially annular and extends coaxially to a longitudinal axis of the pumping device.
  • annular design it is possible in a simple manner to produce a capillary channel, to which high demands with regard to dimensional accuracy and tolerance can be made. This is possible, in particular, by means of a thin-walled, sectionally conically or cylindrically shaped attachment which is attached to the medium reservoir or to the pumping device and interacts with a corresponding section of the medium reservoir or the pumping device.
  • a course of the annular capillary channel coaxial to a longitudinal axis of the pumping device allows a particularly advantageous construction of the metering device, since in particular a substantially rotationally symmetrical design of the components can be selected.
  • the capillary channel in particular at an interface between the medium reservoir and the pumping device, has at least one annular channel that circulates at least in sections.
  • annular channel is provided at an interface between the medium reservoir and the pumping device, a particularly simple mounting of the pumping device on the medium reservoir is ensured, since the annular channel communicates between the capillary channel section on the medium reservoir and the capillary channel section on the pumping device, independently of the communicating connection their Aus ⁇ direction ensures about the longitudinal axis of the pumping device.
  • the annular channel can be provided in a component assigned to the pumping device or the medium reservoir, which likewise enables a simple, non-directional mounting of this component.
  • the capillary channel is designed as a labyrinth system with at least two interconnected ventilation channel sections extending in different directions.
  • a particularly compact design of the capillary channel is made possible by a labyrinth system, on the other hand an increase in the flow resistance can be achieved in a simple manner by the deflection of the medium components or gases flowing in the capillary channel. This further impedes uncontrolled outflow of the evaporated medium components from the capillary channel.
  • the volume of the ventilation device corresponds at least substantially to the volume of the medium discharged with a discharge stroke. It can thus be ensured that the gas volume sucked in to the pressure compensation in the medium reservoir comes completely from the capillary channel, so that gas is sucked from the environment into the capillary channel, but this gas does not penetrate into the medium reservoir. So that can a particularly low diffusion rate can be ensured for the metering device.
  • FIG. 2 is a planar longitudinal section of a detail enlargement of a metering device with a filter device and a capillary channel formed between two components
  • FIG. 3 in a planar longitudinal section illustration a detail enlargement of a metering device according to FIG. 2 with a filter device, a capillary channel formed between two components and an annular channel, FIG.
  • FIG. 3a shows a cross section through the metering device according to Fig. 3 in the region of the section line B-B of Fig. 3, and
  • FIG. 4 shows in a planar sectional view a detail enlargement of a filter device for a metering device with a downstream capillary channel.
  • the metering device 1 essentially shows a pumping device 2, which is suitable for mounting on a non-illustrated Media storage is provided.
  • the pump device 2 has a schematically illustrated piston arrangement 3, which is accommodated in a likewise schematically illustrated cylinder arrangement 4 and is provided for conveying the medium stored in the medium reservoir into an environment of the metering device 1.
  • the cylinder arrangement 4 is accommodated in a substantially conically shaped applicator 5, at the tapered end of which a discharge opening 6 is provided, through which the medium pressurized by the pumping device 2 can be discharged into the environment in finely atomized form.
  • a handle 7 is provided which is provided with finger supports 8.
  • a user can actuate the dosing device 1 by pressing together between the thumb and the index or middle finger, wherein the thumb is placed on a bottom of the medial memory (not shown).
  • a return spring 9 is provided which applies a remind ⁇ adjusting force upon actuation of the metering device 1.
  • the applicator 5 is provided with a protective cover 10, which is removed for the discharge process.
  • an interface 11 is provided for the attachment of the medium storage.
  • the interface 11 has a substantially cylindrically shaped outer shell 12, which accommodates the piston assembly 3 and is in a relatively movable, positive-locking operative connection with the Applika ⁇ gate 5.
  • the outer shell 12 is provided with an internal thread 13 which is provided for the positive reception of a vorgese ⁇ on the medium reservoir henen external thread.
  • the Flat gasket 15 has a vent opening 16, which is provided for a communicating connection of the volume enclosed by the medium storage volume with the environment.
  • the flat seal 15 is substantially flat on an end face 17 of the piston assembly 3.
  • circumferential ventilation groove 18 is provided with a rectangular cross-section.
  • the circulating ventilation groove 18 is in turn in communication with a capillary bore 20, which is designed as a capillary channel and is aligned axially parallel to a longitudinal axis 19 of the pumping device 2.
  • the capillary bore 20 opens into a cavity 21 delimited by the piston device 3, the outer sleeve 12 and the applicator 5, which in turn communicates with the environment in a communicating connection via gaps which are not illustrated, and thus an exchange of gases , in particular ambient air.
  • the ventilation groove 18 and the Kapil ⁇ larbohrung 20 are shown in FIG. 1 for clarity not to scale true scale, but slightly enlarged, but it is evident that the length I of the capillary is many times greater than the diameter d of capillary bore.
  • the ventilation opening 16, the ventilation groove 18, the capillary bore 20 and the cavity 21 form the ventilation device of the metering device 1.
  • Da ⁇ at the ventilation device as a capillary 20longed ⁇ led venting path is provided, ie a leaking from the media storage gas stream, For example, from evaporated medium constituents, must inevitably flow through the ventilation device to leak into the environment. The same applies to the reverse case, that gas from the environment is sucked into the medium reservoir. Again, the ventilation device is to flow completely.
  • FIGS. 2 to 4 the same reference numerals as in FIG. 1 are used for identical or functionally identical components.
  • the metering device 101 shown in FIG. 2 which is shown only as a detail enlargement, substantially the same structure as in the case of the metering device 1 shown in FIG. 1 is present with regard to the regions which are not illustrated.
  • a filter arrangement 22 is additionally provided in the ventilation device, which is connected to a capillary channel guided as a hollow cross section 23.
  • the filter arrangement 22 has a filter cartridge 24 and a filter membrane 25 which is designed as a germ barrier and which is accommodated in a passage bore 26 of the filter cartridge 24.
  • the filter membrane according to an embodiment not shown may be laminated to the filter cartridge.
  • a longitudinal axis of the passage bore 26 is aligned parallel to the longitudinal axis 19 of the Pumpeinhchtung 102.
  • the filter membrane 25 is intended to prevent the entry of contaminating constituents from the environment into the medium reservoir (not shown).
  • the filter cartridge 24 is attached to the piston assembly 2 and can communicate with the media reservoir via the ventilation opening 16 in the flat gasket 15.
  • the through-bore 26 communicates with a gas reservoir 27, which is formed between the outer sleeve 12, filter cartridge 24 and an insert 28 provided for locking the filter cartridge 24.
  • the hollow cross section 23 is, as shown in more detail in the sectional view AA of Fig. 2a, designed as a flattening of the substantially cylindrically shaped outer side of the piston assembly 3 and therefore forms with the adjacent inner surface of the outer sleeve 12 a circular section-like Kanalquer ⁇ cut.
  • the capillary channel opens into a labyrinth gap 28, which in turn communicates with the cavity 121.
  • the labyrinth gap 28 is to be regarded merely as an additional device to the capillary gap, since it is provided with coarse dimensional tolerances due to the relative mobility between applicator 5 and outer sleeve 12 in order to ensure the movability of the components.
  • the labyrinth gap 28 is also conceivable, the labyrinth gap
  • FIG. 3 The embodiment of the invention shown in FIG. 3 is essentially based on the embodiments of FIGS. 1 and 2.
  • a thin-walled attachment 29 is provided in FIG Pumping device 202 is associated with and has a circumferential annular channel 30 and a in Fig. 3a closer dar- asked hollow cross-section 223.
  • the attachment part 29 is placed on the piston assembly 3 and locked in a form-fitting manner. Alternatively, a frictional attachment of the attachment is possible on the Kolbenan ⁇ order. Due to the annular channel 30, the attachment part
  • the thin-walled attachment part has an aligned parallel to the longitudinal axis, in Fig. 3b in detail groove 31 on an inner side. This groove 31 forms with the cylindrically shaped outer side of the piston assembly 3 the desired capillary gap.
  • a capillary channel arranged directly downstream of the filter cartridge 24 is provided.
  • the capillary channel is provided in a wall section of the piston arrangement 3, in which the filter cartridge 24 is accommodated.
  • the illustrated capillary bore 31 is slightly enlarged for clarity and, in a practical embodiment, has a bore length that is many times greater than the bore diameter.
  • the capillary bore 31 is introduced into the wall section with a material-removing or machining production method, in particular with laser drilling.
  • All illustrated embodiments of the invention is based on essentially the same functionality.
  • the necessary pressure equalization between an internal pressure prevailing in the medium reservoir and an external pressure prevailing in the surroundings of the metering device is ensured via the ventilation device.
  • Pressure differences between internal and external pressure can occur, in particular, as a result of heating or cooling of the metering device, which lead to expansion or reduction of the volume of the medium received in the medium reservoir and of the volume of gas components likewise contained in the medium reservoir.
  • the gas constituents can, in an initial state of the metering device, immediately after being filled with medium consist essentially of ambient air remaining in the medium reservoir or an inert gas actively filled in the medium reservoir. With these gas constituents, the evaporated medium components, which emerge from the medium in an Er ⁇ heating of the metering device.
  • At least one capillary channel is provided in the ventilation path of the ventilation device, which prevents unimpeded leakage of the gas mixture present in the medium reservoir. This is achieved by virtue of the fact that the capillary channel opposes the gas mixture with a high flow resistance and only a small interaction surface with the environment is available, which would permit mixing of the gas leaving the medium reservoir with the ambient air gas.
  • the ventilation device has a volume which is equal to or greater than the volume which is necessary for the pressure equalization, the pressure compensation can be carried out completely by suction of the gas mixture received in the ventilation device. This results in only an insignificant change in the concentration of the medium components present in the medium store in the gas mixture, so that additional evaporation or solution of medium constituents is at least reduced as a result of the possibly high concentration of evaporated medium constituents. As a result, undesirable leakage of slightly volatile medium components can be prevented or reduced over a longer period of time.
  • the ventilation device is designed as an antechamber to the ventilation opening of the medium reservoir and has only one or a few ventilation openings with extremely small cross-sections with respect to the environment.
  • the desired microclimate can be accommodated in a particularly advantageous manner in the vestibule, which can be filled with evaporated constituents. charged air does not escape and can be sucked back into the medium reservoir at the next pressure equalization.
  • a volume of the aeration device from the medium reservoir to the mouth of the capillary channel is dimensioned such that this volume is equal to or greater than the volume discharged by the pumping device with a discharge stroke.

Landscapes

  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Closures For Containers (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un dispositif de dosage destiné à au moins une substance, comprenant: un système de pompage qui est en liaison active avec un réservoir de substance pour permettre la sortie de substance; et un système d'aération associé au réservoir de substance. Selon l'invention, le système d'aération présente un canal capillaire qui forme une trajectoire d'aération entre le réservoir de substance et l'environnement extérieur, et dont la longueur est un multiple supérieur à 1 de son diamètre de canal réel. Le dispositif de l'invention peut être utilisé pour des applications pharmaceutiques et cosmétiques.
EP05776351A 2004-09-09 2005-08-23 Dispositif de dosage comprenant une amenee d'air capillaire Withdrawn EP1786570A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004044344A DE102004044344A1 (de) 2004-09-09 2004-09-09 Dosiervorrichtung
PCT/EP2005/009092 WO2006027102A1 (fr) 2004-09-09 2005-08-23 Dispositif de dosage comprenant une amenee d'air capillaire

Publications (1)

Publication Number Publication Date
EP1786570A1 true EP1786570A1 (fr) 2007-05-23

Family

ID=35241010

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05776351A Withdrawn EP1786570A1 (fr) 2004-09-09 2005-08-23 Dispositif de dosage comprenant une amenee d'air capillaire

Country Status (8)

Country Link
US (1) US20070284393A1 (fr)
EP (1) EP1786570A1 (fr)
JP (1) JP2008512312A (fr)
CN (1) CN101014417A (fr)
BR (1) BRPI0515057A (fr)
CA (1) CA2579361A1 (fr)
DE (1) DE102004044344A1 (fr)
WO (1) WO2006027102A1 (fr)

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DE102008027146B4 (de) * 2008-06-02 2012-01-19 Ing. Erich Pfeiffer Gmbh Austragvorrichtung
AU2010260211B2 (en) 2008-12-22 2016-04-21 Acerus Pharmaceuticals USA, LLC Safe desmopressin administration
DE102009006430A1 (de) * 2009-01-23 2010-07-29 Ing. Erich Pfeiffer Gmbh Austragvorrichtung
GB2474520B (en) * 2009-10-19 2015-08-26 London & General Packaging Ltd Spray dispenser
CN110494680B (zh) * 2017-04-11 2022-06-03 乌多·塔勒 用于密封和抽空具有粘稠的液体的容器的设备
EP3427839B1 (fr) * 2017-07-13 2020-12-02 Aptar Radolfzell GmbH Distributeur de liquide ayant une bouteille ventilée et une tête de distribution associée
IT202100027218A1 (it) * 2021-10-22 2023-04-22 Guala Dispensing Spa Testa di erogazione a grilletto con camera pistone ridotta

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Also Published As

Publication number Publication date
US20070284393A1 (en) 2007-12-13
BRPI0515057A (pt) 2008-07-01
CA2579361A1 (fr) 2006-03-16
CN101014417A (zh) 2007-08-08
DE102004044344A1 (de) 2006-03-30
JP2008512312A (ja) 2008-04-24
WO2006027102A1 (fr) 2006-03-16

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