EP1799357B1 - Dispositif de dosage - Google Patents

Dispositif de dosage Download PDF

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Publication number
EP1799357B1
EP1799357B1 EP05804435A EP05804435A EP1799357B1 EP 1799357 B1 EP1799357 B1 EP 1799357B1 EP 05804435 A EP05804435 A EP 05804435A EP 05804435 A EP05804435 A EP 05804435A EP 1799357 B1 EP1799357 B1 EP 1799357B1
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EP
European Patent Office
Prior art keywords
metering device
filter membrane
medium
channel
designed
Prior art date
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Active
Application number
EP05804435A
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German (de)
English (en)
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EP1799357A1 (fr
Inventor
Stefan Ritsche
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Aptar Radolfzell GmbH
Original Assignee
Erich Pfeiffer GmbH
Ing Erich Pfeiffer GmbH
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Publication of EP1799357A1 publication Critical patent/EP1799357A1/fr
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means
    • B05B11/00444—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means with provision for filtering or cleaning the air flow drawn into the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details
    • B05B11/0037—Containers
    • B05B11/0039—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means
    • B05B11/0044—Containers associated with means for compensating the pressure difference between the ambient pressure and the pressure inside the container, e.g. pressure relief means compensating underpressure by ingress of atmospheric air into the container, i.e. with venting means

Definitions

  • the invention relates to a metering device for at least one medium, with a pumping device, which is in operative connection for a medium discharge with a medium reservoir, as well as with a medium storage and / or the pumping device associated ventilation device having a ventilation channel, which communicates a communication of the medium storage enclosed volume with an environment through a ventilation channel associated with the filter membrane allows therethrough.
  • the metering device is used for discharging a medium from a medium reservoir by means of a pumping device in a plurality of, spaced apart from each other or directly successive discharge strokes.
  • the pumping device communicates with the medium reservoir in a communicating operative connection, which allows medium to be discharged from the medium reservoir into an environment of the metering device.
  • the ventilation device according to the EP 1 295 644 A1 has a ventilation duct, which is associated with a filter device as a barrier for contaminating components of the outside air relative to the medium enclosed in the medium storage.
  • Such a filter device is intended to make it possible to dispense with preserving the medium, since the air entering the medium reservoir at a pressure equalization between the environment and the medium reservoir should be kept free of contaminating constituents by the filter device. This is of particular importance in particular for medical substances.
  • Through the filter device is a constant exchange of gas molecules between the in Medium container enclosed medium and the environment possible, so that the desired pressure compensation can take place while leakage of the medium into the ventilation device and penetration of contaminants into the medium storage by the filter device is prevented.
  • the problem underlying the invention is to provide a metering device which ensures improved long-term stability of the enclosed medium and high metering accuracy with regard to the active substance concentration of the medium to be discharged.
  • the diffusion rate is determined on the basis of the volume flow of gas molecules which passes through the filter membrane within a time interval at a given pressure ratio between the internal pressure in the medium reservoir and the external pressure in the environment.
  • a low diffusion rate expresses that with a high pressure difference between the internal pressure in the medium reservoir and the external pressure prevailing in the environment, only a small volume flow of gas molecules passes through the filter membrane.
  • An improvement in the long-term stability of the medium enclosed in the medium container is achieved, on the one hand, by a lower loss of easily soluble medium constituents which otherwise could escape from the medium reservoir as volatile constituents.
  • the evaporated, easily dissolvable medium components are retained in the medium storage due to the reduced diffusion rate of the filter membrane over a longer period of time and also at a higher pressure difference between internal pressure and external pressure. As a result, a change in the concentration of the medium can be substantially prevented or at least reduced.
  • the reduced diffusion rate causes a time-delayed inflow of air from the environment at a negative pressure in the medium reservoir.
  • a filter membrane with a reduced diffusion rate over a long period of time can prevent or at least substantially prevent a change in the concentration of the medium.
  • This influence of the filter membrane on the enclosed medium is an essential criterion in an assessment of the suitability of a metering device for the storage and discharge of medical substances.
  • a simple stability test examines the extent to which weight loss of the dosing device takes place over a longer period of time. This can be concluded on the basis of the original drug concentration on an altered drug concentration in the medium.
  • the reduced diffusion rate ensures that, on the one hand, the pressure equalization required for correct medium discharge can take place and, on the other hand, the long-term stability of the enclosed material. Medium is guaranteed.
  • the proper solution is particularly suitable for the dosage of pharmaceutical products. Suitable media are liquid and solid substances and mixtures thereof, which can be administered in particular as medicaments. Depending on the medium to be discharged from low to high demands on the dosage of the pumping device to be discharged amount of medium and the concentration of optionally medically active ingredients contained therein.
  • the pumping device can be designed, for example, for a nebulized medium discharge or for individual jets of the medium.
  • the ventilation device provided on the metering device serves to equalize the pressure between an internal pressure of a volume enclosed in the medium reservoir and an external pressure prevailing in the vicinity of the medium reservoir.
  • a pressure difference can result from the discharge of medium from the medium reservoir or by thermally induced expansion or shrinkage processes of the medium / media enclosed in the medium reservoir.
  • pressure differences are generally undesirable in such metering devices, since they can have a negative influence on the metering accuracy of the medium to be discharged.
  • the filter membrane has a reduced cross section compared to known filter membranes.
  • the effective cross section is the product of the number of pores provided in the filter membrane and the mean free cross section of these pores.
  • Filter membranes are designed in particular as stretched or perforated plastic films or as sintered materials, but also as metal foils and can be manufactured depending on the selected manufacturing method in terms of the number of pores and the free cross sections of the pores in a wide range.
  • the pores or channels formed in the plastic film or in the sintered material each have a free cross-section, which can be determined on the basis of the maximum molecular size that can pass through the channel. Of the Effective cross-section is directly related to the diffusion rate of the filter membrane.
  • a large number of channels or pores and a large free cross section of the individual channels or pores results in a large effective cross section and allows a high diffusion rate, ie even at a low pressure difference, a large number of molecules can pass through the filter membrane.
  • the effective cross section is reduced compared to known filter membranes, ie the product of the number of pores and the average free cross section of the pores is less than in conventional membranes.
  • the reduced effective cross-section of the filter membrane is realized by a reduced compared to known filter membranes effective area.
  • the effective area of the filter membrane is that pore-penetrated surface area of the membrane which is available for passage of gas molecules. On the effective surface, the pores are arranged, which determine the effective cross-section of the filter membrane.
  • the active surface of the filter membrane is limited by a Strömungsleitgeometrie, which is at least partially conical.
  • a Strömungsleitgeometrie which is at least partially conical.
  • the Strömungsleitgeometrie can be used to hold the filter membrane mechanically, in particular form-fitting and stabilize.
  • the Strömungsleitgeometrie can by at least partially conical design a particularly advantageous inflow and / or outflow of the Gas molecules cause the filter membrane, since a substantially turbulence-free guidance of the gas flow through the conical contour can be achieved.
  • the effective area of the filter membrane is less than 0.6 mm 2 , more preferably less than 0.2 mm 2 . This achieves a reduction of the effective area and the associated diffusion rate compared to a known filter membrane by at least about 15%, preferably by about 60%, particularly preferably by about 85%.
  • a mean free cross section of pores in the filter membrane is smaller than in known filter membranes for the reduced effective cross section. This ensures that the size of the gas molecules that can pass through the filter membrane is reduced. An escape of evaporated medium components from the medium storage is made difficult, as well as the diffusion rate is reduced because not all gas molecules contained in the ambient air can pass through the filter membrane.
  • a reduced number of pores compared to known filter membranes is provided for a reduced effective cross-section.
  • the product of free pore cross-section and the number of pores is reduced in a simple manner and thus achieves the desired reduction of the diffusion rate.
  • a reduction in the pore number depending on the production process of the filter membrane, in particular by introducing a small number of pores by means of a material removal process for a plastic film or by selecting a larger particle size in conjunction with a sintering process at a higher pressure and / or higher temperature for a sintered material reached.
  • the filter membrane has a mean pore number less than 1 million pores per mm 2 , preferably less than 600,000 pores per mm 2 , more preferably less than 300,000 pores per mm 2 .
  • a simple influence on the number of pores can be taken, for example, in a material-removing process in which the pores are introduced into a plastic film by means of high-energy electromagnetic radiation.
  • the filter membrane is arranged on a ventilation channel arranged, in particular between the medium container and pumping means provided sealing means.
  • the filter membrane can be easily integrated into the ventilation device and does not require a separate support for stabilization and / or positioning.
  • a sealing device is provided in known metering devices, which can be designed for example as an annular flat gasket.
  • the filter membrane can be applied, in particular partially or completely, to at least one of the end faces facing the medium reservoir or the pumping device, in particular be laminated on this flat seal.
  • the assembly of the sealing device can be done in the same manner as in known metering devices and includes at the same time the positioning of the filter membrane.
  • the filter membrane for closing a provided in the sealing device the ventilation channel associated passage opening is formed.
  • a passage opening in the sealing device which is assigned to the ventilation channel, a passage cross-section is precisely defined, can flow through the gas molecules from the medium storage in the environment or in the reverse direction in the media storage.
  • This passage cross-section is closed by the filter membrane, so that a diffusion rate can be exactly specified, which results from the passage cross-section and the associated effective area of the filter membrane as well as the resulting effective cross-section of the filter membrane.
  • the filter membrane in the region of a ventilation opening of the medium reservoir and / or the pumping device is mounted, in particular laminated.
  • the filter membrane can already be applied during the production of the medium reservoir and is supported by a wall section of the medium reservoir, whereby a particularly compact design of the filter device can be realized.
  • the filter membrane is preferably applied to the end of a ventilation path on a front or outer surface of a section of the medium reservoir or of a part of the pump device, in particular welded or laminated.
  • the filter device is designed as a discrete filter cartridge.
  • the filter direction can be produced independently of the pumping device or the medium dispenser and optionally checked.
  • the filter device can be provided as a mass product for a variety of different metering devices.
  • the object underlying the invention is also achieved by a metering device of the type mentioned, in which the ventilation channel is at least partially designed as a capillary channel, which has at least partially a ratio between an effective channel diameter and a Kapillarkanalin which is less than 1/25.
  • the ventilation channel has a high flow resistance for liquids and gases and thus reduces undesired outflow of liquid constituents or gases, in particular of evaporated medium constituents, from the medium reservoir.
  • the ratio between the effective channel diameter and the capillary channel length is less than 1/50, in a particularly preferred embodiment less than 1/100.
  • an evaporation rate determined at atmospheric pressure of 1013 hPa, a temperature of 40 degrees Celsius and a relative humidity of 25 percent can be approximately a factor of about 10 , 05 g / week to be reduced to 0.005 g / week.
  • the capillary channel is formed helically.
  • the capillary channel may be provided on an inner surface of a bore in a component and / or on an outer surface of a component.
  • the compact design allows an integration of a capillary channel with a ratio of effective channel diameter and capillary channel length according to the invention, without thereby necessitating a structural enlargement of the dosing device equipped therewith.
  • the capillary channel is designed as a circumferential, helical groove between a conical outer surface and a cover, which has a conical, adapted to the cone outer surface recess.
  • the capillary channel is formed between an outer surface of a cylinder arrangement and an inner surface of a slip-on sleeve, wherein a plurality of webs are provided on the outer surface of the cylinder assembly and / or on the slip-on, which substantially in the direction of a central longitudinal axis of the metering device are aligned and ensure a defined spacing of the slip sleeve.
  • the webs which can be provided in particular each offset by 120 degrees on the cylinder assembly and / or on the slip-on sleeve, an interference or interference fit between the cylinder assembly and the slip-on sleeve can be realized. This allows a secure pressing of the slip-on sleeve on the cylinder assembly, without leading to an undesirable narrowing or deformation of the cylinder bore provided in the cylinder assembly.
  • the capillary channel is introduced in sections in at least one of the webs as a groove.
  • the bridge has a double function as a spacer and as a capillary channel.
  • the introduced in the web groove is closed by, the oppositely arranged component, ie in a cylinder arrangement associated web through the slip-on sleeve or provided in the slip sleeve web through the cylinder assembly and thus forms the desired Kapillarkanal.
  • the capillary channel is formed from at least one annular section and at least one channel section, which is aligned at least substantially along the central longitudinal axis of the metering device.
  • the annular portion which may be arranged circumferentially around the central longitudinal axis, which is arranged parallel to the central longitudinal axis channel portion is connected to the medium reservoir.
  • the ring section is part of the capillary channel and can be formed like the channel portion between the cylinder assembly and the slip sleeve.
  • the ring portion can be realized in particular by two spaced-apart projections between the cylinder assembly and the slip-on sleeve, whereby a simple production of these components in the plastic injection molding process is made possible.
  • the metering device 1 shows essentially a pumping device 2, which is provided for mounting on a medium storage, not shown.
  • the pumping device 2 has a schematically illustrated piston arrangement 3, which is accommodated in a likewise schematically illustrated cylinder arrangement 4 and is provided for conveying a medium stored in the medium reservoir into an environment of the metering device 1.
  • the cylinder assembly 4 is received in a substantially conically shaped applicator 5, at the tapered end of a discharge opening 6 is provided, through which the set of the pumping device 2 under pressure medium can be discharged in finely atomized form into the environment.
  • a handle 7 is provided, which is provided with finger pads 8.
  • a user can operate the metering device 1 by pressing between the thumb and index or middle finger, the thumb is placed on a bottom of the medium storage, not shown.
  • a return spring 9 is provided which applies a restoring force upon actuation of the metering device 1.
  • the applicator 5 is provided with a protective cover 10, which is removed for the discharge process.
  • an interface 11 is provided for the attachment of the medium reservoir.
  • the interface 11 has a substantially cylindrically shaped outer shell 12, which receives the piston assembly 3 and in a relatively movable, positive fit Active connection with the applicator 5 is.
  • the outer shell 12 is provided with an internal thread 13 which is provided for the positive reception of an external thread provided on the medium reservoir.
  • a substantially annular-shaped flat seal 15 which is made of an elastic material and is provided for sealing a provided on the medium storage bottle neck with respect to the pumping device 2.
  • the flat gasket 15 has a vent opening 16, which is provided for a communicating connection of the volume enclosed by the medium storage volume with the environment.
  • the flat gasket 15 On a side facing the interface 11, the flat gasket 15 has a sealing surface 17, which is provided for a sealing effect against the medium reservoir.
  • a recess for a positive reception of a filter cartridge 18 is provided in the piston assembly 3, which is provided with a in the Fig. 2 equipped filter membrane 20 is shown.
  • the filter cartridge 18 communicates with a cavity 19 in communicating connection, which in turn is connected via not shown column in the metering device 1 with the environment. This allows inflow or outflow of gas molecules from or into the medium reservoir.
  • the ventilation opening 16, the filter cartridge 18 and the cavity 19 form the ventilation device of the metering device 1.
  • a gas flow emerging from the medium reservoir for example from evaporated medium components, must inevitably flow through the ventilation device in order to escape into the environment. The same applies to the reverse case, that gas from the environment is sucked into the medium storage, also here is to completely flow through the ventilation device.
  • filter cartridge 18 shown in more detail has a filter membrane 20 which is designed as a germ barrier and which is received in a passage bore 21 of the filter cartridge 18.
  • a longitudinal axis 22 of the passage bore 21 is aligned parallel to a longitudinal axis of the metering device 1.
  • the filter membrane 20 is intended to prevent the entry of contaminants from the environment in the medium storage, not shown.
  • the passage bore 21 has an inner diameter 23 which is at least approximately constant over the entire length of the filter cartridge 18.
  • the filter membrane 20 is injected positively into the executed as a plastic injection molding filter cartridge 18 and is bounded by the passage bore 21.
  • the effective area of the filter membrane 20 is determined by the effective diameter 24, which is smaller than the inner diameter 23.
  • pores or channels 26 Only in the active surface of the filter membrane 20 are pores or channels 26 provided, which allow gas molecules to pass through, while no pores or channels are provided outside the active surface.
  • the provided in the filter membrane 20 channels 26 are shown only schematically, they can also take a curved course depending on the manufacturing process for the filter membrane 20 and have different cross sections over their course.
  • the generation of the channels 26 can be carried out before or after the injection into the filter cartridge 18 and be realized in particular by a bombardment of the filter membrane 20 with a high-energy electromagnetic radiation.
  • Critical to the passage of gas molecules is the minimum free cross section of the channels 26, as this limits the size of the gas molecules that can pass through the channels.
  • the diffusion constant of the filter membrane 20 is additionally determined by the thickness 25 of the filter membrane 20, wherein a greater thickness 25 leads to a reduction of the diffusion constant, since the passage of gas molecules is made more difficult by the increased length of the channels 26 and by the greater thickness of the base material ,
  • the inner diameter 23 of the through-bore 21 is approximately 1.4 mm, while the effective diameter 24 is approximately 0.9 mm, so that the effective area is approximately 0.65 mm 2 .
  • a filter membrane 20 made from the material polyethylene terephthalate (PET, PEPT) may be provided.
  • PET polyethylene terephthalate
  • This filter membrane 20 has a pore size of 0.2 / 1000mm (0.2 ⁇ m) at a membrane thickness of 36 / 1000mm (36 ⁇ m) and an active filter area of less than 0.8mm 2 .
  • Dosing device 1 shown an evaporation rate of about 0.033 g / week.
  • the evaporation rate may be at least 15%, preferably reduced by 30%, more preferably by 50%.
  • the in Fig. 3 illustrated filter cartridge 18 equipped with a filter membrane 20 which has over its entire surface a substantially constant number of channels 26 per unit area.
  • a reduction of the diffusion rate is achieved by providing on one side a conical flow-guiding geometry 27 reaching down to the filter membrane, which leads to a reduction of the effective area.
  • the effective area is therefore determined by the minimum diameter 28 of the Strömungsleitgeometrie 27 and is exemplarily about 0.65 mm 2 , while the inner diameter 23 of the through hole 21 is about 1.4 mm.
  • the filter membrane 20 can be cut from a homogeneous, uniformly interspersed with channels 26 raw material and introduced into the filter cartridge 18 in the plastic injection molding process.
  • filter cartridge 18 is in a modification of Fig. 3 known filter cartridge on both sides of the filter membrane 20 each have a Strömungsleitgeometrie 27 is provided.
  • the effective surface is determined by the minimum diameter 28 of the Strömungsleitgeometrie 27, the filter membrane 20 is as in the embodiment of the Fig. 3 executed as a homogeneous, uniformly interspersed with channels 26 membrane.
  • Strömungsleitgeometrien 27 arranged on both sides, a particularly advantageous stabilization of the filter membrane 20 is achieved, also can be effected by the conical configuration of Strömungsleitgeometrien 27 an advantageous flow behavior of the gas stream passing through the filter membrane.
  • the inner diameter 23 of the passage bore 21 and the minimum diameter 28 the same dimensions apply as for the filter cartridge Fig. 3 ,
  • a filter membrane 20 of polytetrafluoroethylene (PTFE) may be provided.
  • PTFE polytetrafluoroethylene
  • Such a filter membrane 20 has a pore size of .0.2 / 1000mm (0.2pm) and is applied to a support membrane of PET so as to give a total membrane thickness of about 0.2mm.
  • the effective surface area is limited by the Strömungsleitgeometrien 27 to about 0.5 mm 2 , so that an evaporation rate, which is determined at atmospheric pressure of 1013 hPa, a temperature of 40 degrees Celsius and a humidity of 25 percent, of about 0.033 g / week for the filter cartridge 18 when used in the in Fig. 1 set dosing device 1 shown. This represents a reduction in the rate of evaporation compared to known, equipped with conventional filters dosing of about 30 percent.
  • the filter membrane 20 is provided in a recess of the gasket 15 and closes a ventilation opening 16, which is part of the ventilation device.
  • a ventilation channel 29 in communicating Active compound that allows inflow and outflow of gas molecules into the cavity 19.
  • the active surface of the filter membrane 20 is as in the embodiments of Fig. 3 and 4 determined by the minimum diameter of the venting breakthrough 16, while the filter membrane is interspersed with a homogeneous number of channels per unit area.
  • the filter membrane 20 is applied to a surface of the flat gasket 15, in particular laminated.
  • the filter membrane in the region of the ventilation opening 29 of the piston or cylinder assembly 3 is similar Fig. 5 up or down on a corresponding surface of the piston or cylinder assembly 3 applied tight, in particular welded or laminated.
  • the in the Fig. 6 . 7 and 8th Dosing device 1 shown has a provided on the cylinder assembly 4 filter cartridge 18, which according to the embodiments of Fig. 1 to 5 can be designed.
  • the passage bore 21 opens into a distributor bore 30, which communicates via an outlet opening 38 communicatingly with a circumferential annular section designed as an annular channel 31, as in FIG Fig. 6a is shown in more detail.
  • the annular channel 31 is formed by a circumferential stepped shoulder 34 on the cylinder assembly 4 and a correspondingly executed paragraph 43 formed on the slip-on sleeve 32 and is due to its design as a long channel with a narrow cross-section part of the capillary.
  • the channel portion 33 is formed by a groove 37 in a support bar 35 and the support web 35 opposite slip-on sleeve 32.
  • Another function of the support webs 35 is to allow a frictional receiving the slip-on sleeve 32 on the cylinder assembly 4, without the cylinder bore in the cylinder assembly 4 is deformed by the slip-on sleeve 32.
  • a peripheral collar 36 is provided above the mouth of the distributor bore 30, which ensures a circumferentially sealing receiving the slip-on sleeve 32 in an end region facing the medium reservoir, as shown in the Fig. 8 is shown in more detail. In the encircling collar 36 is only in the Fig.
  • the capillary channel has at the in Fig. 6 to 8 is about 60 mm long and has an effective capillary channel diameter of about 0.42 mm, resulting in a ratio of effective capillary channel diameter and capillary channel length of 1/140. With such a ratio, an evaporation rate determined at normal pressure of 1013 hPa, a temperature of 40 degrees Celsius and a humidity of 25 percent can be realized of about 0.005 g / week.
  • the capillary channel is designed as a helical groove between a conical outer surface 39 and a cover 40.
  • the cover 40 has a cone-shaped recess and is pressed with a collar 41 in a retaining groove 42, as shown in the Fig. 9a and 9b is shown in more detail.
  • the penetration of the cover 40 with the cylinder arrangement 4 shows that an interference fit, also referred to as a press fit, is provided between these components to ensure a secure fit of the cover 40 and a good sealing effect of the capillary.
  • the cone outer surface 39 is part of the cylinder assembly 4 and has a helical and helical circumferential shoulder made in the manner of a conical worm.
  • the filter membrane is housed in a recess of the gasket, as shown in the Fig. 5 is shown and is connected to a capillary according to one of Fig. 6 to 9 coupled, which can be a simply constructed and characterized by a very low evaporation rate metering realized.

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  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
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  • Medicines Containing Plant Substances (AREA)
  • Peptides Or Proteins (AREA)

Claims (14)

  1. Dispositif de dosage (1) pour au moins un fluide, avec un dispositif de pompage (2) étant en liaison active avec un réservoir de fluide pour une distribution de fluide, ainsi qu'avec un dispositif d'aération associé au réservoir de fluide et/ou au dispositif de pompage et présentant un canal d'aération (16, 18, 26, 27) qui permet une liaison communicante du volume contenu dans le réservoir de fluide avec un voisinage à travers une membrane filtrante (20) associée au canal d'aération (16, 18, 26, 27), caractérisé en ce que la membrane filtrante (20) est conçue pour un taux de diffusion réduit par le fait que la surface active de la membrane filtrante est inférieure à 1,4 mm2.
  2. Dispositif de dosage selon la revendication 1, caractérisé en ce que la surface active de la membrane filtrante est limitée par une géométrie directrice de flux (27) qui a une forme conique au moins partiellement.
  3. Dispositif de dosage selon la revendication 1 ou 2, caractérisé en ce que la surface active de la membrane filtrante est inférieure à 0,6 mm2, en particulier et de préférence inférieure à 0,2 mm2.
  4. Dispositif de dosage selon l'une des revendications précédentes, caractérisé en ce que la membrane filtrante présente un nombre de pores moyen inférieur à 1 million de pores par mm2, de préférence inférieur à 600 000 pores par mm2, en particulier et de préférence inférieur à 300 000 pores par mm2.
  5. Dispositif de dosage selon l'une des revendications précédentes, caractérisé en ce que la membrane filtrante est prévue sur un dispositif d'étanchement (15) disposé dans le canal d'aération, en particulier entre le récipient de fluide et le dispositif de pompage.
  6. Dispositif de dosage selon la revendication 5, caractérisé en ce que la membrane filtrante est conçue pour obturer un orifice de passage (16) prévu dans le dispositif d'étanchement et associé au canal d'aération.
  7. Dispositif de dosage selon l'une des revendications 1 à 4, caractérisé en ce que la membrane filtrante est placée dans la zone d'une ouverture d'aération du réservoir de fluide et/ou du dispositif de pompage, et est en particulier appliquée par laminage.
  8. Dispositif de dosage selon l'une des revendications 1 à 4, caractérisé en ce que le dispositif de filtrage est conçu comme cartouche filtrante discrète.
  9. Dispositif de dosage selon le préamble de la revendication 1 ou selon l'une des revendications précédentes, caractérisé en ce que le canal d'aération est au moins partiellement conçu comme canal capillaire, qui présente au moins partiellement un rapport entre un diamètre de canal utile (d) et une longueur de canal capillaire (I) qui est inférieur à 1/25, de préférence inférieur à 1/50, en particulier et de préférence inférieur à 1/100.
  10. Dispositif de dosage selon la revendication 9, caractérisé en ce que le canal capillaire a une forme hélicoïdale.
  11. Dispositif de dosage selon la revendication 9, caractérisé en ce que le canal capillaire est réalisé comme gorge circonférentielle hélicoïdale entre une surface extérieure conique et un couvercle qui présente un évidement conique adapté à la surface extérieure conique.
  12. Dispositif de dosage selon la revendication 9, caractérisé en ce que le canal capillaire est formé entre une surface extérieure d'une structure cylindrique et une surface intérieure d'une douille emboîtable, sachant que sur la surface extérieure de la structure cylindrique et/ou sur la douille emboîtable sont prévues plusieurs barrettes qui sont orientées pour l'essentiel en direction d'un axe longitudinal médian du dispositif de dosage et maintiennent la douille emboîtable à une distance définie.
  13. Dispositif de dosage selon la revendication 12, caractérisé en ce que le canal capillaire est partiellement pratiqué comme gorge dans au moins une des barrettes.
  14. Dispositif de dosage selon la revendication 13, caractérisé en ce que le canal capillaire est constitué d'au moins une section annulaire et d'au moins une section de canal qui est au moins pour l'essentiel orientée le long de l'axe longitudinal médian du dispositif de dosage.
EP05804435A 2004-10-13 2005-10-13 Dispositif de dosage Active EP1799357B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004050679A DE102004050679A1 (de) 2004-10-13 2004-10-13 Dosiervorrichtung
PCT/EP2005/010994 WO2006040146A1 (fr) 2004-10-13 2005-10-13 Dispositif de dosage

Publications (2)

Publication Number Publication Date
EP1799357A1 EP1799357A1 (fr) 2007-06-27
EP1799357B1 true EP1799357B1 (fr) 2010-07-28

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EP05804435A Active EP1799357B1 (fr) 2004-10-13 2005-10-13 Dispositif de dosage

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US (1) US20070262090A1 (fr)
EP (1) EP1799357B1 (fr)
JP (1) JP5069563B2 (fr)
AT (1) ATE475484T1 (fr)
DE (2) DE102004050679A1 (fr)
WO (1) WO2006040146A1 (fr)

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DK3679941T3 (da) 2009-06-18 2022-11-14 Serenity Pharmaceuticals Llc Sikker indgivelse af desmopressin
GB2474520B (en) 2009-10-19 2015-08-26 London & General Packaging Ltd Spray dispenser
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DE102012218434A1 (de) 2012-10-10 2014-04-24 Aptar Radolfzell Gmbh Spender mit Kindersicherung
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USD733866S1 (en) * 2012-11-28 2015-07-07 Meadwestvaco Calmar Gmbh Dispenser
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EP3576825B1 (fr) 2017-02-01 2020-12-16 Silgan Dispensing Systems Hemer GmbH Dispositif de distribution pour un milieu fluide
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Also Published As

Publication number Publication date
ATE475484T1 (de) 2010-08-15
EP1799357A1 (fr) 2007-06-27
US20070262090A1 (en) 2007-11-15
WO2006040146A1 (fr) 2006-04-20
JP5069563B2 (ja) 2012-11-07
JP2008515630A (ja) 2008-05-15
DE502005010015D1 (de) 2010-09-09
DE102004050679A1 (de) 2006-04-20

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