EP1761775B1 - Integrierte Analysenvorrichtung passend auf einen Behälter der die zu analysierende Probe enthält - Google Patents

Integrierte Analysenvorrichtung passend auf einen Behälter der die zu analysierende Probe enthält Download PDF

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Publication number
EP1761775B1
EP1761775B1 EP05781796.7A EP05781796A EP1761775B1 EP 1761775 B1 EP1761775 B1 EP 1761775B1 EP 05781796 A EP05781796 A EP 05781796A EP 1761775 B1 EP1761775 B1 EP 1761775B1
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EP
European Patent Office
Prior art keywords
sample
membrane
container
analysis device
analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP05781796.7A
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English (en)
French (fr)
Other versions
EP1761775A1 (de
Inventor
David Mosticone
Pascal Montes
Jean-Claude Raymond
Bruno Colin
Cécile PARIS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomerieux SA
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Biomerieux SA
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Publication date
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Publication of EP1761775A1 publication Critical patent/EP1761775A1/de
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Publication of EP1761775B1 publication Critical patent/EP1761775B1/de
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0672—Integrated piercing tool
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/110833—Utilizing a moving indicator strip or tape
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/112499—Automated chemical analysis with sample on test slide

Definitions

  • the present invention relates generally to the field of analysis for example biological analysis. More specifically, the present invention relates to an integrated analysis device, adaptable to a container of a sample to be analyzed.
  • Contamination can also occur in the opposite direction. Indeed, it sometimes happens that during the taking of biological fluids, such as urine, suspected of being contaminated, the personnel who carries out the sampling contaminates the latter itself, leading to the impossibility of providing a reliable diagnosis from said sample.
  • This culturing generally consists in putting the sample in a plastic bag containing a culture medium, which allows the development of microorganisms, in particular bacteria. After an incubation time necessary for microbiological development, one or more aliquots of the culture medium are made, in order to carry out a microbiological analysis. The aliquots are generally made by opening the bag, at the level of the sample introduction orifice. food and culture medium.
  • Analyzer devices for connection to a biological sample container have already been described. This is the case for example of the document analysis device WO-A-03/030739 .
  • the analysis device described in this application consists of a pocket, containing the analysis reagent, with a connection tube allowing the analysis device to be connected to the container of the biological sample.
  • the document DE-A-35 04 527 also discloses a bag-shaped analytical device containing the assay reagent, with a connecting tube; said device being intended to be connected with a urine bag.
  • this type of device can be adapted to a limited number of containers, more specifically dedicated to the medical field.
  • Another disadvantage of this type of device is that it comprises a fluid connection tube with the outside of the pocket. Even if this tube is initially plugged, there is nevertheless a risk that the closing device of the tube breaks, causing the communication of the bag with the ambient air; this can be a significant source of contamination or degradation of the analysis device.
  • a last disadvantage of such a device is that it does not completely eliminate the risk of contamination of the technical staff at the time of connection of the device to the container of the biological sample.
  • the document US 5,788,863 describes a device for analyzing a liquid which comprises a body comprising a channel, a reservoir and a fluid circulation system (for example a syringe) between which there is a membrane with a capture phase capable of capturing the analyte.
  • the fluid circulation system and the reservoir are coupled so that the fluid can flow through the membrane in both directions.
  • the passage of the fluid in both directions through the membrane is characteristic of this apparatus and the analysis of the liquid requires a movement of the liquid in two directions.
  • the document EP 0 678 745 describes a device in the form of a kit consisting of two separate elements to be assembled for analysis, the first incubation element comprises at least one receptacle adapted to receive the product to be analyzed, the second reaction element comprises at least one cuvette closed by a sealing membrane on the bottom of which is fixed a reaction layer.
  • the device comprises, means for assembling said elements and means for perforation and injection, capable of first perforating the membrane and then injecting the contents of the receptacle into the bowl through said perforated membrane, a once the two elements are assembled. According to this system, a connection of the cavity and the container is therefore necessary in contrast to the system of the present invention.
  • one of the essential objectives of the present invention is to provide an analysis device, with a reduced cost, which can be easily adapted to any type Container containing samples, such as biological samples or samples for quality control; such containers being for example pockets or bags of flexible plastic material.
  • Another object of the present invention is to provide an analysis device which, when adapted to said containers, limits handling of the sample contained in the container, thereby limiting the risk of contamination, ie personnel handling the sample, which is the sample itself.
  • Another object of the present invention is to provide an analysis device less subject to the risk of contamination or degradation.
  • Another object of the present invention is to provide an analysis device that eliminates, if necessary, the use of pipette or syringe sampling equipment.
  • Another object of the present invention is to provide an analysis device which makes it possible to reduce the time required for analyzing the sample.
  • Another object of the present invention is to provide an analysis device for performing different types of analysis.
  • Another objective of the present invention is to provide an analysis device which, being linked to the container of the sample to be analyzed, allows better traceability of the analysis result.
  • Another object of the present invention is to provide an analysis device which allows the sample to be recovered or an aliquot of the sample for subsequent analysis.
  • Another object of the present invention is to provide an analysis device which makes it possible to take a sample through the flexible wall of a container, while maintaining the tightness of said container.
  • a final objective of the present invention is also to provide a container for enclosing a biological sample, said container incorporating, permanently, an analysis device, thus limiting the manipulation of the sample and facilitating the analysis.
  • the means intended to create an inlet channel for the sample inside said internal reaction cavity is constituted by at least one preferential gripping zone, disposed on one of said first or second membrane , making it possible to detach at least partially said first and second membranes from each other, in order to make the internal reaction cavity accessible to the sample contained in the container.
  • the means intended to create an inlet channel for the sample inside said internal reaction cavity is constituted by at least one means intended to act on one of said first or second membrane .
  • this means is a means of perforation.
  • the perforating means is disposed inside the cavity.
  • the means for creating an inlet channel of the sample inside said internal reaction cavity is constituted by the second membrane, made of a material having a value of breaking strength. less than the material constituting the first membrane.
  • this material is taken from the group comprising: aluminum, copper or any laminatable strip.
  • the analysis device comprises a septum integral with the first membrane, at least partially covering the latter.
  • the means of analysis is taken from the group comprising porous reaction media such as pH test strips, immunochromatography strips, biochemical substrate strips or any other equivalent analytical means.
  • Another subject of the invention concerns a container comprising at least one analysis device as defined above.
  • the analysis device is integral with a wall of said container.
  • the second membrane of the analysis device is integral with the wall of the container.
  • the second membrane is in direct contact with the sample to be analyzed.
  • step a) is carried out using the perforation means disposed in the internal reaction cavity.
  • step a) is performed using a perforation means independent of the analysis device.
  • step a) comprises perforating the two membranes of the device and the wall of the container, with the aid of the perforating means, a septum integral with the first membrane delimiting the perforation zone of said first membrane, thereby preventing the sample to be analyzed from escaping out of the analysis device, once the piercing means is removed.
  • step b ') consists in perforating the first or the second membrane of the analysis device.
  • step b ') consists in dissociating at least partially the first and second membranes, with the aid of the preferential gripping zones disposed on said first and second membranes.
  • Another object of the present invention relates to the use of an analysis device for analyzing a sample contained in a container.
  • the analysis device is in the form of a patch 10. It comprises a first membrane 12, constituting the upper membrane on the Figure 1B and a second membrane 14, constituting, in turn, the lower membrane.
  • These two membranes are advantageously made of a plastic material of the polyethylene (PE), polypropylene (PP) type or any equivalent material. Such a material makes it possible to obtain flexible, transparent and watertight membranes. However, it is essential that this material can be perforated.
  • the two membranes are secured to a part of their internal surface by gluing or any other suitable equivalent means such as heat sealing, thus defining an interstitial zone 16, acting as an internal reaction cavity.
  • This cavity is here in the form of a rectangular portion of limited width, extending at one of its ends by a spherical zone. Inside the rectangular part of the internal reaction cavity 16 is disposed an analysis means 18.
  • reaction test for measuring one or more biological and / or physico-chemical parameters of a sample, to demonstrate the presence of a contaminant or a particular marker in said sample.
  • the analysis means may be a reaction strip advantageously used in the environmental quality control, such as the physicochemical analysis of the water, the measurement of the pH, the agri-food control, such as microbiological control, the detection of allergy vectors, bioterrorism, or of course clinical analyzes, such as the chemical or microbiological control of urine, blood, pregnancy tests.
  • the environmental quality control such as the physicochemical analysis of the water, the measurement of the pH, the agri-food control, such as microbiological control, the detection of allergy vectors, bioterrorism, or of course clinical analyzes, such as the chemical or microbiological control of urine, blood, pregnancy tests.
  • This type of tool is well known to those skilled in the art and widely used in both analytical laboratories and industries.
  • the elastic material constituting the septum 20 may be for example a suitable silicone material, such as a crosslinkable silicone material with alkoxy functions or natural rubber.
  • the figure 2 represents a front view of a container of a sample to be analyzed. More specifically, this container 22 is, in this example, a blood collection bag.
  • This container 22 comprises two flexible walls, possibly transparent, an anterior wall 24 and a rear wall not shown in this figure, these two walls being secured at their periphery. It further comprises, in its lower part, a nozzle 26 from which the sample 28 is conveyed into the container. This tip is closed by means of a shutter means not shown.
  • the analysis device 10 On the anterior wall 24 is arranged the analysis device 10, as shown in Figures 1A and 1B . This analysis device 10 is positioned so that it is in contact with a part of the wall 24, itself in contact with the sample 28.
  • FIG. 3A A partial sectional view along the axis III-III of the figure 2 is represented on the figure 3A . It can be seen that the analysis device 10 is secured to the wall 24 of the container 22, via its second membrane 14. This joining can be achieved by means of a sticky film disposed on the outer face of the membrane 14 during the manufacture of the analysis device 10. According to one variant, it is possible to use an adhesive deposit or a piece of double-sided adhesive tape when the analysis device is positioned on the container. It follows that the analysis device is secured to the container 22 and is ready to be used.
  • the technician in charge of the analysis decides to carry out the analysis, he uses a means of perforation, represented on the figure 3B in the general form of a point 32.
  • This point 32 is positioned above the septum 20.
  • the technician then perforates the analysis device at the septum 20 in a movement represented by the double arrow A, so that the perforation means 32 sequentially perforates the septum 20, the membranes 12 and 14 of the analysis device and the anterior wall 24, without however perforating the posterior wall 30 of the container 22.
  • the perforating means 32 is then removed, according to the arrow AT.
  • the internal reaction cavity 16 of the analysis device 10 then communicates with the interior of the container 22 and is thus in contact with the sample 28, as shown in FIG. figure 3C .
  • the latter is, in fact, sucked into the orifice formed in the anterior wall 24 and in the membrane 14 by capillary action, until it reaches the internal reaction cavity 16 and then comes into contact with the analysis means 18.
  • withdrawal of the piercing means 32, the orifice made in septum 20 closes by itself, thanks to the elastic properties of the material constituting the septum, leaving only a simple scar 34 in said septum.
  • the analysis device covers its sealing properties, preventing the sample from spreading out of the analysis device and thus to contaminate the environment or the technician handling the sample.
  • the analysis means 18 being in contact with the sample 28, the analysis can then take place, so that, after the time required for the reaction, the technician can read the result of the analysis on the means of analysis through the membrane 12, since it is made of transparent material.
  • the perforation means represented is a tip, it is nevertheless possible to use any suitable means of perforation from the moment when it is inert vis-à-vis the chemical or biological reactions taking place during the analysis.
  • a second embodiment of the analysis device according to the invention is represented on the Figures 4A and 4B .
  • the analysis device 40 is shown secured to the container 22.
  • the device 40 comprises a first membrane 42 constituting the upper membrane on the Figure 4A and a second membrane 44 constituting the lower membrane.
  • the two membranes are secured to a part of their internal surface by gluing or any other appropriate equivalent means, thereby defining the interstitial zone 46, acting as an internal reaction cavity.
  • Inside the internal reaction cavity 46 is disposed the analysis means 47.
  • the analysis device 40 further comprises a perforation means 48 also disposed inside the internal reaction cavity 46.
  • perforation 48 is constituted by a point integral with the analysis device, by its end 481, opposite the pointed end.
  • This tip can be made of any rigid material such as a metal or a stainless alloy, a plastic material, etc. It is important, however, that this material is inert with respect to the chemical or biological reaction (s) taking place during the analysis.
  • analysis device 40 may advantageously be independent of the container, although this is not shown on the Figures 4A and 4B .
  • the manipulator technician takes the container in his hands in the vicinity of the analysis device and makes a torsion movement of the latter and therefore of the container 22 in accordance with the arrows B, so that the tip of the perforation means 48 comes to perforate the membrane 44 of the analysis device and the front wall 24 of the container 22, without perforating the rear wall 30.
  • the perforating means may comprise a guard to limit the stroke of the latter.
  • the analysis means then comes into contact with the sample, so that in the presence of the analyte or analytes to be detected, a reaction takes place in the internal reaction cavity 46.
  • the result of the analysis can then be read directly through the transparent membrane 42.
  • FIGS. Figures 5A and 5B A third embodiment of the analysis device according to the invention is shown in FIGS. Figures 5A and 5B .
  • the analysis device 501 shown in FIGS. Figures 5A and 5B is here an integral part of the container 50.
  • the analysis device 501 always comprises two membranes, a first membrane 52, constituting the upper membrane on the Figures 5A and 5B and a second membrane 54 constituting the lower membrane.
  • the two membranes are secured to a portion of their internal surface by gluing or any other equivalent equivalent means, thereby defining the interstitial zone 56, acting as an internal reaction cavity.
  • Inside the internal reaction cavity 56 is disposed the analysis means 57.
  • the anterior wall 58 of the container 50 has a cut-out in an area located in line with the analysis device 501 so that the membrane 54 of the analysis device is directly in contact with the sample 28 contained in the container 50, through its outer face.
  • the latter also has a rear wall 59.
  • a perforation means (not shown on the Figures 5A and 5B ).
  • a perforation means may be for example of the clamp type.
  • This clamp may advantageously comprise an arm whose end has a projecting zone, said male part and an arm whose end has a bowl area complementary to the projecting zone, said female part.
  • the manipulator technician thus pinches the container 50 at the analysis device 501, according to the arrows C, so that the membranes of the analysis device and the rear wall 59 of the container are wedged between the male part and the part female. It follows that by exerting sufficient pressure, the membrane 54 breaks, while the membrane 52 and the rear wall 59 resist, because of their superior strength properties.
  • the membrane 54 having a perforation 541 the sample 28 contained in the container infiltrates the internal reaction cavity 56 and thus comes into contact with the analysis means 57. The result of the analysis can then be read directly through the transparent membrane 42.
  • the material constituting the membrane 54 may be a brittle material.
  • the technician to perform the analysis may dispense with the use of a pin-like object to pierce the membrane 54. It suffices to perforate the device with a fingernail or to twist it so as to break the membrane.
  • the container is manufactured with the integrated analysis device. Indeed, the latter can not be attached to one of the walls of the container.
  • another variant of this embodiment consists in an analysis device manufactured independently of the container, so that it can be slid inside the container, directly in contact with the sample. To carry out the analysis, it is then necessary to jam the analysis device in one of the lower corners of the container, so that the manipulator technician can perforate the device using the forceps described above and this, directly to through the container. It is of course necessary for this embodiment to work properly, the walls of the container resist perforation, but also that they are sufficiently flexible to allow perforation of the analysis device. In addition, the walls of the container must be transparent in order to read the result of the analysis.
  • the analysis device 60 described here is adapted to be placed inside a container 70 having two walls 72 and 74 defining a volume. inside which the sample 28 is located.
  • This analysis device 60 consists of a first membrane 62 constituting the upper membrane on the Figure 6A and a second membrane 64 constituting the lower membrane. These two membranes are secured to a portion of their inner surface, thereby defining the interstitial zone 66, acting as an internal reaction cavity. Inside the internal reaction cavity 66 is disposed the analysis means 67.
  • the analysis device 60 further comprises two preferential gripping zones.
  • the first preferential gripping area 621 is disposed in the extension of the membrane 62.
  • the manipulator technician When the manipulator technician wishes to perform the analysis, he catches the analysis device through the container so as to hold the gripping zone 621 with one hand and the gripping zone 641 with the other hand. Between each hand, it therefore holds respectively one of the walls of the container and a gripping area.
  • the membranes 62 and 64 By pulling in the opposite direction on the gripping zones, the membranes 62 and 64 partially separate, so that the internal reaction cavity 66 is in contact with the sample 28, as shown in FIG. Figure 6B . It is advantageous that the securing means of the membranes 62 and 64, in other words the glue used, does not produce a too much solidarity, to ensure easy separation of the two membranes, when pulling on the gripping areas 621 and 641.
  • This parameter is all the more important that the manipulation of the analysis device is done at the inside the container. As a result, the manipulation of the analysis device is limited in terms of space. It is also appropriate for this embodiment, that the container has the most flexible walls possible to facilitate the gripping of the analysis device.
  • this analysis means comprising a concentrate of the sample analyzed, it may be envisaged to use it to perform other analyzes.
  • These analyzes can be, for example, microbiological analyzes.
  • the analysis device can then be used to seed a microbiological culture medium on a Petri dish.
  • the analysis device can be adapted to different types of containers, such as blood bags, bags used for microbiological industrial analysis and more generally to any container that has flexible walls, can be perforated or easily apprehended . It is thus a device of choice to carry out various analyzes on very diverse samples also.
  • Another advantage of the analysis device according to the invention is that it avoids if necessary any direct contact with the sample, in the case where the latter proves to be dangerous.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)

Claims (15)

  1. Behälter, der eine zu analysierende Probe enthält, der mindestens eine Analysevorrichtung aufweist, wobei die Vorrichtung hauptsächlich aufweist:
    • eine erste dichte Membran;
    • eine zweite dichte Membran, die über der ersten Membran angeordnet ist;
    • wobei die erste und die zweite Membran über mindestens einen Teil ihrer Fläche fest miteinander verbunden sind, der eine Umfangszone bildet, um einen Zwischenraum zu definieren, der einen inneren Reaktionshohlraum ohne Fluidverbindungseinrichtung mit der Außenumgebung der Analysevorrichtung bildet;
    • mindestens eine im Inneren des inneren Reaktionshohlraums angeordnete Analyseeinrichtung, die dazu bestimmt ist, mit der Probe in Kontakt gebracht zu werden;
    • mindestens eine Einrichtung, die dazu bestimmt ist, einen Eingangskanal der Probe ins Innere des inneren Reaktionshohlraums zu erzeugen.
  2. Behälter nach dem vorhergehenden Anspruch, wobei die Analysevorrichtung fest mit einer Wand des Behälters verbunden ist.
  3. Behälter nach dem vorhergehenden Anspruch, wobei die zweite Membran der Analysevorrichtung fest mit der Wand des Behälters verbunden ist.
  4. Behälter nach dem vorhergehenden Anspruch, wobei die zweite Membran in direktem Kontakt mit der zu analysierenden Probe ist.
  5. Behälter nach einem der Ansprüche 1 bis 4, wobei die Einrichtung, die dazu bestimmt ist, einen Eingangskanal der Probe ins Innere des inneren Reaktionshohlraums zu erzeugen, aus mindestens einer Einrichtung zur Perforation der ersten oder zweiten Membran der Analysevorrichtung besteht.
  6. Behälter nach Anspruch 5, wobei die Perforationseinrichtung im Inneren des Hohlraums der Analysevorrichtung angeordnet ist.
  7. Behälter nach einem der Ansprüche I bis 6, wobei die Einrichtung, die dazu bestimmt ist, einen Eingangskanal der Probe ins Innere des inneren Reaktionshohlraums zu erzeugen, aus der zweiten Membran besteht, die aus einem Material besteht, das einen Reißfestigkeitswert geringer als derjenige des die erste Membran bildenden Materials aufweist.
  8. Behälter nach dem vorhergehenden Anspruch, wobei das Material aus der Gruppe genommen wird, die enthält: Aluminium, Kupfer oder jedes walzbare Bandmaterial.
  9. Behälter nach einem der vorhergehenden Ansprüche, der außerdem ein Septum aufweist, das fest mit der ersten Membran der Analysevorrichtung verbunden ist und letztere zumindest teilweise bedeckt.
  10. Behälter nach einem der vorhergehenden Ansprüche, wobei die Analyseeinrichtung aus der Gruppe genommen wird, die die porösen Reaktionsträger wie die Messstreifen des pH-Werts, die Immunchromatographie-Streifen, die biochemischen Streifen oder jedes gleichwertige Analysesystem enthält.
  11. Verfahren zur Analyse einer Probe, die in einem Behälter nach einem der Ansprüche 1 bis 10 enthalten ist, der mindestens eine Wand aufweist, die zumindest teilweise aus einem perforierbaren Material besteht, wobei das Verfahren hauptsächlich die folgenden Schritte enthält:
    a) Inkontaktbringen der zu analysierenden Probe mit der Analyseeinrichtung der Analysevorrichtung, mittels Perforieren der zweiten Membran der Analysevorrichtung und des Teils der Wand des Behälters, der sich gegenüber der zweiten Membran befindet, wodurch die Übertragung der Probe in den Reaktionshohlraum ermöglicht wird;
    b) Analyse des von der Analyseeinrichtung gelieferten Resultats.
  12. Verfahren nach dem vorhergehenden Anspruch, wobei der Schritt a) mit Hilfe der im Reaktionshohlraum angeordneten Perforationseinrichtung durchgeführt wird.
  13. Verfahren nach Anspruch 11, wobei der Schritt a) mit Hilfe einer von der Analysevorrichtung unabhängigen Perforationseinrichtung durchgeführt wird.
  14. Verfahren nach Anspruch 13, wobei der Schritt a) darin besteht, die zwei Membranen der Vorrichtung und die Wand des Behälters mit Hilfe der Perforationseinrichtung zu perforieren, wobei ein fest mit der ersten Membran verbundenes Septum die Perforationszone der ersten Membran begrenzet, wodurch verhindert wird, dass die zu analysierende Probe aus der Analysevorrichtung austritt, wenn die Perforationseinrichtung zurückgezogen wurde.
  15. Verwendung eines Behälters nach einem der Ansprüche I bis 10 zur Analyse einer Probe.
EP05781796.7A 2004-06-28 2005-06-24 Integrierte Analysenvorrichtung passend auf einen Behälter der die zu analysierende Probe enthält Not-in-force EP1761775B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0451343A FR2872288B1 (fr) 2004-06-28 2004-06-28 Dispositif d'analyse integre, adaptable sur un conteneur d'un echantillon a analyser
PCT/FR2005/050491 WO2006008407A1 (fr) 2004-06-28 2005-06-24 Dispositif d'analyse integre, adaptable sur un conteneur d'un echantillon a analyser

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Publication Number Publication Date
EP1761775A1 EP1761775A1 (de) 2007-03-14
EP1761775B1 true EP1761775B1 (de) 2014-08-13

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EP05781796.7A Not-in-force EP1761775B1 (de) 2004-06-28 2005-06-24 Integrierte Analysenvorrichtung passend auf einen Behälter der die zu analysierende Probe enthält

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US (1) US8518342B2 (de)
EP (1) EP1761775B1 (de)
JP (1) JP4913732B2 (de)
CN (1) CN1977165B (de)
FR (1) FR2872288B1 (de)
WO (1) WO2006008407A1 (de)

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EP2300164B1 (de) * 2008-06-19 2018-03-14 Boehringer Ingelheim Microparts GmbH Fluiddosierbehälter
FR2958401A1 (fr) * 2010-04-01 2011-10-07 Braun Medical Sas Dispositif de prelevement d'un echantillon de liquide d'une poche souple
WO2011163448A1 (en) * 2010-06-25 2011-12-29 Superior Medical, Llc A device for monitoring a patient for a urinary tract infection
FR2962445B1 (fr) * 2010-07-08 2013-06-28 Biomerieux Sa Procede de detection et d'identification directe d'un microorganisme dans un echantillon biologique dilue dans un bouillon d'enrichissement
CN102401836B (zh) * 2011-09-21 2013-09-25 艾康生物技术(杭州)有限公司 生化分析仪
CN102435608B (zh) * 2011-09-21 2013-09-11 艾康生物技术(杭州)有限公司 医用检测分析仪
DE102014202590A1 (de) * 2014-02-13 2015-08-13 Robert Bosch Gmbh Einheit zum Bereitstellen eines Fluids für eine biochemische Analysevorrichtung sowie Verfahren und Vorrichtung zum Herstellen einer solchen Einheit
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WO2022197708A1 (en) * 2021-03-15 2022-09-22 Lasx Industries, Inc. Functional laminate packaging and method of manufacture

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Also Published As

Publication number Publication date
CN1977165A (zh) 2007-06-06
FR2872288B1 (fr) 2007-08-03
CN1977165B (zh) 2012-03-21
WO2006008407A1 (fr) 2006-01-26
US20080152541A1 (en) 2008-06-26
JP4913732B2 (ja) 2012-04-11
FR2872288A1 (fr) 2005-12-30
EP1761775A1 (de) 2007-03-14
JP2008504547A (ja) 2008-02-14
US8518342B2 (en) 2013-08-27

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