EP1675849A1 - Derives de benzimidazolyle - Google Patents

Derives de benzimidazolyle

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Publication number
EP1675849A1
EP1675849A1 EP04765962A EP04765962A EP1675849A1 EP 1675849 A1 EP1675849 A1 EP 1675849A1 EP 04765962 A EP04765962 A EP 04765962A EP 04765962 A EP04765962 A EP 04765962A EP 1675849 A1 EP1675849 A1 EP 1675849A1
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European Patent Office
Prior art keywords
yloxy
benzimidazol
phenyl
amine
pyridin
Prior art date
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EP04765962A
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German (de)
English (en)
Inventor
Wolfgang Stähle
Hans-Peter Buchstaller
Alfred Jonczyk
Wilfried Rautenberg
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Merck Patent GmbH
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Merck Patent GmbH
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Publication of EP1675849A1 publication Critical patent/EP1675849A1/fr
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Definitions

  • the object of the invention was to find new compounds with valuable properties, in particular those which can be used for the production of medicaments.
  • the present invention relates to compounds in which the inhibition, regulation and / or modulation of the signal transduction of kinases, in particular the tyrosine kinases and / or Raf kinases play a role, furthermore pharmaceutical compositions which contain these compounds, and the use of the compounds for treatment kinase-related diseases.
  • the present invention relates to compounds which inhibit, regulate and / or modulate the signal transduction of the tyrosine kinases, compositions which contain these compounds, and methods for their use for the treatment of tyrosine kinase-related diseases and conditions such as angiogenesis, cancer, tumor growth, Arte ⁇ 'osklerose, age-related macular degeneration, diabetic retinopathy, inflammatory diseases and the like in mammals.
  • Tyrosine kinases are a class of enzymes that catalyze the transfer of the terminal phosphate of adenosine triphosphate to tyrosine residues on protein substrates.
  • tyrosine kinases play an essential role in signal transduction in various cell functions via substrate phosphorylation. Although the exact mechanisms of signal transduction are still unclear, the tyrosine kinases have been shown to be important factors cell proliferation, carcinogenesis and cell differentiation.
  • the tyrosine kinases can be divided into receptor tyrosine kinases and cytosolic tyrosine kinases.
  • the receptor tyrosine kinases have an extracellular part, a transmembrane part and an intracellular part, while the cytosolic tyrosine kinases are only present intracellularly.
  • the receptor tyrosine kinases consist of a large number of transmembrane receptors with different biological effectiveness. About 20 different subfamilies of receptor tyrosine kinases have been identified.
  • a tyrosine kinase subfamily called the HER subfamily consists of EGFR, HER2, HER3 and HER4. Ligands of this receptor subfamily include epithelial growth factor, TGF- ⁇ , amphiregulin, HB-EGF, betacellulin and heregulin.
  • the insulin subfamily which includes INS-R, IGF-IR and IR-R, is another subfamily of these receptor tyrosine kinases.
  • the PDGF subfamily includes the PDGF- ⁇ and ⁇ receptor, CSFIR, c- kit and FLK-II.
  • FLK family which consists of the kinase insert domain receptor (KDR), fetal liver kinase-1 (FLK-1), fetal liver kinase-4 (FLK-4) and fms tyrosine kinase-1 (flt-1 ) consists.
  • KDR kinase insert domain receptor
  • FLK-1 fetal liver kinase-1
  • FLK-4 fetal liver kinase-4
  • flt-1 fms tyrosine kinase-1
  • the PDGF and FLK families are usually discussed together due to the similarities between the two groups.
  • receptor tyrosine kinases see the work of Plowman et al., D / V & P 7 (6): 334-339, 1994, which is hereby incorporated by reference.
  • the cytosolic tyrosine kinases also consist of a large number of subfamilies, including Src, Frk, Btk, Csk, Abi, Zap70, Fes / Fps, Fak, Jak, Ack, and LIMK. Each of these subfamilies is further divided into different receptors.
  • the Src subfamily is one of the largest subfamilies. It includes Src, Yes, Fyn, Lyn, Lck, BIk, Hck, Fgr, and Yrk.
  • the Src enzyme subfamily has been linked to oncogenesis.
  • FLK-1 fetal liver kinase 1
  • the human analogue of FLK-1 is the kinase insert domain-containing receptor KDR, which is also known as vascular endothelial cell growth factor receptor 2 or VEGFR-2, because it binds VEGF with high affinity.
  • VEGFR-2 vascular endothelial cell growth factor receptor 2
  • VEGF and KDR represent a ligand-receptor pair that plays an essential role in the proliferation of the vascular endothelial cells and the formation and sprout of the blood vessels, which are referred to as vasculogenesis or angiogenesis.
  • VEGF vascular endothelial growth factor
  • the KDR induces the mitogenic function of VEGF, while Flt-1 non-mitogenic functions, such as those involved in cell adhesion Connected, seems to modulate. Inhibition of the KDR therefore modulates the level of mitogenic VEGF activity. In fact, it has been shown that tumor growth is affected by the antiangiogenic effects of the VEGF receptor antagonists (Kim et al., Nature 362, pp. 841-844, 1993).
  • VEGFR-1 Flt-1
  • VEGRF-2 Flk-1 or KDR
  • VEGFR-3 Flt-4
  • Solid tumors also called solid tumors, can therefore with
  • Tyrosine kinase inhibitors are treated because these tumors rely on angiogenesis for the formation of the blood vessels required to support their growth.
  • These solid tumors include monocyte leukemia, brain, urogenital, lymphatic, gastric, larynx, and lung cancer, including lung adenocarcinoma and small cell lung cancer.
  • Other examples include carcinomas in which overexpression or activation of Raf-activating oncogenes (e.g. K-ras, erb-B) is observed.
  • These cancers include pancreatic and breast cancer. Inhibitors of these tyrosine kinases are therefore suitable for the prevention and treatment of proliferative diseases which are caused by these enzymes.
  • VEGF vascular endothelial growth factor
  • VEGF mRNA and protein levels in the eye are increased due to conditions such as retinal venous occlusion in the primate and reduced p0 2 levels in the mouse, which lead to neovascularization.
  • Intraocularly injected monoclonal anti-VEGF antibodies, or VEGF receptor immunoconjugates inhibit vascularization in the eye in both the primate and rodent models. Regardless of the reason of the Induction of VEGF in diabetic retinopathy in humans, the inhibition of eye VEGF is suitable for the treatment of this
  • VEGF expression is also greatly increased in hypoxic regions of animal and human tumors in addition to necrosis zones.
  • VEGF is also upregulated by the expression of the oncogenes ras, raf, src and p53 mutant (all of which are important in the fight against cancer).
  • Anti-VEGF monoclonal antibodies inhibit the growth of human tumors in the nude mouse. Although the same tumor cells continue to express VEGF in culture, the antibodies do not decrease their cell division rate.
  • VEGF which originates from tumors, does not act as an autocrine mitogenic factor. VEGF therefore contributes to tumor growth in vivo by promoting angiogenesis through its paracrine vascular endothelial cell chemotaxis and mitogenesis activity.
  • monoclonal antibodies also inhibit the growth of typically less vascularized human colon carcinomas in thymus-less mice and reduce the number of tumors arising from inoculated cells.
  • Embryo stem cells which usually grow in the form of solid tumors in the nude mouse, do not form any detectable tumors when all VEGF alleles are knocked out. These data together show the role of VEGF in the growth of solid tumors. Inhibition of KDR or Flt-1 is involved in pathological angiogenesis, and these receptors are suitable for the treatment of diseases in which angiogenesis is part of the total pathology, for example inflammation, diabetic retinal Vascularization, as well as various forms of cancer, since it is known that tumor growth is dependent on angiogenesis (Weidner et al., N. Engl. J. Med., 324, pp. 1-8, 1991).
  • angiopoietin 1 (Ang1), a ligand for the endothelium-specific
  • Receptor tyrosine kinase TIE-2 is a new angiogenic factor (Davis et al, Cell, 1996, 87: 1161-1169; Partanen et al, Mol. Cell Biol., 12: 1698-1707 (1992); US - Patent Nos. 5,521,073; 5,879,672; 5,877,020; and 6,030,831).
  • TIE stands for "tyrosine kinase with Ig and EGF homology domains”. TIE is used to identify a class of receptor tyrosine kinases that are only expressed in vascular endothelial cells and early hemopoietic cells.
  • TIE receptor kinases are typically characterized by the presence of an EGF- similar domain and an immunoglobulin (IG) -like domain, which consists of extracellular folding units that are stabilized by inter-chain disulfide bonds (Partanen et al. Curr. Topics Microbiol. Immunol., 1999, 237: 159-172)
  • IG immunoglobulin
  • Ang1 and its receptor TIE-2 act during the later stages of vascular development, i.e. during vascular remodeling (reshaping refers to the formation of a vascular lumen) and maturation (Yancopoulos et al, Cell, 1998, 93: 661-664; Peters, KG, Circ. Res., 1998, 83 (3): 342-3; Suri et al, Cell 87, 1171-1180 (1996)).
  • TIE-2 would be expected to disrupt the remodeling and maturation of a new vascular system initiated by angiogenesis and thereby the angiogenesis process. Furthermore, inhibition at the kinase domain binding site of VEGFR-2 would block the phosphorylation of tyrosine residues and serve to interrupt the initiation of angiogenesis. Therefore, one can assume that the inhibition of TIE-2 and / or VEGFR-2 the Prevent tumor angiogenesis and serve to slow or completely eliminate tumor growth. Accordingly, treatment for cancer and other diseases associated with inappropriate angiogenesis could be provided.
  • the present invention is directed to methods for regulating, modulating or inhibiting TIE-2 for the prevention and / or treatment of diseases in connection with unregulated or impaired TIE-2 activity.
  • the compounds according to the invention can also be used in the treatment of certain forms of cancer.
  • the compounds of the invention can be used to provide additive or synergistic effects in certain existing cancer chemotherapies, and / or can be used to restore the efficacy of certain existing cancer chemotherapies and radiation treatments.
  • the present invention is directed to methods for regulating, modulating or inhibiting VEGFR-2 for the prevention and / or treatment of diseases in connection with unregulated or impaired VEGFR-2 activity.
  • the compounds according to the invention are preferably benzimidazolyl derivatives with TIE-2 and / or VEGFR-2 kinase activity.
  • the present invention further relates to the compounds as inhibitors of Raf kinases.
  • Protein phosphorylation is a fundamental process for the regulation of cell functions. The coordinated action of both protein kinases and phosphatases controls the levels of phosphorylation and consequently the activity of specific target proteins.
  • One of the predominant roles of protein phosphorylation is in signal transduction when extracellular signals are amplified and by a cascade of protein Phosphorylation and dephosphorylation events, e.g. B. are propagated in the p21 ras / raf way.
  • the p21 ras gene was discovered as an oncogene of the Harvey and Kirsten rat sarcoma viruses (H-Ras and K-Ras, respectively).
  • H-Ras and K-Ras characteristic mutations in the cellular Ras gene (c-Ras) have been associated with many different types of cancer.
  • c-Ras characteristic mutations in the cellular Ras gene
  • These mutant alleles that make Ras constitutively active have been shown to transform cells, such as the murine cell line NIH 3T3, in culture.
  • the p21 ras oncogene is an important contributing factor in the development and progression of solid human carcinomas and is mutated in 30% of all human carcinomas (Bolton et al. (1994) Ann. Rep. Med. Chem., 29, 165-74; Bos. (1989) Cancer Res., 49, 4682-9).
  • the Ras protein is a key element of the signal transduction cascade, which is controlled by growth factor receptors in almost all tissues (Avruch et al. (1994) Trends Biochem. Sei., 19, 279-83) ,
  • Ras is a guanine nucleotide binding protein, and the cycling between a GTP-linked activated and a GDP-linked quiescent form is strictly controlled by Ras endogenous GTPase activity and other regulatory proteins.
  • the Ras gene product binds to guanine triphosphate (GTP) and guanine diphosphate (GDP) and hydrolyzes GTP to GDP.
  • Ras is active in the GTP-bound state.
  • endogenous GTPase activity is weakened, and consequently the protein emits constitutive growth signals to "downstream" effectors, such as the Raf kinase enzyme. This leads to the cancerous growth of the cells that produce them Mutants carry (Magnuson et al.
  • the Ras proto-oncogene requires a functionally intact C-Raf-1 proto-oncogene in order to be able to and not- Transduce receptor tyrosine kinases initiated growth and differentiation signals.
  • Ras is necessary for the activation of the C-Raf-1 proto-oncogene, the biochemical steps through which Ras activates the Raf-1 protein
  • Raf kinase by antisense oligodeoxynucleotides
  • inhibition of Raf kinase in vitro and in vivo has been associated with the inhibition of growth in a number of different human tumor types (Monia et al., Nat. Med. 1996, 2, 668- 75).
  • Raf-serine and threonine-specific protein kinases are cytosolic enzymes that stimulate cell growth in a number of different cell systems (Rapp, UR, et al. (1988) in The Oncogene Handbook; T. Curran, EP Reddy and A. Skalka (Ed.) Elsevier Science Publishers; Netherlands, pp. 213-253; Rapp, UR, et al. (1988) Cold Spring Harbor Sym. Quant. Biol. 53: 173-184; Rapp, UR, et al. (1990 ) Inv Curr. Top. Microbiol. Immunol. Potter and Melchers (ed.), Berlin, Springer-Verlag 166: 129-139).
  • C-Raf also called Raf-1, C-Raf-1, c-raf-1 or c-raf1
  • A-Raf Beck, TW, et al. (1987) Nucleic Acids Res. 15: 595-609
  • B-Raf Qkawa, S., et al. (1998) Mol. Cell. Biol. 8: 2651 -2654; Sithanandam, G. et al. (1990) Oncogene: 1775.
  • Raf-1 is expressed in all organs and in all cell lines that have been examined, and A- and B-Raf are expressed in urogenital and brain tissues, respectively (Storm, SM (1990) Oncogene 5: 345-351).
  • Raf genes are proto-oncogenes: they can initiate the malignant transformation of cells if they are expressed in specifically modified forms. Genetic changes that lead to oncogenic activation produce a constitutively active protein kinase by removal or interference with an N-terminal negative regulatory domain of the protein (Heidecker, G., et al. (1990) Mol. Cell. Biol. 10: 2503 -2512; Rapp, UR, et al. (1987) in Oncogenes and Cancer; SA Aaronson, J. Bishop, T. Sugimura, M. Terada, K. Toyoshima and PK Vogt (ed.) Japan Scientific Press, Tokyo).
  • Raf-1 protein serine kinase is a candidate for the "downstream" effector of mitogen signal transduction, since Raf oncogenes encounter growth arrest resulting from a blockade of cellular Ras activity due to a cellular mutation (Ras revertant Cells) or microinjection of anti-Ras antibodies results (Rapp, UR, et al. (1988) in The Oncogene Handbook, T. Curran, EP Reddy and A. Skalka (ed.), Elsevier Science Publishers; Netherlands, pp. 213-253; Smith, MR, et al. (1986) Nature (London) 320: 540-543).
  • the C-Raf function is required for transformation by a number of different membrane-bound oncogenes and for growth stimulation by mitogens contained in sera (Smith, M.R., et al. (1986) Nature (London) 320: 540-543).
  • Raf-1 protein serine kinase activity is regulated by mitogens via phosphorylation (Morrison, D.K., et al. (1989) Cell 58: 648-657), which also effects the subcellular distribution
  • Raf-1 activating growth factors include platelet-derived growth factor (PDGF) (Morrison, DK, et al. (1988) Proc. Natl. Acad. Sci. USA 85: 8855-8859), colony-stimulating factor (Baccarini, M., et al. (1990) EMBO J. 9: 3649-3657), insulin (Blackshear, PJ, et al. (1990) J. Biol. Chem.
  • PDGF platelet-derived growth factor
  • colony-stimulating factor Boshearini, M., et al. (1990) EMBO J. 9: 3649-3657
  • insulin Blackshear, PJ, et al. (1990) J. Biol. Chem.
  • EGF epidermal growth factor
  • Interleukin-2 Turner, BC, et al. (1991) Proc. Natl. Acad. Sci. USA 88: 1227
  • Interleukin-3 Interleukin-3 and the granulocyte-macrophage colony stimulating factor
  • Raf-1 protein serine kinase translocates into the perinuclear region and the nucleus (Olah, Z., et al. (1991) Exp. Brain Res. 84: 403; Rapp, UR, et al. (1988) Cold Spring Habor Sym. Quant. Biol. 53: 173-184).
  • Cells containing activated Raf are changed in their gene expression pattern (Heidecker, G., et al. (1989) in Genes and Signal transduction in multistage carcinogenesis, N. Colburn (ed.), Marcel Dekker, Inc., New York, Pp.
  • Raf-oncogenes activate transcription from Ap-1 / PEA3-dependent promotors in transient transfection assays (Jamal, S., et al. (1990) Science 344: 463-466; Kaibuchi, K., et al. (1989) J. Biol. Chem. 264: 20855-20858; Wasylyk, C, et al. (1989) Mol. Cell. Biol. 9: 2247-2250).
  • Raf-1 protein phosphorylation may be a result of a kinase cascade that is amplified by autophosphorylation, or may be entirely caused by autophosphorylation that is initiated by binding a putative activation ligand to the Raf-1 regulator domain, analogous to PKC activation by diacylglycerol (Nishizuka, Y. (1986) Science 233: 305-312).
  • Protein phosphorylation is a process by which intracellular signals are propagated from molecule to molecule, which ultimately results in a cell response.
  • These signal transduction cascades are highly regulated and often overlap, as can be seen from the presence of many protein kinases as well as phosphatases. Phosphorylation of proteins mainly occurs with serine, threonine or tyrosine residues, and protein kinases were therefore classified according to the specificity of the phosphorylation site, ie the serine / threonine kinases and tyrosine kinases.
  • the compounds according to the invention are inhibitors of the enzyme Raf kinase. Since the enzyme is a "downstream" effector of p21 ras , the inhibitors in pharmaceutical compositions for human or veterinary use are found to be useful when inhibiting the Raf kinase pathway, for example in the treatment of tumors and / or cancer cell mediated by Raf kinase
  • the compounds are particularly useful in the treatment of solid carcinomas in humans and animals, e.g., murine cancer, since the progression of these cancers is dependent on the Ras protein signal transduction cascade and therefore the treatment by interrupting the cascade, ie by inhibiting the Raf kinase, responds.
  • the compound of the invention or a pharmaceutically acceptable salt thereof is administered for the treatment of diseases mediated by the Raf kinase route, particularly cancer, including solid carcinomas such as carcinomas (e.g. the lungs, pancreas) , the thyroid gland, the
  • myeloid diseases e.g. myeloid leukemia
  • adenomas e.g. villous colon adenoma
  • pathological angiogenesis e.g. metastatic cell migration.
  • the compounds are also useful in the treatment of complement activation dependent chronic inflammation (Niculescu et al. (2002) Immunol.
  • the compounds according to the invention preferably exhibit an advantageous biological activity which is easily detectable in enzyme-based assays, for example assays as described here. In such enzyme-based assays exhibit and cause the compounds of the invention preferably have an inhibiting effect, which is usually by IC 5 o values in a suitable range, preferably in the micromolar range and more preferably will be documented in the nanomolar range.
  • the compounds of the invention are useful in the prophylaxis and / or treatment of diseases which are dependent on the said signaling pathways through interaction with one or more of the said signaling pathways.
  • the present invention therefore relates to compounds according to the invention as promoters or inhibitors, preferably as inhibitors of the signaling pathways described herein.
  • Preferred objects of the invention are therefore compounds according to the invention as promoters or inhibitors, preferably as inhibitors of the Raf kinase pathway.
  • a preferred subject of the invention is therefore compounds according to the invention as promoters or inhibitors, preferably as inhibitors of Raf kinase.
  • a more preferred subject of the invention are compounds according to the invention as promoters or inhibitors, preferably as inhibitors of one or more Raf kinases, selected from the group consisting of A-Raf, B-Raf and C-Raf-1.
  • a particularly preferred subject of the invention are compounds according to the invention as promoters or inhibitors, preferably as inhibitors of C-Raf-1.
  • the present invention furthermore relates to the use of one or more compounds according to the invention in the treatment and / or prophylaxis of diseases, preferably the diseases described here, which are caused, mediated and / or propagated by Raf kinases and in particular diseases which are caused by
  • Raf kinases selected from the group consisting of A-Raf, B-Raf and C-Raf-1 are caused, mediated and / or propagated.
  • the diseases discussed here are usually divided into two groups, hyperproliferative and non-hyperproliferative diseases.
  • psoriasis, arthritis, inflammation, endometriosis, scarring, benign prostatic hyperplasia, immunological diseases, autoimmune diseases and immunodeficiency diseases are considered non-cancerous diseases, of which arthritis, inflammation, immunological diseases, autoimmune diseases and immunodeficiency diseases are usually considered non-hyperproliferative
  • brain cancer, lung cancer, squamous cell cancer, bladder cancer, stomach cancer, Pancreatic cancer, liver cancer, kidney cancer, colorectal cancer, breast cancer, head cancer, neck cancer, esophageal cancer, gynecological cancer, thyroid cancer, lymphoma, chronic leukemia and acute leukemia are all considered cancerous diseases, all of which are usually considered to be hyperproliferative diseases.
  • cancerous diseases all of which are usually considered to be hyperproliferative diseases.
  • the present invention therefore relates to compounds according to the invention as medicaments and / or active pharmaceutical ingredients in the treatment and / or prophylaxis of the diseases mentioned and the use of compounds according to the invention for the preparation of a pharmaceutical for the treatment and / or prophylaxis of the diseases mentioned and also a method for the treatment of the diseases mentioned, comprising the administration of one or more compounds according to the invention to a patient in need of such an administration.
  • the compounds according to the invention have an in vivo antiproliferative effect in a xenograft tumor model.
  • the compounds of the invention are administered to a patient with a hyperproliferative disease, e.g. For example, to inhibit tumor growth, to reduce inflammation associated with a lymphoproliferative disease, to inhibit graft rejection or neurological damage due to tissue repair, etc.
  • the present compounds are useful for prophylactic or therapeutic purposes.
  • the term "treating" is used to refer to both the prevention of diseases and the treatment of pre-existing conditions.
  • the prevention of proliferation is accomplished by administering the compounds of the invention prior to the development of the apparent disease, e.g., to prevent tumor growth , Prevention of metastatic growth, the reduction of with cardiovascular surgery associated restenosis, etc. achieved.
  • the compounds are used to treat persistent diseases by stabilizing or improving the patient's clinical symptoms.
  • the host or patient can belong to any mammalian species, e.g. B. a primate species, especially humans; Rodents, including mice, rats and hamsters; Rabbits; Horses, cattle, dogs, cats, etc. Animal models are of interest for experimental studies, being a model for treating a disease of the
  • the susceptibility of a particular cell to treatment with the compounds according to the invention can be determined by testing in vitro. Typically, a culture of the cell is combined with a compound of the invention at various concentrations for a period of time sufficient to enable the active agents to induce cell death or to inhibit migration, usually between about an hour and a week. Cultured cells from a biopsy sample can be used for in vitro testing. The viable cells remaining after treatment are then counted.
  • the dose varies depending on the specific compound used, the specific disease, the patient status, etc. Typically, a therapeutic dose is sufficient to avoid the undesirable
  • HTR-FRET time-resolved fluorescence resonance energy transfer
  • FP fluorescence polarization
  • phospho-AK specific phospho-antibodies
  • the phospho-AK only binds the phosphorylated substrate. This binding can be detected with a second peroxidase-conjugated anti-sheep antibody by chemiluminescence (Ross et al., 2002, Biochem. J., immediately before publication, manuscript BJ20020786).
  • the sufferings of interest include, but are not limited to, the following sufferings.
  • the compounds of the invention are useful in the treatment of a number of different conditions in which proliferation and / or migration of smooth muscle cells and / or inflammatory cells is present in the intimal layer of a vessel, resulting in reduced blood flow to this vessel, e.g. B. in neointimal occlusive lesions.
  • Occlusive graft vascular diseases of interest include atherosclerosis, coronary vascular disease after transplantation, venous graft stenosis, peri-anastomotic prosthetic restenosis, restenosis after angioplasty or stent placement and the like.
  • the compounds according to the invention are also suitable as p38 kinases
  • WO 02/44156 describes benzimidazole derivatives other than TIE-2 and / or VEGFR2 inhibitors.
  • WO 99/32436 discloses substituted phenyl ureas as Raf kinase inhibitors. From WO 02/062763 and WO 02/085857, quinolyl, isoquinolyl and pyridylurea derivatives are known as Raf kinase inhibitors. Heteroaryl ureas as p38 kinase inhibitors are described in WO 02/85859.
  • WO 00/42012 describes ⁇ -carboxyaryl-diphenylureas as Raf kinase inhibitors and WO 00/41698 as p38 kinase inhibitors.
  • Other aryl and heteroaryl-substituted heterocyclic ureas are disclosed in WO 99/32455 as Raf kinase inhibitors and in WO 99/32110 as p38 kinase inhibitors.
  • Other diphenyl urea derivatives are known from WO 99/32463.
  • Substituted heterocyclic urea derivatives as p38 kinase inhibitors are disclosed in WO 99/32111.
  • the invention relates to compounds of the formula I.
  • R 2 is independently selected from the meanings given for R 1 and R 1 ' and is preferably selected independently from Shark, A, OH, OA, CN, COOH, COOA, CONH 2 , CONHA or CONAA', E, G, M, Q and U each independently represent a C atom or an N atom, A, A 'are independently selected from unsubstituted or substituted alkyl having 1-10 C atoms, unsubstituted or substituted cycloalky
  • shark F, Cl, Br or I, m, p, q each independently represent 0, 1, 2, 3 or 4, and n 1, 2 or 3, as well as their pharmaceutically usable derivatives, solvates and stereoisomers, including their mixtures in all ratios.
  • the invention also relates to the optically active forms (stereoisomers), the enantiomers, the racemates, the diastereomers and the hydrates and solvates of these compounds.
  • Solvates of the compounds are understood to mean the addition of inert solvent molecules to the compounds, which are formed on account of their mutual attraction. Solvates are e.g. Mono- or dihydrates or alcoholates.
  • compositions are e.g. the salts of the compounds according to the invention and also so-called prodrug compounds.
  • Prodrug derivatives are understood with z. B. alkyl or acyl groups, sugars or oligopeptides modified compounds of formula I, which are quickly cleaved in the organism to the active compounds of the invention.
  • This also includes biodegradable polymer derivatives of the compounds according to the invention, as described, for. B. in Int. J. Pharm. 115, 61-67 (1995).
  • the term "effective amount” means the amount of a drug or active pharmaceutical ingredient that elicits a biological or medical response in a tissue, system, animal or human, e.g. is sought or sought by a researcher or medical professional.
  • terapéuticaally effective amount means an amount which, compared to a subject who has not received this amount, does the following: Improved treatment, healing, prevention or elimination of a disease, a clinical picture, a disease state, a condition, a disorder or side effects or also the reduction in the progression of a disease, a condition or a disorder.
  • terapéuticaally effective amount also includes the amounts that are effective in increasing normal physiological function.
  • the invention also relates to mixtures of the compounds of the formula I according to the invention, e.g. Mixtures of two diastereomers e.g. in a ratio of 1: 1, 1: 2, 1: 3, 1: 4, 1: 5, 1: 10, 1: 100 or 1: 1000. These are particularly preferably mixtures of stereoisomeric compounds.
  • radicals or parameters R 1 , L, R 1 ', R 2 , m, p and q preferably have the meanings given in the formula I, unless expressly stated otherwise.
  • radicals A are preferably selected independently of one another from the meanings given for the radicals A, unless expressly stated otherwise.
  • alkyl is preferably unbranched (linear) or branched, has 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 carbon atoms and can be substituted.
  • substituted alkyl is an alkyl radical as described in this section which has 1-7, preferably 1-5 and particularly preferably 1-3 substituents, which are preferred are selected from sharks, in particular Cl and F, OH, Oalkyl, NH 2 and N (alkyl) 2 , in which alkyl is as described above and is preferably unsubstituted alkyl as described above.
  • substituted alkyl particularly preferably denotes an alkyl radical as described above, in which 1-7 H atoms are replaced by F and / or chlorine, e.g. B. a perchlorinated or perfluorinated alkyl radical.
  • fluorine and / or chlorine-substituted alkyl radicals preferably have 1, 2, 3, 4 or 5 carbon atoms.
  • Preferred fluorine and / or chlorine-substituted alkyl radicals are perfluorinated alkyl radicals, in particular trifluoromethyl radicals.
  • Unsubstituted or substituted alkyl is particularly preferably methyl, furthermore ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl or tert-butyl, furthermore also pentyl, 1-, 2- or 3-methylbutyl, 1, 1-, 1 , 2- or 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1-, 2-, 3- or 4-methylpentyl, 1,1-, 1,2-, 1, 3-, 2,2-, 2 , 3- or 3,3-dimethylbutyl, 1- or 2-ethylbutyl, 1-ethyl-1-methylpropyl, 1-ethyl-2-methylpropyl, 1, 1, 2- or 1, 2,2-trimethylpropyl, further particularly preferably trifluoromethyl.
  • Alkyl very particularly preferably denotes an alkyl radical having 1, 2, 3, 4, 5 or 6 carbon atoms, which can be chlorinated and / or fluorinated as described above and is particularly selected from methyl, ethyl, propyl, isopropyl, butyl, Isobutyl, sec-butyl, tert-butyl, pentyl, hexyl, trifluoromethyl, pentafluoroethyl and 1, 1, 1-trifluoroethyl.
  • unsubstituted cycloalkyl is preferably selected from cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl or cycloheptyl.
  • substituted cycloalkyl is one
  • Cycloalkyl radical as described above which has 1-7, preferably 1-5 and particularly preferably 1-3 substituents, which are preferably selected from shark, in particular Cl and F, OH, Oalkyl, NH 2 and N (alkyl) 2 , wherein alkyl is as described above and is preferably unsubstituted alkyl as described above.
  • unsubstituted alkoxyalkyl is a radical of the formula C u H 2u + ⁇ -0- (CH2) v, in which u and v each independently represent 1 to 6.
  • the radical C u H 2u + ⁇ is preferably an unbranched or branched alkyl radical as described above.
  • substituted alkoxyalkyl is an alkoxyalkyl radical as described above, which is 1-7, preferably 1-5 and particularly preferably 1-3 Has substituents, which are preferably selected from shark, in particular Cl and F, OH, Oalkyl, NH 2 and N (alkyl) 2 , wherein alkyl is as described above and is preferably unsubstituted alkyl as described above.
  • alkylene is preferably an unbranched or branched divalent hydrocarbon radical having 1-10 C atoms, preferably 1 -4 C atoms, which may optionally have 1-7, preferably 1-5 and particularly preferably 1-3 substituents which are preferably selected from sharks, in particular Cl and F, OH, Oalkyl, NH 2 and N (alkyl) 2 , in which alkyl is as described above and preferably unsubstituted alkyl as described above.
  • Unsubstituted alkylene is preferably methylene, ethylene, n-propylene, isopropylene or n-butylene and in particular methylene or ethylene.
  • unsubstituted aryl is preferably a benzene ring, for example a phenyl radical, or a system of benzene rings, such as, for example, anthracene, phenanthrene or naphthalene ring systems or radicals.
  • substituted aryl is an aryl radical as described above which has 1-7, preferably 1-5 and particularly preferably 1-3 substituents, which are preferably selected from shark, in particular Cl and F, OH, Oalkyl, NH 2 and N (alkyl) 2 , wherein alkyl is as described above and is preferably unsubstituted alkyl as described above.
  • unsubstituted arylalkyl is an aryl group as defined above, linked to an alkylene group as defined above.
  • Examples of preferred unsubstituted arylalkyl radicals are benzyl, phenethyl, phenylpropyl and phenylbutyl and in particular benzyl and phenethyl.
  • substituted arylalkyl is an arylalkyl radical as described above which has 1-7, preferably 1-5 and particularly preferably 1-3 substituents which are preferably selected from shark, in particular Cl and F, OH, Oalkyl, NH 2 and N (alkyl) 2 , wherein alkyl is as described above and is preferably unsubstituted alkyl as described above.
  • unsubstituted saturated, unsaturated or aromatic heterocyclyl is a heterocyclic radical with 2-7 C atoms and 1-3 heteroatoms, selected from N, 0 and S.
  • Examples of preferred unsubstituted saturated heterocyclyl are 1-piperidyl,
  • unsubstituted, unsaturated or aromatic heterocyclyl are thiophene-2-yl and thiophene-3-yl, furan-2-yl and furan-3-yI, pyrrol-2-yl and pyrrol-3-yl, 2-, 3- and 4-pyridyl, 2-, 4- and 5-oxazolyl, 2-, 4- and 5-thiazolyl, quinolinyl, isoquinolinyl, 2- and 4-pyridazyl, 2-, 4- and 5-pyrimidyl, and 2- and 3-pyrazinyl.
  • substituted saturated, unsaturated or aromatic heterocyclyl is a heterocyclic radical as described above which has 1-7, preferably 1-5 and particularly preferably 1-3 substituents, which are preferably selected from sharks, in particular Cl and F, OH, Oalkyl, NH 2 and N (alkyl) 2 , wherein alkyl is as described above and is preferably unsubstituted alkyl as described above.
  • substituents which are preferably selected from sharks, in particular Cl and F, OH, Oalkyl, NH 2 and N (alkyl) 2 , wherein alkyl is as described above and is preferably unsubstituted alkyl as described above.
  • Examples of substituted, saturated, unsaturated or aromatic heterocyclyl and in particular substituted saturated heterocyclyl are 1- (4-methyl) -piperazyl, 4-methylpiperazin-1-ylamine, 1- (2-methyl) -pyrazolidinyl and 1- (3-methyl ) -imidazolidinyl.
  • unsubstituted heterocyclylalkyl is a heterocyclyl radical as defined above, linked to an alkylene radical as defined above.
  • substituted heterocyclylalkyl is a heterocyclylalkyl radical as described above, which has 1-7, preferably 1-5 and particularly preferably 1-3 substituents, which are preferably selected from shark, in particular Cl and F, OH, Oalkyl, NH 2 and N (alkyl) 2 , wherein alkyl is as described above and is preferably unsubstituted alkyl as described above.
  • R 1 is preferably selected from A, where A is as defined above and here preferably for unsubstituted and / or substituted alkyl and in particular for methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl , Hexyl, trifluoromethyl, pentafluoroethyl, and / or 1, 1, 1-trifluoroethyl, COOH, COOA; wherein A is as defined above and preferably represents unsubstituted or substituted, particularly preferably unsubstituted alkyl and in particular methyl or ethyl, S0 2 A, wherein A is as defined above and preferably represents unsubstituted or substituted, particularly preferably unsubstituted alkyl and especially trifluoromethyl , Methyl or ethyl, CN, N0 2 , shark, in particular F, Cl and / or
  • R 1 is selected from methyl, trifluoromethyl, F, Cl and Br.
  • R 1 is preferably selected from A, where A is as defined above and here preferably for unsubstituted and / or substituted alkyl and in particular for methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl , Hexyl, trifluoromethyl, pentafluoroethyl, and / or 1, 1, 1-trifluoroethyl, COOH, COOA, in which A is as defined above and is preferably unsubstituted or substituted, particularly preferably unsubstituted alkyl and in particular is methyl or ethyl, CN, N0 2 , shark, especially F, Cl and / or Br.
  • A is as defined above and here preferably for unsubstituted and / or substituted alkyl and in particular for methyl, ethyl, propyl, isopropyl, butyl, iso
  • R 1 is particularly preferably selected from unsubstituted or substituted alkyl, in particular methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, hexyl, trifluoromethyl, pentafluoroethyl, 1, 1, 1-trifluoroethyl , and halogen, in particular F, Cl and / or Br.
  • R 1 ' is very particularly preferably selected from methyl, ethyl, propyl, fluorine and bromine.
  • L is preferably O, S or CH 2 , particularly preferably O.
  • R 2 is preferably selected from A, where A is as defined above and here preferably for unsubstituted and / or substituted alkyl and in particular for methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl , Hexyl, trifluoromethyl, pentafluoroethyl, and / or 1, 1, 1-trifluoroethyl, shark, in particular F, Cl and / or Br, CN, N0 2 , COOH, CONH 2 , NH 2 , and NHA, NAA ', COOA , CONHA and CONAA ', in which A and A' are as defined above and preferably represent unsubstituted or substituted, particularly preferably unsubstituted alkyl and in particular methyl propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-buty
  • R 2 is particularly preferably selected from F, Cl, Br, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, trifluoromethyl, pentafluoroethyl, 1, 1, 1-trifluoroethyl, CN, NO 2 , NH 2 , NHCH 3 , N (CH 3 ) 2 , COOH, COOCH3, COOCH2CH3, CONH2, CONHCH3, CONHCH2CH3, CON (CH 3 ) 2 , S0 2 CH 3 , and S0 2 CF 3 .
  • R 2 is very particularly preferably selected from methyl, ethyl, methoxycarbonyl, ethoxycarbonyl, NH 2 , CONH 2 , CONHCH3, CONHCH2CH3 and CON (CH 3 ) 2 .
  • E, G, M, Q and U each independently represent a C atom or an N atom, preferably at least one of them, E, G, M, Q or U, being N.
  • one, two or three, particularly preferably one or two of E, G, M, Q and U represent an N atom. If one selected from E, G, M, Q and U stands for an N atom, M, G or Q preferably stands for an N atom. If two selected from E, G, M, Q and U stand for N atoms, E and M or U and Q preferably stand for N atoms.
  • the substituents R 2 preferably bind to carbon atoms. Therefore, when one or more of E, G, M, Q and U stand for C atoms, each C atom is preferably selected from CH or CR 2 , with R 2 on each CR 2 being selected independently.
  • the aromatic or preferably heteroaromatic radical bound to L and containing E, G, M, Q and U is therefore preferably selected from phenyl, pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, triazinyl, preferably 1, 2,4-triazinyl and 1, 3, 5-triazinyl, particularly preferably among pyridyl, pyrimidyl, pyridazinyl and pyrazinyl and in particular under pyridyl and pyrimidyl, which may have 1, 2 or 3, preferably none, one or two independently selected substituents R 2 , preferably on a carbon atom of the aromatic or heteroaromatic radicals mentioned above are bound.
  • M or p or q is preferably different from 0.
  • M is particularly preferably different from 0 and additionally p or q is different from 0.
  • M is particularly preferably different from 0 and additionally p or q is different from 0.
  • m preferably denotes 1, 2 or 3 and particularly preferably 2 or 3.
  • p preferably denotes 0 or 1 and particularly preferably 0.
  • q preferably denotes 0, 1 or 2, particularly preferably 0 or 1, or likewise preferably 1 or 2.
  • R 2 A, COOA, CONA or CONH 2 , and q denotes 0, 1 or 2, as well as their pharmaceutically usable derivatives, solvates and stereoisomers, including their mixtures in all ratios.
  • L, R, 2 and q have the meanings given above / below.
  • Q is preferably selected from 0 and 1, or likewise preferably selected from 1 and 2.
  • the group is particularly preferred in the compounds of the formula I.
  • the ring containing U is preferably not fused, but preferably represents a monocyclic aromatic and in particular a monocyclic heteroaromatic ring, since the radical R 2 or
  • R 2 radicals preferably do not represent anellands or anellizing radicals.
  • Particularly preferred compounds of the formula I are compounds of the formula Ia
  • R a and R b are selected independently of one another from the meanings given for R 1 and particularly preferably from the meanings given as preferred, particularly preferred or particularly preferred for R 1 .
  • one of the two radicals R a or R b is particularly preferably different from H or both radicals R a and R b are different from H.
  • R c and R d are selected independently of one another from the meanings given for R 1 and particularly preferably from the meanings given as preferred, particularly preferred or particularly preferred for R 1 .
  • one of the two radicals R c or R d is different from H or both radicals R c and R d are different from H is particularly preferred.
  • Particularly preferred compounds of the formula I are compounds of the formula Ic
  • R e and R f are independently selected from H and the meanings given for R 1 and particularly preferably under H and the meanings given as preferred, particularly preferred or particularly preferred for R 1 . Particularly preferred is particularly preferred in the compounds of the formula Ic one of the two radicals R e or R f is different from H or both radicals R e and R f are different from H.
  • R 1 ' , p L, E, G, M, Q, U, R 2 and q have the meanings given above / below.
  • a reference to the compounds of formula I includes the
  • the compounds of formula I can have one or more chiral centers and therefore exist in various stereoisomeric forms.
  • Formula I encompasses all of these forms.
  • the invention relates in particular to those compounds of the formula I in which at least one of the radicals mentioned has one of the preferred meanings indicated above.
  • Some preferred groups of compounds can be expressed by the following partial forms in 1.1) to 1.12), which correspond to the formula I and in which the radicals not specified have the meaning given for the formula I, but in which in 1.1) R 1 is independently A or shark, preferably alkyl or shark, and m is 1, 2 or 3;
  • R 1 is independently CH 3 , CF 3 , F or Br, and m is 1, 2 or 3;
  • R 2 A COOA, CONHA or CONH 2 , preferably COOalkyl, CONHAlkyl or CONH 2 , q is 0, 1 or 2, and the group
  • R 1 shark or A preferably shark or alkyl, p O or l,
  • R 2 A COOA, CONHA or CONH 2 , preferably COOalkyl, CONHAlkyl or CONH 2 , q is 0, 1 or 2, and the group has the meaning given in 1.9);
  • R 2 A in 1.12) R 2 A, COOA, CONHA or CONH 2 , preferably COOalkyl, CONHAlkyl or CONH 2 , q is 0, 1 or 2, and the group
  • the compounds according to the invention are particularly preferably selected from compounds (1) to (41):
  • the invention relates to the compounds of the formula I and their salts and to a process for the preparation of compounds of the formula as described above / below and their pharmaceutically usable derivatives, solvates and stereoisomers, characterized in that
  • R 1 and m have the meanings given above / below,
  • R 1 , L, E, G, M, Q, U, R 2 and q have the meanings given above / below,
  • the starting materials can also be formed in situ, so that they are not isolated from the reaction mixture, but instead are immediately converted further into the compounds according to the invention.
  • the reaction is usually carried out in an inert solvent, in the presence of a coupling reagent such as e.g. N, N'-diisopropyl carbodiimide.
  • a coupling reagent such as e.g. N, N'-diisopropyl carbodiimide.
  • the reaction time is between a few minutes and 14 days, the reaction temperature is between about 0 ° and 200 °, normally between 20 ° and 150 ° and in particular between 20 ° and 130 °.
  • Suitable inert solvents are, for example, hydrocarbons such as hexane, petroleum ether, benzene, toluene or xylene; chlorinated hydrocarbons such as trichlorethylene, 1, 2-dichloroethane, carbon tetrachloride, chloroform or dichloromethane; Alcohols such as methanol, ethanol, isopropanol, n-propanol, n-butanol or tert-butanol; Ethers such as diethyl ether, diisopropyl ether, tetrahydrofuran (THF) or dioxane; Glycol ethers such as ethylene glycol monomethyl or monoethyl ether (methyl glycol or ethyl glycol), ethylene glycol dimethyl ether (diglyme); Ketones such as acetone or butanone; Amides such as acetamide, dimethylacetamide or dimethylformamide (DMF); Ni
  • the starting compounds are generally known. If they are new, they can be manufactured according to methods known per se.
  • the thioisocyanates of the formula III are preferably obtained from the corresponding aniline derivatives by reaction with, for example, 1,1'-thiocarbonyldiimidazole.
  • a base of the compounds according to the invention can be converted into the associated acid addition salt using an acid, for example by reacting equivalent amounts of the base and the acid in an inert solvent such as ethanol and subsequent evaporation.
  • acids that provide physiologically acceptable salts are suitable for this implementation.
  • inorganic acids can be used, for example sulfuric acid, nitric acid, hydrohalic acids such as hydrochloric acid or hydrobromic acid, phosphoric acids such as orthophosphoric acid, sulfamic acid, and also organic acids, in particular aliphatic, alicyclic, araliphatic, aromatic or heterocyclic mono- or poly-based carbon, sulfonic or Sulfuric acids, e.g.
  • acetic acid trifluoroacetic acid, propionic acid, pivalic acid, diethyl acetic acid, malonic acid, succinic acid, pimelic acid, fumaric acid, maleic acid, lactic acid, tartaric acid, malic acid, citric acid, ethonic acid sulfonic acid, methane acid, isonic acid Hydroxyethanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, naphthalene mono- and disulfonic acids, laurylsulfuric acid. Salts with physiologically unacceptable acids, such as picrates, can be used for Isolation and / or purification of the compounds according to the invention can be used.
  • physiologically unacceptable acids such as picrates
  • the invention further relates to the use of the compounds and / or their physiologically acceptable salts for the preparation of a
  • Medicament in particular by non-chemical means. They can be brought into a suitable dosage form together with at least one solid, liquid and / or semi-liquid carrier or auxiliary and, if appropriate, in combination with one or more further active ingredients.
  • the invention further relates to medicaments containing at least one compound according to the invention and / or their pharmaceutically usable derivatives, solvates and stereoisomers, including their mixtures in all ratios, and, if appropriate, carriers and / or auxiliaries.
  • compositions can be presented in the form of dose units containing a predetermined amount of active ingredient per dose unit.
  • a unit can be, for example, 0.5 mg to
  • a compound according to the invention can be in the form of dosage units which contain a predetermined amount of active ingredient per dose unit.
  • Preferred dosage unit formulations are those which contain a daily dose or partial dose, as stated above, or a corresponding fraction thereof of an active ingredient.
  • such pharmaceutical formulations can be produced using one of the methods generally known in the pharmaceutical field.
  • compositions can be administered for administration by any suitable route, for example by oral (including buccal or sublingual), rectal, nasal, topical (including buccal, sublingual or transdermal), vaginal or parenteral (including subcutaneous, intramuscular, intravenous or intradermal). Ways to customize.
  • Such formulations can be prepared using all methods known in the pharmaceutical field, for example by bringing the active ingredient together with the carrier (s) or auxiliary (s).
  • compositions adapted for oral administration can be used as separate units, e.g. Capsules or tablets; Powder or granules; Solutions or suspensions in aqueous or non-aqueous liquids; edible foams or foam dishes; or oil-in-water liquid emulsions or water-in-oil liquid emulsions.
  • the active ingredient component in the case of oral administration in the form of a tablet or capsule, can be administered with an oral, non-toxic and pharmaceutically acceptable inert carrier, such as e.g. Ethanol, glycerin, water etc. combine.
  • an oral, non-toxic and pharmaceutically acceptable inert carrier such as e.g. Ethanol, glycerin, water etc. combine.
  • Powders are made by comminuting the compound to an appropriate fine size and with a similarly comminuted pharmaceutical carrier such as e.g. an edible carbohydrate such as
  • Starch or mannitol is mixed.
  • a flavor, preservative, dispersant and color may also be present.
  • Capsules are made by making a powder mixture as described above and filling shaped gelatin shells with it.
  • Lubricants and lubricants such as highly disperse silica, talc, magnesium stearate, calcium stearate or polyethylene glycol in solid form can be added to the powder mixture before the filling process.
  • suitable binding agents, lubricants and disintegrants, as well as dyes can also be incorporated into the mixture.
  • Suitable binders include starch, gelatin, natural sugars such as Glucose or beta-lactose, corn sweeteners, natural and synthetic gums such as Acacia, tragacanth or sodium alginate, carboxymethyl cellulose, polyethylene glycol, waxes, etc.
  • the lubricants used in these dosage forms include sodium oleate, sodium stearate, magnesium stearate, sodium benzoate, sodium acetate, sodium chloride and others.
  • Disintegrants include, but are not limited to, starch, methyl cellulose, agar, bentonite, xanthan gum and others.
  • the tablets are formulated by, for example, producing a powder mixture, granulating or pressing them dry, adding a lubricant and a disintegrant and compressing the whole thing into tablets.
  • a powder mixture is made by appropriately comminuting the compound with a diluent or a base as described above and optionally with a binder such as e.g. Carboxymethyl cellulose, an alginate, gelatin or polyvinylpyrrolidone, a solution slower, e.g. Paraffin, a resorption accelerator, e.g. a quaternary salt and / or an absorbent such as e.g. Bentonite, kaolin or dicalcium phosphate is mixed.
  • the powder mixture can be granulated by mixing it with a binder such as e.g. Syrup, starch paste, Acadia slime or solutions made of cellulose or polymer materials are wetted and pressed through a sieve.
  • a binder such as e.g
  • Granulation can be run through a tableting machine, the powder mixture, resulting in irregularly shaped lumps, which in Granules are broken up.
  • the granules can be greased by adding stearic acid, a stearate salt, talc or mineral oil to prevent sticking to the tablet molds. The greased mixture is then compressed into tablets.
  • the compounds according to the invention can also be used with a free-flowing inert
  • a transparent or opaque protective layer consisting of a shellac seal, a layer of sugar or polymer material and a glossy layer of wax may be present. Dyes can be added to these coatings in order to be able to differentiate between different dosage units.
  • Oral liquids e.g. Solution, syrups and elixirs can be prepared in the form of dosage units so that a given one
  • Quantity contains a given amount of the compound.
  • Syrups can be made by dissolving the compound in an aqueous solution with a suitable taste, while elixirs are made using a non-toxic alcoholic vehicle.
  • Suspensions can be formulated by dispersing the compound in a non-toxic vehicle.
  • Solubilizers and emulsifiers e.g. ethoxylated isostearyl alcohols and polyoxyethylene sorbitol ethers, preservatives, flavor additives such as e.g. Peppermint oil or natural sweeteners or saccharin or other artificial sweeteners, etc. can also be added.
  • Dosage unit formulations for oral administration can optionally be enclosed in microcapsules.
  • the formulation can also be prepared in such a way that the release is prolonged or delayed, for example by coating or embedding particulate material in polymers, wax and the like.
  • the compounds according to the invention and salts, solvates and physiologically functional derivatives thereof can also be administered in the form of liposome delivery systems, such as small unilamellar vesicles, large unilamellar vesicles and multilamellar vesicles.
  • Liposomes can be made from various phospholipids, such as
  • Cholesterol, stearylamine or phosphatidylcholines Cholesterol, stearylamine or phosphatidylcholines.
  • the compounds according to the invention and the salts, solvates and physiologically functional derivatives thereof can also be supplied using monoclonal antibodies as individual carriers to which the connecting molecules are coupled.
  • the compounds can also be coupled with soluble polymers as targeted drug carriers.
  • Such polymers can include polyvinyl pyrrolidone, pyran copolymer, polyhydroxypropyl methacrylamide phenol, polyhydroxyethyl aspartamide phenol or polyethylene oxide polylysine substituted with palmitoyl residues.
  • the compounds can be linked to a class of biodegradable polymers suitable for achieving controlled release of a drug, e.g. Polylactic acid, polyepsilon-caprolactone, polyhydroxybutter acid, polyorthoesters, polyacetals, polydihydroxypyrans, polycyanoacrylates and crosslinked or amphipatic block copolymers of hydrogels.
  • compositions adapted for transdermal administration can be administered as independent patches for prolonged, close contact with the epidermis of the recipient.
  • the active ingredient can be supplied from the patch by means of iontophoresis, as generally described in Pharmaceutical Research, 3 (6), 318 (1986).
  • Pharmaceutical compounds adapted for topical administration can be formulated as ointments, creams, suspensions, lotions, powders, solutions, pastes, gels, sprays, aerosols or oils.
  • the formulations are preferably applied as a topical ointment or cream.
  • the active ingredient can be used either with a paraffinic or with a water-miscible cream base.
  • the active ingredient can be formulated into a cream with an oil-in-water cream base or a water-in-oil base.
  • compositions adapted for topical application to the eye include eye drops, the active ingredient being dissolved or suspended in a suitable carrier, in particular an aqueous solvent.
  • compositions adapted for topical application in the mouth include lozenges, lozenges and mouthwashes.
  • compositions adapted for rectal administration can be administered in the form of suppositories or enemas.
  • compositions adapted for nasal administration in which the carrier substance is a solid, contain a coarse powder with a particle size, for example in the range of 20-500 micrometers, which is administered in the manner in which snuff is taken up, ie by rapid inhalation via the nasal passages from a container with the powder held close to the nose.
  • Suitable formulations for administration as a nasal spray or Nasal drops with a liquid as the carrier substance comprise active ingredient solutions in water or oil.
  • Fine particulate dusts or mists which can be generated by means of various types of pressurized metering dispensers with aerosols, nebulizers or insufflators.
  • compositions adapted for vaginal administration can be administered as pessaries, tampons, creams, gels, pastes, foams or spray formulations.
  • compositions adapted for parenteral administration include aqueous and non-aqueous sterile injection solutions which contain antioxidants, buffers, bacteriostatics and solutes, by means of which the formulation is rendered isotonic with the blood of the recipient to be treated; as well as aqueous and non-aqueous sterile suspensions, which can contain suspending agents and thickeners.
  • the formulations can be in single dose or multiple dose containers, e.g. sealed ampoules and vials, presented and stored in the freeze-dried (lyophilized) state so that only the addition of the sterile carrier liquid, e.g. Water for injections is required immediately before use.
  • Injection solutions and suspensions prepared according to the recipe can be made from sterile powders, granules and tablets.
  • formulations may contain, in addition to the above-mentioned components, other means customary in the art with regard to the respective type of formulation; for example, formulations suitable for oral administration may contain flavorings.
  • a therapeutically effective amount of a compound of the present invention depends on a number of factors, including, for example, the age and weight of the animal, the exact condition of the disease requiring treatment, its severity, the nature of the formulation and the route of administration, and will ultimately determined by the attending doctor or veterinarian.
  • an effective amount of a compound according to the invention for the treatment of neoplastic growth is generally in the range from 0.1 to 100 mg / kg body weight of the recipient (mammal) per day and particularly typically in the range from 1 to 10 mg / kg body weight per day.
  • the actual amount per day would usually be between 70 and 700 mg, which amount as a single dose per day or more usually in a series of divided doses (such as two, three, four, five or six) per Day can be given so that the total daily dose is the same.
  • An effective amount of a salt or solvate or a physiologically functional derivative thereof can be determined perse as a proportion of the effective amount of the compound of the invention. It is believed that similar dosages are suitable for the treatment of the other conditions mentioned above.
  • the invention further relates to medicaments containing at least one compound according to the invention and / or their pharmaceutically usable derivatives, solvates and stereoisomers, including their mixtures in all ratios, and at least one further active pharmaceutical ingredient.
  • the invention also relates to a set (kit) consisting of separate packs of (a) an effective amount of a compound according to the invention and / or its pharmaceutically usable derivatives, solvates and Stereoisomers, including their mixtures in all proportions, and (b) an effective amount of another drug.
  • kit consisting of separate packs of (a) an effective amount of a compound according to the invention and / or its pharmaceutically usable derivatives, solvates and Stereoisomers, including their mixtures in all proportions, and (b) an effective amount of another drug.
  • the set contains suitable containers, such as boxes or cartons, individual bottles, bags or ampoules.
  • the set can e.g. contain separate ampoules, in each of which an effective amount of a compound according to the invention and / or its pharmaceutically usable derivatives, solvates and stereoisomers, including their mixtures in all ratios, and an effective amount of a further active pharmaceutical ingredient is dissolved or in lyophilized form.
  • the present compounds are suitable as pharmaceutical active substances for mammals, in particular for humans, in the treatment of tyrosine kinase-related diseases.
  • diseases include tumor cell proliferation, pathological neovascularization (or angiogenesis) that promotes the growth of solid tumors, neovascularization (diabetic retinopathy, age-related macular degeneration and the like), and inflammation (psoriasis, rheumatoid arthritis and the like).
  • the present invention comprises the use of the compounds according to the invention and / or their physiologically acceptable salts and solvates for the manufacture of a medicament for the treatment or prevention of cancer.
  • Preferred carcinomas for the treatment come from the group of brain carcinoma, urogenital tract carcinoma, carcinoma of the lymphatic system, gastric carcinoma, larynx carcinoma and lung carcinoma.
  • Another group of preferred forms of cancer are Monocyte leukemia, lung adenocarcinoma, small cell lung carcinoma, pancreatic cancer, glioblastoma and breast carcinoma.
  • Also included is the use of the compounds according to the invention and / or their physiologically acceptable salts and solvates for the production of a medicament for the treatment or prevention of a disease in which angiogenesis is involved.
  • angiogenesis is an eye disorder such as retinal vascularization, diabetic retinopathy, age-related macular degeneration and the like.
  • eye disorder such as retinal vascularization, diabetic retinopathy, age-related macular degeneration and the like.
  • the use of compounds according to the invention and / or their physiologically acceptable salts and solvates for the manufacture of a medicament for the treatment or prevention of inflammatory diseases also falls within the scope of the present invention.
  • inflammatory diseases include, for example, rheumatoid arthritis, psoriasis, contact dermatitis, late-type hypersensitivity reaction and the like.
  • this method being administered to a sick mammal in need of such treatment with a therapeutically effective amount of a compound of the invention.
  • the therapeutic amount depends on the respective disease and can be determined by the person skilled in the art without any great effort.
  • the present invention also includes the use of the compounds according to the invention and / or their physiologically acceptable salts and solvates for the production of a medicament for the treatment or prevention of retinal vascularization.
  • Methods for treating or preventing eye diseases such as diabetic retinopathy and age-related macular degeneration are also part of the invention.
  • Use for treatment or prevention of inflammatory diseases such as rheumatoid arthritis, psoriasis, contact dermatitis and late types of hypersensitivity reaction, as well as the treatment or prevention of bone pathologies from the group of osteosarcoma, osteoarthritis and rickets also falls within the scope of the present invention.
  • tyrosine kinase-related diseases or ailments refers to pathological conditions which are dependent on the activity of one or more tyrosine kinases.
  • the tyrosine kinases are either directly or indirectly involved in the signal transduction pathways of various cell activities, including proliferation, adhesion and migration and differentiation.
  • Diseases associated with tyrosine kinase activity include tumor cell proliferation, pathological neovascularization that promotes the growth of solid tumors, neovascularization (diabetic retinopathy, age-related macular degeneration, and the like), and inflammation (psoriasis, rheumatoid arthritis, and the like) ).
  • the compounds of the invention can be administered to patients for the treatment of cancer.
  • the present compounds inhibit tumor angiogenesis and thus influence the growth of tumors (J. Rak et al. Cancer Research, 55: 4575-4580, 1995).
  • the angiogenesis-inhibiting properties of the compounds according to the invention are also suitable for the treatment of certain forms of blindness which are associated with retinal vascularization.
  • the compounds according to the invention are also suitable for the treatment of certain bone pathologies such as osteosarcoma, osteoarthritis and rickets, which is also known under the name oncogenic osteomalacia (Hasegawa et al., Skeletal Radiol. 28, pp. 41-45, 1999; Gerber et al ., Nature Medicine, Vol. 5, No.
  • VEGF directly promotes osteoclastic bone resorption through the KDR / Flk-1 expressed in mature osteoclasts (FEBS Let. 473: 161-164 (2000); Endocrinology, 141: 1667 (2000)), the present ones are suitable Compounds also used to treat and prevent conditions related to bone resorption, such as osteoporosis and Paget's disease.
  • the compounds can also be used to reduce or prevent tissue damage that occurs after cerebral ischemic events such as stroke (Drug News Perspect 11: 265-270 (1998); J. Clin. Invest. 104: 1613-1620 (1999)).
  • the invention thus relates to the use of compounds according to the invention, and their pharmaceutically usable derivatives, solvates and stereoisomers, including their mixtures in all ratios, for the manufacture of a medicament for the treatment of diseases in which the inhibition, regulation and / or modulation of signal transduction by Kinases plays a role.
  • Kinases are preferably selected from the group of tyrosine kinases and Raf kinases.
  • the tyrosine kinases are preferably TIE-2.
  • Medicament for the treatment of diseases which are influenced by inhibition of TIE-2 by the compounds according to the invention.
  • the use for the treatment of a disease is particularly preferred, the disease being a solid tumor.
  • the solid tumor is preferably selected from the group of brain tumor, tumor of the genitourinary tract, tumor of the lymphatic
  • the solid tumor is also preferably selected from the group consisting of monocyte leukemia, lung adenocarcinoma, small cell lung carcinoma, pancreatic cancer, glioblastoma and breast carcinoma.
  • the invention further relates to the use of the compounds according to the invention for the treatment of a disease in which angiogenesis is involved.
  • the disease is preferably an eye disease.
  • the invention further relates to the use for the treatment of retinal vascularization, diabetic retinopathy, age-related macular degeneration and / or inflammatory diseases.
  • the inflammatory disease is preferably selected from the group rheumatoid arthritis, psoriasis, contact dermatitis and late-type hypersensitivity reaction.
  • the invention further relates to the use of the compounds according to the invention for the treatment of bone pathologies, the bone pathology coming from the group of osteosarcoma, osteoarthritis and rickets.
  • the compounds according to the invention are suitable for the production of a medicament for the treatment of diseases which are caused, mediated and / or propagated by Raf kinases, the Raf kinase being selected from the group consisting of A-Raf, B-Raf and Raf-1 becomes.
  • Preferred is the use for the treatment of diseases, preferably from the group of hyperproliferative and non-hyperproliferative diseases.
  • non-cancerous diseases are selected from the group consisting of psoriasis, arthritis, inflammation, endometriosis, scarring, benign prostatic hyperplasia, immunological diseases, autoimmune diseases and immune deficiency diseases.
  • the cancerous diseases are selected from the group consisting of brain cancer, lung cancer, squamous cell cancer, bladder cancer, stomach cancer, pancreatic cancer, liver cancer, kidney cancer, colorectal cancer, breast cancer, head cancer, neck cancer, esophageal cancer, gynecological cancer, thyroid cancer, lymphoma and chronic leukemia, chronic leukemia.
  • the compounds according to the invention can also be administered together with other well-known therapeutic agents which are selected on the basis of their suitability for the condition being treated.
  • other well-known therapeutic agents which are selected on the basis of their suitability for the condition being treated.
  • antiresorptive bisphosphonates such as alendronate and risedronate, integrin blockers (as defined below), such as ⁇ vß3 antagonists, conjugated estrogens such as Prempro®, Premarin® and Endometrion® used in hormone therapy
  • SERMs selective estrogen receptor modulators
  • the present compounds are also suitable for combination with known anti-cancer agents.
  • known anti-cancer agents include the following: estrogen receptor modulators, androgen receptor modulators, retinoid receptor modulators, cytotoxics, antiproliferative agents, prenyl protein transferase inhibitors, HMG-CoA reductase inhibitors,
  • HIV protease inhibitors HIV protease inhibitors, reverse transcriptase inhibitors and other angiogenesis inhibitors.
  • the present compounds are particularly suitable for joint use with radiotherapy.
  • the synergistic effects of inhibiting VEGF in combination with radiotherapy have been described in the specialist field (see WO 00/61186).
  • Estrogen receptor modulators refers to compounds that interfere with or inhibit the binding of estrogen to the receptor, regardless of how this is done.
  • the estrogen receptor modulators include, for example, tamoxifen, raloxifene, idoxifene,
  • LY353381 LY 117081, toremifene, fulvestrant, 4- [7- (2,2-dimethyl-1-oxopropoxy-4-methyl-2- [4- [2- (1 - piperidinyl) ethoxy] phenyl] -2H-1 - benzopyran-3-yl] phenyl-2,2-dimethylpropanoate, 4,4'-dihydroxybenzophenon-2,4-dinitrophenylhydrazone and SH646, which, however, is not intended to be a limitation.
  • Androgen receptor modulators refers to compounds that interfere with or inhibit the binding of androgens to the receptor, regardless of how this is done.
  • the androgen receptor modulators include, for example, finasteride and other 5 ⁇ -reductase inhibitors, Nilutamide, Flutamide, Bicalutamide , Liarozole and abiraterone acetate.
  • Retinoid receptor modulators refers to compounds that interfere with or inhibit the binding of retinoids to the receptor, regardless of how this is done.
  • retinoid receptor modulators include, for example, bexarotene, tretinoin, 13-cis-retinoic acid, 9- cis-retinoic acid, ⁇ -difluoromethylomithine, ILX23-7553, trans-N- (4'-hydroxyphenyl) retinamide and N-4-carboxyphenylretinamide.
  • Cytotoxics refers to compounds that cause cell death primarily through direct action on cell function or that inhibit or interfere with cell myosis, including alkylating agents, tumor necrosis factors, intercalating agents, microtubulin inhibitors and topoisomerase inhibitors.
  • Cytotoxic agents include, for example tirapazimine, sertenef, cachectin, ifosfamide, tasonermin, lonidamine, carboplatin, altretamine, prednimustine, Dibromdulcit, ranimustine, fotemustine, nedaplatin, oxaliplatin, temozolomide, heptaplatin, estramustine, improsulfan tosylate, trofosfamide, nimustine, Dibrospidium- chloride, Pumitepa, lobaplatin, satraplatin, profiromycin, cisplatin, irofulven, dexifosfamide, cis-amine dichloro (2-methylpyridine) platinum, benzylguanine, glufosfamide, GPX100, (trans, trans, trans) -bis-mu- (hexane-1, 6 -diamine) -mu-
  • microtubulin inhibitors include, for example, paclitaxel, vindesin sulfate, S ' ⁇ ' - Dideshydro ⁇ '- deoxy- ⁇ '-norvincaleukoblastin, docetaxol, rhizoxin, dolastatin, mivobulin isethionate, auristatin, cemadotin, RPR1097676, VinMSin Cryptophycin, 2,3,4,5,6-pentafluoro-N- (3-fluoro-4-methoxyphenyl) benzenesulfonamide, anhydrovinblastine, N, N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl -L-prolyl-L-prolin-t-butylamide, TDX258 and BMS188797.
  • paclitaxel vindesin sulfate
  • Topoisomerase inhibitors are, for example, topotecan, hycaptamine, irinotecan, rubitecan, 6-ethoxypropionyl-3 ', 4'-0-exo-benzylidene-chartreusin, 9-methoxy-N, N-dimethyl-5-nitropyrazolo [3,4, 5-kl] acridin-2- ( ⁇ H) propanamine, 1-amino-9-ethyl-5-fluoro-2,3-dihydro-9-hydroxy-4-methyl- 1 H, 12H-benzo [de] pyrano [3 ', 4': b, 7jindolizino [1, 2b] quinoline-10,13 (9H, 15H) - dione, lurtotecan, 7- [2- (N-isopropylamino) ethyl] - (20S) camptothecin, BNP1350, BNPI1100, BN80915, BN80942, e
  • antiproliferative agents include antisense RNA and DNA oligonucleotides such as G3139, ODN698, RVASKRAS, GEM231 and INX3001, as well as antimetabolites such as enocitabine, Carmofur, Tegafur, pentostatin, doxifluridine, trimetrexate, flabinarababin, capud ocfosfat, fosteabin sodium hydrate, raltitrexed, paltitrexide,
  • antiproliferative agents include others monoclonal antibodies against growth factors as already mentioned under the “angiogenesis inhibitors”, such as trastuzumab, and tumor suppressor genes, such as p53, which can be released via recombinant virus-mediated gene transfer (see, for example, US Pat. No. 6,069,134).
  • the invention furthermore relates to the use of the compounds according to the invention for the production of a medicament for the treatment of diseases, the disease being characterized by disturbed angiogenesis.
  • the disease is preferably cancer.
  • the disturbed angiogenesis preferably results from an impaired VEGFR-1, VEGFR-2 and / or VEGFR-3 activity.
  • the use of the compounds according to the invention for the production of a medicament for inhibiting VEGFR-2 activity is therefore particularly preferred.
  • VEGF receptor kinase assay The VEGF receptor kinase activity is determined by incorporating radioactively marked phosphate in 4: 1 polyglutamic acid / tyrosine substrate (pEY). The phosphorylated pEY product is on a filter membrane recorded, and the incorporation of the radioactively labeled phosphate is quantified by scintillation counting.
  • the intracellular tyrosine kinase domains of human KDR (Terman, BI et al. Oncogene (1991) Vol. 6, pp. 1677-1683.) And Flt-1 (Shibuya, M. et al. Oncogene (1990) Vol. 5 , Pp. 519-524) were cloned as glutathione-S-transferase (GST) gene fusion proteins. This was done by cloning the cytoplasmic domain of the KDR kinase as a read-frame fusion at the carboxy terminus of the GST gene.
  • GST glutathione-S-transferase
  • the soluble recombinant GST-kinase domain fusion proteins were expressed in Spodoptera frugiperda (Sf21) insect cells (Invitrogen) using a baculovirus expression vector (pAcG2T, Pharmingen). lysis buffer
  • Millipore #MAFC NOB GF / C 96-well glass fiber plate.
  • the Sf21 cells were with the recombinant virus in a m.o.i. (Multiplicity of infection) of 5 virus particles / cell infected and grown for 48 hours at 27 ° C.
  • Count scintillation counters type Wallac Microbeta.
  • Mitogenesis assay on human umbilical vein endothelial cells The expression of VEGF receptors that mediate mitogenic reactions to the growth factor is largely restricted to vascular endothelial cells.
  • Cultivated human umbilical vein endothelial cells proliferate in response to treatment with VEGF and can be used as an assay system to quantify the effects of KDR kinase inhibitors on VEGF stimulation.
  • single cell layers of HUVECs are treated with the constituent or the test compound at rest 2 hours before the addition of VEGF or "basic fibroblast growth factor" (bFGF).
  • the mitogenic response to VEGF or bFGF is measured by measuring the incorporation of [ 3 H] thymidine determined in the cell DNA.
  • Frozen HUVECs as primary culture isolates are obtained from Clonetics Corp. The cells are in the endothelial growth medium (endothelial
  • NUNCLON 96-well polystyrene tissue culture plates NUNC # 167008.
  • Test connections With the working stock solutions of the test connections, 100%
  • DMSO Dimethyl sulfoxide
  • HUVEC single cell layers kept in EGM are harvested by trypsin treatment and inoculated in a density of 4000 cells per 100 ⁇ l assay medium per well in 96-well plates. The growth of the cells is stopped for 24 hours at 37 ° C. in a humid atmosphere containing 5% CO 2 . Procedure 2
  • the growth stop medium is replaced by 100 ul assay medium containing either the constituent (0.25% [v / v] DMSO) or the desired final concentration of the test compound. All determinations are carried out in triplicate. The cells then become 2 Incubated for hours at 37 ° C / 5% C0 2 , so that the test compounds in the
  • the cells are then incubated at 37 ° C / 5% CO 2 .
  • the medium is suctioned off and the cells are washed twice with cell washing medium (400 ⁇ l / well, then 200 ⁇ l / well).
  • the washed, adherent cells are then solubilized by adding cell lysis solution (100 ⁇ l / well) and heating to 37 ° C. for 30 minutes.
  • the cell lysates are transferred to 7 ml glass scintillation tubes containing 150 ul water.
  • the scintillation cocktail (5 ml / tube) is added and the radioactivity associated with the cells is determined by liquid scintillation spectroscopy.
  • the compounds of the formula I are VEGF inhibitors and are therefore suitable for inhibiting angiogenesis, such as in the treatment of eye diseases, for example diabetic retinopathy, and for the treatment of carcinomas, for example solid tumors.
  • the present compounds inhibit VEGF-stimulated mitogenesis of cultured human vascular endothelial cells with HK50 values of 0.01-5.0 ⁇ M.
  • These compounds are also selective in comparison to related tyrosine kinases (eg FGFR1 and Src family; for the relationship between Src kinases and VEGFR kinases see Eliceiri et al., Molecular Cell, Vol. 4, pp. 915-924, December 1999) ,
  • the TIE-2 tests can be carried out, for example, analogously to the methods specified in WO 02/44156.
  • the assay determines the inhibitory activity of the substances to be tested in the phosphorylation of the substrate poly (Glu, Tyr) by Tie-2-kinase in the presence of radioactive 33 P-ATP.
  • the phosphorylated substrate binds to the surface of a "flashplate" microtiter plate during the incubation period. After removing the reaction mixture, it is washed several times and then the radioactivity is measured on the surface of the microtiter plate. An inhibitory effect of the substances to be measured results in a lower radioactivity compared to an undisturbed enzymatic reaction.
  • the compounds according to the invention can be purified by HPLC, preferably as described below:
  • Example A Injection glasses
  • a solution of 100 g of an active ingredient according to the invention and 5 g of disodium hydrogenphosphate is adjusted to pH 6.5 in 3 l of double-distilled water with 2N hydrochloric acid, sterile filtered, filled into injection glasses, lyophilized under sterile conditions and sealed sterile. Each injection jar contains 5 mg of active ingredient.
  • a mixture of 20 g of an active ingredient according to the invention is melted with 100 g soy lecithin and 1400 g cocoa butter, poured into molds and allowed to cool. Each suppository contains 20 mg of active ingredient.
  • a solution of 1 g of an active ingredient is prepared according to the invention, 9.38 g of NaH 2 P0 4 • 2 H 2 0, 28.48 g Na 2 HP0 4 • 12 H 2 0 and 0.1 g of benzalkonium chloride in 940 ml of double-distilled water , It is adjusted to pH 6.8, made up to 1 l and sterilized by irradiation. This solution can be used in the form of eye drops.
  • Example D ointment 500 mg of an active ingredient according to the invention are mixed with 99.5 g of petroleum jelly under aseptic conditions.
  • Example E tablets A mixture of 1 kg of active ingredient, 4 kg of lactose, 1, 2 kg of potato starch,
  • each tablet contains 10 mg of active ingredient.
  • Example F Coated tablets Analogously to Example E, tablets are pressed, which are then coated in a conventional manner with a coating of sucrose, potato starch, talc, tragacanth and colorant.
  • Example G Capsules 2 kg of active ingredient are filled in a conventional manner into hard gelatin capsules, so that each capsule contains 20 mg of the active ingredient.
  • a solution of 1 kg of an active ingredient according to the invention in 60 l of double-distilled water is sterile filtered, filled into ampoules, lyophilized under sterile conditions and sealed sterile. Each ampoule contains 10 mg of active ingredient.

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Abstract

L'invention concerne de nouveaux composés de la formule I (I) où R<l>, R<1'>, L, E, G, M, Q, U, R<2>, m, p et q ont la signification donnée dans la revendication 1. Ces nouveaux composés sont des inhibiteurs des tyrosinekinases, notamment TIE-2, et des rafkinases et peuvent servir à traiter des tumeurs.
EP04765962A 2003-10-24 2004-10-14 Derives de benzimidazolyle Withdrawn EP1675849A1 (fr)

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DE10349587A DE10349587A1 (de) 2003-10-24 2003-10-24 Benzimidazolylderivate
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US20080108672A1 (en) * 2002-01-11 2008-05-08 Bernd Riedl Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors
WO2003068228A1 (fr) * 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Urees aryliques a activite inhibitrice d'angiogenese
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AU2004285643A1 (en) 2005-05-12
DE10349587A1 (de) 2005-05-25
KR20060123124A (ko) 2006-12-01
ZA200604148B (en) 2007-09-26
JP4856546B2 (ja) 2012-01-18
AU2004285643B2 (en) 2011-06-02
AR046140A1 (es) 2005-11-23
JP2007509096A (ja) 2007-04-12
US20070066660A1 (en) 2007-03-22
MXPA06004405A (es) 2006-06-14
CA2543346A1 (fr) 2005-05-12
US20090082404A1 (en) 2009-03-26
WO2005042520A1 (fr) 2005-05-12
CN1871232A (zh) 2006-11-29
BRPI0415760A (pt) 2006-12-19
US7470702B2 (en) 2008-12-30

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