EP1673961B1 - Valve and dispensing device comprising one such valve - Google Patents
Valve and dispensing device comprising one such valve Download PDFInfo
- Publication number
- EP1673961B1 EP1673961B1 EP04805724A EP04805724A EP1673961B1 EP 1673961 B1 EP1673961 B1 EP 1673961B1 EP 04805724 A EP04805724 A EP 04805724A EP 04805724 A EP04805724 A EP 04805724A EP 1673961 B1 EP1673961 B1 EP 1673961B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- valve
- valve member
- valve according
- channel
- blind hole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012530 fluid Substances 0.000 claims description 7
- 239000000945 filler Substances 0.000 claims 4
- 230000014759 maintenance of location Effects 0.000 description 8
- 238000006073 displacement reaction Methods 0.000 description 4
- 230000005484 gravity Effects 0.000 description 3
- 230000000994 depressogenic effect Effects 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 229940127557 pharmaceutical product Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 1
- 229940082150 encore Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
- B65D83/44—Valves specially adapted therefor; Regulating devices
- B65D83/52—Valves specially adapted therefor; Regulating devices for metering
- B65D83/54—Metering valves ; Metering valve assemblies
Definitions
- valve may move slightly with respect to its central axis, which may cause leaks at the junction between the seals and said valve.
- This problem is particularly troublesome when the valve is a metering valve, that is to say a valve having a metering chamber defining a precise dose of product dispensed with each actuation of the valve.
- imprecision or non-reproducibility of the dose can be harmful for the user.
- Another problem which arises in particular in the metering valves concerns the precision and reproducibility of the metering even in the case of storage between two actuations.
- the present invention also relates to a fluid dispenser device comprising a valve as described above.
- the hollow sleeve 15 forming the guide element can be blind, as shown in FIG. figure 1 .
- Another variant, represented on the figures 2 and 5 shows a hollow sleeve 15 passing through, the valve possibly being able to project out of the valve body 10, inside the tank (not shown), when the valve 20 is depressed in dispensing position.
- the valve can not deviate during its displacement of this axis X because of the guide element 15 which axially guides the displacement of the guided portion 29 of the valve, and therefore of the entire valve. This avoids any risk of shift of the valve during actuation, and therefore any risk of leakage especially at the upper seal of the valve.
- the valve 20 comprises an upper part 21, which incorporates the dispensing orifice 25, and a lower part 22 which incorporates the guided part 29. These upper and lower parts 21, 22 are assembled one in the other, preferably sealingly, to at least partially define the filling channel 26.
- the lower part 22 of the valve 20 comprises a blind hole 23 which comprises two lateral through-holes 27, 28, one of which opens into the metering chamber 30 in the rest position of the valve 20, and the other opens at the outside of this metering chamber 30 in a portion connected to the reservoir.
- At least one of said lateral orifices 27, 28, preferably both, is made at least partially conical, preferably completely conical, as shown in FIGS. figure 1 and 2 , narrowing towards the interior of the central channel 23.
- the minimum diameter of the orifices (s) conical (s) 27, 28 is about 0.3 millimeter. With such a diameter, it is almost impossible for the product contained in the metering chamber 30 to flow back through the filling channel 26, the diameter being too small to allow a passage of the product by simple gravity.
- the conical shape of the holes makes it possible to achieve the minimum diameter of these with a very small value of the order of 0.3 millimeters.
- cylindrical pins for molding cylindrical holes of such a size would be too fragile, so that it would be very difficult and expensive to make cylindrical through holes of size about 0.3 millimeter in diameter.
- tapered holes narrowing inwardly of the channel 23 the desired result is obtained, namely a retention of the dose in the metering chamber 30 while allowing a molding and a simple and inexpensive embodiment of these holes by means of very strong conical pins, of which only the end has a reduced dimension of the order of 0.3 millimeters.
Landscapes
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
Description
La présente invention concerne une valve ainsi qu'un dispositif de distribution de produit fluide comportant une telle valve. Plus particulièrement, la présente invention est notamment destinée aux valves doseuses.The present invention relates to a valve and a fluid dispenser device comprising such a valve. More particularly, the present invention is particularly intended for metering valves.
Les valves sont bien connues dans l'état de la technique (voir par exemple le document
La présente invention a pour but de fournir une valve, notamment une valve doseuse, pour distribuer du produit fluide, qui ne reproduit pas les inconvénients susmentionnés. Plus particulièrement, la présente invention a pour but de fournir une telle valve qui garantisse une précision et une reproductibilité optimale du dosage à chaque actionnement de la valve.The present invention aims to provide a valve, including a metering valve, for dispensing fluid product, which does not reproduce the aforementioned drawbacks. More particularly, the object of the present invention is to provide such a valve which guarantees an accuracy and optimum reproducibility of the dosage each time the valve is actuated.
La présente invention a également pour but de fournir une telle valve qui garantisse un fonctionnement sure et fiable de celle-ci même lorsque l'utilisateur exerce une force qui n'est pas tout a fait axiale sur la soupape.The present invention also aims to provide such a valve that ensures safe and reliable operation thereof even when the user exerts a force that is not quite axial on the valve.
La présente invention a également pour objet de fournir une telle valve qui soit simple et peu coûteuse à fabriquer et à assembler.The present invention also aims to provide such a valve that is simple and inexpensive to manufacture and assemble.
La présente invention a donc pour objet une valve de distribution de produit fluide comportant un corps de valve et une soupape coulissant dans ledit corps de valve entre une position de repos et une position de distribution, ladite soupape comportant un orifice de distribution, ladite valve comportant un élément de guidage axial coopérant avec une partie guidée de la soupape, ladite partie guidée étant opposée audit orifice de distribution, et ladite soupape comporte une partie haute comportant l'orifice de distribution, et une partie basse comportant ladite partie guidée, lesdites parties haute et basse étant assemblées l'une dans l'autre.The present invention therefore relates to a fluid dispensing valve having a valve body and a valve sliding in said valve body between a rest position and a dispensing position, said valve having a dispensing orifice, said valve comprising an axial guide member cooperating with a guided portion of the valve, said guided portion being opposed to said dispensing orifice, and said valve comprises an upper portion having the dispensing orifice, and a lower portion including said guided portion, said upper portions; and bass being assembled one into the other.
Avantageusement, ledit élément de guidage est solidaire, notamment monobloc, dudit corps de valve.Advantageously, said guide element is integral, in particular monobloc, of said valve body.
Avantageusement, ledit élément de guidage est un manchon creux dont le diamètre interne est environ égal au diamètre externe de la partie guidée de la soupape coulissant dans ledit manchon creux.Advantageously, said guide element is a hollow sleeve whose inner diameter is approximately equal to the outer diameter of the guided portion of the valve sliding in said hollow sleeve.
Selon une première variante de réalisation, ledit manchon creux est borgne. Selon une seconde variante de réalisation, ledit manchon creux est traversant.According to a first variant embodiment, said hollow sleeve is blind. According to a second embodiment, said hollow sleeve is through.
Avantageusement, ladite valve est une valve doseuse comportant une chambre de dosage, ladite soupape comportant un canal de distribution reliant la chambre de dosage audit orifice de distribution en position de distribution de la soupape, et un canal de remplissage pour remplir ladite chambre de dosage lorsque la soupape revient vers sa position de repos.Advantageously, said valve is a metering valve comprising a metering chamber, said valve comprising a distribution channel connecting the metering chamber at said dispensing orifice in dispensing position of the valve, and a filling channel for filling said metering chamber when the valve returns to its rest position.
Avantageusement, la partie basse de la soupape comporte un trou borgne comprenant deux orifices latéraux traversant dont l'un débouche dans la chambre de dosage en position de repos de la soupape, la partie haute de la soupape étant emmanchée dans ledit trou borgne pour obturer axialement ledit trou borgne.Advantageously, the lower part of the valve comprises a blind hole comprising two through-side orifices, one of which opens into the metering chamber in the rest position of the valve, the upper part of the valve being fitted into said blind hole to seal axially. said blind hole.
Selon un premier mode de réalisation, le trou borgne de la partie basse de la soupape forme un canal axial central relié audit deux orifices latéraux, formant ainsi ledit canal de remplissage, l'extrémité inférieure de ladite partie haute de la soupape délimitant axialement ledit canal central.According to a first embodiment, the blind hole of the lower part of the valve forms a central axial channel connected to said two lateral orifices, thus forming said filling channel, the lower end of said upper part of the valve axially delimiting said channel. central.
Avantageusement, ledit canal central a une section transversale polygonale, notamment triangulaire.Advantageously, said central channel has a polygonal cross section, in particular triangular.
Selon un second mode de réalisation, la partie haute de la soupape comporte une rainure s'étendant axialement et définissant avec ledit trou borgne de ladite partie basse de la soupape au moins une partie du canal de remplissage.According to a second embodiment, the upper part of the valve comprises an axially extending groove defining with said blind hole of said lower part of the valve at least a portion of the filling channel.
Avantageusement, au moins un desdits orifices latéraux est au moins partiellement conique en se rétrécissant en direction du trou borgne.Advantageously, at least one of said lateral orifices is at least partially conical by narrowing towards the blind hole.
Avantageusement, le diamètre minimal dudit au moins un orifice conique est environ 0,3 millimètre.Advantageously, the minimum diameter of said at least one conical orifice is approximately 0.3 millimeters.
La présente invention a également pour objet un dispositif de distribution de produit fluide comportant une valve telle que décrite ci-dessus.The present invention also relates to a fluid dispenser device comprising a valve as described above.
D'autres caractéristiques et avantages de la présente invention apparaîtront plus clairement au cours de la description détaillée suivante de plusieurs modes de réalisation celle-ci, faite en référence aux dessins joints, donnés à titre d'exemples non limitatifs, et sur lesquels :
- la
figure 1 est une vue schématique en section transversale d'une valve selon un premier mode de réalisation de la présente invention; - la
figure 2 est une vue similaire à celle de lafigure 1 , montrant un autre mode de réalisation de la présente invention ; - la
figure 3 est une vue en coupe selon la ligne de coupe CC de lafigure 2 ; - la
figure 4 est une vue en coupe selon la ligne de coupe BB de lafigure 2 ; - la
figure 5 est une vue similaire auxfigures 1 et2 , montrant encore un autre mode de réalisation de la présente invention ; - la
figure 6 est une vue agrandie du détail A de lafigure 5 ; - la
figure 7 est une vue en coupe selon la ligne de coupe BB de lafigure 5 ; et - la
figure 8 est une vue en coupe selon la ligne de coupe CC de lafigure 5 .
- the
figure 1 is a schematic cross-sectional view of a valve according to a first embodiment of the present invention; - the
figure 2 is a view similar to that of thefigure 1 showing another embodiment of the present invention; - the
figure 3 is a sectional view along the section line CC of thefigure 2 ; - the
figure 4 is a sectional view along the section line BB of thefigure 2 ; - the
figure 5 is a view similar tofigures 1 and2 showing yet another embodiment of the present invention; - the
figure 6 is an enlarged view of detail A of thefigure 5 ; - the
figure 7 is a sectional view along the section line BB of thefigure 5 ; and - the
figure 8 is a sectional view along the section line CC of thefigure 5 .
En se référant aux figures, la valve comporte un corps de valve 10 dans lequel coulisse une soupape 20 entre une position de repos (représentée sur les
La soupape 20 comporte un orifice de distribution 25 et, selon un premier aspect de la présente invention, une partie 29 opposée audit orifice de distribution 25. Selon l'invention, cette partie 29 coopère avec un élément de guidage axial 15, de telle sorte que le déplacement de la soupape 20 est toujours exactement aligné sur l'axe central X de la valve. Cette partie guidée 29 de la soupape 20 qui coopère avec l'élément de guidage 15 est avantageusement formé par l'extrémité de la soupape 20 qui est opposée à l'orifice de distribution 25, pour optimiser le guidage axial. L'élément de guidage axial 15 est de préférence solidaire, notamment réalisé de manière monobloc, avec ledit corps de pompe 10, comme cela est représenté sur les
Dans un mode de réalisation avantageux de l'invention, la valve est une valve doseuse, c'est-à-dire comportant une chambre de dosage 30. La soupape 20 comporte avantageusement un canal de distribution 24 qui relie la chambre de dosage 30 à l'orifice de distribution 25 lorsque la soupape est en position de distribution. De même, un canal de remplissage 26 est avantageusement prévu pour remplir la chambre de dosage 30 lorsque la soupape revient de sa position de distribution vers sa position de repos. En particulier lorsque la valve est utilisée en position inversée mais stockée en position droite, il peut se poser un problème de rétention de la dose dans la chambre de dosage 30 entre deux actionnements de la valve. Pour supprimer ce problème, la présente invention prévoit de réduire au maximum la section du canal de remplissage 26 afin d'éviter que du produit contenu dans la chambre de dosage ne puisse s'écouler en retour vers le réservoir à travers ce canal.In an advantageous embodiment of the invention, the valve is a metering valve, that is to say having a
Les
Les
Bien évidemment, en combinant un canal de remplissage 26 fournissant une rétention optimal de la dose dans la chambre de dosage 30, avec les moyens de guidage 15 de la soupape 20, assurant un déplacement parfaitement axial de celle-ci, on arrive à garantir une reproductibilité et une précision optimale du dosage à chaque actionnement de la valve. Il est toutefois entendu que ces aspects pourraient être réalisés séparément l'un de l'autre en fonction des spécificités requises.Of course, by combining a filling
Bien que l'invention ait été décrite en référence à plusieurs modes de réalisation de celle-ci, il est entendu qu'elle n'est pas limitée par les exemples représentés. Au contraire, un homme du métier peut y apporter toutes modifications utiles sans sortir du cadre de la présente invention tel que défini par les revendications annexées.Although the invention has been described with reference to several embodiments thereof, it is understood that it is not limited by the examples shown. On the contrary, a person skilled in the art can make any useful modifications without departing from the scope of the present invention as defined by the appended claims.
Claims (14)
- A fluid dispenser valve comprising a valve body (10) and a valve member (20) that is slidable in said valve body (10) between a rest position and a dispensing position, said valve member (20) including a dispenser orifice (25), said valve being characterized in that it includes an axial guide element (15) that co-operates with a guided portion (29) of the valve member (20), said guided portion (29) being remote from said dispenser orifice (25), and in that said valve member (20) comprises a top portion (21) including the dispenser orifice (25), and a bottom portion (22) including said guided portion (29), said top and bottom portions (21, 22) being assembled one in the other.
- A valve according to claim 1, in which said guide element (15) is secured to said valve body (10), in particular by being made integrally therewith.
- A valve according to claim 1 or claim 2, in which said guide element (15) is a hollow sleeve having an inside diameter that is approximately equal to the outside diameter of the guided portion (29) of the valve member that is slidable in said hollow sleeve.
- A valve according to claim 3, in which said hollow sleeve (15) has a blind hollow.
- A valve according to claim 3, in which said hollow sleeve (15) has a through hollow.
- A valve according to any preceding claim, in which said valve is a metering valve including a metering chamber (30), said valve member (20) including a dispenser channel (24) connecting the metering chamber (30) to said dispenser orifice (25) when the valve member (20) is in its dispensing position, and a filler channel (26) for filling said metering chamber (30) when the valve member (20) returns to its rest position.
- A valve according to claim 6, in which said top and bottom portions are assembled one in the other so as to define said filler channel (26).
- A valve according to claim 7, in which the bottom portion (22) of the valve member (20) includes a blind hole (23) including two lateral through orifices (27, 28), with one orifice opening out into the metering chamber (30) when the valve member is in its rest position (20), the top portion (21) of the valve member (20) being fitted in said blind hole (23) so as to close said blind hole (23) axially.
- A valve according to claim 8, in which the blind hole (23) of the bottom portion (22) of the valve member (20) forms a central axial channel (23) that is connected to said two lateral orifices (27, 28), thereby forming said filler channel (26), the bottom end of said top portion (21) of the valve member (20) axially defining said central channel (23).
- A valve according to claim 9, in which said central channel (23) has a cross-section that is polygonal, and in particular triangular.
- A valve according to claim 8, in which the top portion (21) of the valve member includes a groove (23') that extends axially and that co-operates with said blind hole (23) of said bottom portion of the valve member (20) to define at least one portion of the filler channel (26).
- A valve according to any one of claims 8 to 11, in which at least one of said lateral orifices (27, 28) is conical in part, tapering towards the blind hole (23).
- A valve according to claim 12, in which the minimum diameter of said at least one conical orifice (27, 28) is about 0.3 mm.
- A fluid dispenser device, characterized in that it includes a valve according to any preceding claim.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0311719A FR2860503B1 (en) | 2003-10-07 | 2003-10-07 | VALVE AND DISPENSING DEVICE COMPRISING SUCH A VALVE. |
PCT/FR2004/050481 WO2005032970A2 (en) | 2003-10-07 | 2004-10-04 | Valve and dispensing device comprising one such valve |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1673961A2 EP1673961A2 (en) | 2006-06-28 |
EP1673961B1 true EP1673961B1 (en) | 2008-04-09 |
Family
ID=34307484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04805724A Expired - Lifetime EP1673961B1 (en) | 2003-10-07 | 2004-10-04 | Valve and dispensing device comprising one such valve |
Country Status (7)
Country | Link |
---|---|
US (1) | US20070131722A1 (en) |
EP (1) | EP1673961B1 (en) |
JP (1) | JP2007533558A (en) |
CN (1) | CN1879448A (en) |
DE (1) | DE602004013033T2 (en) |
FR (1) | FR2860503B1 (en) |
WO (1) | WO2005032970A2 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2917073B1 (en) * | 2007-06-11 | 2012-10-05 | Valois Sas | FLUID PRODUCT DISPENSING VALVE AND FLUID PRODUCT DISPENSING DEVICE COMPRISING SUCH A VALVE |
FR2918044B1 (en) * | 2007-06-28 | 2012-01-20 | Valois Sas | RING FOR FLUID PRODUCT DISPENSING VALVE. |
ES2551720T3 (en) * | 2010-07-20 | 2015-11-23 | Toyo Aerosol Industry Co., Ltd. | Aerosol device for dispensing multiple fluids |
FR2993250B1 (en) | 2012-10-12 | 2014-08-01 | Rexam Healthcare La Verpillier | DOSING VALVE FOR DISTRIBUTING AN AEROSOL |
FR2996827B1 (en) * | 2012-10-12 | 2014-10-31 | Rexam Healthcare La Verpillier | DOSING VALVE FOR DISTRIBUTING AN AEROSOL |
FR2999542B1 (en) * | 2012-12-17 | 2014-12-05 | Rexam Healthcare La Verpillier | DOSING VALVE FOR DISTRIBUTING AN AEROSOL |
FR3006300B1 (en) | 2013-06-04 | 2015-07-03 | Aptar France Sas | DOSING VALVE AND DEVICE FOR DISPENSING FLUID PRODUCT COMPRISING SUCH A VALVE. |
GB2535796A (en) * | 2015-02-27 | 2016-08-31 | 3M Innovative Properties Co | Improvements in or relating to metered dose inhalers |
FR3049275B1 (en) * | 2016-03-23 | 2019-07-19 | Aptar France Sas | DOSING VALVE AND DEVICE FOR DISPENSING FLUID PRODUCT COMPRISING SUCH A VALVE |
FR3065891B1 (en) * | 2017-05-05 | 2021-12-24 | Aptar France Sas | METERING VALVE AND FLUID PRODUCT DISTRIBUTION DEVICE COMPRISING SUCH A VALVE. |
JP7144079B2 (en) * | 2018-08-31 | 2022-09-29 | 株式会社三谷バルブ | Fixed-quantity injection mechanism for aerosol container and aerosol-type product equipped with this fixed-quantity injection mechanism |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1334243A (en) * | 1962-09-19 | 1963-08-02 | Risdon Mfg Co | Aerosol container valve |
US3187962A (en) * | 1962-11-09 | 1965-06-08 | Meshberg Philip | Valve and mounting and sealing means therefor |
US3394851A (en) * | 1965-09-20 | 1968-07-30 | Sterling Drug Inc | Metered aerosol valve for use with compressed gas |
FR1605152A (en) * | 1966-04-14 | 1973-03-23 | ||
US3581958A (en) * | 1969-06-11 | 1971-06-01 | Philip Meshberg | Seal-isolating means for sealed containers |
US4362257A (en) * | 1980-05-05 | 1982-12-07 | Ethyl Products Company | Pressure fillable dispensing device |
GB8624670D0 (en) * | 1986-10-15 | 1986-11-19 | Glaxo Group Ltd | Valve for aerosol container |
GB8917285D0 (en) * | 1989-07-28 | 1989-09-13 | Harris Pharma Ltd | A valve for an aerosol dispenser |
JPH11501892A (en) * | 1995-03-10 | 1999-02-16 | ミネソタ マイニング アンド マニュファクチャリング カンパニー | Aerosol valve |
GB2324121A (en) * | 1997-04-07 | 1998-10-14 | Bespak Plc | Seal arrangements for pressurised dispensing containers |
GB2326156B (en) * | 1997-06-10 | 2000-08-16 | Bespak Plc | Improvements in a metering valve |
FR2833584B1 (en) * | 2001-12-13 | 2004-04-23 | Valois Sa | FLUID PRODUCT DISTRIBUTION VALVE AND FLUID PRODUCT DISPENSING DEVICE HAVING SUCH A VALVE |
GB0302812D0 (en) * | 2003-02-07 | 2003-03-12 | Wickham Mark D | Metering valves for dispensers |
-
2003
- 2003-10-07 FR FR0311719A patent/FR2860503B1/en not_active Expired - Fee Related
-
2004
- 2004-10-04 DE DE602004013033T patent/DE602004013033T2/en not_active Expired - Fee Related
- 2004-10-04 JP JP2006530456A patent/JP2007533558A/en not_active Withdrawn
- 2004-10-04 EP EP04805724A patent/EP1673961B1/en not_active Expired - Lifetime
- 2004-10-04 WO PCT/FR2004/050481 patent/WO2005032970A2/en active IP Right Grant
- 2004-10-04 CN CNA2004800331070A patent/CN1879448A/en active Pending
- 2004-10-04 US US10/574,817 patent/US20070131722A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2005032970A3 (en) | 2005-07-21 |
CN1879448A (en) | 2006-12-13 |
FR2860503A1 (en) | 2005-04-08 |
DE602004013033D1 (en) | 2008-05-21 |
EP1673961A2 (en) | 2006-06-28 |
DE602004013033T2 (en) | 2009-05-14 |
FR2860503B1 (en) | 2007-11-02 |
US20070131722A1 (en) | 2007-06-14 |
JP2007533558A (en) | 2007-11-22 |
WO2005032970A2 (en) | 2005-04-14 |
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