EP1659408A1 - Vorrichtung zur automatisierten klinischen Probenanalyse - Google Patents

Vorrichtung zur automatisierten klinischen Probenanalyse Download PDF

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Publication number
EP1659408A1
EP1659408A1 EP05380244A EP05380244A EP1659408A1 EP 1659408 A1 EP1659408 A1 EP 1659408A1 EP 05380244 A EP05380244 A EP 05380244A EP 05380244 A EP05380244 A EP 05380244A EP 1659408 A1 EP1659408 A1 EP 1659408A1
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EP
European Patent Office
Prior art keywords
samples
reaction containers
tubes
supports
automated clinical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP05380244A
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English (en)
French (fr)
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EP1659408B1 (de
Inventor
Josep Pagés Pinyol
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Grifols SA
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Grifols SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grifols SA filed Critical Grifols SA
Publication of EP1659408A1 publication Critical patent/EP1659408A1/de
Application granted granted Critical
Publication of EP1659408B1 publication Critical patent/EP1659408B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0427—Sample carriers, cuvettes or reaction vessels nestable or stockable
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0444—Rotary sample carriers, i.e. carousels for cuvettes or reaction vessels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/046—General conveyor features
    • G01N2035/0465—Loading or unloading the conveyor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis

Definitions

  • the present invention is intended to disclose an apparatus for the automated clinical analysis of samples which provides significant characteristics of novelty and inventive step with respect to the prior art.
  • the apparatus basically comprises an entry module for reaction containers, an entry module for samples, a reagent store, a sample transport arm device, a reagent arm device and a scanning device. These modules carry out functions associated with one another and coordinated by a central control unit, interacting with one another in a random manner and with an incubator, remaining adjacent to the latter.
  • reaction containers takes place through a zone through which the operator introduces into the system the disposable reaction containers on which dispensing and the reactions will be carried out. It is located adjacent to the incubator and outside same, preferably comprising two seats, each one for a support or rack of reaction containers, and in the shape of respective arcs of circumference that are concentric with the incubator and with a loading device equipped with a pusher for the reaction containers.
  • the entry for samples is the zone through which the operator introduces individually the primary tubes for analysing and collects the processed tubes. It is separate from the incubator and has a continuous loading system capable of presenting all the tubes, one by one, at a specific position which is the pipetting point, where the sample is drawn up, and maintaining them in a recirculation zone in case it is necessary to repeat or increase the number of analyses and return the tubes already dealt with to a specific area of the entry.
  • a sample arm device is intended to link the sample entry with the incubator, being capable of dispensing the sample in one or more positions of said incubator and by rotation of the latter, in any reaction container.
  • a reagent store is constituted in the shape of a circular ring internally concentric with the incubator, containing a plurality of removable small steps provided with circular movement for housing reagents and diluents for the analysis of samples.
  • a reagent arm device is located inside the reagent store, having freedom of movement according to a system of polar co-ordinates, that is, radial and angular, thereby making it possible to have access to any position in the reagent store.
  • the reader device has a body in the shape of a circular ring externally concentric with the incubator, preferably having a multiplicity of seats for reaction containers in the form of channels arranged radially in order to allow the introduction of the reaction containers from the incubator and their exit through the other end.
  • the device is provided with a lid (not shown) on its upper part which can be partially uncovered in order to permit the dispensing of additional reagents.
  • the apparatus is completed by means of various secondary elements which, on a non-limiting basis, are listed below:
  • the machine of the present invention comprises a module for the entry of reaction containers, indicated generally by the number 1, a module for the entry of samples 2, a reagent store 3, a sample arm device 4, a reagent arm device 5 and a scanning device 7.
  • Each of said modules combines with the rest and with a central incubator 6, the assembly being controlled by means of a control unit with a built-in computer which can be monitored via the screen 8.
  • the entry for reaction containers is the zone in which the operator introduces the disposable reaction containers on which dispensing and the reactions will be carried out.
  • It is located adjacent to the incubator 6, arranged externally with respect to same, and comprises two supports 9 and 10, each intended for the introduction of a rack of reaction containers, being arranged in the shape of respective arcs of circumference that are concentric with respect to the incubator 6 and to a load introduction device 11 which contains the pusher for the reaction containers, which transfers the reaction containers, one by one, directly from the racks to one of the cavities of the incubator 6 which is free.
  • the pusher goes to the other rack and the user can replace the emptied one without stopping the process taking place, that is, there is continuous loading of the racks.
  • Said racks in a preferred case, contain eight columns, as can be seen in the detail of Figure 21, which shows a support 12 which can assume the curved shape which can be seen in Figure 22 and which comprises eight vertical channels such as 13, 13', 13"... intended to receive the reaction containers inside them, having at the bottom in one of its faces the apertures 14, 14', 14"... intended to permit the individual expulsion of the reaction containers contained inside it through the openings or apertures 15, 15', 15"... existing in the part opposed to the first ones.
  • the apertures 15, 15', 15" are slightly narrower than the reaction containers so that the latter can always remain held in the rack except when they are pushed by the pusher device 11. When a reaction container is withdrawn by gravity from one of the columns 13, another reaction container becomes available in the lower part of the rack until the reaction containers of the column are used up.
  • each rack Preferably, the eight columns of each rack are joined by a thin plate 16 at one face, remaining loose on the other face, so that they can curve as is shown in Figure 22.
  • the rack is preferably made of a transparent semirigid material and is equipped with an upper lid (not shown) and in the lower end has small flanges 17 which prevent the reaction containers from falling.
  • the racks are introduced vertically and through the lower end of each column enter turrets on which the reaction containers rest so that they can slide for their withdrawal.
  • a label (not shown) which contains an electronic system or "tag" on which information can be recorded and recovered by means of an antenna (not shown) contained in the apparatus.
  • this device it is possible to check at any time the number of reaction containers available, said information being updated each time that a reaction container is extracted from the rack.
  • this device may contain information regarding the manufacturing batch or specific characteristics of the reaction containers or the rack.
  • the tag may contain this or other information in coded form, in order to render impossible, practically, the voluntary modification or replication thereof by third persons, and in this way to prevent the use of the apparatus with racks or reaction containers different from the originals.
  • the sample entry module 2 is shown in greater detail in Figures 17 to 20, comprising a table 18 on which the supports 19 for the tubes of samples 20 move. Said table 18 is divided in practice into two zones, one for the entry of the samples and the other for the exit of same, both having been shown by way of example by means of the corresponding vectors 21 and 22.
  • the individual supports 19 have means for the self-centred fastening of the tubes of samples 20, as will be explained, and at the bottom they have magnetic elements which interact with movable magnetic elements 23 and 24, located beneath the table 18 and which allow automatic entry, by means of the aforesaid magnetic means, of the tubes of samples from the entry of the table 18 to the feeder, in the form of an endless chain 25, provided with individual seats such as 26, 26', 26" in which the supports 19 fit in succession and are moved towards the sample-taking zone.
  • each of the supports 19 has a flat lower base 27 in which is associated a magnetic device 28, Figure 13, capable of producing rotation on interacting with external magnetic means, therefore allowing the agitation of the tube of samples.
  • the magnetic devices 28 also allow interaction with the magnetic devices 23 and 24 for having the tube supports to slide on the table 18.
  • each of the supports 19 has three rotatory arms 29, 30 and 31 ( Figure 11) between which a tube of-samples 20 can be held fast, Figures 14, 15 and 16.
  • Said arms 29, 30 and 31 are rotatable on their lower axes 32, 33 and 34, which extend in toothed sectors 35, 36 and 37 which are meshed in the same central crown gear 38.
  • the sample arm device 4 can be seen in detail in Figures 5 and 6.
  • Said sample arm is intended to collect the sample from the tubes stopped by the device 25 in one or more positions of the incubator 6, and by rotation of the latter, in any of the reaction containers deposited in the incubator.
  • Dispensing is effected by means of a probe 39 connected to a suitable fluid system which is capable of perforating stoppers of tubes of sample or other reagents.
  • the sample arm is also capable of aspirating a diluent from the desired position of the reagent store 3, dispensing it at the corresponding position of the incubator 6.
  • the three positions which the sample arm can reach that is, the pipetting point, shown correspondingly with the tube of samples 19 in Figure 5, the dispensing point and the point of aspiration of the diluent, are arranged in a straight line so that the arm 4 displaces the probe linearly, the probe also being provided with vertical movement for access to the interior of the tubes of samples, reaction containers and vials of reagents.
  • the reagent store 3 is formed by a circular ring internally concentric with respect to the incubator 6. It preferably comprises a plurality of removable small steps provided with circular movement to accomodate the reagents and diluents necessary for the sample analyses. It may be equipped with a cooling system for maintaining the reagents at the temperature necessary for preserving them. The steps have various types of seats for tubes and vials of different sizes depending on the presentation of the reagents and diluents provided preferably, but not exclusively, with a self-centred system which avoids the use of adaptors. A plurality of positions of reagents are provided with magnetic agitation for the reagents that require it.
  • the arm device 5 for the reagents is located concentrically in the interior of the reagent carousel, Figure 2, and has freedom of movement in a polar direction, that is, radial and angular, thereby making it possible to have access to any position of the store of reagents for the aspiration of same and to any position of the incubator 6 or of the scanner 7 for dispensing the aspirated reagent.
  • Aspiration is effected by means of a probe 40, preferably tempered, and capable of vertical movement. It has a radial actuator 41 for pushing reaction containers from the incubator to the scanner 7.
  • the polar displacement may be limited in order to avoid collisions with the sample arm device 4.
  • the scanner 7 is in the shape of an arc of a circular ring concentric with the incubator 6, Figures 1, 2 and 8.
  • it has a multiplicity of seats in the form of radial channels 42 open at both ends to allow the introduction of the reaction containers from the incubator and their exit through the other end.
  • the channels are covered by a lid (not shown) which is partially uncovered to allow the dispensing of additional reagents.
  • Said channels 42 face the same number of cavities of the incubator 6, so that the reaction containers can be transferred directly from the incubator when they are prepared for scanning. The transfer is effected by pushing by means of the radial actuator 41 of the reagent arm 5 towards one of the channels 42 of the scanner 7.
  • the reaction container which enters for scanning pushes out the reaction container which has already been scanned previously, through the same channel towards a waste container, through the aperture 43 provided for this purpose.
  • the scanner 7 is equipped with an optical system which makes it possible to pass a beam of light through each of the reaction containers, picking up the transmitted light and being capable of processing it subsequently in order to obtain optical information on the reaction which has taken place in each reaction container.
  • the readings are independent and may be taken simultaneously and asynchronously.
  • One of the essential advantages of the apparatus of the present invention is the division into a series of modules which carry out individual functions and which work in a coordinated but independent manner with one another, simultaneous in time.
  • the modules which interact are contiguous with one another so that the reaction containers can be loaded in a plurality of positions, independently and simultaneously with other operations.
  • having two loading devices available for reaction containers allows continuous loading of the racks of reaction containers without holding up the process of the apparatus.
  • reaction containers may be transferred between the entry for the reaction containers and the scanner contiguous with the incubator merely by means of a pushing movement, as may be observed by the arrangement of the reaction containers 44, 44', 44", Figure 7, which minimises the distance for the transport of the reaction containers between modules, reducing the transport time and therefore increasing the speed of working, and further avoiding any complications of the transport system.
  • the pushing system also makes it easy to implement the continuous loading system of reaction containers and the random access of any reaction container.
  • the incubator provided with movement reduces the complexity of the sample arm device 4, since the incubator 6 is what places the reaction container 44 in the position for dispensing the sample and enables the sample arm device 4 to move horizontally in a single direction, rendering the mechanism simpler and minimising the problems of overlapping with the reagent arm 5.
  • the movement of the incubator 6 allows access to any cavity of the carousel for seating reaction containers.
  • the operator In the operating process of the apparatus of the invention, the operator, prior to and during the execution of the tests, must carry out a series of operations. In order to start the tests, there must be in the reagent store 3 all the reagents necessary for the tests which may be requested. He must also maintain the containers of liquids. He also has to place racks of reaction containers in the corresponding magazines 9 and 10.
  • the computer of the analysis system sends to the host the results of the tests when they are completed.

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  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
EP05380244.3A 2004-11-18 2005-10-31 Vorrichtung zur automatisierten klinischen Probenanalyse Active EP1659408B1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200402773A ES2234440B1 (es) 2004-11-18 2004-11-18 Aparato para analisis clinico automatizado de muestras.

Publications (2)

Publication Number Publication Date
EP1659408A1 true EP1659408A1 (de) 2006-05-24
EP1659408B1 EP1659408B1 (de) 2018-05-09

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Family Applications (1)

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EP05380244.3A Active EP1659408B1 (de) 2004-11-18 2005-10-31 Vorrichtung zur automatisierten klinischen Probenanalyse

Country Status (5)

Country Link
US (1) US7622078B2 (de)
EP (1) EP1659408B1 (de)
JP (1) JP4232982B2 (de)
ES (2) ES2234440B1 (de)
TR (1) TR201806894T4 (de)

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US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
WO2009088781A1 (en) * 2008-01-04 2009-07-16 Pion Inc. Methods and systems for in situ physicochemical property testing
EP2238235A1 (de) * 2008-01-23 2010-10-13 CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Développement Mikroinjektionsvorrichtung und verfahren
EP2683831B1 (de) 2011-03-07 2015-09-23 Accelerate Diagnostics, Inc. Schnelle zellreinigungssysteme
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
JP6165961B2 (ja) 2013-03-15 2017-07-19 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ 前処理カルーセルを有する診断分析装置および関連方法
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
WO2014144627A1 (en) 2013-03-15 2014-09-18 Abbott Laboratories Automated diagnostic analyzers having rear accessible track systems and related methods
US9400285B2 (en) 2013-03-15 2016-07-26 Abbot Laboratories Automated diagnostic analyzers having vertically arranged carousels and related methods
CN103604938A (zh) * 2013-11-26 2014-02-26 苏州长光华医生物医学工程有限公司 一种全自动化学发光测定仪反应杯的限位存储装置
US20160238627A1 (en) 2015-02-13 2016-08-18 Abbott Laboratories Decapping and capping apparatus, systems and methods for use in diagnostic analyzers
US10023895B2 (en) 2015-03-30 2018-07-17 Accelerate Diagnostics, Inc. Instrument and system for rapid microogranism identification and antimicrobial agent susceptibility testing
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
FR3066275B1 (fr) * 2017-05-10 2020-09-18 Stago Diagnostica Automate pour la conduite automatisee d'analyses, notamment medicales
EP3669987A1 (de) * 2018-12-21 2020-06-24 Roche Diagnostics GmbH Probenbehälterträger, laborprobenverteilungssystem und laborautomationssystem
CA3137749C (en) * 2019-05-03 2023-12-05 Gen-Probe Incorporated Receptacle transport system for an analytical system
CN110239946B (zh) * 2019-06-27 2024-08-20 深圳市爱康生物科技股份有限公司 一种冷藏样本自动交接装置
CN111766232A (zh) * 2020-06-29 2020-10-13 苏州长光华医生物医学工程有限公司 具有辅助加样位的内外圈温育盘装置及温育方法
CN113884007B (zh) * 2021-09-29 2024-07-02 中元汇吉生物技术股份有限公司 位置检测系统、分析仪承载装置及分析仪
CN118209430B (zh) * 2024-05-21 2024-07-19 宝鸡特钢钛业股份有限公司 一种钛管水压试验工装

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Cited By (5)

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Publication number Priority date Publication date Assignee Title
WO2011012657A1 (en) * 2009-07-29 2011-02-03 F. Hoffmann-La Roche Ag Automatic analyzer
CN102818907A (zh) * 2009-07-29 2012-12-12 日立高新技术有限公司 自动分析仪
EP2520939A3 (de) * 2009-07-29 2013-01-09 Hitachi High-Technologies Corporation Automatisches Analysegerät
US8916096B2 (en) 2009-07-29 2014-12-23 Hitachi High-Technologies Corporation Automatic analyzer
CN102818907B (zh) * 2009-07-29 2015-10-28 日立高新技术有限公司 自动分析仪

Also Published As

Publication number Publication date
ES2670170T3 (es) 2018-05-29
US7622078B2 (en) 2009-11-24
EP1659408B1 (de) 2018-05-09
JP4232982B2 (ja) 2009-03-04
TR201806894T4 (tr) 2018-06-21
ES2234440B1 (es) 2006-02-16
US20060104862A1 (en) 2006-05-18
ES2234440A1 (es) 2005-06-16
JP2006145534A (ja) 2006-06-08

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