EP1633718A4 - Zusammensetzungen und verfahren zur inhibierung von tgf-s - Google Patents
Zusammensetzungen und verfahren zur inhibierung von tgf-sInfo
- Publication number
- EP1633718A4 EP1633718A4 EP04755413A EP04755413A EP1633718A4 EP 1633718 A4 EP1633718 A4 EP 1633718A4 EP 04755413 A EP04755413 A EP 04755413A EP 04755413 A EP04755413 A EP 04755413A EP 1633718 A4 EP1633718 A4 EP 1633718A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- compositions
- methods
- inhibiting tgf
- tgf
- inhibiting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47948803P | 2003-06-17 | 2003-06-17 | |
PCT/US2004/019225 WO2004112710A2 (en) | 2003-06-17 | 2004-06-15 | COMPOSITIONS AND METHODS FOR INHIBITING TGF-ß |
Publications (3)
Publication Number | Publication Date |
---|---|
EP1633718A2 EP1633718A2 (de) | 2006-03-15 |
EP1633718A4 true EP1633718A4 (de) | 2008-11-19 |
EP1633718B1 EP1633718B1 (de) | 2012-06-06 |
Family
ID=33539181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04755413A Expired - Lifetime EP1633718B1 (de) | 2003-06-17 | 2004-06-15 | Zusammensetzungen und verfahren zur inhibierung von tgf-s |
Country Status (4)
Country | Link |
---|---|
US (2) | US7314939B2 (de) |
EP (1) | EP1633718B1 (de) |
ES (1) | ES2389258T3 (de) |
WO (1) | WO2004112710A2 (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2314295B1 (de) * | 2005-07-29 | 2015-01-28 | Resverlogix, Inc | Arzneimittel zur Prävention und Behandlung komplexer Erkrankungen und deren Freisetzung mittels einsetzbarer Medizinprodukte |
AU2007301981A1 (en) | 2006-09-25 | 2008-04-03 | Universiteit Maastricht | Means and methods for diagnosing and/or treating a subject at risk of developing heart failure |
US8053440B2 (en) | 2007-02-01 | 2011-11-08 | Resverlogix Corporation | Compounds for the prevention and treatment of cardiovascular diseases |
US8470360B2 (en) | 2008-04-18 | 2013-06-25 | Warsaw Orthopedic, Inc. | Drug depots having different release profiles for reducing, preventing or treating pain and inflammation |
WO2009092087A2 (en) | 2008-01-18 | 2009-07-23 | The Brigham And Women's Hospital, Inc. | Selective differentiation, identification, and modulation of human th17 cells |
US20090263456A1 (en) * | 2008-04-18 | 2009-10-22 | Warsaw Orthopedic, Inc. | Methods and Compositions for Reducing Preventing and Treating Adhesives |
JP2011521969A (ja) * | 2008-05-30 | 2011-07-28 | スムマ ヘルス システムズ エルエルシー | 眼疾患を治療するためのTGF−β受容体阻害剤又はアクチビン様キナーゼ(ALK)5阻害剤、A−83−01及びSB−431542の使用方法及び創傷治療条件 |
PT2346837E (pt) | 2008-06-26 | 2015-04-02 | Resverlogix Corp | Métodos de preparação de derivados de quinazolinona |
ES2542835T3 (es) | 2009-01-08 | 2015-08-12 | Resverlogix Corporation | Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares |
BRPI1009315B8 (pt) | 2009-03-18 | 2021-05-25 | Resverlogix Corp | composto anti-flamatórios e suas composições farmacêuticas |
JP2012524073A (ja) * | 2009-04-17 | 2012-10-11 | スムマ ヘルス システムズ エルエルシー | 眼球瘢痕化を抑制するための形質転換成長因子−β受容体阻害剤の使用 |
TR201818390T4 (tr) | 2009-04-22 | 2019-01-21 | Resverlogix Corp | Yeni̇ anti̇-i̇nflamatuvar ajanlar |
US8765940B2 (en) | 2009-06-25 | 2014-07-01 | Amgen Inc. | Heterocyclic compounds and their uses |
MX2011013666A (es) | 2009-06-25 | 2012-03-06 | Amgen Inc | Compuestos heterociclicos y sus usos. |
KR20130025860A (ko) * | 2009-11-07 | 2013-03-12 | 메르크 파텐트 게엠베하 | Tgf-베타 수용체 키나아제 저해제로서의 헤테로아릴아미노퀴놀린 |
WO2012003283A1 (en) * | 2010-06-30 | 2012-01-05 | Amgen Inc. | Heterocyclic compounds and their use as inhibitors of pi3k activity |
WO2012167261A2 (en) | 2011-06-03 | 2012-12-06 | Yale University | Compositions and methods for treating and preventing neointimal stenosis |
PL2773354T3 (pl) | 2011-11-01 | 2019-12-31 | Resverlogix Corp. | Doustna formulacja o natychmiastowym uwalnianiu dla podstawowych chinazolinów |
EP2906712A1 (de) | 2012-10-10 | 2015-08-19 | Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis | Verfahren und mittel zur vorhersage der resistenz gegen eine krebsbehandlung |
WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
CA2895905A1 (en) | 2012-12-21 | 2014-06-26 | Zenith Epigenetics Corp. | Novel heterocyclic compounds as bromodomain inhibitors |
SI2970890T1 (sl) | 2013-03-14 | 2020-10-30 | The Brigham And Women's Hospital, Inc. | Sestavki in postopki za razmnoževanje in kultiviranje epitelijskih matičnih celic |
CA2935392C (en) | 2014-01-01 | 2022-07-26 | Medivation Technologies, Inc. | Amino pyridine derivatives for the treatment of conditions associated with excessive tgf.beta activity |
JP6527534B2 (ja) * | 2014-06-16 | 2019-06-05 | ファンダシオン パラ ラ インベスティガシオン メディカ アプリカダFundacion Para La Investigasion Medica Aplicada | ヒストンメチルトランスフェラーゼ及びdnaメチルトランスフェラーゼの二重阻害剤としての新規化合物 |
EP3189134A1 (de) | 2014-09-03 | 2017-07-12 | The Brigham and Women's Hospital, Inc. | Zusammensetzungen, systeme und verfahren zur erzeugung von innenohrhaarzellen zur behandlung von gehörverlust |
CA2964113A1 (en) * | 2014-10-14 | 2016-04-21 | La Jolla Institute Of Allergy & Immunology | Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof |
US10111885B2 (en) | 2015-03-13 | 2018-10-30 | Resverlogix Corp. | Compositions and therapeutic methods for the treatment of complement-associated diseases |
US20160332971A1 (en) * | 2015-05-15 | 2016-11-17 | University Of Kentucky Research Foundation | Arylquinoline, arylquinolone and arylthioquinolone derivatives and use thereof to treat cancer |
WO2016210292A1 (en) | 2015-06-25 | 2016-12-29 | Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance |
WO2017100782A1 (en) | 2015-12-11 | 2017-06-15 | Research Institute At Nationwide Children's Hospital | Systems and methods for optimized patent specific tissue engineering vascular grafts |
US11021687B2 (en) | 2016-01-08 | 2021-06-01 | The Brigham And Women's Hospital, Inc. | Production of differentiated enteroendocrine cells and insulin producing cells |
US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
US11260130B2 (en) | 2016-03-02 | 2022-03-01 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV |
EP4049665A1 (de) | 2016-03-15 | 2022-08-31 | Children's Medical Center Corporation | Verfahren und zusammensetzungen im zusammenhang mit der expansion hämatopoetischer stammzellen |
SG10201910821XA (en) | 2016-12-30 | 2020-01-30 | Frequency Therapeutics Inc | 1h-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells |
WO2018204176A1 (en) | 2017-05-01 | 2018-11-08 | Sanford Burnham Prebys Medical Discovery Institute | Inhibitors of low molecular weight protein tyrosine phosphatase (lmptp) and uses thereof |
EP3768267A4 (de) | 2018-03-20 | 2022-04-20 | Icahn School of Medicine at Mount Sinai | Kinaseinhibitorverbindungen und zusammensetzungen und verfahren zur verwendung |
US20210254006A1 (en) | 2018-06-06 | 2021-08-19 | Ideaya Biosciences, Inc. | Methods of culturing and/or expanding stem cells and/or lineage committed progenitor cells using lactam compounds |
WO2020037326A1 (en) | 2018-08-17 | 2020-02-20 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating foxo |
AU2019321641A1 (en) | 2018-08-17 | 2021-04-15 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by upregulating Jag-1 |
CA3124700A1 (en) | 2018-12-31 | 2020-07-09 | Icahn School Of Medicine At Mount Sinai | Kinase inhibitor compounds and compositions and methods of use |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000012497A2 (en) * | 1998-08-28 | 2000-03-09 | Scios Inc. | Quinazoline derivatives as medicaments |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61188582A (ja) * | 1985-02-18 | 1986-08-22 | 三菱電機株式会社 | マルチウインドウ書込み制御装置 |
US4733665C2 (en) | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
CA1322628C (en) | 1988-10-04 | 1993-10-05 | Richard A. Schatz | Expandable intraluminal graft |
GB9312891D0 (en) * | 1993-06-22 | 1993-08-04 | Boots Co Plc | Therapeutic agents |
GB9910580D0 (en) * | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
GB9910579D0 (en) * | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
SE0101161D0 (sv) | 2001-03-30 | 2001-03-30 | Astrazeneca Ab | New compounds |
US20050009815A1 (en) * | 2001-11-27 | 2005-01-13 | Devita Robert J. | 4-Aminoquinoline compounds |
-
2004
- 2004-06-15 ES ES04755413T patent/ES2389258T3/es not_active Expired - Lifetime
- 2004-06-15 WO PCT/US2004/019225 patent/WO2004112710A2/en active Application Filing
- 2004-06-15 US US10/869,321 patent/US7314939B2/en not_active Expired - Fee Related
- 2004-06-15 EP EP04755413A patent/EP1633718B1/de not_active Expired - Lifetime
-
2007
- 2007-11-16 US US11/941,284 patent/US7943640B2/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000012497A2 (en) * | 1998-08-28 | 2000-03-09 | Scios Inc. | Quinazoline derivatives as medicaments |
Also Published As
Publication number | Publication date |
---|---|
US7314939B2 (en) | 2008-01-01 |
ES2389258T3 (es) | 2012-10-24 |
US20050032835A1 (en) | 2005-02-10 |
US20080108656A1 (en) | 2008-05-08 |
WO2004112710A2 (en) | 2004-12-29 |
US7943640B2 (en) | 2011-05-17 |
EP1633718A2 (de) | 2006-03-15 |
WO2004112710A3 (en) | 2005-05-06 |
EP1633718B1 (de) | 2012-06-06 |
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