EP1578910A4 - Nitrilasen - Google Patents

Nitrilasen

Info

Publication number
EP1578910A4
EP1578910A4 EP02780877A EP02780877A EP1578910A4 EP 1578910 A4 EP1578910 A4 EP 1578910A4 EP 02780877 A EP02780877 A EP 02780877A EP 02780877 A EP02780877 A EP 02780877A EP 1578910 A4 EP1578910 A4 EP 1578910A4
Authority
EP
European Patent Office
Prior art keywords
nitrilases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02780877A
Other languages
English (en)
French (fr)
Other versions
EP1578910A2 (de
Inventor
Grace Desantis
Jennifer Ann Chaplin
David Paul Weiner
Aileen Milan
Ellen Chi
Jay M Short
Mark Madden
Mark Burk
Dan Robertson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Enzymes LLC
Original Assignee
Verenium Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Verenium Corp filed Critical Verenium Corp
Priority to EP08075753A priority Critical patent/EP2039762A3/de
Priority to EP10189100.0A priority patent/EP2327765B1/de
Priority to EP20100190399 priority patent/EP2327767B1/de
Priority to EP10190401.9A priority patent/EP2319919B1/de
Priority to EP10190397.9A priority patent/EP2327766B1/de
Publication of EP1578910A2 publication Critical patent/EP1578910A2/de
Publication of EP1578910A4 publication Critical patent/EP1578910A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/002Nitriles (-CN)
    • C12P13/004Cyanohydrins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Processing Of Solid Wastes (AREA)
  • Treatment Of Sludge (AREA)
EP02780877A 2001-06-21 2002-05-15 Nitrilasen Withdrawn EP1578910A4 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP08075753A EP2039762A3 (de) 2001-06-21 2002-05-15 Nitralasen
EP10189100.0A EP2327765B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP20100190399 EP2327767B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP10190401.9A EP2319919B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP10190397.9A EP2327766B1 (de) 2001-06-21 2002-05-15 Nitralasen

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US30018901P 2001-06-21 2001-06-21
US300189P 2001-06-21
US30900601P 2001-07-30 2001-07-30
US309006P 2001-07-30
US35133602P 2002-01-22 2002-01-22
US351336P 2002-01-22
PCT/US2002/015983 WO2003000840A2 (en) 2001-06-21 2002-05-15 Nitrilases

Related Child Applications (5)

Application Number Title Priority Date Filing Date
EP10190401.9A Division EP2319919B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP08075753A Division EP2039762A3 (de) 2001-06-21 2002-05-15 Nitralasen
EP10190397.9A Division EP2327766B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP10189100.0A Division EP2327765B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP20100190399 Division EP2327767B1 (de) 2001-06-21 2002-05-15 Nitralasen

Publications (2)

Publication Number Publication Date
EP1578910A2 EP1578910A2 (de) 2005-09-28
EP1578910A4 true EP1578910A4 (de) 2008-06-04

Family

ID=27404717

Family Applications (6)

Application Number Title Priority Date Filing Date
EP08075753A Withdrawn EP2039762A3 (de) 2001-06-21 2002-05-15 Nitralasen
EP02780877A Withdrawn EP1578910A4 (de) 2001-06-21 2002-05-15 Nitrilasen
EP10190401.9A Expired - Lifetime EP2319919B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP20100190399 Expired - Lifetime EP2327767B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP10189100.0A Expired - Lifetime EP2327765B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP10190397.9A Expired - Lifetime EP2327766B1 (de) 2001-06-21 2002-05-15 Nitralasen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP08075753A Withdrawn EP2039762A3 (de) 2001-06-21 2002-05-15 Nitralasen

Family Applications After (4)

Application Number Title Priority Date Filing Date
EP10190401.9A Expired - Lifetime EP2319919B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP20100190399 Expired - Lifetime EP2327767B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP10189100.0A Expired - Lifetime EP2327765B1 (de) 2001-06-21 2002-05-15 Nitralasen
EP10190397.9A Expired - Lifetime EP2327766B1 (de) 2001-06-21 2002-05-15 Nitralasen

Country Status (6)

Country Link
EP (6) EP2039762A3 (de)
JP (2) JP4405258B2 (de)
AU (2) AU2006252258B2 (de)
CA (2) CA2677781C (de)
DK (3) DK2327767T3 (de)
WO (1) WO2003000840A2 (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040005673A1 (en) 2001-06-29 2004-01-08 Kevin Jarrell System for manipulating nucleic acids
US20040002147A1 (en) * 1999-12-29 2004-01-01 Desantis Grace Nitrilases
US7608445B1 (en) 1999-12-29 2009-10-27 Verenium Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
US7521216B2 (en) 1999-12-29 2009-04-21 Verenium Corporation Nitrilases and methods for making and using them
US7300775B2 (en) 1999-12-29 2007-11-27 Verenium Corporation Methods for producing α-substituted carboxylic acids using nitrilases and strecker reagents
US7435562B2 (en) 2000-07-21 2008-10-14 Modular Genetics, Inc. Modular vector systems
AU2003251523A1 (en) 2002-06-13 2003-12-31 Diversa Corporation Processes for making (r)-ethyl 4-cyano-3-hydroxybutyric acid
US7985572B2 (en) 2003-02-27 2011-07-26 Basf Se Modified nitrilases and their use in methods for the production of carboxylic acids
AR044519A1 (es) 2003-05-02 2005-09-14 Novartis Ag Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
US7198926B2 (en) 2003-05-08 2007-04-03 E. I. Du Pont De Nemours And Company Preparation of (E)- and (Z)-2-methyl-2-butenoic acids
GB0401334D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
GT200500281A (es) 2004-10-22 2006-04-24 Novartis Ag Compuestos organicos.
CA2590245A1 (en) 2004-11-11 2006-05-18 Modular Genetics, Inc. Ladder assembly and system for generating diversity
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
KR20080049113A (ko) 2005-10-21 2008-06-03 노파르티스 아게 Il-13에 대항한 인간 항체 및 치료적 용도
WO2007094885A2 (en) * 2005-12-07 2007-08-23 Southern Methodist University Identification of a nitrilase from b. japonicum by rational genome mining and methods of use
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
ES2440317T3 (es) 2006-04-21 2014-01-28 Novartis Ag Derivados de purina para su uso como agonistas del receptor de adenosina A2A
CN100500832C (zh) * 2006-04-29 2009-06-17 浙江工业大学 枯草芽孢杆菌zjb-063及其应用
ATE502943T1 (de) 2006-09-29 2011-04-15 Novartis Ag Pyrazolopyrimidine als pi3k-lipidkinasehemmer
MX2009007476A (es) 2007-01-10 2009-07-22 Irm Llc Compuestos y composiciones como inhibidores de proteasa activadora de canal.
WO2008106662A2 (en) * 2007-03-01 2008-09-04 Verenium Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
PE20090733A1 (es) 2007-05-07 2009-07-17 Novartis Ag Derivados de pirazina como bloqueadores de los canales de sodio epitelial
KR101578235B1 (ko) 2007-12-10 2015-12-16 노파르티스 아게 유기 화합물
JP5165393B2 (ja) * 2008-01-10 2013-03-21 旭化成ケミカルズ株式会社 グリコール酸又はグリコール酸アンモニウムの製造方法
WO2009087224A1 (en) 2008-01-11 2009-07-16 Novartis Ag Pyrimidines as kinase inhibitors
US8268834B2 (en) 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
KR20110040818A (ko) 2008-06-10 2011-04-20 노파르티스 아게 상피 나트륨 채널 차단제로서의 피라진 유도체
SI2391366T1 (sl) 2009-01-29 2013-01-31 Novartis Ag Substituirani benzimidazoli za zdravljenje astrocitomov
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
CA2770873A1 (en) 2009-08-12 2011-02-17 Novartis Ag Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation
SG178454A1 (en) 2009-08-17 2012-03-29 Intellikine Inc Heterocyclic compounds and uses thereof
IN2012DN01453A (de) 2009-08-20 2015-06-05 Novartis Ag
EP2490687A1 (de) 2009-10-22 2012-08-29 Vertex Pharmaceuticals Incorporated Zusammensetzungen für die behandlung von mukoviszidose und anderen chronischen erkrankungen
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
US8637516B2 (en) 2010-09-09 2014-01-28 Irm Llc Compounds and compositions as TRK inhibitors
US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
US20130324526A1 (en) 2011-02-10 2013-12-05 Novartis Ag [1,2,4] triazolo [4,3-b] pyridazine compounds as inhibitors of the c-met tyrosine kinase
JP5808826B2 (ja) 2011-02-23 2015-11-10 インテリカイン, エルエルシー 複素環化合物およびその使用
MA34969B1 (fr) 2011-02-25 2014-03-01 Irm Llc Composes et compositions en tant qu inibiteurs de trk
GB201111639D0 (en) * 2011-07-07 2011-08-24 Waterford Inst Technology A process for producing amides and acids using a nitrile-metabolising enzyme
GB201111637D0 (en) * 2011-07-07 2011-08-24 Waterford Inst Technology A process for producing amides and acids using a nitrile-metabolising enzyme
UY34305A (es) 2011-09-01 2013-04-30 Novartis Ag Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar
CA2848809A1 (en) 2011-09-15 2013-03-21 Novartis Ag 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyradines as c-met tyrosine kinase
CN103946221B (zh) 2011-09-16 2016-08-03 诺华股份有限公司 用于治疗囊性纤维化的杂环化合物
EP2755652B1 (de) 2011-09-16 2021-06-02 Novartis AG N-substituierte heterocyclische carboxamide
WO2013038381A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine/pyrazine amide derivatives
WO2013038378A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
WO2013038373A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
CA2856803A1 (en) 2011-11-23 2013-05-30 Intellikine, Llc Enhanced treatment regimens using mtor inhibitors
CN102363775B (zh) * 2011-11-30 2014-04-02 重庆大学 一种纯化腈水解酶的方法
US8809340B2 (en) 2012-03-19 2014-08-19 Novartis Ag Crystalline form
EP3964513A1 (de) 2012-04-03 2022-03-09 Novartis AG Kombinationsprodukte mit tyrosinkinaseinhibitoren und deren verwendung
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
WO2014151147A1 (en) 2013-03-15 2014-09-25 Intellikine, Llc Combination of kinase inhibitors and uses thereof
TW201605450A (zh) 2013-12-03 2016-02-16 諾華公司 Mdm2抑制劑與BRAF抑制劑之組合及其用途
BR112016024533A8 (pt) 2014-04-24 2021-03-30 Novartis Ag derivados de amino pirazina como inibidores de fosfatidilinositol 3-cinase ou sal, seu uso, e composição e combinação farmacêuticas
CN106458966B (zh) 2014-04-24 2019-05-07 诺华股份有限公司 作为磷脂酰肌醇3-激酶抑制剂的吡嗪衍生物
PL3134396T3 (pl) 2014-04-24 2020-04-30 Novartis Ag Pochodne aminopirydyny jako inhibitory 3-kinazy fosfatydyloinozytolu
WO2016011658A1 (en) 2014-07-25 2016-01-28 Novartis Ag Combination therapy
AU2015294889B2 (en) 2014-07-31 2018-03-15 Novartis Ag Combination therapy
CN104774825B (zh) * 2015-03-23 2017-11-07 浙江工业大学 腈水解酶突变体及其应用
CN108368033B (zh) * 2015-11-19 2021-05-04 Gsp作物科学有限公司 一种用于制备肟菌酯的方法
CN106854673B (zh) * 2016-12-23 2020-05-15 枣庄市杰诺生物酶有限公司 利用腈水解酶工程菌制备r-邻氯扁桃酸的方法
CN109111043B (zh) * 2018-09-16 2021-11-09 苏州渭中科技发展有限公司 一种高盐高cod废水的处理方法
CN113614242A (zh) * 2019-01-22 2021-11-05 巴斯夫欧洲公司 4-氰基苯甲酸或其盐的生产方法
AU2020290094B2 (en) 2019-06-10 2024-01-18 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF, COPD, and bronchiectasis
UY38860A (es) 2019-08-28 2021-02-26 Novartis Ag Derivados de 1,3–fenil heteroarilo sustituidos, composiciones para su uso en el tratamiento de enfermedades y formas cristalinas
TW202140550A (zh) 2020-01-29 2021-11-01 瑞士商諾華公司 使用抗tslp抗體治療炎性或阻塞性氣道疾病之方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0780471A2 (de) * 1995-07-31 1997-06-25 Nitto Chemical Industry Co., Ltd. Neues Nitrilase-Gen

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US813998A (en) 1903-10-31 1906-02-27 Rail Joint Co Insulated rail-joint.
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
WO1991016427A1 (en) 1990-04-24 1991-10-31 Stratagene Methods for phenotype creation from multiple gene populations
US5331573A (en) 1990-12-14 1994-07-19 Balaji Vitukudi N Method of design of compounds that mimic conformational features of selected peptides
JP2676568B2 (ja) 1991-06-26 1997-11-17 日東化学工業株式会社 R(−)−マンデル酸およびその誘導体の製造法
US5241087A (en) 1992-03-09 1993-08-31 Bend Research, Inc. Enantiomeric enrichment of cyanohydrins
US5631280A (en) 1995-03-29 1997-05-20 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5958672A (en) 1995-07-18 1999-09-28 Diversa Corporation Protein activity screening of clones having DNA from uncultivated microorganisms
US6030779A (en) 1995-07-18 2000-02-29 Diversa Corporation Screening for novel bioactivities
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
US5939250A (en) 1995-12-07 1999-08-17 Diversa Corporation Production of enzymes having desired activities by mutagenesis
DE19848129A1 (de) 1998-10-19 2000-04-20 Basf Ag Verfahren zur Herstellung chiraler Carbonsäuren aus Nitrilen mit Hilfe einer Nitrilase oder Mikroorganismen, die ein Gen für die Nitrilase enthalten
DE19929365A1 (de) 1999-06-25 2000-12-28 Basf Lynx Bioscience Ag Teilsequenzen der Gene des Primär- und Sekundärmetabolismus aus Corynebacterium glutamicum und ihr Einsatz zur mikrobiellen Herstellung von Primär- und Sekundärmetaboliten
US7300775B2 (en) * 1999-12-29 2007-11-27 Verenium Corporation Methods for producing α-substituted carboxylic acids using nitrilases and strecker reagents
AU2001228808A1 (en) 2000-01-25 2001-08-07 Kaneka Corporation Process for producing optically active carboxylic acid substituted in 2-position
AU2014284148B2 (en) 2013-06-21 2017-02-23 Bio-Rad Laboratories, Inc. Microfluidic system with fluid pickups

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0780471A2 (de) * 1995-07-31 1997-06-25 Nitto Chemical Industry Co., Ltd. Neues Nitrilase-Gen

Also Published As

Publication number Publication date
DK2327767T3 (en) 2015-07-27
EP2327765A1 (de) 2011-06-01
WO2003000840A2 (en) 2003-01-03
CA2445046A1 (en) 2003-01-03
EP2327767B1 (de) 2015-04-29
AU2010212259A1 (en) 2010-09-02
EP2327765B1 (de) 2015-04-01
EP2327766A1 (de) 2011-06-01
DK2327766T3 (en) 2016-03-07
EP2039762A2 (de) 2009-03-25
AU2006252258A1 (en) 2007-01-25
JP2007252382A (ja) 2007-10-04
EP2039762A3 (de) 2009-07-29
AU2010212259B2 (en) 2012-11-29
AU2006252258B2 (en) 2010-07-22
DK2327765T3 (en) 2015-07-13
EP2327767A1 (de) 2011-06-01
WO2003000840A3 (en) 2007-11-15
EP2327766B1 (de) 2015-12-02
EP2319919B1 (de) 2015-08-12
CA2445046C (en) 2009-11-24
CA2677781C (en) 2013-01-29
JP4405258B2 (ja) 2010-01-27
EP2319919A1 (de) 2011-05-11
JP4405528B2 (ja) 2010-01-27
JP2005509407A (ja) 2005-04-14
CA2677781A1 (en) 2003-01-03
EP1578910A2 (de) 2005-09-28

Similar Documents

Publication Publication Date Title
EP1578910A4 (de) Nitrilasen
DE60209787D1 (en) Flächiges implantat
DE50202400D1 (en) Baw-resonator
DE50201180D1 (en) Organopolysiloxan/polyharnstoff/polyurethan-blockcopolymere
DE60213216D1 (en) Metalloproteinaseinhibitoren
DE50209614D1 (en) 2-heteroarylcarbonsäureamide
DE50211022D1 (en) Heteroarylcarbonsäureamide
DE60214551D1 (en) Modulares airbagaufblassystem
DE60210819D1 (en) Pyrazolopyridazinderivate
DE60141364D1 (en) Polyphenylensulfidharzzusammensetzung
DE50202633D1 (en) Ophthalmoskop
DE60141362D1 (en) Ösophagus-stoma-knopf
AU2002360430A8 (en) 14-methyl-epothilones
DE60223825D1 (en) Ethynylierungsverfahren
DE60107296D1 (en) Kabelverstärkerverbindungsanordnung
DE60204140D1 (en) 5-ethyl-imidazotriazinone
DE60216319D1 (en) Heteroaryl-substituierte aminocyclohexan-derivate
DE50206483D1 (en) Displaymodul
DE50203686D1 (en) Substituierte c-furan-2-yl-methylamin- und c-thiophen-2-yl-methylamin-derivate
GB0102319D0 (en) Light-diffuser
DE50201028D1 (en) Diarylgelbpigmentpraeparationen
DE50214962D1 (en) Heterocyclylarylsulfonamide
DE60206072D1 (en) Aroylpyridinone
AU2002313943A8 (en) Electromobile
GB0106567D0 (en) Mutuagenesis Technique

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20031103

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: VERENIUM CORPORATION

PUAK Availability of information related to the publication of the international search report

Free format text: ORIGINAL CODE: 0009015

RIC1 Information provided on ipc code assigned before grant

Ipc: C07K 1/00 20060101ALI20071213BHEP

Ipc: C12P 7/62 20060101ALI20071213BHEP

Ipc: C12P 7/00 20060101ALI20071213BHEP

Ipc: C12P 1/00 20060101ALI20071213BHEP

Ipc: C07H 21/02 20060101ALI20071213BHEP

Ipc: C12N 15/00 20060101ALI20071213BHEP

Ipc: C12N 1/20 20060101ALI20071213BHEP

Ipc: C12N 9/78 20060101ALI20071213BHEP

Ipc: C12N 9/00 20060101AFI20071213BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20080508

17Q First examination report despatched

Effective date: 20081111

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20090526