EP1569664A4 - Poly(ortho esters) bioerodables prepares a partir de di(cetene acetals) a base de dioxane et copolymeres sequences contenant ceux-ci - Google Patents

Poly(ortho esters) bioerodables prepares a partir de di(cetene acetals) a base de dioxane et copolymeres sequences contenant ceux-ci

Info

Publication number
EP1569664A4
EP1569664A4 EP03786759A EP03786759A EP1569664A4 EP 1569664 A4 EP1569664 A4 EP 1569664A4 EP 03786759 A EP03786759 A EP 03786759A EP 03786759 A EP03786759 A EP 03786759A EP 1569664 A4 EP1569664 A4 EP 1569664A4
Authority
EP
European Patent Office
Prior art keywords
block copolymers
ortho esters
dioxane
bioerodible
ketene acetals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP03786759A
Other languages
German (de)
English (en)
Other versions
EP1569664B1 (fr
EP1569664A2 (fr
Inventor
Jorge Heller
Steven Y Ng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heron Therapeutics LLC
Original Assignee
AP Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AP Pharma Inc filed Critical AP Pharma Inc
Publication of EP1569664A2 publication Critical patent/EP1569664A2/fr
Publication of EP1569664A4 publication Critical patent/EP1569664A4/fr
Application granted granted Critical
Publication of EP1569664B1 publication Critical patent/EP1569664B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2/00—Addition polymers of aldehydes or cyclic oligomers thereof or of ketones; Addition copolymers thereof with less than 50 molar percent of other substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2/00—Addition polymers of aldehydes or cyclic oligomers thereof or of ketones; Addition copolymers thereof with less than 50 molar percent of other substances
    • C08G2/18—Copolymerisation of aldehydes or ketones
    • C08G2/24—Copolymerisation of aldehydes or ketones with acetals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G61/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G61/12—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/002—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
    • C08G2650/38—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group
    • C08G2650/42—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group containing orthoester groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polyethers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
EP03786759A 2002-11-15 2003-11-13 Poly(ortho esters) bioerodables prepares a partir de di(cetene acetals) a base de dioxane et copolymeres sequences contenant ceux-ci Expired - Lifetime EP1569664B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US298151 2002-11-15
US10/298,151 US7045589B2 (en) 2002-11-15 2002-11-15 Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
PCT/US2003/036616 WO2004046328A2 (fr) 2002-11-15 2003-11-13 Poly(ortho esters) bioerodables prepares a partir de di(cetene acetals) a base de dioxane et copolymeres sequences contenant ceux-ci

Publications (3)

Publication Number Publication Date
EP1569664A2 EP1569664A2 (fr) 2005-09-07
EP1569664A4 true EP1569664A4 (fr) 2006-11-02
EP1569664B1 EP1569664B1 (fr) 2008-02-13

Family

ID=32297370

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03786759A Expired - Lifetime EP1569664B1 (fr) 2002-11-15 2003-11-13 Poly(ortho esters) bioerodables prepares a partir de di(cetene acetals) a base de dioxane et copolymeres sequences contenant ceux-ci

Country Status (11)

Country Link
US (2) US7045589B2 (fr)
EP (1) EP1569664B1 (fr)
JP (1) JP2006506514A (fr)
KR (1) KR20050075414A (fr)
CN (1) CN1726043A (fr)
AT (1) ATE385801T1 (fr)
AU (1) AU2003295563B2 (fr)
CA (1) CA2506241A1 (fr)
DE (1) DE60319128T2 (fr)
ES (1) ES2299746T3 (fr)
WO (1) WO2004046328A2 (fr)

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US7350479B2 (en) * 2004-09-10 2008-04-01 United States Of America As Represented By The Secretary Of The Army System and method for controlling growth of aquatic plants utilizing bio-eroding means implanted in triploid grass carp
KR20070122521A (ko) * 2005-03-31 2007-12-31 에이피 파마, 인코포레이티드 Ｐｅｇ-폴리아세탈 및 ｐｅｇ-폴리아세탈-ｐｏｅ 그래프트공중합체 및 약학 조성물
US20070264339A1 (en) * 2006-05-12 2007-11-15 Ap Pharma, Inc. Base-stabilized polyorthoester formulations
US20070264338A1 (en) * 2006-05-12 2007-11-15 Shah Devang T Base-stabilized polyorthoester formulations
US20070281870A1 (en) * 2006-06-02 2007-12-06 Halliburton Energy Services, Inc. Stimuli-degradable gels
US7306040B1 (en) * 2006-06-02 2007-12-11 Halliburton Energy Services, Inc. Stimuli-degradable gels
EP2044142A2 (fr) 2006-06-29 2009-04-08 Medtronic, Inc. Polymères de poly(orthoester) et leurs procédés de préparation et d'utilisation
EP2042538A1 (fr) * 2007-09-18 2009-04-01 Nirvana's Tree House Copolymères amphiphiles et compositions contenant de tels polymères
US8940315B2 (en) * 2008-04-18 2015-01-27 Medtronic, Inc. Benzodiazepine formulation in a polyorthoester carrier
US8956642B2 (en) * 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
MX2011000629A (es) 2008-07-17 2011-04-26 Merial Ltd Formulaciones analgesicas inyectables de larga duracion para animales.
BRPI0922189A2 (pt) * 2008-12-11 2018-10-23 A P Pharma Inc "métodos para aumentar a estabilidade de poliortoésteres e suas formulações".
WO2013142152A1 (fr) * 2012-03-23 2013-09-26 Regents Of The University Of Minnesota Systèmes d'administration semi-solide
CN105358129A (zh) 2013-03-15 2016-02-24 赫伦治疗有限公司 聚原酸酯和质子惰性溶剂的组合物
KR102063027B1 (ko) 2013-10-31 2020-01-07 (주)아모레퍼시픽 캡슐화된 향기를 포함하는 조성물
JP6232280B2 (ja) * 2013-12-25 2017-11-15 株式会社ダイセル 含酸素飽和ヘテロ環を有する重合体及びその製造方法
JP2023515918A (ja) 2020-01-13 2023-04-17 デュレクト コーポレーション 不純物が低減された徐放性薬物送達システム及び関連の方法
CN113980254A (zh) * 2020-07-10 2022-01-28 南京泛太化工医药研究所 一种具有酸敏感降解、温敏性质的系列聚合物及其载药组合物

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Also Published As

Publication number Publication date
KR20050075414A (ko) 2005-07-20
JP2006506514A (ja) 2006-02-23
CN1726043A (zh) 2006-01-25
AU2003295563A1 (en) 2004-06-15
ES2299746T3 (es) 2008-06-01
DE60319128T2 (de) 2009-02-05
WO2004046328A3 (fr) 2004-08-26
EP1569664B1 (fr) 2008-02-13
US20040096506A1 (en) 2004-05-20
AU2003295563B2 (en) 2009-01-08
CA2506241A1 (fr) 2004-06-03
ATE385801T1 (de) 2008-03-15
US7163694B2 (en) 2007-01-16
US7045589B2 (en) 2006-05-16
WO2004046328A2 (fr) 2004-06-03
DE60319128D1 (de) 2008-03-27
EP1569664A2 (fr) 2005-09-07
US20060155101A1 (en) 2006-07-13

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