EP1551541A1 - Disposable mixer and homogeniser - Google Patents

Disposable mixer and homogeniser

Info

Publication number
EP1551541A1
EP1551541A1 EP03753192A EP03753192A EP1551541A1 EP 1551541 A1 EP1551541 A1 EP 1551541A1 EP 03753192 A EP03753192 A EP 03753192A EP 03753192 A EP03753192 A EP 03753192A EP 1551541 A1 EP1551541 A1 EP 1551541A1
Authority
EP
European Patent Office
Prior art keywords
laboratory test
test vessel
lid
cutting
disposable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP03753192A
Other languages
German (de)
French (fr)
Other versions
EP1551541B1 (en
Inventor
Franz G. Bucher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Miltenyi Biotec Swiss AG
Original Assignee
Medic Tools AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medic Tools AG filed Critical Medic Tools AG
Publication of EP1551541A1 publication Critical patent/EP1551541A1/en
Application granted granted Critical
Publication of EP1551541B1 publication Critical patent/EP1551541B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
    • B01F27/272—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed axially between the surfaces of the rotor and the stator, e.g. the stator rotor system formed by conical or cylindrical surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/83—Mixing plants specially adapted for mixing in combination with disintegrating operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
    • B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
    • B02C18/08—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives within vertical containers
    • B02C18/12—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives within vertical containers with drive arranged below container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
    • B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
    • B02C18/16—Details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
    • B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
    • B02C18/16—Details
    • B02C18/18—Knives; Mountings thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C19/00—Other disintegrating devices or methods
    • B02C19/0056—Other disintegrating devices or methods specially adapted for specific materials not otherwise provided for
    • B02C19/0075—Other disintegrating devices or methods specially adapted for specific materials not otherwise provided for specially adapted for disintegrating medical waste
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
    • B01F27/272—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed axially between the surfaces of the rotor and the stator, e.g. the stator rotor system formed by conical or cylindrical surfaces
    • B01F27/2721—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed axially between the surfaces of the rotor and the stator, e.g. the stator rotor system formed by conical or cylindrical surfaces provided with intermeshing elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/836—Mixing plants; Combinations of mixers combining mixing with other treatments
    • B01F33/8361—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating
    • B01F33/83611—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating by cutting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/60—Safety arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/08—Ergonomic or safety aspects of handling devices
    • B01L2200/082—Handling hazardous material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
    • B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
    • B02C18/16—Details
    • B02C18/18—Knives; Mountings thereof
    • B02C2018/188—Stationary counter-knives; Mountings thereof

Definitions

  • the invention relates to a device for mixing and homogenizing materials, in particular infectious or smelly or chemically aggressive materials, in a laboratory test vessel.
  • Magnetic stirrers and mechanical stirrers are generally known and used in laboratory operations. When crushing infectious tissue fragments in non-hermetically sealed containers, there is a high risk of infection due to uncontrolled splashes that can escape through the opening of the laboratory test vessel, through unintentional tipping over of the laboratory test vessel and through the use of reusable mixers. This is particularly the case with test tubes and mixers known for this.
  • the cover is provided with the at the same time the laboratory test vessel is hermetically sealed and materials in the laboratory test vessel are processed, in particular mixed and homogenized, the occupational safety of the user performing the processing is significantly increased.
  • a complete homogenization of the tissue fragments can thus be achieved in a safe manner by hermetically sealing the laboratory test vessel.
  • a pierceable membrane allows the homogenate or mixed material to be diluted or removed by means of a pipetting needle or disposable tip without removing the disposable lid from the laboratory test vessel, or analyzed by means of a sensor or tempered by means of a heating or cooling rod, without the lid having to be removed from the laboratory test vessel.
  • the lid is advantageously designed as a disposable lid, so that it is disposed of immediately after use and thus contamination during further work in the laboratory is reliably avoided.
  • FIG. 1 shows a schematic top view of the one-way cover
  • Fig. 2 is a schematic partially sectioned side
  • FIG. 3 a schematic partially sectioned side view of the hollow axis
  • FIG. 4 a schematic partially sectioned top view of the hollow axis
  • FIG. 5 a schematic top view of the stirring element with the cutting knife and squeezing elements which pierceable membrane and a labyrinth
  • Fig. 6 is a schematic partially sectioned side
  • Fig. 7 is a schematic plan view of the retaining sleeve with squeeze grooves
  • Fig. 8 is a schematic partially sectioned side view of the retaining sleeve with squeeze grooves
  • Fig. 9 is a schematic partially sectioned side
  • FIG. 1 shows a schematic top view
  • FIG. 9 shows a schematic, partially sectioned side view of the disposable lid 10.
  • the interior of a cylindrical laboratory test vessel 70 with a conically tapering tip 72 is filled with the materials 71 to be mixed or homogenized.
  • the laboratory test vessel 70 is then closed with the disposable screw cap 10 or the disposable snap cap 10 and then turned upside down.
  • a stirring element 30 with a radial coarse cutting knife 31, three pairs of center crushers 33 and three fine crushers triplets made of plastic or metal are provided the cutting edges of the grooves 41, 43, 45 of the retaining sleeve 40 are guided past.
  • This stirring element 30 is driven with the aid of the hollow axis 50 from outside the laboratory test vessel 70 by an external six-point quick coupling bolt.
  • the laboratory test vessel 70 with the to be mixed and homogenized The materials are placed in a non-positive manner on the external six-point quick coupling bolt of an external drive when the vessel position is upside down as shown in FIG. 9.
  • the substances and liquids 71 located in the interior of the laboratory test vessel 70 are mixed in three phases by the coarse cutting knife 31, the three pairs of central squeezers 33 and the three fine squirrel triplets 35 on the grooves 41, 43, 45 of the retaining sleeve 40 , homogenized and redirected upwards.
  • the hydraulic labyrinth lip seal 22, 36 which also comprises three ring-shaped, interlocking axial grooves and cams, prevents the liquid 71 from escaping.
  • the speed of rotation is defined in a material-specific manner for optimum homogenization.
  • the number of processing elements 31, 33 and 35 (1, 2, 3 etc.) can be freely selected, the number of which the person skilled in the art also determines by the height and the type of cutting edges selected.
  • the hydraulic labyrinth lip seal 22, 36 in the lid 10 hermetically seals the material 71 inside the laboratory test vessel 70 both in the idle state and during the rotational movement of the stirring element 30 and thereby prevents contamination with the surroundings and the escape of aerosols , during and after mixing or homogenizing.
  • FIG. 2 shows a schematic, partially sectioned side view of the threaded body 20.
  • the double-start thread 21 is used to easily hold the laboratory test vessel 70.
  • the sealing lip 24 provides additional security against the leakage of the liquid 71. Twelve lateral grooves 25 prevent the threaded body from rotating when the hollow shaft 50 is driven.
  • FIG. 3 shows a schematic partially sectioned side view of the hollow body 50 and FIG. 4 shows a schematic partially sectioned top view of the hollow body 50.
  • Six axial notches 52 take over the torque from the external six-point quick coupling bolt in a force-locking manner.
  • the hollow body 50 is force-fitted into the stirring element 30.
  • FIG. 5 shows a schematic top view of the stirring element 30
  • FIG. 6 shows a partially sectioned view of the stirring element 30.
  • the membrane 32 enables a pipetting needle, a disposable tip, a sensor or a heating / cooling component to be carried out in the upright laboratory test vessel 70 without having to remove the disposable lid 10 from the laboratory test vessel 70. This greatly minimizes possible contamination and aerosols.
  • the laboratory test vessel 70 With a snap lid in the opening 54 shown in FIG. 3 of the hollow body 50, the laboratory test vessel 70 can be hermetically closed again after the membrane 32 has been pierced.
  • the central arrangement of the feedthrough or hollow axis 53 is advantageous here.
  • the stirring element 30, together with the retaining sleeve 40 enables homogenization in three phases.
  • the radial coarse cutting knife 31, together with the grooves 41 in the retaining sleeve 40 in FIG. 8 cuts the mix into coarse fragments.
  • the three radial pairs of central crushers 33 further crush the mixed material with the aid of the grooves 43.
  • the fine squirrel triplets 35 together with the grooves 45 homogenize the mix to form the actual homogenate.
  • FIG. 7 shows a schematic top view of the retaining sleeve 40 and FIG. 8 shows a partially sectioned side view of the retaining sleeve 40.
  • the pairs of cams 41 and 42 are offset radially and axially so that the retaining sleeve 40 is inserted into the one-way cover 10 at all times or can be removed from the disposable cover 10.
  • the grooves 41, 43, 45 in the cams 42, 44 and the cams 42, 44 themselves serve to hold back, pinch, cut and crush the mixture 71 in the upright laboratory test vessel 70 and rotating stirring element 30.
  • the mix 71 is mixed, extracted or slurried more gently when the stirring element 30 is rotating.
  • sensor lines can be passed through the threaded body 20, which have electrical connections on the outward-facing side.
  • a sensor can thus be arranged in a simple manner in the region 27 of the material 71 to be processed during the mixing.
  • a light guide can also be introduced or a feed line which forms a heating element or a Peltier element in region 27.
  • About the Thermally conductive drive shaft 50 can introduce thermal energy into the laboratory test vessel 70 or can be dissipated to the outside thereof.
  • the speed profile of the stirring element 30 in the sample test vessel 70 and the mixing time play a decisive role in achieving a desired mixing or homogenization. All forms of speed accelerations and decelerations as well as ultrasonic waves can be supplied to the stirring element 30 via the coupling element 50.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Environmental & Geological Engineering (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Accessories For Mixers (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Liquid Crystal Substances (AREA)
  • Mechanical Pencils And Projecting And Retracting Systems Therefor, And Multi-System Writing Instruments (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention relates to a device for the mixing, homogenizing, extraction, or slurrying of materials, in particular infectious, or malodorous or chemically-aggressive materials (71) in a laboratory test vessel (70) which may be hermetically sealed with a lid (10). A stirrer element (30) is provided in the lid (10) for processing of the material (71) placed in the laboratory test vessel (70), with the stirrer element being connected to a coupling piece (50). Cutting and/or crushing elements (31; 33, 35) arranged directly adjacent to cutting edges (42, 44; 41, 43, 45) on a retainer sleeve (40), comminute the material. The stirrer element (30) is a hollow cylinder (53) and is provided with a central sealing cap (32) such that the homogenate (71) can be manually or automatically diluted or pipetted from the laboratory test vessel (70) by means of a pipette or a needle or disposable tip without removing the disposable lid (10), or analyzed with a sensor or heated or cooled by means of a heating or cooling bar.

Description

Einweg-Mischer und Homogenis tor Disposable mixer and homogenizer
Die Erfindung betrifft eine Vorrichtung zum Mischen und Homogenisieren von Materialien, insbesondere infektiösen oder über riechenden oder chemisch aggressiven Materialien, in einem La- bortestgefäss.The invention relates to a device for mixing and homogenizing materials, in particular infectious or smelly or chemically aggressive materials, in a laboratory test vessel.
Magnetrührer und mechanische Rührer sind im Laborbetrieb allgemein bekannt und gebräuchlich. Bei der Zerkleinerung von infektiösen Gewebefragmenten in nicht hermetisch abgeschlossenen Ge- fassen besteht eine grosse Infektionsgefahr durch unkontrollierte Spritzer, die durch die Öffnung des Labortestgefässes nach aussen dringen können, durch unbeabsichtigtes Umkippen des Labortestgefässes und durch die Verwendung von Mehrwegmixern. Dies ist insbesondere bei Reagenzgläsern und hierfür bekannte Mischer der Fall.Magnetic stirrers and mechanical stirrers are generally known and used in laboratory operations. When crushing infectious tissue fragments in non-hermetically sealed containers, there is a high risk of infection due to uncontrolled splashes that can escape through the opening of the laboratory test vessel, through unintentional tipping over of the laboratory test vessel and through the use of reusable mixers. This is particularly the case with test tubes and mixers known for this.
Ausgehend von diesem Stand der Technik ist es Aufgabe der vorliegenden Erfindung, eine Vorrichtung der eingangs genannten Art zu schaffen, der eine hermetische Verschliessung des Labortest- gefässes und eine vollständige Durchmischung und Homogenisation von mischbaren Stoffen und Flüssigkeiten erlaubt und eine Entnahme der Mischung und des Homogenats oder eine Zugabe von Flüssigkeiten ohne Entfernung der Vorrichtung erlaubt .Starting from this prior art, it is an object of the present invention to provide a device of the type mentioned at the outset which permits hermetic sealing of the laboratory test vessel and complete mixing and homogenization of miscible substances and liquids and removal of the mixture and the homogenate or adding liquids without removing the device.
Diese Aufgabe wird erfindungsgemäss mit einer Vorrichtung mit den Merkmalen des Anspruchs 1 gelöst .According to the invention, this object is achieved with a device having the features of claim 1.
Dadurch, dass der Deckel vorgesehen ist, mit dem gleichzeitig das Labortestgefass hermetisch verschlossen wird und in dem Labortestgefass befindliche Materialien verarbeitet werden, insbesondere gemischt und homogenisiert, wird die Arbeitssicherheit des die Verarbeitung vornehmenden Benutzers wesentlich erhöht.In that the cover is provided with the at the same time the laboratory test vessel is hermetically sealed and materials in the laboratory test vessel are processed, in particular mixed and homogenized, the occupational safety of the user performing the processing is significantly increased.
Damit sind auch infektiöse Gewebefragmente in sicherer Weise behandelbar. Durch die hermetische Verschliessung des Labortestge- fässes kann so in sicherer Weise eine vollständige Homogenisierung der Gewebefragmente erreicht werden. Eine durchstechbare Membrane lässt es zu, dass das Homogenat oder Mischgut mittels Pipettiernadel oder Disposable Tip ohne Entfernung des Einwegdeckels vom Labortestgefass verdünnt oder entnommen oder mittels Sensor analysiert oder mittels Heiz- oder Kühlstab temperiert werden kann, ohne dass der Deckel vom Labortestgefass entfernt werden muss.Infectious tissue fragments can thus be treated safely. A complete homogenization of the tissue fragments can thus be achieved in a safe manner by hermetically sealing the laboratory test vessel. A pierceable membrane allows the homogenate or mixed material to be diluted or removed by means of a pipetting needle or disposable tip without removing the disposable lid from the laboratory test vessel, or analyzed by means of a sensor or tempered by means of a heating or cooling rod, without the lid having to be removed from the laboratory test vessel.
Vorteilhafterweise ist der Deckel als Einwegdeckel ausgestaltet, so dass er direkt nach Gebrauch entsorgt wird und somit eine Kontamination bei der weiteren Arbeit im Labor sicher vermieden wird.The lid is advantageously designed as a disposable lid, so that it is disposed of immediately after use and thus contamination during further work in the laboratory is reliably avoided.
Die Erfindung wird nachfolgend an verschiedenen Ausführungsbeispielen unter Bezugnahme auf die beigefügten Zeichnungen näher erläutert. Es zeigen: Fig. 1 eine schematische Draufsicht auf den Einwegdeckel,The invention is explained in more detail below using various exemplary embodiments with reference to the accompanying drawings. 1 shows a schematic top view of the one-way cover,
Fig. 2 eine schematische teilweise geschnittene seitlicheFig. 2 is a schematic partially sectioned side
Ansicht des Gewindekörpers, Fig. 3 eine schematische teilweise geschnittene seitliche Ansicht der Hohlachse, Fig. 4 eine schematische teilweise geschnittene Draufsicht auf die Hohlachse, Fig. 5 eine schematische Draufsicht auf das Rührelement mit den Schneidmesser- und Quetschelementen, die durch- stechbaren Membrane und einer Labyrinth-3 a schematic partially sectioned side view of the hollow axis, FIG. 4 a schematic partially sectioned top view of the hollow axis, FIG. 5 a schematic top view of the stirring element with the cutting knife and squeezing elements which pierceable membrane and a labyrinth
Lippendichtung, Fig. 6 eine schematische teilweise geschnittene seitlicheLip seal, Fig. 6 is a schematic partially sectioned side
Ansicht des Rührelementes mit den Schneidmesser- und Quetschelementen, der durchstechbaren Membrane und einer Labyrinth-Lippendichtung, Fig. 7 eine schematische Draufsicht auf die Rückhaltehülse mit Quetschnuten, Fig. 8 eine schematische teilweise geschnittene seitliche Ansicht der Rückhaltehülse mit Quetschnuten,View of the stirring element with the cutting knife and squeeze elements, the pierceable membrane and a labyrinth lip seal, Fig. 7 is a schematic plan view of the retaining sleeve with squeeze grooves, Fig. 8 is a schematic partially sectioned side view of the retaining sleeve with squeeze grooves,
Fig. 9 eine schematische teilweise geschnittene seitlicheFig. 9 is a schematic partially sectioned side
Ansicht des Einwegdeckels.View of the one-way cover.
Die Fig. 1 zeigt eine schematische Draufsicht und Fig. 9 eine schematische teilweise geschnittene seitliche Ansicht des Einwegdeckels 10. Das Innere eines zylindrischen Labortestgefasses 70 mit konisch zulaufender Spitze 72 wird mit den zu mischenden oder homogenisierenden Materialien 71 gefüllt. Anschliessend wird das Labortestgefass 70 mit dem Einweg- Schraubverschlussdeckel 10 oder der Einweg-Schnappkappe (Snap- Cap) 10 verschlossen und dann auf den Kopf gestellt.FIG. 1 shows a schematic top view and FIG. 9 shows a schematic, partially sectioned side view of the disposable lid 10. The interior of a cylindrical laboratory test vessel 70 with a conically tapering tip 72 is filled with the materials 71 to be mixed or homogenized. The laboratory test vessel 70 is then closed with the disposable screw cap 10 or the disposable snap cap 10 and then turned upside down.
Im Einweg-Schraubverschlussdeckel 10 oder in der Einweg- Schnappkappe (Snap-Cap) 10 des hermetisch abdichtbaren Labor- testgefässes 70 ist ein Rührelement 30 mit einem radialen Grobschneidmesser 31, drei Mittelquetschpaare 33 und drei Feinquet- scherdrillinge aus Kunststoff oder Metall vorgesehen, die an den schneidenden Kanten der Nuten 41, 43, 45 der Rückhaltehülse 40 vorbeigeführt werden Dieses Rührelement 30 wird mit Hilfe der Hohlachse 50 von ausserhalb des Labortestgefasses 70 von einem externen Sechspunkte-Schnellkupplungsbolzen angetrieben.In the disposable screw cap 10 or in the disposable snap cap 10 of the hermetically sealable laboratory test vessel 70, a stirring element 30 with a radial coarse cutting knife 31, three pairs of center crushers 33 and three fine crushers triplets made of plastic or metal are provided the cutting edges of the grooves 41, 43, 45 of the retaining sleeve 40 are guided past. This stirring element 30 is driven with the aid of the hollow axis 50 from outside the laboratory test vessel 70 by an external six-point quick coupling bolt.
Das Labortestgefass 70 mit den zu mischenden und homogenisieren- den Materialien wird bei kopfstehender Gefässstellung entsprechend Fig. 9 kraftschlüssig auf den externen Sechspunkte- Schnellkupplungsbolzen eines externen Antriebs gestellt . Durch die übertragene Drehbewegung werden die sich im Innenraum des Labortestgefasses 70 befindlichen Stoffe und Flüssigkeiten 71 in drei Phasen durch das Grobschneidemesser 31, die drei Mittel- quetscherpaare 33 und die drei Feinquetscherdrillinge 35 an den Nuten 41, 43, 45 der Rückhaltehülse 40 zerquetscht, vermischt, homogenisiert und nach oben umlenkt. Die hydraulische Labyrinth- lippendichtung 22, 36, bestehend auch drei ringförmigen, ineinanderlaufenden axialen Nuten und Nocken, verhindert das Auslaufen der Flüssigkeit 71. Die Drehzahl ist materialspezifisch für eine optimale Homogenisierung festgelegt. Die Anzahl der Bearbeitungselemente 31, 33 und 35 (1, 2, 3 etc.) ist frei wählbar, wobei der Fachmann deren Anzahl unter anderem auch durch die Bauhöhe und die Art der gewählten Schneiden festlegt .The laboratory test vessel 70 with the to be mixed and homogenized The materials are placed in a non-positive manner on the external six-point quick coupling bolt of an external drive when the vessel position is upside down as shown in FIG. 9. As a result of the transferred rotary movement, the substances and liquids 71 located in the interior of the laboratory test vessel 70 are mixed in three phases by the coarse cutting knife 31, the three pairs of central squeezers 33 and the three fine squirrel triplets 35 on the grooves 41, 43, 45 of the retaining sleeve 40 , homogenized and redirected upwards. The hydraulic labyrinth lip seal 22, 36, which also comprises three ring-shaped, interlocking axial grooves and cams, prevents the liquid 71 from escaping. The speed of rotation is defined in a material-specific manner for optimum homogenization. The number of processing elements 31, 33 and 35 (1, 2, 3 etc.) can be freely selected, the number of which the person skilled in the art also determines by the height and the type of cutting edges selected.
Die hydraulische Labyrinthlippendichtung 22, 36 im Deckel 10 dichtet das Material 71 im Inneren des Labortestgefasses 70 so- wohl im Ruhezustand wie auch während der Drehbewegung des Rührelementes 30 hermetisch gegen die Umgebung ab und verhindert dadurch eine Kontamination mit der Umgebung und das Austreten von Aerosolen vor, während und nach dem Mischen oder Homogenisieren.The hydraulic labyrinth lip seal 22, 36 in the lid 10 hermetically seals the material 71 inside the laboratory test vessel 70 both in the idle state and during the rotational movement of the stirring element 30 and thereby prevents contamination with the surroundings and the escape of aerosols , during and after mixing or homogenizing.
Anstelle des Einsatzes der in dem dargestellten Ausführungsbeispiel gezeigten hydraulischen Labyrinthlippendichtung 22, 36 ist es ebenso möglich, eine einfache Gummidichtung, beispielsweise in Gestalt eines Dichtringes, oder einen anderen dem Fachmann geläufigen Dichtungstyp zur Abdichtung des Labortestgefasses 70 nach Aussen zu verwenden.Instead of using the hydraulic labyrinth lip seal 22, 36 shown in the exemplary embodiment shown, it is also possible to use a simple rubber seal, for example in the form of a sealing ring, or another type of seal familiar to the person skilled in the art for sealing the laboratory test vessel 70 to the outside.
Die Fig. 2 zeigt eine schematische teilweise geschnittene seitliche Ansicht des Gewindekörpers 20. Das doppelgängige Gewinde 21 dient zur einfachen Aufnahme des Labortestgefasses 70. Die Dichtlippe 24 gewährt eine zusätzliche Sicherheit gegen das Auslaufen der Flüssigkeit 71. Zwölf seitliche Nuten 25 verhindern, dass sich der Gewindekörper während des Antriebs der Hohlachse 50 mitdreht.2 shows a schematic, partially sectioned side view of the threaded body 20. The double-start thread 21 is used to easily hold the laboratory test vessel 70. The sealing lip 24 provides additional security against the leakage of the liquid 71. Twelve lateral grooves 25 prevent the threaded body from rotating when the hollow shaft 50 is driven.
Die Fig. 3 zeigt eine schematische teilweise geschnittene seitliche Ansicht des Hohlkörpers 50 und die Fig. 4 zeigt eine schematische teilweise geschnittene Draufsicht des Hohlkörpers 50. Sechs axiale Kerben 52 übernehmen vom externen Sechspunkte- Schnellkupplungsbolzen kraftschlüssig das Drehmoment. Der Hohlkörper 50 wird in das Rührelement 30 kraftschlüssig eingepresst.FIG. 3 shows a schematic partially sectioned side view of the hollow body 50 and FIG. 4 shows a schematic partially sectioned top view of the hollow body 50. Six axial notches 52 take over the torque from the external six-point quick coupling bolt in a force-locking manner. The hollow body 50 is force-fitted into the stirring element 30.
Die Fig. 5 zeigt eine schematische Draufsicht des Rührelements 30 und die Fig. 6 zeigt eine teilweise geschnittene Ansicht des Rührelements 30. Die Membrane 32 ermöglicht beim aufrechtstehenden Labortestgefass 70 die Durchführung einer Pipettiernadel, eines Disposable Tips, eines Messfühlers oder einer Heiz- /Kühlkomponente, ohne dass der Einwegdeckel 10 vom Labortestge- fäss 70 entfernt werden muss. Dadurch werden mögliche Kontaminationen und Aerosole stark minimiert . Mit einem Snapdeckel in die in Fig. 3 dargestellte Öffnung 54 des Hohlkörpers 50 lässt sich das Labortestgefass 70 nach erfolgter Durchstechung der Membrane 32 wieder hermetisch schliessen. Vorteilhaft ist hierbei die zentrale Anordnung der Durchführung oder Hohlachse 53. Diese gestattet die hermetische Verschliessung auch dadurch, dass zentral beim Rotieren der Membran 32 auf diesen Mittelteil nur geringe Fliehkräfte wirken, die eine seitliche Membran deformieren und damit undicht machen könnten. Sofern die Membrane 32 durchstochen oder durchbrochen ist, kann auch vorgesehen sein, dass ein Snapdeckel aus Kunststoff oder Metall im Bereich 54 den Deckel 10 wieder hermetisch verschliesst . Das Rührelement 30 ermöglicht zusammen mit der Rückhaltehülse 40 die Homogenisation in drei Phasen. In der ersten Phase schneidet das radiale Grobschneidemesser 31 zusammen mit den Nuten 41 in der Rückhaltehülse 40 in Fig. 8 das Mischgut in grobe Fragmente. In einer zweiten Phase zerkleinern die drei radialen Mittelquetscherpaare 33 das Mischgut unter Mithilfe der Nuten 43 weiter. In der letzten Phase homogenisieren die Feinquetscherdrillinge 35 zusammen mit den Nuten 45 das Mischgut zum eigentlichen Homogenat .FIG. 5 shows a schematic top view of the stirring element 30 and FIG. 6 shows a partially sectioned view of the stirring element 30. The membrane 32 enables a pipetting needle, a disposable tip, a sensor or a heating / cooling component to be carried out in the upright laboratory test vessel 70 without having to remove the disposable lid 10 from the laboratory test vessel 70. This greatly minimizes possible contamination and aerosols. With a snap lid in the opening 54 shown in FIG. 3 of the hollow body 50, the laboratory test vessel 70 can be hermetically closed again after the membrane 32 has been pierced. The central arrangement of the feedthrough or hollow axis 53 is advantageous here. This also permits hermetic sealing by the fact that, when the membrane 32 rotates, only slight centrifugal forces act on this central part, which could deform a lateral membrane and thus make it leaky. If the membrane 32 is pierced or perforated, it can also be provided that a snap lid made of plastic or metal in the area 54 hermetically seals the lid 10 again. The stirring element 30, together with the retaining sleeve 40, enables homogenization in three phases. In the first phase, the radial coarse cutting knife 31, together with the grooves 41 in the retaining sleeve 40 in FIG. 8, cuts the mix into coarse fragments. In a second phase, the three radial pairs of central crushers 33 further crush the mixed material with the aid of the grooves 43. In the last phase, the fine squirrel triplets 35 together with the grooves 45 homogenize the mix to form the actual homogenate.
Die Fig. 7 zeigt eine schematische Draufsicht auf die Rückhaltehülse 40 und die Fig. 8 zeigt eine teilweise geschnittene seitliche Ansicht der Rückhaltehülse 40. Die Nockenpaare 41 und 42 sind radial und axial so versetzt, dass sich die Rückhaltehülse 40 jederzeit in den Einwegdeckel 10 einstecken oder aus dem Einwegdeckel 10 entfernen lässt. Die Nuten 41, 43, 45 in den Nocken 42, 44 und die Nocken 42, 44 selbst dienen dazu, das Mischgut 71 im kopfstehenden Labortestgefass 70 und drehenden Rührelement 30 zurück zu halten, einzuklemmen, zu zerschneiden und zerquet- sehen. Durch das Entfernen der Rückhaltehülse 40 aus dem Einwegdeckel 10 wird das Mischgut 71 bei drehendem Rührelement 30 schonender gemischt, extrahiert oder aufgeschlämmt .FIG. 7 shows a schematic top view of the retaining sleeve 40 and FIG. 8 shows a partially sectioned side view of the retaining sleeve 40. The pairs of cams 41 and 42 are offset radially and axially so that the retaining sleeve 40 is inserted into the one-way cover 10 at all times or can be removed from the disposable cover 10. The grooves 41, 43, 45 in the cams 42, 44 and the cams 42, 44 themselves serve to hold back, pinch, cut and crush the mixture 71 in the upright laboratory test vessel 70 and rotating stirring element 30. By removing the retaining sleeve 40 from the one-way cover 10, the mix 71 is mixed, extracted or slurried more gently when the stirring element 30 is rotating.
In den Zeichnungen nicht dargestellt sind folgende Merkmale, die in der dargestellten Ausführungsform des Einwegdeckels 10 aufgenommen werden können. In Fig. 9 im Bereicht 29 können Sensorleitungen durch den Gewindekörper 20 durchgeführt werden, die auf der nach aussen weisenden Seite über elektrische Verbindungen verfügen. Somit kann in einfacher Weise ein Sensor während des Mischens im Bereich 27 des zu bearbeitenden Materials 71 angeordnet werden. Anstelle von Sensorleitungen kann auch ein Lichtleiter eingeführt werden oder eine Zuleitung, welche im Bereich 27 ein Heizkörper oder ein Peltierelement ausbildet. Über die wärmeleitende Antriebsachse 50 kann Wärmeenergie in das Labortestgefass 70 eingeführt oder aus diesem nach aussen abgeleitet werden. Für die Erzielung einer gewünschten Vermischung oder Homogenisation spielen das Drehzahlprofil des Rührelements 30 im Probentestgefass 70 und die Mischdauer eine entscheidende Rolle. Über das Kupplungselement 50 können alle Formen der Drehzahlbeschleunigungen und -Verzögerungen sowie Ultraschallwellen auf das Rührelement 30 zugeführt werden. The following features, which can be included in the illustrated embodiment of the disposable cover 10, are not shown in the drawings. 9 in area 29, sensor lines can be passed through the threaded body 20, which have electrical connections on the outward-facing side. A sensor can thus be arranged in a simple manner in the region 27 of the material 71 to be processed during the mixing. Instead of sensor lines, a light guide can also be introduced or a feed line which forms a heating element or a Peltier element in region 27. About the Thermally conductive drive shaft 50 can introduce thermal energy into the laboratory test vessel 70 or can be dissipated to the outside thereof. The speed profile of the stirring element 30 in the sample test vessel 70 and the mixing time play a decisive role in achieving a desired mixing or homogenization. All forms of speed accelerations and decelerations as well as ultrasonic waves can be supplied to the stirring element 30 via the coupling element 50.

Claims

Patentansprüche claims
1. Vorrichtung zum Mischen, Homogenisieren, Extrahieren, Aufschlämmen von Materialen, insbesondere infektiösen oder übel riechenden oder chemisch aggressiven Materialien (71) , in einem Labortestgefass (70) , das mit einem Deckel (10) hermetisch ver- schliessbar ist, wobei in dem Deckel (10) zur Bearbeitung des in das Labortestgefass (70) einbringbaren Materials (71) ein Rühr- element (30) vorgesehen ist, das mit einem Kupplungsstück (50) verbunden ist, und wobei das sich um die Längsachse des Labortestgefasses (70) drehende Rührelement (30) mit Schneid- und/oder Quetschelementen (31; 33, 35) versehen ist, welche in unmittelbarer Nähe zu Schneidkanten (42, 44; 41, 43, 45) einer Rückhaltehülse (40) angeordnet ist, dadurch gekennzeichnet, dass das Rührelement (30) hohlzylindrisch (53) ist und mit einer zentrischen Abschlusskappe (32) versehen ist.1. Device for mixing, homogenizing, extracting, slurrying materials, in particular infectious or malodorous or chemically aggressive materials (71), in a laboratory test vessel (70), which can be hermetically sealed with a lid (10), in which Cover (10) for processing the material (71) which can be introduced into the laboratory test vessel (70), a stirring element (30) is provided which is connected to a coupling piece (50) and which extends around the longitudinal axis of the laboratory test vessel (70). rotating stirring element (30) is provided with cutting and / or crushing elements (31; 33, 35) which is arranged in the immediate vicinity of cutting edges (42, 44; 41, 43, 45) of a retaining sleeve (40), characterized in that that the stirring element (30) is hollow cylindrical (53) and is provided with a central end cap (32).
2. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass die zentrische Abschlusskappe (32) eine durchstechbare oder durchbrechbare Membrane (32) ist.2. Device according to claim 1, characterized in that the central end cap (32) is a pierceable or breakable membrane (32).
3. Vorrichtung nach Anspruch 1 oder 2 , dadurch gekennzeichnet, dass die Schneid- und/oder Quetschelemente Grobschneidemes- ser (31) und Quetscher (33, 35) umfasst, die in unmittelbarer Nähe zu den Schneidkanten angeordnet sind, die durch Nocken (42, 44) und Nuten (41, 43, 45) gebildet werden, wobei die Schneid- und/oder Quetschelemente insbesondere aus Kunststoff oder Metall bestehen.3. Device according to claim 1 or 2, characterized in that the cutting and / or squeezing elements comprises coarse cutting knives (31) and squeezers (33, 35) which are arranged in close proximity to the cutting edges which are formed by cams (42 , 44) and grooves (41, 43, 45) are formed, the cutting and / or squeezing elements in particular made of plastic or metal.
4. Vorrichtung nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, dass die Rückhaltehülse (40) als aufsteckbares oder entfernbares, innen offenes Zusatzelement vorgesehen ist. 4. Device according to one of claims 1 to 3, characterized in that the retaining sleeve (40) is provided as an attachable or removable, internally open additional element.
5. Vorrichtung nach einem der Ansprüche 1 bis 4, dadurch gekennzeichnet, dass der Deckel ein Einwegdeckel (10) ist und/oder dass er einen Schraubverschluss oder einen Schnappverschluss aufweist, der zu einem entsprechenden Element an dem Labortestgefass (70) komplementär ist.5. Device according to one of claims 1 to 4, characterized in that the lid is a disposable lid (10) and / or that it has a screw cap or a snap closure which is complementary to a corresponding element on the laboratory test vessel (70).
6. Vorrichtung nach einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, dass die Labortestgefässe (70) zylindrisch oder quaderförmig sind und/oder dass die Labortestgefässe (70) aus Kunststoff oder Glas bestehen.6. Device according to one of claims 1 to 5, characterized in that the laboratory test vessels (70) are cylindrical or cuboid and / or that the laboratory test vessels (70) consist of plastic or glass.
7. Vorrichtung nach einem der Ansprüche 1 bis 6, dadurch gekennzeichnet, dass die Bearbeitung des Materials (71) dessen Zerquetschung, Mischung, -Homogenisierung, Extraktion und Auf- schlämmung umfasst.7. Device according to one of claims 1 to 6, characterized in that the processing of the material (71) comprises its crushing, mixing, homogenization, extraction and slurry.
8. Vorrichtung nach einem der Ansprüche 1 bis 7, dadurch gekennzeichnet, dass der Deckel (10) über einen Gummidichtring, eine Spanndichtung oder eine hydraulische Labyrinthlippendichtung (22, 36) zum hermetischen Verschluss zwischen dem Gefässin- neren (71) des Labortestgefasses (70) und der äusseren Umgebung verfügt .8. Device according to one of claims 1 to 7, characterized in that the lid (10) via a rubber sealing ring, a tension seal or a hydraulic labyrinth lip seal (22, 36) for hermetic sealing between the interior of the vessel (71) of the laboratory test vessel (70 ) and the outside environment.
9. Vorrichtung nach einem der Ansprüche 1 bis 8, dadurch gekennzeichnet, dass das Kupplungsstück (50) hohl ausgestaltet ist und/oder dass es ein Innen-Sechspunkte-Schnellkupplungsring (50) ist, so dass Rotationsenergie von aussen mechanisch zuführbar ist.9. Device according to one of claims 1 to 8, characterized in that the coupling piece (50) is hollow and / or that it is an internal six-point quick coupling ring (50), so that rotational energy can be mechanically supplied from the outside.
10. Vorrichtung nach einem der Ansprüche 1 bis 9, dadurch gekennzeichnet, dass über die wärmeleitende Antriebsachse Wärmeenergie in das Labortestgefass (70) einführbar oder aus diesem nach aussen ableitbar ist.10. Device according to one of claims 1 to 9, characterized in that thermal energy can be introduced into or out of the laboratory test vessel (70) via the heat-conducting drive axis is derivable to the outside.
11. Vorrichtung nach einem der Ansprüche 1 bis 10, dadurch gekennzeichnet, dass durch den Bereich (26) im Gewindekörper (20) elektrische Leitungen oder Lichtleiter zu Sensoren oder Heiz- oder Peltierelementen im Inneren des Labortestgefasses (70) geführt werden.11. Device according to one of claims 1 to 10, characterized in that through the area (26) in the threaded body (20) electrical lines or light guides to sensors or heating or Peltier elements inside the laboratory test vessel (70) are guided.
12. Vorrichtung nach einem der Ansprüche 1 bis 11, dadurch gekennzeichnet, dass durch die durchstechbare oder durchbrechbare Membrane (32) im Einwegdeckel (10) bei aufrechtstehendem Labortestgefass (70) das Homogenat mit einem Sensor oder einem Heiz- oder Peltierelement manuell oder maschinell analysiert oder temperiert werden kann, ohne den Deckel (10) vom Labortest- gefäss (70) entfernen zu müssen.12. Device according to one of claims 1 to 11, characterized in that through the pierceable or breakable membrane (32) in the disposable cover (10) with the laboratory test vessel (70) upright, the homogenate is analyzed manually or mechanically with a sensor or a heating or Peltier element or can be tempered without having to remove the lid (10) from the laboratory test vessel (70).
13. Vorrichtung nach einem der Ansprüche 1 bis 12, dadurch gekennzeichnet, dass die durchstochene oder durchbrochene Membrane (32) im Einwegdeckel (10) mit einem Snapdeckel aus Kunst- stoff oder Metall im Bereich (54) wieder hermetisch verschlossen werden kann. 13. Device according to one of claims 1 to 12, characterized in that the pierced or perforated membrane (32) in the disposable cover (10) with a snap cover made of plastic or metal in the area (54) can be hermetically closed again.
EP03753192A 2002-10-15 2003-10-15 Disposable mixer and homogeniser Expired - Lifetime EP1551541B1 (en)

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EP1551541B1 (en) 2008-09-03
US7490976B2 (en) 2009-02-17
WO2004035191A1 (en) 2004-04-29
US20060013064A1 (en) 2006-01-19
DE50310447D1 (en) 2008-10-16

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