EP1551541B1 - Disposable mixer and homogeniser - Google Patents
Disposable mixer and homogeniser Download PDFInfo
- Publication number
- EP1551541B1 EP1551541B1 EP03753192A EP03753192A EP1551541B1 EP 1551541 B1 EP1551541 B1 EP 1551541B1 EP 03753192 A EP03753192 A EP 03753192A EP 03753192 A EP03753192 A EP 03753192A EP 1551541 B1 EP1551541 B1 EP 1551541B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- laboratory test
- cover
- test container
- cutting
- disposable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000009533 lab test Methods 0.000 claims abstract description 38
- 239000000463 material Substances 0.000 claims abstract description 18
- 238000002156 mixing Methods 0.000 claims abstract description 10
- 238000007789 sealing Methods 0.000 claims abstract description 8
- 230000008878 coupling Effects 0.000 claims abstract description 6
- 238000010168 coupling process Methods 0.000 claims abstract description 6
- 238000005859 coupling reaction Methods 0.000 claims abstract description 6
- 208000015181 infectious disease Diseases 0.000 claims abstract description 6
- 238000010438 heat treatment Methods 0.000 claims abstract description 5
- 230000002458 infectious effect Effects 0.000 claims abstract description 5
- 239000004033 plastic Substances 0.000 claims description 5
- 229920003023 plastic Polymers 0.000 claims description 5
- 239000002184 metal Substances 0.000 claims description 4
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 238000001816 cooling Methods 0.000 abstract description 3
- 238000000605 extraction Methods 0.000 abstract 1
- 238000003756 stirring Methods 0.000 description 12
- 239000012528 membrane Substances 0.000 description 8
- 239000000203 mixture Substances 0.000 description 7
- 238000000265 homogenisation Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000012634 fragment Substances 0.000 description 4
- 238000011109 contamination Methods 0.000 description 3
- 239000000443 aerosol Substances 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5082—Test tubes per se
- B01L3/50825—Closing or opening means, corks, bungs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
- B01F27/272—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed axially between the surfaces of the rotor and the stator, e.g. the stator rotor system formed by conical or cylindrical surfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/50—Movable or transportable mixing devices or plants
- B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
- B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/83—Mixing plants specially adapted for mixing in combination with disintegrating operations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
- B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
- B02C18/08—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives within vertical containers
- B02C18/12—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives within vertical containers with drive arranged below container
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
- B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
- B02C18/16—Details
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
- B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
- B02C18/16—Details
- B02C18/18—Knives; Mountings thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C19/00—Other disintegrating devices or methods
- B02C19/0056—Other disintegrating devices or methods specially adapted for specific materials not otherwise provided for
- B02C19/0075—Other disintegrating devices or methods specially adapted for specific materials not otherwise provided for specially adapted for disintegrating medical waste
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
- B01F27/272—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed axially between the surfaces of the rotor and the stator, e.g. the stator rotor system formed by conical or cylindrical surfaces
- B01F27/2721—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed axially between the surfaces of the rotor and the stator, e.g. the stator rotor system formed by conical or cylindrical surfaces provided with intermeshing elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/836—Mixing plants; Combinations of mixers combining mixing with other treatments
- B01F33/8361—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating
- B01F33/83611—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating by cutting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/60—Safety arrangements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/08—Ergonomic or safety aspects of handling devices
- B01L2200/082—Handling hazardous material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/042—Caps; Plugs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/046—Function or devices integrated in the closure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C18/00—Disintegrating by knives or other cutting or tearing members which chop material into fragments
- B02C18/06—Disintegrating by knives or other cutting or tearing members which chop material into fragments with rotating knives
- B02C18/16—Details
- B02C18/18—Knives; Mountings thereof
- B02C2018/188—Stationary counter-knives; Mountings thereof
Definitions
- the invention relates to a device for mixing and homogenizing materials, in particular infectious or smelling or chemically aggressive materials, in a laboratory test vessel.
- Magnetic stirrers and mechanical stirrers are well known and commonly used in the laboratory. When shredding infectious tissue fragments in non-hermetically sealed vessels, there is a high risk of infection due to uncontrolled splashes that can escape through the opening of the laboratory test vessel, accidental tipping over of the laboratory test vessel, and the use of reusable mixers. This is the case in particular with test tubes and mixers known therefor.
- a puncturable membrane allows the homogenate or mixture to be diluted or removed from the laboratory test vessel by means of a pipetting needle or disposable tip without removing the disposable lid or analyzed by a sensor or heated by a heating or cooling bar without having to remove the lid from the laboratory test vessel.
- the lid is designed as a disposable lid, so that it is disposed of immediately after use and thus contamination in the further work in the laboratory is safely avoided.
- the Fig. 1 shows a schematic plan view and Fig. 9 a schematic partially sectioned side view of the disposable lid 10.
- the interior of a cylindrical laboratory test tube 70 with a tapered tip 72 is filled with the materials to be mixed or homogenizing 71. Subsequently, the laboratory test vessel 70 is closed with the disposable screw cap 10 or the disposable snap cap (snap-cap) 10 and then turned upside down.
- a stirring element 30 with a radial coarse cutter 31, three Heilquetschpase 33 and three Feinquetscherdrillinge of plastic or metal provided at the cutting edges of the Grooves 41, 43, 45 of the retaining sleeve 40 are guided past this stirring element 30 is driven by means of the hollow shaft 50 from outside the laboratory test vessel 70 by an external six-point quick-release pin.
- the laboratory test vessel 70 with the mixing and homogenizing Materials will be appropriate for inverted vessel position Fig. 9 non-positively placed on the external six-point quick-release pin of an external drive. Due to the transmitted rotational movement, the substances and liquids 71 located in the interior of the laboratory test vessel 70 are mixed, mixed and homogenized in three phases by the coarse cutting knife 31, the three middle squeezer pairs 33 and the three fine squeezer wringers 35 at the grooves 41, 43, 45 of the retaining sleeve 40 and turns upwards.
- the hydraulic labyrinth lip seal 22, 36 consisting also of three annular intermeshing axial grooves and cams, prevents leakage of the liquid 71.
- the speed is material-specifically set for optimal homogenization.
- the number of processing elements 31, 33 and 35 (1, 2, 3, etc.) is arbitrary, with the expert determines their number, among other things, by the height and type of cutting selected.
- the hydraulic labyrinth lip seal 22, 36 in the lid 10 hermetically seals the material 71 in the interior of the laboratory test vessel 70 both at rest and during the rotational movement of the stirring element 30 against the environment, thereby preventing contamination with the environment and the escape of aerosols before and after mixing or homogenizing.
- the Fig. 2 shows a schematic partially sectioned side view of the threaded body 20 of the lid.
- the double thread 21 serves to easily receive the laboratory test vessel 70.
- the sealing lip 24 provides additional security against leakage of the liquid 71. Twelve lateral grooves 25 prevent the threaded body from rotating during the drive of the hollow shaft 50.
- the Fig. 3 shows a schematic partially sectioned side view of the hollow body 50 and the Fig. 4 shows a schematic partially sectioned plan view of the hollow body 50.
- Six axial notches 52 take over from the external six-point quick release bolt frictionally the torque.
- the hollow body 50 is pressed force-fit into the stirring element 30.
- the Fig. 5 shows a schematic plan view of the stirring member 30 and the Fig. 6 shows a partially sectioned view of the stirring element 30.
- the membrane 32 allows the upright laboratory test vessel 70, the implementation of a pipetting needle, a disposable tip, a probe or a heating / cooling component without the disposable lid 10 must be removed from the laboratory test vessel 70. This greatly minimizes potential contamination and aerosols.
- opening 54 of the hollow body 50 can be the laboratory test tube 70 after completing the piercing of the membrane 32 again hermetically close.
- the central arrangement of the passage or hollow shaft 53 is advantageous.
- the stirring element 30, together with the retaining sleeve 40 enables the homogenization in three phases.
- the radial coarse cutting blade 31 cuts together with the grooves 41 in the retaining sleeve 40 in Fig. 8 the mix into rough fragments.
- the three radial Mittelquetschercrue 33 crush the mix with the help of the grooves 43 on.
- the fine squeezer 35 together with the grooves 45 homogenize the mix to the actual homogenate.
- the Fig. 7 shows a schematic plan view of the retaining sleeve 40 and the Fig. 8 shows a partially sectioned side view of the retaining sleeve 40.
- the cam pairs 41 and 42 are radially and axially offset so that the retaining sleeve 40 at any time plug in the disposable lid 10 or can be removed from the disposable lid 10.
- the grooves 41, 43, 45 in the cams 42, 44 and the cams 42, 44 themselves serve to retain the mix 71 in the overhead laboratory test vessel 70 and rotating agitator 30, pinch, cut and crush.
- sensor lines may be passed through the threaded body 20 having electrical connections on the outward-facing side.
- a sensor can be easily arranged during mixing in the region 27 of the material 71 to be processed.
- a light guide can be introduced or a supply line which forms a radiator or a Peltier element in the region 27.
- heat energy can be introduced into the laboratory test vessel 70 or discharged to the outside.
- the speed profile of the stirring element 30 in the sample test vessel 70 and the mixing time play a decisive role. Via the coupling element 50, all forms of speed accelerations and decelerations as well as ultrasonic waves can be supplied to the stirring element 30.
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Environmental & Geological Engineering (AREA)
- Sampling And Sample Adjustment (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Accessories For Mixers (AREA)
- Materials For Medical Uses (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Mechanical Pencils And Projecting And Retracting Systems Therefor, And Multi-System Writing Instruments (AREA)
- Liquid Crystal Substances (AREA)
Abstract
Description
Die Erfindung betrifft eine Vorrichtung zum Mischen und Homogenisieren von Materialien, insbesondere infektiösen oder über riechenden oder chemisch aggressiven Materialien, in einem Labortestgefäss.The invention relates to a device for mixing and homogenizing materials, in particular infectious or smelling or chemically aggressive materials, in a laboratory test vessel.
Magnetrührer und mechanische Rührer sind im Laborbetrieb allgemein bekannt und gebräuchlich. Bei der Zerkleinerung von infektiösen Gewebefragmenten in nicht hermetisch abgeschlossenen Gefässen besteht eine grosse Infektionsgefahr durch unkontrollierte Spritzer, die durch die Öffnung des Labortestgefässes nach aussen dringen können, durch unbeabsichtigtes Umkippen des Labortestgefässes und durch die Verwendung von Mehrwegmixern. Dies ist insbesondere bei Reagenzgläsern und hierfür bekannte Mischer der Fall.Magnetic stirrers and mechanical stirrers are well known and commonly used in the laboratory. When shredding infectious tissue fragments in non-hermetically sealed vessels, there is a high risk of infection due to uncontrolled splashes that can escape through the opening of the laboratory test vessel, accidental tipping over of the laboratory test vessel, and the use of reusable mixers. This is the case in particular with test tubes and mixers known therefor.
Ausgehend von diesem Stand der Technik ist es Aufgabe der vorliegenden Erfindung, eine Vorrichtung der eingangs genannten Art zu schaffen, der eine hermetische Verschliessung des Labortestgefässes und eine vollständige Durchmischung und Homogenisation von mischbaren Stoffen und Flüssigkeiten erlaubt und eine Entnahme der Mischung und des Homogenats oder eine Zugabe von Flüssigkeiten ohne Entfernung der Vorrichtung erlaubt.Based on this prior art, it is an object of the present invention to provide a device of the type mentioned above, which allows a hermetic closure of the laboratory test vessel and a complete mixing and homogenization of miscible substances and liquids and a removal of the mixture and the homogenate or a Addition of liquids allowed without removal of the device.
Diese Aufgabe wird erfindungsgemäss mit einer Vorrichtung mit den Merkmalen des Anspruchs 1 gelöst.This object is achieved according to the invention with a device having the features of claim 1.
Dadurch, dass der Deckel vorgesehen ist, mit dem gleichzeitig das Labortestgefäss hermetisch verschlossen wird und in dem Labortestgefäss befindliche Materialien verarbeitet werden, insbesondere gemischt und homogenisiert, wird die Arbeitssicherheit des die Verarbeitung vornehmenden Benutzers wesentlich erhöht.The fact that the lid is provided with the same time the laboratory test vessel is hermetically sealed and processed in the laboratory test tube materials are processed, in particular mixed and homogenized, the safety of the user processing processing is substantially increased.
Damit sind auch infektiöse Gewebefragmente in sicherer Weise behandelbar. Durch die hermetische Verschliessung des Labortestgefässes kann so in sicherer Weise eine vollständige Homogenisierung der Gewebefragmente erreicht werden. Eine durchstechbare Membrane lässt es zu, dass das Homogenat oder Mischgut mittels Pipettiernadel oder Disposable Tip ohne Entfernung des Einwegdeckels vom Labortestgefäss verdünnt oder entnommen oder mittels Sensor analysiert oder mittels Heiz- oder Kühlstab temperiert werden kann, ohne dass der Deckel vom Labortestgefäss entfernt werden muss.Infectious tissue fragments can therefore also be treated safely. By hermetically sealing the laboratory test vessel, a complete homogenization of the tissue fragments can thus be achieved in a secure manner. A puncturable membrane allows the homogenate or mixture to be diluted or removed from the laboratory test vessel by means of a pipetting needle or disposable tip without removing the disposable lid or analyzed by a sensor or heated by a heating or cooling bar without having to remove the lid from the laboratory test vessel.
Vorteilhafterweise ist der Deckel als Einwegdeckel ausgestaltet, so dass er direkt nach Gebrauch entsorgt wird und somit eine Kontamination bei der weiteren Arbeit im Labor sicher vermieden wird.Advantageously, the lid is designed as a disposable lid, so that it is disposed of immediately after use and thus contamination in the further work in the laboratory is safely avoided.
Die Erfindung wird nachfolgend an verschiedenen Ausführungsbeispielen unter Bezugnahme auf die beigefügten Zeichnungen näher erläutert. Es zeigen:
- Fig. 1
- eine schematische Draufsicht auf den Einwegdeckel,
- Fig. 2
- eine schematische teilweise geschnittene seitliche Ansicht des Gewindekörpers des Deckels,
- Fig. 3
- eine schematische teilweise geschnittene seitliche Ansicht der Hohlachse,
- Fig. 4
- eine schematische teilweise geschnittene Draufsicht auf die Hohlachse,
- Fig. 5
- eine schematische Draufsicht auf das Rührelement mit den Schneidmesser- und Quetschelementen, die durchstechbaren Membrane und einer Labyrinth-Lippendichtung,
- Fig. 6
- eine schematische teilweise geschnittene seitliche Ansicht des Rührelementes mit den Schneidmesser- und Quetschelementen, der durchstechbaren Membrane und einer Labyrinth-Lippendichtung,
- Fig. 7
- eine schematische Draufsicht auf die Rückhaltehülse mit Quetschnuten,
- Fig. 8
- eine schematische teilweise geschnittene seitliche Ansicht der Rückhaltehülse mit Quetschnuten,
- Fig. 9
- eine schematische teilweise geschnittene seitliche Ansicht des Einwegdeckels.
- Fig. 1
- a schematic plan view of the disposable lid,
- Fig. 2
- a schematic partially sectioned side view of the threaded body of the lid,
- Fig. 3
- a schematic partially sectioned side view of the hollow axle,
- Fig. 4
- a schematic partially sectioned plan view of the hollow axle,
- Fig. 5
- a schematic plan view of the stirring element with the Schneidmesser- and squeezing, the pierceable Membrane and a labyrinth lip seal,
- Fig. 6
- a schematic partially sectioned side view of the stirring element with the Schneidmesser- and squeezing, the pierceable membrane and a labyrinth lip seal,
- Fig. 7
- a schematic plan view of the retaining sleeve with Quetschnuten,
- Fig. 8
- a schematic partially sectioned side view of the retaining sleeve with Quetschnuten,
- Fig. 9
- a schematic partially sectioned side view of the disposable lid.
Die
Im Einweg-Schraubverschlussdeckel 10 oder in der Einweg-Schnappkappe (Snap-Cap) 10 des hermetisch abdichtbaren Labortestgefässes 70 ist ein Rührelement 30 mit einem radialen Grobschneidmesser 31, drei Mittelquetschpaare 33 und drei Feinquetscherdrillinge aus Kunststoff oder Metall vorgesehen, die an den schneidenden Kanten der Nuten 41, 43, 45 der Rückhaltehülse 40 vorbeigeführt werden Dieses Rührelement 30 wird mit Hilfe der Hohlachse 50 von ausserhalb des Labortestgefässes 70 von einem externen Sechspunkte-Schnellkupplungsbolzen angetrieben.In the
Das Labortestgefäss 70 mit den zu mischenden und homogenisierenden Materialien wird bei kopfstehender Gefässstellung entsprechend
Die hydraulische Labyrinthlippendichtung 22, 36 im Deckel 10 dichtet das Material 71 im Inneren des Labortestgefässes 70 sowohl im Ruhezustand wie auch während der Drehbewegung des Rührelementes 30 hermetisch gegen die Umgebung ab und verhindert dadurch eine Kontamination mit der Umgebung und das Austreten von Aerosolen vor, während und nach dem Mischen oder Homogenisieren.The hydraulic
Anstelle des Einsatzes der in dem dargestellten Ausführungsbeispiel gezeigten hydraulischen Labyrinthlippendichtung 22, 36 ist es ebenso möglich, eine einfache Gummidichtung, beispielsweise in Gestalt eines Dichtringes, oder einen anderen dem Fachmann geläufigen Dichtungstyp zur Abdichtung des Labortestgefässes 70 nach Aussen zu verwenden.Instead of using the hydraulic
Die
Die
Die
Das Rührelement 30 ermöglicht zusammen mit der Rückhaltehülse 40 die Homogenisation in drei Phasen. In der ersten Phase schneidet das radiale Grobschneidemesser 31 zusammen mit den Nuten 41 in der Rückhaltehülse 40 in
Die
In den Zeichnungen nicht dargestellt sind folgende Merkmale, die in der dargestellten Ausführungsform des Einwegdeckels 10 aufgenommen werden können. In
Claims (13)
- Device for mixing, homogenising, extracting, slurrying materials, more especially infectious or foul smelling or chemically aggressive materials (71), in a laboratory test container (70), which is hermetically sealable by means of a cover (10), wherein an agitating element (30) is provided in the cover (10) for processing the material (71) that is introducible into the laboratory test container (70), the said agitating element being connected to a coupling piece (50), and wherein the agitating element (30) that rotates about the longitudinal axis of the laboratory test container (70) is provided with cutting and/or crushing elements (31; 33, 35), which are disposed in the direct vicinity of cutting edges (42, 44; 41, 43, 45) of a retaining sleeve (40), characterised in that the agitating element (30) is hollow cylindrical (53) and is provided with a central end cap (32).
- Device according to claim 1, characterised in that the central end cap (32) is a diaphragm (32) that can be penetrated or ruptured.
- Device according to claim 1 or 2, characterised in that the cutting and/or crushing elements comprise coarse cutting blade (31) and crushers (33, 35), which are disposed in the direct vicinity of the cutting edges, which are formed by cams (42, 44) and grooves (41, 43, 45), wherein the cutting and/or crushing elements are produced more especially from plastics material or metal.
- Device according to one of claims 1 to 3, characterised in that the retaining sleeve (40) is provided as an attachable or removable additional element that is open inside.
- Device according to one of claims 1 to 4, characterised in that the cover is a disposable cover (10) and/or in that the said cover includes a screw-type closure or a snap-type closure, which is complementary to a corresponding element on the laboratory test container (70).
- Device according to one of claims 1 to 5, characterised in that the laboratory test containers (70) are cylindrical or cuboidal and/or in that the laboratory test containers (70) are produced from plastics material or glass.
- Device according to one of claims 1 to 6, characterised in that means for crushing, mixing, homogenising, extracting and slurrying the material (71) are provided for its processing.
- Device according to one of claims 1 to 7, characterised in that the cover (10) includes a rubber sealing ring, a clamping sealing ring or a hydraulic labyrinth sealing ring (22, 36) for the hermetic closure between the container interior (71) of the laboratory test container (70) and the exterior environment.
- Device according to one of claims 1 to 8, characterised in that the coupling piece (50) is hollow and/or in that the said coupling piece is a hexagon rapid action coupling ring (50) such that rotational energy can be supplied mechanically from outside.
- Device according to one of claims 1 to 9, characterised in that thermal energy is introducible into the laboratory test container (70) or can be removed from the said laboratory test container to the outside by means of a heat conducting driving axle.
- Device according to one of claims 4 to 10, characterised in that electric lines or optical waveguides lead to sensors or heating elements or Peltier elements in the interior of the laboratory test container (70) through a region (26) in the thread body (20) of the cover.
- Device according to one of claims 2 to 11, characterised in that through the penetratable or rupturable diaphragm (32) in the disposable cover (10), with the laboratory test container (70) standing in the upright position, the homogenate can be manually or automatically analysed or tempered by means of a sensor or a heating or Peltier element without the cover (10) having to be removed from the laboratory test container (70).
- Device according to one of claims 2 to 12, characterised in that the penetrated or ruptured diaphragm (32) in the disposable cover (10) can be re-sealed hermetically in the region (54) by means of a snap-type cover made of plastics material or metal.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH17222002 | 2002-10-15 | ||
CH17222002 | 2002-10-15 | ||
PCT/CH2003/000675 WO2004035191A1 (en) | 2002-10-15 | 2003-10-15 | Disposable mixer and homogeniser |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1551541A1 EP1551541A1 (en) | 2005-07-13 |
EP1551541B1 true EP1551541B1 (en) | 2008-09-03 |
Family
ID=32097396
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP03753192A Expired - Lifetime EP1551541B1 (en) | 2002-10-15 | 2003-10-15 | Disposable mixer and homogeniser |
Country Status (8)
Country | Link |
---|---|
US (1) | US7490976B2 (en) |
EP (1) | EP1551541B1 (en) |
AT (1) | ATE406952T1 (en) |
AU (1) | AU2003271483A1 (en) |
DE (1) | DE50310447D1 (en) |
DK (1) | DK1551541T3 (en) |
ES (1) | ES2314230T3 (en) |
WO (1) | WO2004035191A1 (en) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006076820A1 (en) * | 2005-01-21 | 2006-07-27 | Medic Tools Ag | One-way mixer, homogeniser, extractor, fractioner or slurry producer |
DE502005005225D1 (en) * | 2005-01-21 | 2008-10-09 | Medic Tools Ag | DISPOSABLE fractionator |
US7927006B2 (en) | 2005-02-01 | 2011-04-19 | Medic Tools Ag | Device for extracting, fragmenting, mixing and homogenizing especially infectious, malodorous, chemically corrosive or sterile substances |
DE102005020460B4 (en) * | 2005-04-29 | 2007-03-29 | Ika - Werke Gmbh & Co. Kg | Stirring or dispersing device |
FR2925066B1 (en) * | 2007-12-18 | 2014-12-19 | Bertin Technologies Sa | DEVICE FOR MILLING A BIOLOGICAL SAMPLE |
US9034635B2 (en) * | 2008-02-20 | 2015-05-19 | Streck, Inc. | Thermocycler and sample vessel for rapid amplification of DNA |
US20100270410A1 (en) * | 2009-04-27 | 2010-10-28 | SSI Shredding Sytems, Inc. | Material Shredder including reverse-facing, pass-by-interlocking, rotor-cutter/bed-knife cutting edges |
EP2429704A2 (en) * | 2009-05-14 | 2012-03-21 | Streck Inc. | Sample processing cassette, system, and method |
CN101803884B (en) * | 2010-04-12 | 2012-04-25 | 王晓东 | Shear type pulverizing cutter structure of food processor |
KR101288929B1 (en) * | 2010-05-26 | 2013-07-22 | 배주한 | disk type heavy oil homogenizer |
FR2960863B1 (en) * | 2010-06-07 | 2012-07-13 | Fillon Technologies | CLOSURE COVER FOR A CONTAINER EQUIPPED WITH A SEAL |
WO2012001607A1 (en) * | 2010-06-29 | 2012-01-05 | Yadav, Omprakash | Disposable homogenizer kit |
EP2478962A1 (en) | 2011-01-24 | 2012-07-25 | Miltenyi Biotec GmbH | Heating device for cylindrical laboratory vessels |
CA2835654A1 (en) | 2011-06-01 | 2012-12-06 | Streck, Inc. | Rapid thermocycler system for rapid amplification of nucleic acids and related methods |
ES2574666T3 (en) | 2011-06-27 | 2016-06-21 | Miltenyi Biotec Gmbh | Tissue fragment device |
SE536456C2 (en) * | 2011-12-15 | 2013-11-12 | Metso Paper Sweden Ab | Mixing unit comprising at least two rotor bodies for use in a mixing device and a mixing device |
DE102012004491B4 (en) * | 2012-03-06 | 2013-10-31 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Handling device for handling tubes for cell and / or tissue digestion and method for cell and / or tissue digestion |
US9932632B2 (en) | 2012-08-10 | 2018-04-03 | Streck, Inc. | Real-time optical system for polymerase chain reaction |
US10006861B2 (en) | 2013-06-28 | 2018-06-26 | Streck, Inc. | Devices for real-time polymerase chain reaction |
CN203436142U (en) * | 2013-07-31 | 2014-02-19 | 惠阳亚伦塑胶电器实业有限公司 | Juice extractor |
DE102015007435A1 (en) * | 2015-06-15 | 2016-12-15 | Pallmann Maschinenfabrik Gmbh & Co. Kg | Device and grinding tool for crushing feed |
CN107999230A (en) * | 2017-12-28 | 2018-05-08 | 郑州游爱网络技术有限公司 | A kind of broken pre- stirring drawing mechanism of feed screening |
CN109364810A (en) * | 2018-10-23 | 2019-02-22 | 温碧君 | A kind of efficient mixed stirring device of chemical fertilizer |
WO2020124263A1 (en) * | 2018-12-21 | 2020-06-25 | Nanorial Technologies Ltd. | Apparatus, methods, and systems for mixing, dispersing substances |
CN111249996A (en) * | 2020-03-13 | 2020-06-09 | 山东厚俞实业有限公司 | Dry-wet separation type dosing device |
CN114100484B (en) * | 2021-10-28 | 2023-01-24 | 焦作熠星智能电子科技有限公司 | Lithium battery electrode slurry mixing equipment and mixing method |
CN117380068B (en) * | 2023-12-13 | 2024-02-20 | 河北特美特实业集团股份有限公司 | Tomato ketchup processing is with allotment jar device |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
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US119387A (en) * | 1871-09-26 | Improvement in churns | ||
US3060702A (en) * | 1959-04-01 | 1962-10-30 | Samuel Dane | Refrigerated beverage dispenser |
US3704864A (en) * | 1970-04-28 | 1972-12-05 | Virginia Olga Lee | Mixing apparatus |
US4330215A (en) * | 1979-05-03 | 1982-05-18 | Rubber & Plastics Research Assoc Of Gb | Mixing device |
JPS577243A (en) * | 1980-06-13 | 1982-01-14 | Matsushita Electric Ind Co Ltd | Mixer |
DE8024382U1 (en) * | 1980-09-12 | 1988-03-24 | Maschinenfabrik Heger GmbH & Co KG, 7033 Herrenberg | Shredding device |
EP0333111B1 (en) * | 1988-03-14 | 1995-08-09 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Continuous two-liquid type mixer |
US5450368A (en) * | 1993-12-28 | 1995-09-12 | Three Bond Co., Ltd. | Two liquid type mixer |
US6338569B1 (en) * | 1998-10-27 | 2002-01-15 | Mcgill Shane R. | Food blending apparatus |
DE19925139A1 (en) * | 1999-06-02 | 2000-12-07 | Desoi Gmbh | Hand-held electric drill powered paint mixer with support frame hold the drill and mixer steady without the requirement for a second person |
US6447158B1 (en) * | 2000-08-29 | 2002-09-10 | Frank E. Farkas | Apertured-disk mixer |
CA2363476C (en) * | 2001-11-20 | 2010-06-08 | Udo Hendrick Verkerk | A device for the addition of a compound or compound mixture to another under various reaction conditions, parallel or otherwise |
-
2003
- 2003-10-15 AU AU2003271483A patent/AU2003271483A1/en not_active Abandoned
- 2003-10-15 EP EP03753192A patent/EP1551541B1/en not_active Expired - Lifetime
- 2003-10-15 AT AT03753192T patent/ATE406952T1/en not_active IP Right Cessation
- 2003-10-15 US US10/526,647 patent/US7490976B2/en active Active
- 2003-10-15 DE DE50310447T patent/DE50310447D1/en not_active Expired - Lifetime
- 2003-10-15 DK DK03753192T patent/DK1551541T3/en active
- 2003-10-15 WO PCT/CH2003/000675 patent/WO2004035191A1/en active IP Right Grant
- 2003-10-15 ES ES03753192T patent/ES2314230T3/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US7490976B2 (en) | 2009-02-17 |
EP1551541A1 (en) | 2005-07-13 |
ES2314230T3 (en) | 2009-03-16 |
AU2003271483A1 (en) | 2004-05-04 |
DE50310447D1 (en) | 2008-10-16 |
WO2004035191A1 (en) | 2004-04-29 |
DK1551541T3 (en) | 2008-12-08 |
ATE406952T1 (en) | 2008-09-15 |
US20060013064A1 (en) | 2006-01-19 |
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