EP1534820A4 - EX-VIVO EXPANSION OF HUMATOPOETIC STEM CELL POPULATIONS IN MONONUCLEOUS CELL CULTURES - Google Patents

EX-VIVO EXPANSION OF HUMATOPOETIC STEM CELL POPULATIONS IN MONONUCLEOUS CELL CULTURES

Info

Publication number
EP1534820A4
EP1534820A4 EP03787995A EP03787995A EP1534820A4 EP 1534820 A4 EP1534820 A4 EP 1534820A4 EP 03787995 A EP03787995 A EP 03787995A EP 03787995 A EP03787995 A EP 03787995A EP 1534820 A4 EP1534820 A4 EP 1534820A4
Authority
EP
European Patent Office
Prior art keywords
hematopoietic stem
vivo expansion
stem cell
cell cultures
cell populations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03787995A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1534820A2 (en
Inventor
Tony Peled
Avi Treves
Oren Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gamida Cell Ltd
Original Assignee
Gamida Cell Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL15290402A external-priority patent/IL152904A0/xx
Priority claimed from PCT/IL2003/000062 external-priority patent/WO2003062404A1/en
Application filed by Gamida Cell Ltd filed Critical Gamida Cell Ltd
Publication of EP1534820A2 publication Critical patent/EP1534820A2/en
Publication of EP1534820A4 publication Critical patent/EP1534820A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/145—Thrombopoietin [TPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP03787995A 2002-08-19 2003-08-17 EX-VIVO EXPANSION OF HUMATOPOETIC STEM CELL POPULATIONS IN MONONUCLEOUS CELL CULTURES Withdrawn EP1534820A4 (en)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US40413702P 2002-08-19 2002-08-19
US40414502P 2002-08-19 2002-08-19
US404137P 2002-08-19
US404145P 2002-08-19
IL15290402A IL152904A0 (en) 2002-01-24 2002-11-17 Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
IL15290402 2002-11-17
PCT/IL2003/000062 WO2003062404A1 (en) 2002-01-25 2003-01-23 Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
WOPCT/IL03/00062 2003-01-23
WOPCT/IL03/00064 2003-01-26
PCT/IL2003/000064 WO2003062369A2 (en) 2002-01-24 2003-01-26 Expansion of renewable stem cell populations
US45254503P 2003-03-07 2003-03-07
US452545P 2003-03-07
PCT/IL2003/000681 WO2004016731A2 (en) 2002-08-19 2003-08-17 Ex-vivo expansion of hematopoietic stem cell populations in mononuclear cell cultures

Publications (2)

Publication Number Publication Date
EP1534820A2 EP1534820A2 (en) 2005-06-01
EP1534820A4 true EP1534820A4 (en) 2006-04-26

Family

ID=56290470

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03787995A Withdrawn EP1534820A4 (en) 2002-08-19 2003-08-17 EX-VIVO EXPANSION OF HUMATOPOETIC STEM CELL POPULATIONS IN MONONUCLEOUS CELL CULTURES

Country Status (7)

Country Link
EP (1) EP1534820A4 (enExample)
JP (1) JP2006508692A (enExample)
AU (1) AU2003250519A1 (enExample)
BR (1) BR0314402A (enExample)
CA (1) CA2495824A1 (enExample)
MX (1) MXPA05001992A (enExample)
WO (1) WO2004016731A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2344653A1 (en) 1998-09-29 2000-04-06 Gamida Cell Ltd. Methods of controlling proliferation and differentiation of stem and progenitor cells
IL152904A0 (en) 2002-01-24 2003-06-24 Gamida Cell Ltd Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
EP1465982A4 (en) 2002-01-25 2006-06-07 Gamida Cell Ltd PROCESS FOR EXPANSION OF STEM AND PRESERVATIVE CELLS AND EXPANDED CELL POPULATIONS THEREWITH OBTAINED
EP1601759A4 (en) * 2003-03-07 2007-02-14 Gamida Cell Ltd EXPANSION OF RENEWABLE STEM CELL POPULATIONS USING PI-3 KINASE MODULATORS
US8361976B2 (en) 2004-07-09 2013-01-29 University Of Massachusetts Therapeutic alteration of transplantable tissues through in situ or ex vivo exposure to RNA interference molecules
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
EP1974012B1 (en) * 2005-11-29 2013-02-27 Gamida Cell Ltd. Methods of improving stem cell homing and engraftment
JP5646990B2 (ja) 2007-04-23 2014-12-24 ストワーズ インスティテュート フォー メディカル リサーチ 幹細胞自己複製のための方法及び組成物
EP2250251B1 (en) * 2008-01-09 2017-11-22 Sartorius Stedim Cellca GmbH Improved culture media additive and process for using it
JP6348848B2 (ja) 2012-02-13 2018-06-27 ガミダ セル リミテッド 間葉系幹細胞の増殖
US9175266B2 (en) 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
US20190119636A1 (en) 2017-10-23 2019-04-25 Poseida Therapeutics, Inc. Modified stem cell memory t cells, methods of making and methods of using same
KR102588469B1 (ko) * 2016-09-30 2023-10-11 포세이다 테라퓨틱스, 인크. 변형된 줄기세포 기억 t 세포, 이의 제조 방법 및 사용 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003078567A2 (en) * 2002-03-18 2003-09-25 Gamida-Cell Ltd. Methods of inducing differentiation in ex vivo expanded stem cells

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003078567A2 (en) * 2002-03-18 2003-09-25 Gamida-Cell Ltd. Methods of inducing differentiation in ex vivo expanded stem cells

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BHATIA M ET AL: "PURIFICATION OF PRIMITIVE HUMAN HEMATOPOIETIC CELLS CAPABLE OF REPOPULATING IMMUNE-DEFICIENT MICE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 94, May 1997 (1997-05-01), pages 5320 - 5225, XP001055074, ISSN: 0027-8424 *
COUTINHO ET AL., BLOOD, vol. 75, no. 11, 1990, pages 2118 *
FIBACH EITAN ET AL: "Retinoic Acid Antagonist Inhibits CD38 Antigen Expression on Human Hematopoietic Cells.", BLOOD, vol. 100, no. 11, 16 November 2002 (2002-11-16), & 44TH ANNUAL MEETING OF THE AMERICAN SOCIETY OF HEMATOLOGY; PHILADELPHIA, PA, USA; DECEMBER 06-10, 2002, pages Abstract No. 644, XP009058480, ISSN: 0006-4971 *
KOEHLER T ET AL: "Defining optimum conditions for the ex vivo expansion of human umbilical cord blood cells. Influences of progenitor enrichment, interference with feeder layers, early-acting cytokines and agitation of culture vessels", STEM CELLS, ALPHAMED PRESS, DAYTON, OH, US, vol. 17, no. 1, 1999, pages 19 - 24, XP002177251, ISSN: 1066-5099 *
LEWANDOWSKI DANIEL ET AL: "Phosphatidylinositol 3-kinases are involved in the all-trans retinoic acid-induced upregulation of CD38 antigen on human haematopoietic cells", BRITISH JOURNAL OF HAEMATOLOGY, vol. 118, no. 2, 25 July 2002 (2002-07-25), pages 535 - 544, XP002357786, ISSN: 0007-1048 *
PODESTA MARINA ET AL: "Extracellular cyclic ADP-ribose increases intracellular free calcium concentration and stimulates proliferation of human hemopoietic progenitors", FASEB JOURNAL, vol. 14, no. 5, April 2000 (2000-04-01), pages 680 - 690, XP002357785, ISSN: 0892-6638 *
SAMMONS J ET AL: "Mechanisms mediating the inhibitory effect of all-trans retinoic acid on primitive hematopoietic stem cells in human long-term bone marrow culture", STEM CELLS (MIAMISBURG), vol. 18, no. 3, 2000, pages 214 - 219, XP002357789, ISSN: 1066-5099 *
SAUVE ANTHONY A ET AL: "Mechanism-based inhibitors of CD38: A mammalian cyclic ADP-ribose synthetase", BIOCHEMISTRY, vol. 41, no. 26, 2 July 2002 (2002-07-02), pages 8455 - 8463, XP002357788, ISSN: 0006-2960 *
WALL KATHERINE A ET AL: "Inhibition of the intrinsic NAD+ glycohydrolase activity of CD38 by carbocyclic NAD analogues", BIOCHEMICAL JOURNAL, vol. 335, no. 3, 1 November 1998 (1998-11-01), pages 631 - 636, XP002357787, ISSN: 0264-6021 *

Also Published As

Publication number Publication date
WO2004016731A3 (en) 2004-09-10
JP2006508692A (ja) 2006-03-16
EP1534820A2 (en) 2005-06-01
MXPA05001992A (es) 2005-08-03
AU2003250519A8 (en) 2004-03-03
AU2003250519A1 (en) 2004-03-03
WO2004016731A2 (en) 2004-02-26
BR0314402A (pt) 2005-07-19
CA2495824A1 (en) 2004-02-26

Similar Documents

Publication Publication Date Title
AU2003295444A1 (en) Methods for in vitro expansion of hematopoietic stem cells
AU2003250519A8 (en) Ex-vivo expansion of hematopoietic stem cell populations in mononuclear cell cultures
EP1465982A4 (en) PROCESS FOR EXPANSION OF STEM AND PRESERVATIVE CELLS AND EXPANDED CELL POPULATIONS THEREWITH OBTAINED
IL164531A0 (en) Modulation of stem and progenitor cell differentiation, assays, and uses thereof
AU2003216058A8 (en) Mammalian neural stem cells, compositions and uses thereof
GB2405642B (en) Methods of regulating differentiation in stem cells
IL182782A0 (en) Methods of expanding myeloid cell populations and uses thereof
WO2004070013A3 (en) Use of islet 1 as a marker for isolating or generating stem cells
AU2003302701A8 (en) Method of dynamically culturing embryonic stem cells
EP1485464A4 (en) METHODS OF INDUCING DIFFERENTIATION IN EX VIVO EXPANDED STEM CELLS
IL184262A0 (en) Cell culture method and utilization of the same
AU2003260351A8 (en) Cell culture insert
AU2003273332A8 (en) Method of enhancing proliferation and/or hematopoietic differentiation of stem cells
AU2003216822A1 (en) Stem cell culture
AU2003280687A1 (en) Composition for culturing multipotent stem cells and utilization of the same
PL376085A1 (en) Methods of increasing platelet and hematopoietic stem cell production
AU2003296432A8 (en) Methods and compositions for inhibiting the growth of hematopoietic malignant cells
AU2003249227A8 (en) Methods and systems for extended in vitro culture of neuronal cells
WO2007028079A3 (en) Methods of stimulating expansion of hematopoietic stem cells
AU2003284314A8 (en) Stem cell populations
GB2422843B (en) Cell culture base
EP1539997A4 (en) HIGH-PERFORMANCE PROLIFERATION ASSAY OF HEMATOPOIETIC STRAINS AND PROGENITOR CELLS
HK1078897A (en) Ex-vivo expansion of hematopoietic stem cell populations in mononuclear cell cultures
IL164507A0 (en) Enhancement of hematopoietic stem cell survival
SI1542714T1 (sl) Postopki za povečanje proizvodnje krvnih ploščic in hematopoetskih matičnih celic

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20050316

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK

DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 5/00 20060101AFI20050323BHEP

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1078897

Country of ref document: HK

A4 Supplementary search report drawn up and despatched

Effective date: 20060310

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20091215

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1078897

Country of ref document: HK