EP1516042B1 - Foam disinfectant - Google Patents

Abstract

The invention relates to an aqueous foam disinfectant comprised of a special surfactant system, which consists of non-ionic and amphoteric surfactants, and of a synergistic disinfectant constituent, which consists of an antimicrobial agent having amino groups and of at least one additional antimicrobial agent.

Description

The present invention relates to aqueous foam disinfectants comprising a foam system capable of surfactant system of nonionic and amphoteric surfactants and a synergistic disinfectant combination. As a further object, the present invention contains a method for foam disinfection of surfaces with the aid of a foam-producing device and the use of the foam disinfectant according to the invention for the disinfection of surfaces.

The use of compositions which are applied to surfaces in the form of a foam has already been described in various documents. An example of this is the German application DE 20 01 317.

In most prior art formulations, the corresponding formulations contain anionic surfactants such as sodium lauryl sulfate, sodium dodecylbenzenesulfonate, sodium salts of laurylsaccosinate and, in some instances, surfactants which further enhance the stability of the foam, such as lauryldiethanolamide. The main advantage of foam-forming formulations is that they can be used much more effectively with respect to the cleaning and disinfection of surfaces compared to other formulations. This is primarily due to the better wetting, especially of non-horizontal surfaces. This ensures that the agent adhere to the surface for a longer time and therefore is increased due to the longer contact time of the disinfecting effect. A further advantage of foam-forming formulations is that during spraying drops of a size are formed which, due to their size, do not allow for any relevant inhalative exposure. This is particularly important in the use of microbicides or other formulation ingredients that have potentially irritating or corrosive properties. However, the surfactant systems commonly used are not equally useful in all formulations. In particular, when it comes to formulating formulations with aminic or cationic biocides, anionic surfactants are not benign because of possible precipitations.

On the one hand, it is known to the person skilled in the art that long-chain fatty amines and their salts as well as aliphatic diamines are very effective microbicides with a broad spectrum of activity.

For example, US Pat. No. 5,856,290 describes a hard surface cleaner composition containing a corresponding disinfectant which moreover has enhanced bacterial reduction efficiency by addition of a mixture of alkyl or alkenyl oligoglycoside and certain C ₈ -C ₁₈ alkyl ethers ,

In addition, DE 196 15 286 A1 describes antimicrobial active substance concentrates which comprise a) amidation products of N-substituted propylenediamines with 2-aminoglutaric acid esters and b) esterquats. The agents have a synergistic performance enhancement in the killing of microorganisms.

On the other hand, it is also known in practice that the use of amine biocides can lead to sensitization of skin surfaces. This is expressed by redness in the skin areas in contact with the amines.
The ecotoxicity of such amines is often a disadvantage. At too high concentrations, it may even happen that, depending on the circumstances, the microflora of each wastewater treatment plant is severely disturbed. It was therefore an object of the present invention to formulate and apply aminic microbicides in such a way that the smallest possible amounts are required.

Accordingly, the present invention was primarily concerned with finding new combinations of foamable surfactant systems and amine biocides in combination with other antimicrobial agents.

The present invention provides foam disinfectants comprising from 0.1 to 10% by weight of a surfactant system comprising nonionic and amphoteric surfactants capable of foaming in contact with amines, and a synergistic disinfectant combination consisting of an antimicrobial agent having amino groups and at least one other antimicrobial agent.

These are preferably to be understood as meaning foam disinfectants which contain nonionic surfactants selected from the groups of the fatty alcohol ethoxylates as surfactant system and alkylpolyglycosides, and amphoteric surfactants selected from the group of acetobetaines.

It is very particularly preferred if the said surfactant system contains at least one surfactant each from the groups of fatty alcohol ethoxylates, alkylpolyglycosides and acetobetaines.

It is preferred if the said surfactant groups of the fatty alcohol ethoxylates, alkyl polyglycosides and acetobetaines to each other in a weight-amount ratio of (5 to 7) to (2 to 4) to (0.5 to 1.5).

With regard to the amine-containing microbicide, the foam disinfectant of the present invention preferably contains an antimicrobial agent having amino groups in an amount of 0.001 to 10% by weight in total, based on the whole agent.

It has been found to be particularly advantageous when said antimicrobial agent having amino groups is selected from alkylamines of the formula (I) and / or (II)

R ^{1 is} -NH- (CH ₂ ) ₃ NH ₂ (I),

R ¹ -N - [(CH ₂ ) ₃ NH ₂ ] ₂ (II),

which may be unneutralized, partially or completely neutralized, wherein R ^{1 is} an alkyl radical having 8 to 18 C-atoms, preferably 12 to 14 C-atoms, and / or
Active substances obtained by reacting a propylenediamine of the formula (I),

R ^{1 is} -NH- (CH ₂ ) ₃ NH ₂ (I),

with glutamic acid or glutamic acid derivatives according to formula (III),

R ^{2 is} -O-CO- (CH ₂ ) ₂ -CH (NH ₂ ) -COOH (III),

in which R ^{2 is} hydrogen or an alkyl radical having 1 to 4 carbon atoms, and optionally reaction of the product thus obtained with ethylene oxide and / or propylene oxide and optionally further reaction with organic or inorganic acids are obtainable.

in der R³, R⁴ und R⁵ unabhängig voneinander H-Atome oder Alkylreste mit jeweils 1 bis 3 C-Atomen umfassen, wobei die Gesamtzahl der C-Atome nicht größer als 6 ist, kombiniert.As stated in the introduction, amine-containing microbicides are not easily used.
To overcome disadvantages, the foam disinfectant according to the invention with at least one further antimicrobial active ingredient, preferably selected from the group of monohydric low molecular weight alcohols according to formula (IV),

in which R ³ , R ⁴ and R ⁵ independently of one another comprise H atoms or alkyl radicals having in each case 1 to 3 C atoms, the total number of C atoms being not greater than 6, combined.

It should be noted that the object is achieved particularly well if the foam disinfectant according to the invention contains an alcohol selected from ethanol, 1-propanol and 2-propanol or mixtures thereof, wherein the total content of alcohols, based on the total agent, preferably a total of 20 to 50 wt .-% makes, more preferably 20 to 40 wt .-%. The desired foaming and foam stability are particularly pronounced when ethanol and / or i-propanol are present in the foam disinfectant.

Of course, it is also possible that the foam disinfectant according to the invention as antimicrobial active ingredient next to or instead of said alcohol, another antimicrobial component selected from the groups of alcohols not falling under formula (IV), the antimicrobial acids, carboxylic acid esters, acid amides, phenols, Phenol derivatives, diphenyls, diphenylalkanes, urea derivatives, oxygen, nitrogen acetals and formals, benzamidines, isothiazolines, phthalimide derivatives, pyridine derivatives, antimicrobial surface-active compounds, guanidines, antimicrobial amphoteric compounds, quinolines, 1,2-dibromo-2,4-dicyanobutane, iodo-2-propynyl-butyl-carbamate, iodine, iodophores, in particular undecylenic acid, citric acid, 2-benzyl-4-chlorophenol, 2,2'-methylenebis (6-bromo-4-chlorophenol), 2,4 , 4'-Trichloro-2'-hydroxydiphenyl ether, N- (4-chlorophenyl) -N- (3,4-dichlorophenyl) -urea, N, N '- (1,10-decanediyldi-1-pyridinyl-4-ylidene ) -bis- (1-octanamine) - dihydrochloride, N, N'-bis (4-chlorophenyl) -3,12-diimino-2,4,11,13-tetraaza-tetradecandiimidamide, quaternary ammonium compounds, guanidines, amphoteric agents.

Of particular note in this context are quaternary ammonium compounds, as also expressed in Examples (E1).

Preferably, the foam disinfectant according to the invention contains, based on the total agent,
0.005 to 2.0 wt .-% of said antimicrobial agent with amino groups and
20 to 40 wt .-% of said alcohols according to formula IV or mixtures thereof and
0.5 to 5 wt .-% of said surfactant system, and
0 to 6 wt .-% of conventional additives such as complexing agents and perfume
and, if desired, the remainder to 100% by weight of water and / or other customary auxiliaries and additives.

Another object of the present invention is a method for foam disinfection of surfaces, in which a foam disinfectant according to the invention is applied with the aid of a foam-generating device, such as a foam spray bottle on said surfaces in the form of a foam, wherein the foam, if desired after sufficient exposure time by rinsing with Water or wiping with textile fabric is removed again.

Likewise an object of the present invention is the use of the foam disinfectant according to the invention for the disinfection of surfaces.

In this case, the use according to the invention has proved to be particularly useful in the disinfection of surfaces in the medical field, in the food-producing and / or processing industry, in the hotel industry, in public buildings and institutions.

In the trial of the inventive disinfectants has proven to be an advantage that the formulations according to the invention with sufficient antimicrobial activity and despite the high alcohol content in the application form a stable foam. In addition, after application, the surfaces are dry again within a very short time

EXAMPLES 1. Preparation of test solutions

By simply combining different individual constituents, preferably while stirring, the test solutions E1 to E3 according to the invention and the comparative solutions V1 to V4 according to Table 1 were prepared. <b> Table 1: Test Solutions </ b> Individual components (% by weight) (relative to the total solution) E1 E2 E3 V1 V2 V3 V4 Alkyl (C8-C14) - polyglucoside (Glucopon ^® 650) 0.75 0.75 0.5 - 1.6 - - Dimethyl-C8-C18-acylamido-propyl acetobetaine (Dehyton ^® K) 0.25 0.25 0.2 - - - 1.6 Isotridecyl fatty alcohol ethoxylate (8EO) (Lutensol ^® TO 89) 1.5 1.5 0.9 - - 1.6 - Dimethylalkyl (C12-C14) benzylammonium chloride - 0.15 - - - - - Glucoprotamine ^® - 0.05 - - - - - - lauryldipropylenetriamine - - 0.3 0.3 0.3 0.3 0.3 Ethanol (96 vol.%) 5.0 5.0 - - - 40.0 - 2-propanol 25.0 25.0 30.0 40.0 30.0 - - 1-propanol - - - - - 40.0 water

2. Testing the effectiveness of the inventive examples E1 and E2 against the Gram-positive bacterium Staphylococcus aureus.

The bactericidal effectiveness tests were carried out in a quantitative suspension test according to the guidelines of the German Society for Hygiene and Microbiology against the test bacterium Staphylococcus aureus with the undiluted mixtures E1 and E2. The results are summarized in Table 2. It turns out that some of the above mixtures have an excellent effect already after 0.5 minutes (E2) and in particular after 3 minutes. <b> Table 2: </ b> Effectiveness of the inventive examples E1 and E2 against the Gram-positive bacterium Staphylococcus aureus Germ reduction (log levels) investigational 0.5 min 1 min 3 min Mixture E1 <1,10 1.98 4.82 Mix E2 > 5.49 > 5.41 > 5.38

3. Examination of the drying behavior of the inventive examples E1 and E2

In order to determine the drying behavior on surfaces, 0.3 g of the mixtures E1 and E2 were applied to 100 cm ² ceramic tiles by means of a foam spraying device and the period until the visible drying of the surface was determined.
The results are summarized in Table 3. <b> Table 3: </ b> Drying behavior of the inventive examples E1 and E2 investigational Drying time (min) Mixture E1 2.0 Mix E2 2.5

4. Testing of the foaming behavior of the inventive examples E1 to E3 in comparison to the comparative solutions V1 to V4

To test the foam behavior, the mixtures E1 to E4 and V1 to V4 were applied to a PVC surface by means of a lattice foam spray device. For optimal application, starting with a clear solution, a strong foam should form when sprayed, which will disintegrate within 1 to 2 minutes after application to the surface.
The results are summarized in Table 4.
It can be clearly seen that the combinations E1 to E4 according to the invention have advantages over the comparative formulations V1 to V4 with regard to the foaming behavior. <b> Table 4: </ b> Testing the foaming behavior of E1 to E3 compared to V1 to V4 Test parameters mixture Appearance of the solution Consistency of the foam Stability of the foam V1 Clear, colorless Thin foam None V2 Cloudy, milky Medium foam Approximately 3,5 min V3 Clear, colorless Strong foam Approximately 30 sec V4 Clear, colorless Thin foam Approximately 5 sec E1 Minimal haze, colorless Strong foam Approximately 90 sec E2 Minimal haze, colorless Strong foam about 90 sec E3 Clear, colorless Strong foam Approximately 90 sec

Claims (12)

1. An aqueous foam disinfectant comprising 0.1 to 10wt.-% of a surfactant system of non-ionic and amphoteric surfactants, which system is capable of forming foam upon contact with amines, and a synergistic disinfectant component consisting of an antimicrobial agent with amino groups and at least one additional antimicrobial agent,
   said additional antimicrobial agent being selected from the group of monohydric low-molecular weight alcohols according to formula (IV),

   

   wherein R³, R⁴ and R⁵ independently comprise H atoms or alkyl residues having 1 to 3 C atoms, the total number of C atoms not being greater than 6,
   said alcohols, or mixtures thereof, constituting a total of 20 to 50 wt.-%, based on the overall disinfectant
2. The foam disinfectant according to claim 1, characterized in that the non-ionic surfactants are selected from the groups of fatty alcohol ethoxylates and alkylpolyglycosides and the amphoteric surfactants are selected from the group of acetobetaines.
3. The foam disinfectant according to claim 2, characterized in that the above-mentioned surfactant system comprises at least one surfactant from each of the groups of fatty alcohol ethoxylates, alkylpolyglycosides and acetobetaines.
4. The foam disinfectant according to claim 3, characterized in that the above-mentioned fatty alcohol ethoxylate, alkylpolyglycoside and acetobetaine groups of surfactants are present at a weight ratio of 5-7 : 2-4 : 0.5-1.5.
5. The foam disinfectant according to one or more of claims 1 to 4, characterized in that the above-mentioned antimicrobial agent with amino groups constitutes a total of 0.001 to 10 wt.-%, based on the overall disinfectant.
6. The foam disinfectant according to one or more of claims 1 to 5, characterized in that the above-mentioned antimicrobial agent with amino groups is selected from alkylamines of formulas (I) and/or (II)
   
           R¹-NH-(CH₂)₃NH₂     (I),
   
           R¹-N[(CH₂)₃NH₂]₂     (II),
   
   which can be present in a non-neutralized, partially or completely neutralized form,
   wherein R¹ represents an alkyl residue with 8 to 18 C atoms, preferably 12 to 14 C atoms, and/or
   active substances which can be obtained by reacting a propylenediamine in accordance with formula (I),
   
           R¹-NH-(CH₂)₃NH₂     (I),
   
   with glutamic acid or glutamic acid derivatives in accordance with formula (III),
   
           R²-O-CO-(CH₂)₂CH(NH₂)-COOH     (III),
   
   wherein R² represents hydrogen or an alkyl residue with 1 to 4 carbon atoms, and optionally reacting the product thus obtained with ethylene oxide and/or propylene oxide, and optionally further reacting with organic or inorganic acids.
7. The foam disinfectant according to one or more of claims 1 to 6, characterized in that the above-mentioned additional antimicrobial agent is further selected from the group of quaternary ammonium compounds.
8. The foam disinfectant according to one or more of claims 1 to 7, characterized in that the above-mentioned alcohol is selected from ethanol, 1-propanol and 2-propanol.
9. The foam disinfectant according to one or more of claims 7 or 8, characterized in that the disinfectant, based on the overall disinfectant, includes
   0.005 to 2.0 wt.-% of the above-mentioned antimicrobial agent with amino groups,
   20 to 40 wt.-% of the above-mentioned alcohol,
   0.5 to 5 wt.-% of the above-mentioned surfactant system, as well as
   0 to 2 wt.-% of a quaternary ammonium compound, and
   0 to 6 wt.-% of standard additives such as complexing agents and perfumes.
10. A method for the foam disinfection of surfaces, characterized in that an aqueous foam disinfectant in accordance with any of claims 1 to 9 is applied on the above-mentioned surfaces in the form of a foam, using a foam-generating device such as a foam spray bottle, and, if desired, the foam is removed by rinsing with water after a sufficient time of exposure.
11. Use of the foam disinfectants in accordance with any of claims 1 to 9 in the disinfection of surfaces.
12. The use according to claim 11, characterized in that surfaces are subjected to treatment in the medical sector, in the food producing and/or processing industry, in the hotel business, in public buildings and institutions.