EP1137338A1 - Disinfecting agents - Google Patents

Disinfecting agents

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Publication number
EP1137338A1
EP1137338A1 EP99958179A EP99958179A EP1137338A1 EP 1137338 A1 EP1137338 A1 EP 1137338A1 EP 99958179 A EP99958179 A EP 99958179A EP 99958179 A EP99958179 A EP 99958179A EP 1137338 A1 EP1137338 A1 EP 1137338A1
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EP
European Patent Office
Prior art keywords
alkyl
piperazine
disinfectant composition
compositions according
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP99958179A
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German (de)
French (fr)
Inventor
Michael LÜTZELER
Volker Ranft
Florian Lichtenberg
Joachim Fritschi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
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Lonza AG
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Application filed by Lonza AG filed Critical Lonza AG
Priority to EP99958179A priority Critical patent/EP1137338A1/en
Publication of EP1137338A1 publication Critical patent/EP1137338A1/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/04—Nitrogen directly attached to aliphatic or cycloaliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds

Definitions

  • the invention relates to synergistic disinfectant compositions based on amines and / or quaternary ammonium salts, which are particularly suitable for instrument disinfection.
  • the object of the present invention was therefore to provide such synergistic compositions, the synergists of course not causing any deterioration in the other properties of use (e.g. toxic or allergenic effects on humans, corrosiveness to materials to be treated) and should not significantly increase the costs. According to the invention, this object is achieved by the disinfectant compositions according to claim 1.
  • R 8 and R 9 independently of one another are hydrogen, C 1-4 alkyl, amino or 2-hydroxyethyl, the quantitative ratio of biocide (Ia, Ib) to piperazine (II) being 1:10 to 10: 1 can be increased significantly .
  • C, _ "- alkyl here and below are to be understood to mean all linear or branched alkyl groups having 1 to n carbon atoms, but preferably linear alkyl groups.
  • alkyl groups with 6 or more carbon atoms those with an even number of carbon atoms are preferred, among them in turn those with 10 or more carbon atoms.
  • the anions formate, acetate, propionate and butyrate are combined under the name C ⁇ -alkanoate. Acetate and propionate are preferred.
  • the C ⁇ alkanoate ions can carry substituents such as hydroxyl groups or halogen atoms. Glycolate and lactate are to be mentioned in particular among the substituted C 1-4 alkanoates.
  • the quantitative ratio of biocide (Ia, Ib) to piperazine (II) is preferably in the range from 1: 5 to 5: 1.
  • compositions according to the invention are preferably liquid with water as the solvent.
  • compositions according to the invention can additionally contain one or more auxiliaries from the group consisting of organic solvents (preferably alcohols, glycols and glycol ethers), cationic or nonionic surfactants, complexing agents, fragrances and dyes.
  • auxiliaries from the group consisting of organic solvents (preferably alcohols, glycols and glycol ethers), cationic or nonionic surfactants, complexing agents, fragrances and dyes.
  • compositions according to the invention are particularly suitable for instrument and surface disinfection.
  • Another preferred area of application is the use in chemical toilets, for example in aircraft.
  • Another preferred area of application is the use as a protective and preservative for construction materials such as wood or sealing compounds.
  • a disinfectant cleaner formulation (concentrate) was made from:
  • the two solid sodium salts were first dissolved in water with stirring at 40-60 ° C. and then the remaining constituents were added until a clear, homogeneous solution was obtained.

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention relates to disinfecting agents based on quaternary ammonium salts and/or tertiary amines with the addition of optionally substituted piperazines. The combination of piperazine with quaternary ammonium salt or with tertiary amine induces a strong synergistic effect. The inventive disinfecting agents are especially suited for disinfecting instruments.

Description

DesinfektionsmittelDisinfectant
Die Erfindung betrifft synergistische Desinfektionsmittelzusamrnensetzungen auf Basis von Aminen und/oder quartären Ammoniumsalzen, welche sich insbesondere zur Instrumentendesinfektion eignen.The invention relates to synergistic disinfectant compositions based on amines and / or quaternary ammonium salts, which are particularly suitable for instrument disinfection.
Es ist bekannt, dass quartäre Ammoniumsalze und tertiäre Amine mit einer oder mehreren langkettigen Alkylgruppen wie beispielsweise Didecyldimethylammo iumchlorid oder N,N-Bis(3-aminopropyl)dodecylamin biozide Eigenschaften haben, wobei die letztgenannte Verbindung sogar gegen sonst schwierig zu bekämpfende Keime wie Myko- bakterien wirksam ist (EP-A-0 343 605). Sowohl aus ökologischen wie auch aus ökonomischen Gründen ist es jedoch wünschenswert, Desinfektionsmittelzusammensetzungen zur Verfügung zu haben, die aufgrund synergistischer Effekte bei gleicher Wirkstoffkonzentration eine noch bessere Wirksamkeit bzw. bei gleicher Wirksamkeit eine geringere Wirkstoffkonzentration aufweisen. Aufgabe der vorliegenden Erfindung war daher die Bereitstellung solcher synergistischer Zusammensetzungen, wobei selbstverständlich die Synergisten keine Verschlechterung der sonstigen Gebrauchseigenschaften (z. B. toxische oder allergene Wirkung auf den Menschen, Korrosivität gegen zu behandelnde Werkstoffe) bewirken und die Kosten nicht wesentlich erhöhen sollten. Erfindungsgemäss wird diese Aufgabe durch die Desinfektionsmittelzusammensetzungen nach Patentanspruch 1 gelöst.It is known that quaternary ammonium salts and tertiary amines with one or more long-chain alkyl groups, such as, for example, didecyldimethylammonium chloride or N, N-bis (3-aminopropyl) dodecylamine, have biocidal properties, the latter compound even against germs which are otherwise difficult to control, such as myco- bacteria is effective (EP-A-0 343 605). For both ecological and economic reasons, however, it is desirable to have disinfectant compositions available which, due to synergistic effects, have an even better activity with the same active substance concentration or a lower active substance concentration with the same effectiveness. The object of the present invention was therefore to provide such synergistic compositions, the synergists of course not causing any deterioration in the other properties of use (e.g. toxic or allergenic effects on humans, corrosiveness to materials to be treated) and should not significantly increase the costs. According to the invention, this object is achieved by the disinfectant compositions according to claim 1.
Es wurde überraschend gefunden, dass die biozide Wirkung von an sich bekannten Aminen und/oder quartären Ammoniumsalzen der allgemeinen FormelIt has surprisingly been found that the biocidal action of amines and / or quaternary ammonium salts known per se of the general formula
und/oder and or
worin R1 oder Benzyl, R2 C,_lg-Alkyl, R3 C,_18-Alkyl oder -[CH2-CH2-O]m-H mit m = 1-8, R4 C,_6-Alkyl und R5 bedeuten, R6 und R7 unabhängig voneinander für Wasserstoff, C,_6-Alkyl oder -(CH2)„-NH2 mit n = 2-5 stehen und X Chlorid, Bromid, Iodid oder gegebenenfalls substituiertes C^-Alkanoat ist, durch Zusatz von mindestens einem Piperazin der allgemeinen Formelwhere R 1 or benzyl, R 2 C, _ lg -alkyl, R 3 C, _ 18 -alkyl or - [CH 2 -CH 2 -O] m -H with m = 1-8, R 4 C, _ 6 -alkyl and R 5 mean, R 6 and R 7 independently of one another are hydrogen, C, _ 6 -alkyl or - (CH 2 ) "- NH 2 with n = 2-5 and X is chloride, bromide, iodide or optionally substituted C ^ alkanoate , by adding at least one piperazine of the general formula
worin R8 und R9 unabhängig voneinander Wasserstoff, C^-Alkyl, Amino oder 2-Hydroxyethyl bedeuten, wobei das Mengenverhältnis von Biozid (Ia, Ib) zu Piperazin (II) 1 : 10 bis 10: 1 beträgt, bedeutend gesteigert werden kann.in which R 8 and R 9 independently of one another are hydrogen, C 1-4 alkyl, amino or 2-hydroxyethyl, the quantitative ratio of biocide (Ia, Ib) to piperazine (II) being 1:10 to 10: 1 can be increased significantly .
Unter C,_„-Alkyl sind hier und im folgenden alle linearen oder verzweigten Alkylgruppen mit 1 bis n Kohlenstoffatomen zu verstehen, vorzugsweise jedoch lineare Alkylgruppen. Unter den Alkylgruppen mit 6 oder mehr Kohlenstoffatomen sind diejenigen mit gerader Kohlenstoffanzahl bevorzugt, unter diesen wiederum diejenigen mit 10 oder mehr Kohlenstoffatomen.C, _ "- alkyl here and below are to be understood to mean all linear or branched alkyl groups having 1 to n carbon atoms, but preferably linear alkyl groups. Among the alkyl groups with 6 or more carbon atoms, those with an even number of carbon atoms are preferred, among them in turn those with 10 or more carbon atoms.
Unter den Gruppen der Formel -(CH2)„-NH2 sind diejenigen mit n = 3 bevorzugt. Unter der Bezeichnung C^-Alkanoat sind die Anionen Formiat, Acetat, Propionat und Butyrat zusammengefasst. Bevorzugt sind Acetat und Propionat. Die C^-Alkanoationen können Substituenten wie beispielsweise Hydroxygruppen oder Halogenatome tragen. Unter den substituierten C^-Alkanoaten sind insbesondere Glykolat und Lactat zu nennen. Das Mengenverhältnis von Biozid (Ia, Ib) zu Piperazin (II) liegt vorzugsweise im Bereich von 1:5 bis 5:1.Among the groups of the formula - (CH 2 ) “- NH 2 , those with n = 3 are preferred. The anions formate, acetate, propionate and butyrate are combined under the name C ^ -alkanoate. Acetate and propionate are preferred. The C ^ alkanoate ions can carry substituents such as hydroxyl groups or halogen atoms. Glycolate and lactate are to be mentioned in particular among the substituted C 1-4 alkanoates. The quantitative ratio of biocide (Ia, Ib) to piperazine (II) is preferably in the range from 1: 5 to 5: 1.
Die erfindungsgemassen Zusammensetzungen sind vorzugsweise flüssig mit Wasser als Lösungsmittel.The compositions according to the invention are preferably liquid with water as the solvent.
Die erfindungsgemassen Zusammensetzungen können noch zusätzlich einen oder mehrere Hilfsstoffe aus der Gruppe bestehend aus organischen Lösungsmitteln (vorzugsweise Alkoholen, Glycolen und Glycolethern), kationischen oder nichtionischen Tensiden, Komplexbildnern, Duftstoffen und Farbstoffen enthalten.The compositions according to the invention can additionally contain one or more auxiliaries from the group consisting of organic solvents (preferably alcohols, glycols and glycol ethers), cationic or nonionic surfactants, complexing agents, fragrances and dyes.
Die erfindungsgemassen Zusammensetzungen eignen sich insbesondere zur Instrumenten- und Flächendesinfektion.The compositions according to the invention are particularly suitable for instrument and surface disinfection.
Ein weiteres bevorzugtes Anwendungsgebiet ist der Einsatz in chemischen Toiletten, beispielsweise in Flugzeugen.Another preferred area of application is the use in chemical toilets, for example in aircraft.
Ein ebenfalls bevorzugtes Anwendungsgebiet ist der Einsatz als Schutz- und Konservierungsmittel für Konstruktionsmaterialien wie Holz oder Dichtungsmassen.Another preferred area of application is the use as a protective and preservative for construction materials such as wood or sealing compounds.
Die folgenden Beispiele dienen zur näheren Erläuterung der vorliegenden Erfindung, ohne dass darin eine Einschränkung zu sehen ist.The following examples serve to explain the present invention in more detail, without any limitation being to be seen therein.
Die Wirksamkeitstests wurden, soweit nichts anderes angegeben ist, mit Aspergillus niger ATCC 16404 als Testkeim nach dem in AFNOR NF T 72-201 bzw. CEN 1275 spezifizierten Verfahren durchgeführt. Konzentrationswerte sind in Gewichtsprozenten, soweit nichts anderes angegeben ist. Beispiel 1Unless otherwise stated, the effectiveness tests were carried out using Aspergillus niger ATCC 16404 as the test germ according to the method specified in AFNOR NF T 72-201 or CEN 1275. Unless otherwise stated, concentration values are in percent by weight. example 1
Eine Lösung von 2% N,N-Bis(3-aminopropyl)dodecylamin (Ib, R5 = n-C12H25, R6 = R7 = -[CH2]3-ΝH2; LONZABAC® 12) und 2% Piperazin (II, R8 = R9 = H) in entsalztem Wasser ohne organische Belastung (pH der Lösung = 11) wurde bei 20 °C und 15 min Kontaktzeit getestet. Der Logarithmus der Keimzahlreduktion betrug ca. 3.A solution of 2% N, N-bis (3-aminopropyl) dodecylamine (Ib, R 5 = nC 12 H 25 , R 6 = R 7 = - [CH 2 ] 3 -ΝH 2 ; LONZABAC ® 12) and 2% Piperazine (II, R 8 = R 9 = H) in deionized water without organic contamination (pH of the solution = 11) was tested at 20 ° C and 15 min contact time. The logarithm of the bacterial count reduction was approx. 3.
Vergleichsbeispiel 1Comparative Example 1
Es wurde wie in Beispiel 1 verfahren, jedoch ohne Zusatz von Piperazin. Der Logarithmus der Keimzahlreduktion betrug nur ca. 1.The procedure was as in Example 1, but without the addition of piperazine. The logarithm of the bacterial count reduction was only approx. 1.
Beispiel 2Example 2
Es wurde eine Desinfektionsreiniger-Formulierung (Konzentrat) hergestellt aus:A disinfectant cleaner formulation (concentrate) was made from:
9,0% Didecyldimethylammoniumchlorid (Ia, R1 = R2 = n-C10H21, R3 = R4 = Me, X" - Cf ; BARDAC® 22) 5,0% Piperazin9.0% didecyldimethylammonium chloride (Ia, R 1 = R 2 = nC 10 H 21 , R 3 = R 4 = Me, X " - Cf; BARDAC ® 22) 5.0% piperazine
6,0% C13-Fettalkoholρolyglykolether (8-9 mol Ethylenoxid) 5,0% Trilon® B (als 40%ige Lösung) 1,0% Natriumcarbonat (wasserfrei) 0,5%o Natriummetasilikat (Pentahydrat) 73,5% Wasser.6.0% C 13 fatty alcohol polyglycol ether (8-9 mol ethylene oxide) 5.0% Trilon ® B (as a 40% solution) 1.0% sodium carbonate (anhydrous) 0.5% o sodium metasilicate (pentahydrate) 73.5% Water.
Hierzu wurden zuerst bei 40-60 °C die beiden festen Natriumsalze unter Rühren im Wasser aufgelöst und dann die restlichen Bestandteile zugegeben, bis eine klare homogene Lösung vorlag.For this purpose, the two solid sodium salts were first dissolved in water with stirring at 40-60 ° C. and then the remaining constituents were added until a clear, homogeneous solution was obtained.
Die Wirksamkeit wurde mit einer Verdünnung aus 7 Teilen dieses Konzentrats und 93 Teilen Wasser bei 20 °C und 15 min Kontaktzeit getestet. Der Logarithmus der Keimzahlreduktion war >4,0. Vergleichsbeispiel 2The effectiveness was tested with a dilution of 7 parts of this concentrate and 93 parts of water at 20 ° C and 15 min contact time. The logarithm of the bacterial count reduction was> 4.0. Comparative Example 2
Es wurde verfahren wie in Beispiel 2 beschrieben, mit dem Unterschied, dass das Piperazin durch die gleiche Menge Wasser ersetzt wurde. Unter den gleichen Testbedingungen war die Formulierung praktisch unwirksam.The procedure was as described in Example 2, with the difference that the piperazine was replaced by the same amount of water. The formulation was practically ineffective under the same test conditions.
Beispiele 3-9, Vergleichsbeispiele 3-7Examples 3-9, Comparative Examples 3-7
Es wurden Lösungen unterschiedlicher Konzentrationen von Didecyldimethylammonium- chlorid (DDAC) und/oder Piperazin (P), l-Amino-4-mefhylpiperazm (AMP), l-(2-Hydroxyethyl)piperazin (HEP) und 1-Methylpiperazin (MP) hergestellt und, wie in den vorangehenden Beispielen beschrieben, getestet. Die Ergebnisse sind in der folgenden Tabelle 1 zusammengefasst.Solutions of different concentrations of didecyldimethylammonium chloride (DDAC) and / or piperazine (P), l-amino-4-methylpiperazm (AMP), l- (2-hydroxyethyl) piperazine (HEP) and 1-methylpiperazine (MP) were prepared and tested as described in the previous examples. The results are summarized in Table 1 below.
Tabelle 1Table 1
Die Resultate zeigen einen erheblichen synergistischen Effekt im untersuchten The results show a considerable synergistic effect in the examined
Konzentrationsbereich.Concentration range.
Beispiele 10-11, Vergleichsbeispiele 8-10Examples 10-11, Comparative Examples 8-10
Es wurden folgende Desinfektionsmittelformulierungen hergestellt:The following disinfectant formulations were produced:
Beispiel 10:Example 10:
11% N,N-Bis(3-aminopropyl)dodecylamin11% N, N-bis (3-aminopropyl) dodecylamine
6% Didecyldimethylammoniumchlorid 5% Lauroy lmethylglucamide (IΝCI-Νame)6% didecyldimethylammonium chloride 5% lauroymethylglucamide (IΝCI-Νame)
3 % Ethylendiamintetraessigsäure3% ethylenediaminetetraacetic acid
15% Butyldiglykol15% butyl diglycol
4% Piperazin4% piperazine
Wasser ad 100% (Biozidgehalt total 17%)Water ad 100% (total biocide content 17%)
Beispiel 11 :Example 11:
11% N,N-Bis(3-aminopropyl)dodecylamin11% N, N-bis (3-aminopropyl) dodecylamine
7,5% Didecyl-methyl-polyoxyethyl-ammoniumpropionat (BARDAP™ 26) 5% Lauroylmethylglucamide7.5% didecyl methyl polyoxyethyl ammonium propionate (BARDAP ™ 26) 5% lauroyl methyl glucamide
3% Ethylendiamintetraessigsäure3% ethylenediaminetetraacetic acid
15% Butyldiglykol15% butyl diglycol
4% Piperazin Wasser ad 100%4% piperazine water ad 100%
(Biozidgehalt total 18,5%)(Total biocide content 18.5%)
Nergleichsbeispiel 8:Comparative example 8:
10,5% N,N-Bis(3-aminopropyl)dodecylamin10.5% N, N-bis (3-aminopropyl) dodecylamine
7% Didecyldimethylammoniumchlorid7% didecyldimethylammonium chloride
2,5% Lauroylmethylglucamide 1,5% Ethylendiamintetraessigsäure2.5% lauroylmethylglucamide, 1.5% ethylenediaminetetraacetic acid
7,5% Butyldiglykol Wasser ad 100% (Biozidgehalt total 17,5%)7.5% butyl diglycol Water ad 100% (total biocide content 17.5%)
Nergleichsbeispiel 9: 10,5% N,N-Bis(3-aminopropyl)dodecylaminComparative Example 9: 10.5% N, N-bis (3-aminopropyl) dodecylamine
7% Kokosalkyl-dimethyl-benzylammoniumchlorid7% coconut alkyl dimethyl benzyl ammonium chloride
2,5% Lauroylmethylglucamide2.5% lauroylmethylglucamide
1,5% Ethylendiamintetraessigsäure1.5% ethylenediaminetetraacetic acid
7,5% Butyldiglykol Wasser ad 100%7.5% butyl diglycol water ad 100%
(Biozidgehalt total 17,5%)(Total biocide content 17.5%)
Nergleichsbeispiel 10:Comparative example 10:
11% N,N-Bis(3-aminopropyl)dodecylamin 7,5%) Didecyl-methyl-polyoxyethyl-ammoniumpropionat11% N, N-bis (3-aminopropyl) dodecylamine 7.5%) didecyl-methyl-polyoxyethyl-ammonium propionate
5% Lauroylmethylglucamide5% lauroylmethylglucamide
3% Ethylendiamintetraessigsäure3% ethylenediaminetetraacetic acid
15% Butyldiglykol15% butyl diglycol
4% Diethylentriamin Wasser ad 100%4% diethylene triamine water ad 100%
(Biozidgehalt total 18,5%)(Total biocide content 18.5%)
Mit diesen Formulierungen wurden qualitative Suspensionstests nach DGHM (Kontaktzeit: 15 min) durchgeführt. Die Ergebnisse sind in der folgenden Tabelle 2 zusammengefasst. Angegeben sind jeweils die erforderlichen Gebrauchskonzentrationen (in Volumenprozenten) für die Testkeime Mycobacterium terrae (ATCC 15755), Staphylococcus aureus (ATCC 6538) und Pseudomonas aeruginosa (ATCC 15442), bezogen auf die obenstehenden Formulierungen (100 Vol.%). Tabelle 2Qualitative suspension tests according to DGHM (contact time: 15 min) were carried out with these formulations. The results are summarized in Table 2 below. The required use concentrations (in volume percent) for the test germs Mycobacterium terrae (ATCC 15755), Staphylococcus aureus (ATCC 6538) and Pseudomonas aeruginosa (ATCC 15442) are given, based on the above formulations (100% by volume). Table 2
Auch diese Beispiele zeigen den starken synergistischen Effekt von Piperazin. Das chemisch ähnliche offenkettige Amin Diethylentriamin weist ebenfalls einen, allerdings deutlich schwächeren, synergistischen Effekt auf (Vergleichsbeispiel 10). These examples also show the strong synergistic effect of piperazine. The chemically similar open-chain amine diethylenetriamine also has a synergistic effect, albeit a much weaker one (comparative example 10).

Claims

Patentansprüche claims
1. Desinfektionsmittelzusammensetzung auf Basis von Aminen und/oder quartären Ammoniumsalzen, dadurch gekennzeichnet, dass sie mindestens eine biozide Verbindung der allgemeinen Formel1. Disinfectant composition based on amines and / or quaternary ammonium salts, characterized in that they have at least one biocidal compound of the general formula
und/oderand or
worin R1 oder Benzyl,where R 1 or benzyl,
^ C^s-Alkyl, R3 C,_18-Alkyl oder -[CH2-CH2-O]w-H mit m = 1-8,^ C ^ s-alkyl, R 3 C, _ 18 alkyl or - [CH 2 -CH 2 -O] w -H with m = 1-8,
R4 C^-Alkyl,R 4 C ^ alkyl,
R5 C^-Alkyl,R 5 C ^ alkyl,
R6 und R7 unabhängig voneinander Wasserstoff, C,_6-Alkyl oder -(CH2)„-NH2 mit n = 2-5, und X Chlorid, Bromid, lodid oder gegebenenfalls substituiertes C^-Alkanoat bedeuten, sowie mindestens ein Piperazin der allgemeinen Formel R 6 and R 7 independently of one another are hydrogen, C, _ 6 -alkyl or - (CH 2 ) "- NH 2 with n = 2-5, and X is chloride, bromide, iodide or optionally substituted C 1-4 alkanoate, and at least a piperazine of the general formula
worin R8 und R9 unabhängig voneinander Wasserstoff, C1-4-Alkyl, Amino oder 2-Hydroxyethyl bedeuten, enthält, wobei das Mengenverhältnis von Biozid (Ia, Ib) zu Piperazin (II) 1 : 10 bis 10:1 beträgt.wherein R 8 and R 9 independently of one another are hydrogen, C 1-4 -alkyl, amino or 2-hydroxyethyl, the ratio of biocide (Ia, Ib) to piperazine (II) being 1:10 to 10: 1.
2. Desinfektionsmittelzusammensetzung nach Anspruch 1, dadurch gekennzeichnet, dass das Mengenverhältnis von Biozid (Ia, Ib) zu Piperazin (II) 1 :5 bis 5:1 beträgt.2. Disinfectant composition according to claim 1, characterized in that the quantitative ratio of biocide (Ia, Ib) to piperazine (II) is 1: 5 to 5: 1.
3. Desinfektionsmittelzusammensetzung nach Anspruch 1 oder 2, dadurch gekennzeichnet, dass sie in flüssiger Form vorliegt und Wasser als Lösungsmittel enthält.3. Disinfectant composition according to claim 1 or 2, characterized in that it is in liquid form and contains water as a solvent.
4. Desinfektionsmittelzusammensetzung nach einem der Ansprüche 1 bis 3, dadurch ge- kennzeichnet, dass sie zusätzlich einen oder mehrere Hilfsstoffe aus der Gruppe bestehend aus Alkoholen, kationischen oder nichtionischen Tensiden, Komplexbildnern, Duftstoffen und Farbstoffen enthält.4. Disinfectant composition according to one of claims 1 to 3, characterized in that it additionally contains one or more auxiliaries from the group consisting of alcohols, cationic or nonionic surfactants, complexing agents, fragrances and dyes.
5. Verwendung der Zusammensetzungen gemass Ansprüchen 1 bis 4 zur Instrumenten- und Flächendesinfektion.5. Use of the compositions according to claims 1 to 4 for instrument and surface disinfection.
6. Verwendung der Zusammensetzungen gemass Ansprüchen 1 bis 4 als Desinfektionsmittel in chemischen Toiletten.6. Use of the compositions according to claims 1 to 4 as disinfectants in chemical toilets.
7. Verwendung der Zusammensetzungen gemass Ansprüchen 1 bis 4 als Schutz- und Konservierungsmittel für Konstruktionsmaterialien wie Holz oder Dichtungsmassen. 7. Use of the compositions according to claims 1 to 4 as a protective and preservative for construction materials such as wood or sealants.
EP99958179A 1998-12-11 1999-12-08 Disinfecting agents Ceased EP1137338A1 (en)

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EP99958179A EP1137338A1 (en) 1998-12-11 1999-12-08 Disinfecting agents

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Application Number Priority Date Filing Date Title
EP98123656 1998-12-11
EP98123656 1998-12-11
EP99958179A EP1137338A1 (en) 1998-12-11 1999-12-08 Disinfecting agents
PCT/EP1999/009637 WO2000035283A1 (en) 1998-12-11 1999-12-08 Disinfecting agents

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