DE3639635A1 - Disinfectant - Google Patents

Abstract

A disinfectant for use in dental laboratories and/or dental practices, in particular for disinfecting and/or cleaning dental materials, equipment and/or instruments, is described. The disinfectant contains as active ingredient an organic quaternary ammonium compound and/or an organic heterocyclic compound with at least one nitrogen atom in the heterocyclic ring.

Description

The present invention relates to a disinfectant according to the preamble of claim 1.

The well-known, in dental laboratories and / or at dentists Disinfectants used, which are usually called water-containing solutions are present as active ingredients Formaldehyde, aliphatic or aromatic alcohols, such as phenols or cresols. Both in the dental laboratories and dental surgeries such disinfectants are used for antibacterial and / or antimicrobial treatment of the Instruments or devices used there, as in for example drills, dental impression plates or the like, and / or for cleaning and / or storing jaw or Dental impressions or dentures. So will these Disinfectant for cleaning laboratory and ar workplaces used.

The well-known disinfectants that act as active ingredients Contain formaldehyde, phenols or cresols have the Disadvantage that they often skin irritation or allergies  or cause irritation to the mucous membranes. Also such active substances from human skin ad or absorbed and thus get into the bloodstream and can damage organs such as the liver cause damage. Hence the use such disinfectants with special care measures connected. In addition, are against such Disinfectant-resistant bacterial strains or micro organisms known.

The present invention is based on the object a disinfectant of the specified type is available to provide a particularly high biocidal effect compared to those in dental laboratories and dental practices bacteria, microorganisms and fungi occurring.

This object is achieved by a disinfectant tion means with the characteristic features of the patent claim 1 solved.

The disinfectant according to the invention for des infect and / or clean dental materials, Devices and / or instruments in the dental laboratories and / or dental practices is used in contrast to the formaldehyde, phenol or cresol disinfectants as Active ingredient is an organic quaternary ammonium compound and / or an organic heterocyclic compound, wherein the heterocyclic compound is at least one Has nitrogen atom in the heterocyclic ring.

The disinfectant according to the invention has a Number of advantages. It was found that a such disinfectant in addition to its disinfectant Effect also excellent for removing  for example blood residues or mucus residues from in the tooth impression materials used in medical practices, dentures, dental instruments and devices are used can. Because quaternary ammonium compounds or the aforementioned heterocyclic compounds are not are ad- or absorbed by human skin and thus cannot enter the bloodstream those required for known disinfectants Protective measures for the disinfectant according to the invention superfluous. Quaternary ammonium compounds also call or the heterocyclic compounds according to the invention no irritation of the mucous membranes. Furthermore they are relatively biodegradable, and therefore the disinfectant according to the invention is particularly environmental friendly. Furthermore, an aqueous or water-containing foam Quaternary solution, dispersion, suspension or emulsion Ammonium compound or the corresponding nitrogenous heterocyclic compounds not or at most only very low, so that the Des Infectants can also be used in disinfection baths is where there is high turbulence of the disinfectant having cleaning liquor occurs. About that it is also combined with surfactants, especially cationic ones and nonionic surfactants, particularly good ver inert, so that, if necessary, such surfactants even in high Concentrations as cleaning enhancers to the invention appropriate disinfectants can be added. Depending on the respective active ingredient and its concentration the disinfectant according to the invention against a high Number of microorganisms such as Staphylococcus aurens, Escherichia coli, Klebsiella pneumonia, Citrobacter freundii, Proteus vulgaris, Pseudomonas aeroginosa, Xanthomokas malvacearum, Erwinia caratovora, Erwinia amylovora, Desulforilrio desulforiaus, Bacillus cereus var mycoides, Bacillus subtilis, Brevibacterium ammoniagenes, Sarcina luter, Achromobacter parvalus,  Salmonella typhosa, Stingella sonei, Aspergillus niger, Penicillium funiculosum, effective.

The disinfectant according to the invention usually has the active ingredient in a concentration between about 10 ppm and about 2% by weight. Especially in one Drug concentration range between about 100 ppm and about 0.2% by weight of the desin according to the invention disinfectant has a very good disinfectant effect compared to the examples listed above Microorganisms, being such a relatively minor Concentration range additionally has the advantage that regardless of chemical composition no foam of the active ingredient used in each case occurs and also with particularly sensitive users no impairments, even during extended use, such as skin irritation, irritation of the Mucous membranes or allergies.

Is in the disinfectant according to the invention as Active ingredient used a quaternary ammonium compound, it has the following general formula:

In the general formula listed above, R₁-R₄ can be an alkyl, alkylbenzyl, dialkylbenzyl, tri alkylbenzyl group or derivative thereof, it being possible for all four ligands R₁-R₄ to be identical. It is also possible that any combination of the groups mentioned above are bonded as ligands R₁-R₄ with the central nitrogen atom. The X radical of the above formula is selected from the group consisting of halogens, SO₃H ^- , SO₃ ^2- , SO₄H ^- , SO₄ ^2- , SO₃R₅ ^- and / or SO₄R₅ ^- , wherein R₅C₆-C₁₈ alkyl groups, a mixture of C₈- , C₁₀ and C₁₂ alkyl groups and / or the group

means.

Such quaternary ammonium compounds are examples as alkyldimethylbenzylammonium halide, in particular Lauryldimethylbenzylammonium chloride, alkyldimethyl dichlorobenzylammonium chloride, dialkyldimethylammonium chloride, especially didecyldimethylammonium chloride, Alkyldimethylbenzylammonium saccharat, diisobutylcresoxy ethoxyethyldimethylbenzylammonium chloride, diisobutyl phenoxyethoxyethyl dimethyl benzyl ammonium chloride, methyl dodecylbenzyltrimethylammonium chloride or methyldodecyl xylenebistrimethylammonium chloride.

The heterocyclic compounds in which he disinfectants according to the invention are used, have in particular the isothiazolenes, such as N-octyl-isothiazolenes, or corresponding derivatives thereof, such as 5-chloro-2-methyl-4-isothia zoline-oxy or 2-methyl-4-isothiazolines, excellent biocidal effects on the above Connections are represented as follows:  

Hydantoin and / or corresponding substances can be used as well Hydantoin derivatives such as dime thyloldimethylhydantoin, which is reproduced below has chemical structural formula can be used.

The formulas listed above are usually located three active substances in the form of halides of am Nitrogen atom protonated heterocycles.  

Also 1 (3-chloroalkyl) -3,5,7-triazo-azonium adamant chloride according to the structural formula shown below is as an active ingredient for the desin invention suitable for fection agents.

Preferably the above isothiazolines used in the form of a weak complex, where an inorganic salt as complexing agent, in particular Chlorides, bromides or iodides of calcium and / or Magnesium, serves. This dissociates Complex once it has been associated with water is so that the disinfectant effect of the isotiazolines comes into its own.

Of course, it is possible that the invention Disinfectant both a quaternary ammonium compound as well as one or more of the above mentioned heterocyclic compounds. Preferential the ammonium compounds and the heterocyclic become wise Compound used in the same ratio, however, for special areas of application also others Ratios, such as 20-40% ammo nium compound and correspondingly 80-60% heterocyclic Compound or heterocyclic compounds, conceivable are.

The disinfectant according to the invention usually has a liquid dosage form. This will  the active ingredient, which also consists of a mixture of the above listed compounds can exist in water or dissolved, dispersed in a water-alcohol mixture, emulsified or suspended. As alcohol in particular Ethanol or n-propanol and a mixture of ethanol and n-propanol used. The alcohol concentration is about 5 to about 75% by weight, preferably about 15 up to about 35% by weight. They can also be glycolic Solvents such as B. propylene glycol, butyl glycol and / or Polyethylene glycol with a molecular weight of about 200 to about 20,000, preferably with one molecular weight between about 200 and 600, are added. Dar moreover, in cases where the disinfec detergent should also have a cleaning effect at the same time, Surfactants are added, preferably nonionic Surfactants, such as fatty alcohol polyglycol ether, Alkylphenol polyglycol ether or cationic surfactants be used. The surfactant is usually concentration in such a cleaning disinfectant agent about 0.5 to about 2 wt .-%.

Should the disinfectant according to the invention as a hand disinfectants can be used for dentists there are also lipid-replenishing substances, such as Amine oxides or proteins, in one concentration between about 0.5 and about 1.5% by weight. Also there may also be perfume additives in concentration between about 0.05 and about 0.5% by weight as well as builder for example based on phosphates, borates or inorganic or organic complexing agents.

Since the optimal pH of the disinfectant according to the invention tion agent in a range between about pH 4.5 and pH is around 8.5, is used to adjust the pH the disinfectant also a weak organic Acid such as acetic acid, citric acid,  Tartaric acid, gluconic acid, amidosulfonic acid, isethionic acid or sulfophthalic acid added, their Amount according to the acid used and the adjusted pH value.

A particularly preferred dosage form of the invention According disinfectant provides that the solution, dispersion, emulsion or Suspension of the active ingredient or ingredients, the or those from the ammonium compounds described above or the heterocyclic compounds, adsorbed on a carrier material or by a Carrier material is absorbed. This leads to one the disinfectant and possibly cleaning agent in impregnated support material, which is still a sufficient has great moisture on its surface, so that it can be directly disinfected and cleaned if necessary Dental practices and dental laboratories can be used. As a carrier material come adequately absorbent and wettable materials, such as felts, nonwovens made of paper or corresponding textile fabrics, such as felts, nonwovens, woven fabrics or knitted fabrics, to use. Usually these become carriers materials between about 60% and 160%, preferably between about 80% and 120%, based on the weight per unit area of the respective carrier material, with the solution, Dispersion, suspension or emulsion of the active ingredient loaded and then packed individually or in groups, so that evaporation or evaporation of the solvent or the solvent is excluded. A such dosage form is characterized by a special easy handling from that with the active ingredient impregnated or wetted carrier material immediately after removal from the packaging for disinfection and if necessary cleaning of dental materials, Devices and / or instruments can be used.  

Advantageous developments of the Des according to the invention infectious agents are specified in the subclaims.

The disinfectant according to the invention is as follows explained in more detail using exemplary embodiments.

example 1

A disinfectant spray for dental prostheses was under Made using the following ingredients:

35% by weight of ethyl alcohol 30% by weight isopropanol 10 wt .-% polyethylene glycol, average Mo molecular weight 200 0.25% by weight alkyldimethylbenzylammonium saccharat 0.1% by weight of an ethoxylated fatty alcohol sulfate 24.65 wt% distilled water.

The disinfectant solution thus prepared was used to disinfect and clean dentures tried. For this she was on in dental surgeries Blood and mucus stained dentures as well Sprayed dental impressions. It could be determined that the blood and mucus stains immediately were rinsed off.

The quaternary ammonium compound used in this example, which is an alkyldimethylbenzylammo acted niumsaccharat, has the described below chemical structural formula on:

Here R denotes a methyl group.

Example 2

A disinfection spray and a wetting solution of a support material was made using the following Components made:

35% by weight of ethyl alcohol 15% by weight i-propanol 10 wt .-% polyethylene glycol, (average molecular weight weight about 400) 0.03 wt% 5-chloro-2-methyl-4-iso-thiazoline-oxy 0.1% by weight of an anionic fatty alcohol sulfate 38.87 wt% distilled water.

The solution thus prepared had a pH of about 5.5 on.

When spraying on dirty dental instruments could be determined that no undesirable Foam development occurred and that on the instruments blood and mucus contamination immediately were rinsed off.

Example 3

A disinfectant spray and a solution for soaking of a carrier material was made using a mixture a quaternary ammonium compound and a he terocyclic compound produced. The solution pointed the following ingredients:

15% by weight of ethyl alcohol 35% by weight i-propanol 10 wt .-% polyethylene glycol, (average molecular weight weight about 400)  0.075% by weight of N-octyl-iso-thiazolenes 0.01 wt% lauryldimethylbenzylammonium chloride 0.05% by weight ether sulfate 0.25% by weight of nonionic surfactant based on a ethoxylated fatty alcohol with a Degree of ethoxylation of 8 39.615 wt% water.

The pH of the solution was between about 5.5 and 6. Despite the common use of cationic and anionic surfactants did not appear in the solution cases. The result of the bacterial count is reproduced in Table 1 below.

Example 4

A hand disinfectant, especially for use by dentists, was made using the following Components made:

15% by weight of ethyl alcohol 40% by weight i-propanol 10 wt .-% polyethylene glycol, (average molecular weight weight about 400) 1.5% by weight of nonionic surfactant based on a ethoxylated fatty alcohol 0.15% by weight didecyldimethylammonium chloride 33.35 wt% water.

Even with repeated, multiple use the called above Disinfectant solution listed no redness the skin and also no irritation of the mucous membranes forth. The result of the bacterial count is in the Table 1 below.  

Example 5

A cleaner for surfaces such as floors or Laboratory tables were made using the following inventory parts manufactured:

35% by weight of ethyl alcohol 15% by weight i-propanol 10 wt .-% polyethylene glycol, (average molecular weight weight about 600) 0.1% by weight didecyldimethylammonium chloride 1% by weight of ethoxylated fatty alcohol with an ethoxy grade of 8 0.02% by weight ether sulfate 38.88 wt% water.

The cleaning disinfectant thus produced showed an excellent cleaning power, especially compared greasy soiling.

Example 6

Two disinfectant hand cleaners for dentists were made according to the following recipes:

a) 15% by weight of ethyl alcohol 50% by weight i-propanol 0.1% by weight of a nonionic surfactant based on a ethoxylated fatty alcohol with an ethoxy grade of 8 2.5% by weight of polyethylene glycol, (average molecular weight weight about 200) 0.15% by weight didecyldimethylammonium chloride 32.25 wt% water.

The second disinfectant had the following together  set to:

b) 20% by weight of ethyl alcohol 30% by weight n-propanol 10 wt .-% polyethylene glycol, (average molecular weight weight about 400) 2% by weight of amine oxide 0.1% by weight of an anionic surfactant based on a Fatty ether sulfate 0.25% by weight of a nonionic surfactant based of an ethoxylated fatty alcohol with a Degree of ethoxylation of 8 0.15% by weight of a quaternary ammonium compound Formula listed below 0.05% by weight of perfume oil 37.45 wt% water.

The disinfectant hand cleaning solutions produced in this way did not lead to skin allergies or irritation of the eye or nose mucous membranes even after long-term use. The quaternary ammonium compound used in the recipe last shown had the following structural formula, where R and R 'are a mixture of the organic radicals of the general formula C _n H _{2 n + 1} with n = 6, 8, 10 and 12 and X is a chloride.

Example 7

Two disinfectants, especially for cleaning of surfaces, such as floors, laboratory spaces etc., can be used, showed the following compositions  on:

a) 32% by weight of ethyl alcohol 11% by weight g-propanol 3% by weight of 2-ethylhexanol 400 ppmn-octyl-isothiazolenes 2.5% by weight of a surfactant mixture of nonionic and cationic surfactants 0.1% by weight perfume oils 51.4 wt% water

b) 25% by weight of ethyl alcohol 35% by weight n-propanol 50 ppm 5-chloro-2-methyl-4-isothiazoline-oxy, com plexed as magnesium chloride 40% by weight water.

The results of the bacteriological examination are reproduced in Table 1.

The disinfectants described above were examined bacteriologically. For this purpose, the one half of tooth impression plates with distilled Water and the other half with the corresponding des rinsed off infectious agents and the rinsing liquids caught. By immersing a culture medium, on the one hand with MacConkey agar and on the other other side is coated with CLED agar, the Bak the bacterial count of the respective rinsing solution is determined. Before the culture media were in for 24 hours incubated in an incubator at 37 ° C. The used distilled water had a bacterial count between 1000 and 10,000.

The results of the bacterial count determination are as follows Table 1 reproduced.  

Germ count per ml
Liquid concentrate

a) Disinfectant according to Example 1 <1000 b) dest. Water 100,000

a) Disinfectant according to Example 21000 b) dest. Water∼50,000

a) Disinfectant according to Example 3 <1000 b) dest. Water∼70,000

a) Disinfectant according to Example 4-5000 b) dest. Water∼200,000

a) Disinfectant according to Example 5-2000 b) dest. Water∼80,000

a) Disinfectant according to Example 6b <1000 b) dest. Water 100,000

a) Disinfectant according to Example 7a <1000 b) dest. Water∼200,000

In the table above, the bacterial counts per ml Liquid concentrate reproduced. Here were the desin used for rinsing the dental impression plates detergents or the distilled water used, which serves as a comparison value, collected and by vacuum distillation to a 100th of the original Crowd focused. Due to the fact that different amounts of bacteria on the different Tooth impression plates were present differ naturally also in the case of distilled water indicated bacterial counts per ml of liquid concentrate.

Claims (13)

1. Disinfectant for use in dental laboratories and / or dental practices, in particular for disinfecting and / or cleaning dental materials, devices and / or instruments, characterized in that it contains an organic quaternary ammonium compound and / or an organic heterocyclic compound with at least comprises a nitrogen atom in the heterocyclic ring. 2. Disinfectant according to claim 1, characterized in that it's the active ingredient in a concentration between about 10 ppm and about 2% by weight. 3. Disinfectant according to claim 2, characterized in that it's the active ingredient in a concentration between about 100 ppm and about 0.2% by weight. 4. Disinfectant according to one of the preceding claims, characterized in that the active ingredient is a quaternary ammonium compound of the formula is, where R₁-R₄ are both alkyl, alkylbenzyl, dialkylbenzyl, trialkylbenzyl groups and / or derivatives thereof and any combination of these groups and X are halogens, SO₃H ^- -, SO₃ ^2- -, SO₄H ^- -, SO₄ ^2- -, SO₃R₅ ^- and / or SO₄R₅ ^{- are} radicals, wherein R₅C₆-C₁₈ alkyl groups and a mixture of C₈-, C₁₀- and C₁₂-alkyl groups and / or the group means. 5. Disinfectant according to one of claims 1-3, characterized in that the active ingredient is a heterocyclic compound of the formula and / or a derivative thereof, where X and X 'are fluorine, chlorine, bromine and / or iodine radicals. 6. Disinfectant according to one of claims 1-3, characterized in that the active ingredient is a heterocyclic compound of the formula is, where R₆ is hydrogen, halogens and / or alkyl groups and R₇ is hydrogen or alkyl groups, especially methyl or octyl groups. 7. Disinfectant according to claim 6, characterized in that the active ingredient as a complex compound inorganic salt, in particular alkaline earth metal salt. 8. Disinfectant according to one of claims 1-3, characterized in that the active ingredient is a heterocyclic compound of the formula is, where R₈ and R₉ are hydrogen and / or an alkyl group or alkyl groups and R₁₀ and R₁₁ are hydrogen and / or a methylol group or methyl groups. 9. Disinfectant according to one of the preceding claims, characterized in that there are equal amounts the quaternary ammonium compounds and heterocyclic Connections. 10. Disinfectant according to one of the preceding Claims, characterized in that it is a spray solution suitable dosage form. 11. Disinfectant according to one of claims 1-9, characterized in that the active ingredient in a water containing medium dissolved, dispersed, suspended and / or is emulsified. 12. Disinfectant according to claim 11, characterized ge indicates that the solution, dispersion, suspension and / or emulsion of the active ingredient further contains surfactants. 13. Disinfectant according to claim 11 or 12, characterized characterized in that the solution, dispersion, suspension and / or Emulsion of the active ingredient on a carrier material adsorbed and / or absorbed by a carrier material is.