EP1473992A1 - Produit chimique agricole a liberation prolongee et procede de preparation associe - Google Patents

Produit chimique agricole a liberation prolongee et procede de preparation associe

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Publication number
EP1473992A1
EP1473992A1 EP03731847A EP03731847A EP1473992A1 EP 1473992 A1 EP1473992 A1 EP 1473992A1 EP 03731847 A EP03731847 A EP 03731847A EP 03731847 A EP03731847 A EP 03731847A EP 1473992 A1 EP1473992 A1 EP 1473992A1
Authority
EP
European Patent Office
Prior art keywords
active substance
sustained release
weight
unit
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03731847A
Other languages
German (de)
English (en)
Inventor
Hae-Jun Park
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio Dreams Co Ltd
Original Assignee
Bio Dreams Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Dreams Co Ltd filed Critical Bio Dreams Co Ltd
Priority claimed from KR10-2003-0004457A external-priority patent/KR100408157B1/ko
Publication of EP1473992A1 publication Critical patent/EP1473992A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form

Definitions

  • the present invention relates to a sustained release composition containing biologically active substance and a preparation method thereof. More particularly, the invention relates to a biologically active sustained release composition having biologically active substances of agricultural chemicals or fertilizers, a coating matrix and a release regulator contained in a porous carrier, and a preparation method thereof.
  • composition according to the present invention can control a manifesting time of effects of agricultural chemicals or fertilizers, and can provide agricultural chemicals or fertilizers with reduced harmful damages.
  • Agricultural chemicals used to prevent damages by blight and harmful insects in vegetables, fruits, flowers or crops and fertilizers used as an important source of nutrient for these crops are generally in a fluid form mixed with water, or granular form mixed with a filler.
  • agricultural chemical or fertilizer components may diffuse out of a sprinkled area, may retard in dispersion or may be evaporated, so that the concentration of effective components rapidly decreases. Since the normal duration of efficacy is very short, fertilizers are generally sprinkled several times in a larger concentration than actually needed. Problems with the use of excessive agricultural chemicals or fertilizers include various harmful damages to the health of crop producers or consumers, and serous harm to the environment due to salt accumulation or hypereutrophic state due to continued sprinkling or irrigation of fertilizers.
  • Known methods of preparing sustained release agricultural chemicals include: 1) encapsulating an agricultural chemical active substance into a microcapsule; 2) entrapping active substance of an agricultural chemical into cyclodextrin; and 3) coating a resin on particles produced by mixing particulate or powdery active substances of agricultural chemical compositions alone or in combination with an extender.
  • Japanese Patent No. hei 6-116103 discloses a method of providing a sustained release property by introducing a biodegradable resin agricultural chemicals dissolved in a solvent to a plate-injected biodegradable resin injected in a plate shape.
  • Japanese Patent No. hei 5-85902 describes a method of preparing sustained release agricultural chemicals by mixing a raw material of an agricultural chemical with a biodegradable polymer, dissolving the mixture in chloroform, adsorbing the resultant product into particulate zeolite, and heating to evaporate chloroform therefrom.
  • U.S. Patent No. 4,647,537 discloses a method of encapsulating plant pathogenic microorganisms in a carrageenan polymer matrix.
  • U.S. Patent No. 4,382,813 describes coagulation or precipitation of entrapped insecticide by rapidly insolubilizing starch alkoxide containing divalent cations selected from the group consisting of calcium, barium, and strontium.
  • Korean Patent Publication No. 1989-1145 describes coating of particulate agricultural chemicals, wherein the particulate agricultural chemicals are primarily coated with a mixture of isocyanate and flowable paraffin and then secondarily coated with organic or inorganic powder.
  • Korean Patent Publication No. 1989-4995 describes that agricultural chemical active substances are coated with solid, water-insoluble, low-melting point soldering materials and immobilized in a particulate fertilizer.
  • Korean Patent Publication No. 1992-7002910 describes a method of forming a polyurea barrier layer by performing interface polymerization between a carrier containing agricultural chemicals and a polyhydroxylated compound or polyisocyanate.
  • Korean Patent Publication No. 2000-42895 describes mixing agricultural chemical active substance with a biodegradable resin and a release controlling agent and injection-molding the same.
  • Korean Patent Publication No. 2000-2248 a sustained releasing agent of increasing the sustained release property of fertilizers or agricultural chemicals, by which the sustained release property of active substances immobilized in a matrix, e.g., pulp including waste paper, by immersing the active substances of fertilizers or agricultural chemicals into the matrix and forming a first resin coating and a second sulfur coating.
  • some agricultural chemical compounds may not be used as sustained release composition because there may be agricultural chemical compounds incapable of encapsulating or forming a clathrate compound with cyclodextrin.
  • preparation methods of sustained release agricultural chemicals are complicated and raw materials used in preparation thereof are expensive, there are many problems to be solved from the viewpoints of technology and cost.
  • Korean Patent Application No. 2000-17801 describes a method of coating polysaccharide derived from microorganisms on the microorganism to provide heat resistance and acid resistance.
  • microorganism coating techniques are for the purpose of protecting microorganisms advantageously used for human body, e.g., lactic acid bacteria, etc., from gastric acid and various intestinal digestive enzymes in the case of intake of the microorganisms microorganism, thereby allowing the microorganisms to be safely seated in small and large intestines. Therefore, according to the microorganism coating method, while maintaining acid resistance, heat resistance and resistance to digestive enzymes, coating should be removed immediately when the microorganism reaches predetermined intestinal parts, e.g., small or large intestines so that the microorganism can attach thereto and grow therein. Thus, the microorganism coating is quite different from the preparation process of sustained release agricultural chemicals, in which active substances of the sustained release agricultural chemicals are slowly released. Disclosure of the Invention
  • the present invention provides a sustained release composition of biologically active substances, which can be simply prepared, and a preparation method thereof.
  • the present invention also provides a sustained release composition of biologically active substances, which is cheap in raw materials and easily commercially available, and a preparation method thereof. Also, the present invention provides a biologically active substance composition which is environmentally friendly and has a good sustained release property, and a preparation method thereof.
  • a sustained release composition of a biologically active substance comprising an adsorbing carrier having 0.0005—50 unit by weight of a biologically active substance adsorbed in 1000 unit by weight of a porous carrier; and a sustained release layer having a mixture of 0.05 — 15 unit by weight of polysaccharide, 0.3—20 unit by weight of inorganic alkali, and 0.25 —20 unit by weight of one or more release regulators made of either organic or inorganic acid selected from the group consisting of phosphorous acid, phosphoric acid, acetic acid and hydrochloric acid, the mixture coated on the surface of the adsorbing carrier.
  • the biologically active substance may be adsorbed into the porous carrier as described above. Otherwise, the biologically active substance may exist on the sustained release layer.
  • the present invention provides a sustained release composition of a biologically active substance, comprising 1000 unit by weight of a porous carrier, and a sustained release layer having a mixture of 0.0005-50 unit by weight of a biologically active substance, 0.05- 15 unit by weight of polysaccharide, 0.3—20 unit by weight of inorganic alkali, and 0.25—20 unit by weight of one or more release regulators made of either organic or inorganic acid selected from the group consisting of phosphorous acid, phosphoric acid, acetic acid and hydrochloric acid, the mixture coated on the surface of the porous carrier.
  • the inorganic alkali may be KOH or NaOH.
  • the sustained release composition according to the present invention may be adsorbed into the porous carrier coated with the biologically active substance or may be evenly distributed in a coating layer, that is, the sustained release layer.
  • the release regulator regulates release of the biologically active substance and controls biodegradation of the matrix (polysaccharide) for a considerable period, thereby allowing the active substance to be slowly released out of the sustained release composition.
  • the present invention has the following effects.
  • release is sustained by adsorption between a carrier itself and active substance.
  • polysaccharide coating layer may sustain release of an active substance.
  • a release regulator made of either organic acid or inorganic acid, such as phosphorous acid, phosphoric acid, acetic acid or hydrochloric acid, is first released to produce fine holes and the biologically active substance is then released through the fine holes, thereby enhancing a sustained release property and increasing a working convenience in sprinkling agricultural chemicals.
  • the release regulator contained in the sustained release layer sustains natural degradation (by microorganisms) of polysaccharide, thereby the sustained release property in actual practice.
  • the adsorbing carrier for agriculturally active components one or more mixtures of natural minerals which are commonly used as main components of a filler and an extender in preparing soil-improving agents and agricultural chemicals, that is, zeolite, pearlite, vermiculite, diatomite, ceramic, sand and activated carbon.
  • any carrier that has a soil affinity can be used as the adsorbing carrier.
  • the carrier may be used in natural forms without any treatment, or in processed forms in which raw material is subjected to heat treatment at 600 ° C or higher , for removing internal impurity and optimizing the carrier state.
  • the porous carrier absolutely reduces dffusibility of biologically active substance by adsorbing the same and widens a contact area for preventing the sustained release layer coated on the surface thereof from stripping.
  • the sustained release composition according to the present invention is generally sprinkled to the soil manually or using a sprinkler.
  • the diameter of a particle is preferably in the range of 0.5 — 5 mm, more preferably 2 mm or more in view of workability and utilization efficiency when applied to the soil. According to uses, the particle size may be increased or decreased.
  • the polysaccharide is naturally degradable, and usable examples thereof include pestan, levan, xanthan gum, pullulan, polysaccharide-7, cellulose, zooglan, gellan, curdlan or suitable mixtures thereof.
  • the biologically active substance examples include an insecticide, a herbicide, a plant growth regulator, a nematocide, a fungicide, a biocide, a raticide, a fumigant, an animal and insect repellant, a biological insecticide, pheromone, a sex stimulant, a flavoring agent, a deordorant, a dietary supplement, drug and fertilizers.
  • the amount of a biologically active substance can be suitably selected according to the kind and specific activity of the biologically active substance.
  • Examples of agricultural chemical components include, but not limited to, an insecticide active component, a biocide active component, a herbicide active component and a plant growth regulator active component.
  • insecticid active component include acephate, isoxathion, imidacloprid, ethylthiodemeton, ethofenprox, cartap, carbosulfan, clofentezine, cyclopyrifas-methyl, fenbutatin-oxide, cycloprothrin, dimetylrinphos, dimethoate, silafluofen, diazinon, thiodicarb, thiocyclam, tebufenozide, nitenpyram, vamidothion, bifenthrin, pyridaphenthion, pyridaben, pyrimiphos-methyl, fipronil, phenisobromolate, buprofezin, furathiocarb, propaf
  • biocide active component examples include phosphorous acid salt, acibenzolar-S-methyl, azoxystrobin, bitanol, isoprothiolane, isoprodion, iminoctadine triacetate, oxolinic acid, oxone-copper, kasugamycin, carpropamid, captan, diclomezine, thiabendazole, thifluzamide, tecloftalam, tricyclazole, validamycin, hydroxyisoxazole, pyroquilon, fenarimol, ferimzone, fthalide, blasticidin, polyoxin, methasulfocarb), metalaxl, metalaxl-M, metominostrobin, mepronil, ampiciline, CNA, IBP, DF-351 , NNF-9425 and NNF-9850.
  • herbicide active component and plant growth regulator active component examples include azimsulfuron, atrazine, ametryn, inabenfide, imazosulfuron, nuiconazole, esprocarb, etobenzanid, oxadiazon, cafenstrole, quizalofop-ethyl, quinclorac, cumylron, chlomethoxynil, cyclosulfamuron, dithiopyr, cinosulfuron, cyhalofop-butyl, simazine, dimetametryn, dimepiperate, cinmethylin, dymron, thenylchor, triapenthenol, naproanilide, paclobutrazol, bifenox, piperophos, pyrazoxyfen, pyrazosulfuron-ethyl, pyrazolate, pyributicarb, pyriminobac-methyl, butachlor, butamif
  • the biologically active substances may be used alone or in combination of a plurality of active substances.
  • FIG. 1 shows gelation characteristics of polysaccharides depending on the amounts of organic acid and inorganic acid
  • FIG. 2A shows the biodegradation delay effect of polysaccharide, caused by the organic acid
  • FIG. 2B shows the biodegradation delay effect of polysaccharide in the soil, caused by the organic acid
  • FIG. 3 shows visual models of a sustained release composition
  • FIG. 4 shows an elution test result of a sustained release composition model
  • FIG. 5 shows another elution test result of a sustained release composition model
  • FIG. 6A is a graphical representation showing a sustained release of salicylic acid
  • FIG. 6B is a graphical representation showing a sustained release of ampiciline
  • FIG. 6C is a graphical representation showing a sustained release of metalaxyl.
  • FIG. 7 visualizes pesticidal effects of sustained release compositions.
  • Solvents used throughout the description may be suitably selected from water, organic solvent or mixed solvent according to the polarity and stability of active components. Since the solvent and water are evaporated and removed in the preparation process, the amount of the same used is not important and can be arbitrarily determined in consideration of workability.
  • the sustained composition according to the present invention having an active substance adsorbed into a porous carrier is prepared as follows. First, 0.0005 — 50 g of a predetermined biologically active substance is dissolved in a predetermined volume, e.g., 100 ml, of a solvent according to the specific activity and desired activity thereof, thereby acquiring an active substance solution (Solution acquiring step). 1000 g of the porous carrier and the mixture is immobilized in the acquired active substance solution to then be homogenously mixed and dried at 25 — 150 ° C, thereby obtaining an active substance adsorbing carrier (Immersing and drying step).
  • the obtained adsorbing carrier is homogenously mixed with the coating solution, the resultant mixture is coated on the surface of the adsorbing carrier and dried at 25 — 150°C and a sustained release layer is finally formed (Coating step), thereby completing preparation of a sustained release composition of a biologically active substance according to the present invention.
  • the drying temperature may be appropriately determined according to the heat resistance of the active substance. From the viewpoints of storage and workability, the drying is preferably performed such that moisture contained in the active substance is 40% or less.
  • coating of polysaccharide may be performed once or several times according to the kind and characteristics of the active substance and the desired extent of sustained release.
  • a sustained release composition according to another embodiment of the present invention is prepared in the following manner.
  • the preparation method of the present embodiment is simplified by simultaneously performing adsorption of active substance and coating of polysaccharide.
  • 0.0005 — 50 g of the biologically active substance is dissolved in a predetermined volume, e.g., 50 ml, of a solvent, thereby acquiring an active substance solution (Solution acquiring step).
  • 0.05 — 15 g of suitable polysaccharide, 0.3 — 13 g of inorganic alkali, e.g., KOH, and 0.25 — 10 g of one or more mixtures made of either organic or inorganic acid selected from the group consisting of phosphorous acid, phosphoric acid, acetic acid and hydrochloric acid, are homogenously mixed and a suspend coating solution is prepared (Coating solution preparation step)
  • the acquired active substance solution is homogenously mixed with the coating solution, thereby obtaining a coating solution containing the active substance (Active coating solution preparation step). Then, the coating solution containing the active substance and 1000 g of a porous carrier are homogenously mixed, and dried at 25 — 150 ° C so as to form a sustained release layer on the carrier (Coating step). Thereby, the preparation of a sustained release composition of a biologically active substance according to the present invention is completed.
  • the drying temperature may be appropriately determined according to the heat resistance of the active substance. From the viewpoints of storage and workability, the drying is preferably performed such that moisture contained in the active substance is 40% or less.
  • coating of polysaccharide may be performed once or several times according to the kind and characteristics of the active substance and the desired extent of sustained release.
  • an active substance is adsorbed into a porous carrier in a high concentration and diffusion of the adsorbed active substance is noticeably reduced due to the carrier, compared to the case where the active substance exists singly in a high concentration, thereby primarily attaining a sustained lease property.
  • natural polysaccharide is coated on the surface of an adsorbent having an active substance adsorbed thereinto or polysaccharide containing effective active substances is coated on/adsorbed into an adsorbing carrier. That is, the active substance and the carrier are incorporated and coated components are slowly decomposed, thereby exhibiting a sustained release property in a double manner.
  • the organic and inorganic acids added as coating components e.g., phosphorous acid, phosphoric acid, acetic acid, hydrochloric acid and the like, prevent polysaccharide from rapidly decomposing, thereby maintaining durability of a sustained release layer and promoting biological active substances to be diffused out through fine holes produced while the organic and inorganic acids are diffused out.
  • phosphorous acid salt was used as an active substance
  • zeolite was used as a carrier
  • curdlan was used as a coating agent derived from microorganisms
  • KOH was used as inorganic alkali.
  • the agricultural component, carrier and coating agent used in the examples of the present invention are selected by way of example, and a variety of the above-referenced exemplary materials are also can be used. It is obvious to one skilled in the art that two or more combinations of agricultural chemical components can also be used.
  • the pH levels were 13.1 — 13.3 and 3.4—5.6. Meanwhile, in the case where the organic acids were added in an amount of 5 g, the pH level for phosphoric acid was 11.7, but there was a negligible change in pH level for phosphorous acid and acetic acid.
  • the extent of gelation was sensitive to a change in pH, caused by addition of organic acid, rather than to the amount of organic acid added.
  • the pH level of a curdlan solution is preferably 12 or less.
  • the sustained release composition according to the present invention is not biodegradable, it may undesirably cause environmental.
  • the natural condition that is, the condition in which phosphorous acid salt of the sustained release composition is repeatedly eluted, a time elapsed for occurrence of biodegradation was measured.
  • the treated group was soaked in 400 ml water with an interval of 3 days, taken out of water, and then allowed to stand at room temperature. After the elution test was carried out 10 times, the treated group was biodegraded.
  • FIG. 2B photographically shows the amounts of the control group and treated group remaining after 3 months.
  • the treated group with more than 0.5 g of phosphorous acid, more than 0.42 g of phosphoric acid or 0.39 g of acetic acid added remained in the soil in a considerable amount.
  • organic acids can considerably delay the period of biodegradation of polysaccharide.
  • a composition comprising methyl violet As a carrier model with a biologically active substance adsorbed, a composition comprising methyl violet, which is widely used as a colorant for agricultural chemicals, was used.
  • the methyl violet composition has 0.5 g of methyl violet adsorbed into 1 Kg of sand.
  • 8.3 g of KOH was dissolved in 100 ml of an aqueous solution and 2.5, 5 and 10g of curdlan were added to the resultant solution (Treated groups 1 , 2 and 3), followed by adding 10 g of phosphorous acid, thereby preparing coating compositions, respectively.
  • To the respective coating compositions were added each 1 Kg of methyl violet composition, and uniformly stirred, followed by hot-air drying, thereby producing sustained release composition models. Uncoated methyl violet composition was used as a control group. Photographs of the respective compositions are shown in FIG. 3.
  • each 100 mg of treated group compositions was placed in a test tube and 5 ml deionized distilled water (DDW) was added thereto, and the resultant product was kept one day and then recovered. This procedure was repeated over 16 days, and changes in the color of recovered water were observed, as shown in FIG. 4, in which the respective test tubes are arranged in the order of recovered dates.
  • the uncoated composition underwent vigorous elution of methyl violet, that is, a large amount of methyl violet was eluted, from the first day, and the elution was nearly finished after the ninth day.
  • the treated groups only a small amount of methyl violet was eluted and weak elution was continued over time. In particular, as the amount of curdlan added increased, the duration of release was increased and the amount of methyl violet eluted was reduced.
  • the test was carried out in the same manner as described above, except that 2 g of ampiciline as an antibiotic was used as a biologically active substance, instead of sodium salicylate (FIG. 6B).
  • metalaxyl was used as a biologically active substance, instead of sodium salicylate. Except that metalaxyl was first dissolved in 50 ml methanol, and mixed with a coating solution obtained by adding 10 g of phosphoric acid to 150ml of an aqueous solution containing 8.3 g of KOH and stirring the resultant mixture (FIG. 6C).
  • Example 1 Preparation of sustained release composition having active substance adsorbed into carrier
  • the prepared adsorbing carrier was homogenously mixed with the coating solution, the resultant mixture was coated on the surface of the adsorbing carrier and dried at 100 ° C such that moisture contained in the active substance is 35% or less, and a sustained release layer was finally formed (Coating step), thereby completing preparation of a sustained release composition of a biologically active substance according to the present invention.
  • Example 2 Preparation of sustained release composition having active substance contained in sustained release layer
  • the prepared active substance solution and the coating solution were homogenously mixed, thereby preparing a coating solution containing the active substance (Active substance solution preparation step).
  • the active substance solution and 1000 g of dry zeolite were homogenously mixed, the resultant mixture was coated on the surface of a dry adsorbing carrier and dried at 100 ° C such that moisture is 35% or less, thereby preparing a sustained release layer on the adsorbing carrier (Coating step) , thereby completing preparation of a sustained release composition of a biologically active substance according to the present invention.
  • sustained release group 1 the result was similar to that of sustained release group 2. However, the photograph corresponding to sustained release group 1 was not shown in the drawing, which is because it has been damaged during experimentation. [Table 5]
  • the sustained release group with treatment of the sustained release composition according to the present invention has much higher pesticidal activity than the non-sustained release group. Also, even if preparation methods used are somewhat different from each other, the sustained release compositions prepared in Example 1 and Example 2, respectively, have substantially the same sustained release effect and pesticidal activity.
  • sustained release composition allows effective control of the period and amount of release of active substances of agricultural chemicals or fertilizers, thereby effectuating the effects of the agricultural chemicals or fertilizers. Therefore, it is not necessary to repeatedly apply heavily concentrated agricultural chemicals or fertilizers while maintaining the same efficiency.
  • the amount of agricultural chemicals or fertilizers used and agricultural labor force can be greatly reduced and harmful damages can almost be eliminated.
  • the sustained released composition according to the present invention has advantageous effects in terms of environmental preservation.

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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

L'invention concerne une composition à libération prolongée d'une substance biologiquement active et un procédé de préparation associé. Cette composition à libération prolongée comprend un support adsorbant ayant 0,0005 50 unités en poids de substance biologiquement active adsorbée dans 1000 unités en poids d'un support poreux, et une couche à libération prolongée comportant un mélange de 0,05 15 unités en poids de polysaccharide, 0,3 20 unités en poids d'alcali inorganique et 0,25 20 unités en poids d'un ou de plusieurs régulateurs de libération composés d'acide organique ou inorganique sélectionné dans le groupe constitué par l'acide phosphoreux, l'acide phosphorique, l'acide acétique et l'acide hydrochlorique, le mélange étant enduit à la surface du support adsorbant.
EP03731847A 2002-01-23 2003-01-23 Produit chimique agricole a liberation prolongee et procede de preparation associe Withdrawn EP1473992A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR20020003833 2002-01-23
KR2002003833 2002-01-23
KR10-2003-0004457A KR100408157B1 (ko) 2002-01-23 2003-01-23 생물학적 활성물질의 서방성 제제 및 그의 제조방법
KR2003004457 2003-01-23
PCT/KR2003/000143 WO2003061383A1 (fr) 2002-01-23 2003-01-23 Produit chimique agricole a liberation prolongee et procede de preparation associe

Publications (1)

Publication Number Publication Date
EP1473992A1 true EP1473992A1 (fr) 2004-11-10

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EP03731847A Withdrawn EP1473992A1 (fr) 2002-01-23 2003-01-23 Produit chimique agricole a liberation prolongee et procede de preparation associe

Country Status (3)

Country Link
EP (1) EP1473992A1 (fr)
JP (1) JP3694305B2 (fr)
WO (1) WO2003061383A1 (fr)

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