EP1468918A1 - Appareil de remplissage aseptique de flacons - Google Patents

Appareil de remplissage aseptique de flacons Download PDF

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Publication number
EP1468918A1
EP1468918A1 EP04252232A EP04252232A EP1468918A1 EP 1468918 A1 EP1468918 A1 EP 1468918A1 EP 04252232 A EP04252232 A EP 04252232A EP 04252232 A EP04252232 A EP 04252232A EP 1468918 A1 EP1468918 A1 EP 1468918A1
Authority
EP
European Patent Office
Prior art keywords
sterile zone
filling
containers
sterile
dispenser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04252232A
Other languages
German (de)
English (en)
Inventor
Paul Stewart
Paul Hendrickx
Frans Damen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Linde LLC
Original Assignee
BOC Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BOC Group Inc filed Critical BOC Group Inc
Publication of EP1468918A1 publication Critical patent/EP1468918A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02—Sterilising, e.g. of complete packages
    • B65B55/025—Packaging in aseptic tunnels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like

Definitions

  • the invention relates generally to a filling apparatus and, more particularly, to an improved filling apparatus configured to fill containers, for example, vials, with liquid products, for example, pharmaceuticals and the like.
  • an improved apparatus for filling pharmaceutical containers in a substantially clean and sterile environment.
  • the apparatus may include an upright wall dividing the apparatus into a substantially contamination free sterile zone and a non-sterile zone and an enclosure cooperating with the upright wall to define the sterile zone or, alternatively, the non-sterile zone.
  • the apparatus may also include a transfer apparatus that receives empty containers from a point outside the sterile zone and a transport at least partially disposed within the sterile zone that moves the containers through the sterile zone.
  • the apparatus may include a filling apparatus that fills the containers with pharmaceuticals in the sterile zone as the containers are moved through the sterile zone.
  • sterile cabinet 63 further comprises a front plate 65 that is shown as corresponding generally in size to the back plate 61 in the schematic representation of FIG. 1. However, and as shown in FIG. 2, the front plate 65 includes several outward steps to accommodate various of the components described above. Referring again to FIG. 1, a cabinet top 66 and cabinet bottom 67 interconnect the back plate 61 and front plate 65, and the cabinet ends are enclosed by end plates 68, 69.
  • Sterile zone 64 may be maintained at a pressure higher than that of the ambient surroundings to cause an outflow of air through the vial outlet between the star wheels, thus resisting contaminant entry.
  • the means for maintaining such pressure which is not shown, is conventional and typically includes a supply of air that is filtered to remove contaminants.
  • the filling apparatus may include the filling station 47, a product supply manifold 411, at least one supply line 412, and a filler configured to fill containers, for example, a vial filling device 414.
  • the product supply manifold may be positioned in the sterile zone 64 or in the non-sterile zone 70.
  • Each supply line 412 may be disposed between the product supply manifold 411 and the vial filling device 414.
  • Each supply line 412 may be configured as a conduit, at least a portion 413 of which may be elastically deformable.
  • the vial filling device 414 may include at least one dispenser 49. It should be appreciated that one supply line 412 may be provided for and associated with each dispenser 49.
  • the dispensers 49 may be configured, for example, as filling needles, nozzles, or the like.
  • the dispensers 49 may be provided with mechanical, electrical, or electro-mechanical out-of-position sensors 417.
  • Drive shaft segment 138A is connected to shaft segment 138B through a right angle drive 144.
  • a right angle drive 145 is connected between drive shaft segments 138B-C, the purpose of which is to drive the star wheel 44 through a pulley/belt configuration 146 and a drive connection 147.
  • Drive connection 147 extends through mounting plate 59 of cabinet 63 through a seal of the same type as seal 143.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Basic Packing Technique (AREA)
EP04252232A 2003-04-18 2004-04-16 Appareil de remplissage aseptique de flacons Withdrawn EP1468918A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/418,087 US20040020558A1 (en) 2001-08-14 2003-04-18 Filling apparatus
US418087 2003-04-18

Publications (1)

Publication Number Publication Date
EP1468918A1 true EP1468918A1 (fr) 2004-10-20

Family

ID=32908350

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04252232A Withdrawn EP1468918A1 (fr) 2003-04-18 2004-04-16 Appareil de remplissage aseptique de flacons

Country Status (3)

Country Link
US (1) US20040020558A1 (fr)
EP (1) EP1468918A1 (fr)
JP (1) JP2004323110A (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102011113358A1 (de) 2011-09-15 2013-03-21 Groninger & Co. Gmbh Verfahren und Vorrichtung zum Füllen und Verschließen von pharmazeutischen Objekten
MX2017011603A (es) 2015-03-10 2018-04-24 Regeneron Pharma Sistema y método de perforación aséptica.
EP4062957A1 (fr) 2017-05-05 2022-09-28 Regeneron Pharmaceuticals, Inc. Auto-injecteur
IT201700072715A1 (it) * 2017-06-29 2018-12-29 Gd Spa Sistema per l’assemblaggio ed il riempimento di sigarette elettroniche
USD1007676S1 (en) 2021-11-16 2023-12-12 Regeneron Pharmaceuticals, Inc. Wearable autoinjector

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5673535A (en) * 1994-03-02 1997-10-07 Tl Systems Corporation Vial filling apparatus
US20030034086A1 (en) * 2001-08-14 2003-02-20 Paul Stewart Filling apparatus

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3788370A (en) * 1972-02-10 1974-01-29 Shell Oil Co Particulate solids tube loading apparatus
US4142561A (en) * 1977-06-27 1979-03-06 National Instrument Company, Inc. Filling machine with environmental control
US4570822A (en) * 1981-06-19 1986-02-18 Cozzoli Machine Co. Computer operated filling system
US4401141A (en) * 1981-09-10 1983-08-30 National Instrument Company, Inc. Filling machine
US4508148A (en) * 1983-05-06 1985-04-02 Tl Systems Corporation Pharmaceutical filler apparatus
GB2208412B (en) * 1987-06-05 1991-01-23 Eg & G Ltd Bellows seal arrangement
DE4341934A1 (de) * 1993-12-09 1995-06-14 Bosch Gmbh Robert Verfahren und Vorrichtung zum Dosieren und Abfüllen einer Flüssigkeit in Verpackungsbehälter
US5551493A (en) * 1994-08-05 1996-09-03 Reagent Chemical & Research, Inc. Filling apparatus with traveling nozzle
US5797436A (en) * 1995-06-26 1998-08-25 Oden Corporation Liquid filling machine technical field
DE29713155U1 (de) * 1997-07-24 1998-09-10 Krones Ag Hermann Kronseder Maschinenfabrik, 93073 Neutraubling Rotationsfüller
JPH1191701A (ja) * 1997-09-17 1999-04-06 Shikoku Kakoki Co Ltd 液体充填装置
US5848350A (en) * 1997-10-31 1998-12-08 Flomet, Inc. Nickel-free stainless steel alloy processible through metal injection molding techniques to produce articles intended for use in contact with the human body
DE19808236A1 (de) * 1998-02-27 1999-09-02 Tetra Laval Holdings & Finance Vorrichtung zum Belüften von Packungen unter keimarmen Bedingungen
DE19917441C2 (de) * 1999-04-17 2001-10-11 Bosch Gmbh Robert Vorrichtung zum Dosieren und Abfüllen einer Flüssigkeit in Verpackungsbehälter
DE19947786A1 (de) * 1999-10-05 2001-04-19 Bosch Gmbh Robert Verpackungsmaschine, insbesondere zum Abfüllen und Verschliessen von flüssigen Pharmazeutika enthaltenden Behältnissen
US6837281B2 (en) * 2001-08-17 2005-01-04 Philip Morris Incorporation Apparatus and method for filling cavities with metered amounts of granular particles

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5673535A (en) * 1994-03-02 1997-10-07 Tl Systems Corporation Vial filling apparatus
US20030034086A1 (en) * 2001-08-14 2003-02-20 Paul Stewart Filling apparatus

Also Published As

Publication number Publication date
US20040020558A1 (en) 2004-02-05
JP2004323110A (ja) 2004-11-18

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