EP1435893B1 - Sicherheitsverpackung für eine flasche für medizinische anwendungen - Google Patents

Sicherheitsverpackung für eine flasche für medizinische anwendungen Download PDF

Info

Publication number
EP1435893B1
EP1435893B1 EP20020796303 EP02796303A EP1435893B1 EP 1435893 B1 EP1435893 B1 EP 1435893B1 EP 20020796303 EP20020796303 EP 20020796303 EP 02796303 A EP02796303 A EP 02796303A EP 1435893 B1 EP1435893 B1 EP 1435893B1
Authority
EP
European Patent Office
Prior art keywords
bottle
packaging device
tube
storage position
partition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP20020796303
Other languages
English (en)
French (fr)
Other versions
EP1435893A1 (de
Inventor
Farid Hamedi-Sangsari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MAPTECH
Original Assignee
MAPTECH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MAPTECH filed Critical MAPTECH
Publication of EP1435893A1 publication Critical patent/EP1435893A1/de
Application granted granted Critical
Publication of EP1435893B1 publication Critical patent/EP1435893B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2065—Connecting means having aligning and guiding means

Definitions

  • the subject of the present invention is a safety packaging device for a bottle for medical use, in particular for a bottle containing substances that are potentially dangerous for users or the environment (anticancer drugs, antibiotics, etc.).
  • These medicinal substances are generally packaged in glass vials capped by a pierceable elastomeric stopper, itself fixed inviolably on the vial by crimping an aluminum cap.
  • These drugs can be in the form of a liquid, a powder or a lyophilisate. They are intended to be transferred to an infusion bag containing an infusion fluid (NaCl, glucose, etc.) and then injected to the patient. Drugs stored in the vial as a liquid can be directly transferred to the infusion bag, those in the form of a powder or lyophilizate must first be reconstituted by dissolution in a solvent.
  • the object of the present invention is therefore to provide a device offering the best guarantees of safety with regard to both the risk of breakage of the bottle, the risk of accidental puncture and the risk of leakage.
  • the patent FR1380706 describes a device for transferring a container into another consisting of a plate traversed by two hollow needles pointed at both ends.
  • the patent FR1545963 discloses a transfer device constituted by a hollow cylinder provided with a stop diaphragm traversed by a perforated needle having two tips.
  • the patent FR2302134 discloses a device for transferring the liquid contents of a container through the stopper or lid of motivation-ci into a second container comprising a tubular body covering the necks of the two containers, a hollow needle having two pointed ends of a length sufficient to cross the caps or lids of the containers and another hollow needle, one end of which passes through the plug or cap of one of the containers and the other end remains in communication with the atmosphere.
  • Licences EP0192661 and EP0195018 describe devices for reconstituting drugs for connecting a powder vial and an infusion bag with a bi-tip needle and including means to prevent accidental separation of the elements.
  • the FR2780878 discloses a transfer cap for the passage of a medicament between a vial and a solute bag comprising a tubular monoblock body and a needle, characterized by particular detent means.
  • connection devices between a closed container and a container in particular form of ready-to-use assemblies.
  • a device for the preparation of a liquid drug solution reconstituted from two components comprising at least one element carrying a cannula for communicating the two containers when they are arranged head to tail and a conduit arranged to open through a first port in the container containing the active substance and to terminate, through a second port, to a transfer tip of the reconstituted liquid drug substance.
  • the present invention is defined in claim 1 and provides a cheap transfer device, easy to manufacture and meeting both the objectives of personnel safety and protection against breakage.
  • the device may be a one-piece cylindrical plastic body consisting of two parts: a lower part intended to completely cover the glass bottle and possibly comprising at its base means of stabilization of the device in vertical position and a lower part of smaller diameter constituted by a cylindrical chamber containing means, for example a bi-tip needle, for transferring the contents of the vial into a container, such as an infusion bag.
  • FIG. 1 represents a standard glass bottle (1) closed by an elastomer stopper (2) fixed on the bottle by an aluminum capsule (3).
  • the vial contains a drug in the form of a powder or lyophilizate (4). But it can be a sterile liquid.
  • Figure 2 shows a standard infusion bag (6) provided with an injection site (5) for transferring the drug.
  • FIG. 3 represents a device constituted by a tubular monobloc body comprising a partition (12), perpendicular to the axis of the tubular body, which delimits two open chambers (A) and (B).
  • the partition (12) which constitutes the base of the chamber (A) is provided with means for holding in place a two-point needle (10, 11).
  • the height of the cylindrical chamber (A) is chosen so as to completely protect the tip (10) of the needle.
  • the inside diameter of the chamber (A) is less than that of the chamber (B) but sufficient to accept the passage of the injection sites (5) equipping the infusion bags.
  • the two-point needle (10, 11) can be held in the partition (12) by any appropriate means, such as gluing, welding, overmolding.
  • the chamber (B) in which opens the other end (11) of the bi-tip needle is constituted by a tube (13).
  • This chamber (B) is intended to cover the bottle (1).
  • the diameter of the tube (13) is therefore chosen so as to insert the bottle (1) into the tube.
  • the diameter of the tube (13) is slightly greater than the diameter of the body of the bottle (1).
  • the tube (13) is narrowed at its upper end forming a tube (13a) of smaller diameter than that of the tube (13), the diameter of the tube (13a) being slightly greater than the diameter of the lid (3). ) of the bottle.
  • the diameters are chosen so as to allow the insertion of bottles of slightly different dimensions.
  • the height of the tube (13a) is chosen as a function of the height h plug (2) - operculum (3) of the bottle (1).
  • This embodiment comprising a tube (13) and a tube (13a) makes it possible to match the shape of the bottle (1) by improving the connection between the bottle (1) and the tip (11).
  • the wall of the tube (13) covering the bottle may be full or have recesses over part or all of the height.
  • the bottle is held in the storage position by means of retaining means (8) intended to prevent the bottle from leaving the chamber (B) and retaining means (7) intended to prevent drilling. inadvertent plug.
  • the retaining means (8) are sufficiently elastic to allow the force introduction of the bottle into the device.
  • a continuous annular bead can be used.
  • these retaining means are constituted by axial ribs formed inside the tube (13) which provide a frictional force on the body of the bottle.
  • the device can be used for bottles having slightly different diameters.
  • the retaining means (8) can be replaced by a perforable seal by the thumb (film or welded paper) or by a captive plug.
  • the retaining means (7) may be formed by any means capable of providing an elastic stop function, for example a continuous annular bead or no.
  • the tube (13) comprises at its base means for increasing the stability of the device in vertical position.
  • This is for example a flange (9), optionally comprising additional means, for example flats, to prevent the device from rolling when in the horizontal position.
  • the tubular monobloc body is made of a shockproof plastic material, to avoid the risk of breakage, and preferably transparent to allow reading of the information mentioned on the body of the bottle and the monitoring of its contents. Any plastic material having such properties as polypropylene, polycarbonate or K resin may be used.
  • the contents of the bottle (1) are placed in communication with the contents of the infusion bag (6) after perforation of the stopper (2) by the tip (11) and the injection site (5) by the tip (10).
  • the bottle (1) slides in the chamber (B) under the action of a thrust exerted on the bottom (14) of the bottle.
  • the bottle moves until it abuts on the partition (12), which allows the tip (11) to pierce the stopper (2).
  • it is pushed on the bottom (14) of the bottle with the thumb.
  • the retaining means (7) make it possible to keep the bottle in the use position and to avoid the axial displacement of the bottle downwards.
  • the injection site (5) of the infusion bag (6) is pierced in a conventional manner by force introduction of the site in the chamber (A).
  • FIG. 5 represents a particular embodiment of the abutment means (7) preventing the inadvertent piercing of the plug.
  • the elastic retaining means consist of tabs (15, 16) whose free ends are oriented towards the inside of the tube (13a).
  • the thrust exerted on the bottom of the bottle separates the tabs (15, 16) which, after drilling the stopper (2), prevent the bottle from falling back to the bottom of the device.
  • the elastic means (8) may also consist of tongues such as tongues (15, 16).
  • FIG. 6 represents a particular embodiment of the base of the device.
  • the base of the tube (13) has one or more openings (17) to facilitate the thrust on the bottom of the bottle. Systems with a single opening are preferred to avoid the risk of the bottle being pulled out.
  • the figures illustrate an embodiment in which a vial (1) and an infusion bag (6) are placed in communication.
  • the system can be used to port a vial to another type of container.
  • the exemplified embodiments relate to a device with a two-point needle, but a device with a bottle-side needle and a pouch-side luer site can also be used.
  • the device is a one-piece plastic body. It is therefore easy to produce using the conventional processes of the plastics industry.
  • the device is sterilized with ethylene oxide, steam or radiation.
  • the device is placed in advance on the bottle (1).
  • the device / vial assembly is pre-assembled, placed in a blister and sterilized as above.
  • the device may be provided with a removable cap sealingly sealing the chamber A, then after mounting the bottle in the chamber B the bottom of the chamber B may be sealed with a "heat sealable" paper, allowing sterilization from the assembly to ethylene oxide or steam.
  • a "heat sealable” paper allowing sterilization from the assembly to ethylene oxide or steam.
  • the device is placed on the bottle (1) at the time of its use. Just remove the cap (3) and forcefully insert the vial into the tube (13).

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Buffer Packaging (AREA)
  • Closures For Containers (AREA)

Claims (11)

  1. Sicherheitsverpackungsvorrichtung für ein Fläschchen (1) mit medizinischer Nutzung, die ermöglicht, den Inhalt des Fläschchens (1) direkt in ein aufnehmendes Element wie etwa einen Perfusionsbeutel (6) zu übertragen, mit
    - einem zylindrischen, röhrenförmigen Körper, der die Seitenwände des Fläschchens (1) sowohl in der Aufbewahrungsposition als auch in der Verwendungsposition des Fläschchens auf dessen gesamter Höhe abdeckt, und
    - einer Trennwand (12), die zu der Achse des röhrenförmigen Körpers senkrecht ist,
    ✔ wobei die Trennwand eine offene erste Kammer (A) und eine offene zweite Kammer (B) definiert, wobei die zweite Kammer (B) durch ein Rohr (13) gebildet ist, das erste Rückhaltemittel (7), die in der Aufbewahrungsposition über dem Fläschchen (1) angeordnet sind, und zweite Rückhaltemittel (8), die in der Aufbewahrungsposition unter dem Fläschchen (1) angeordnet sind, enthält,
    ■ wobei die ersten Rückhaltemittel (7) dazu bestimmt sind, eine unerwünschte Durchlochung des Stopfens des Fläschchens (1) in der Aufbewahrungsposition und die axiale Verlagerung nach unten des Fläschchens in der Verwendungsposition zu verhindern, und ausreichend elastisch sind, um die axiale Verlagerung des Fläschchens zu den Übertragungsmitteln unter der Wirkung eines auf den Boden (14) des Fläschchens ausgeübten Schubs zuzulassen, und
    ■ wobei die zweiten Rückhaltemittel (8) dazu bestimmt sind, ein Austreten des Fläschchens (1) aus der zweiten Kammer (B) in der Aufbewahrungsposition zu verhindern, und ausreichend elastisch sind, um die Einführung des Fläschchens in die Vorrichtung zuzulassen,
    ✔ wobei die Trennwand mit Mitteln versehen ist, um die Mittel zum Übertragen des Inhalts des Fläschchens (1) in das aufnehmende Element festzuhalten.
  2. Verpackungsvorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass die Übertragungsmittel durch eine Doppelspitzen-Nadel (10, 11) gebildet sind.
  3. Verpackungsvorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass die Übertragungsmittel durch eine Nadel auf Seiten des Fläschchens (1) und durch einen Stecker- oder Buchsen-Luersitz auf Seiten des aufnehmenden Elements gebildet sind.
  4. Verpackungsvorrichtung nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, dass das Rohr (13) an seinem oberen Ende eingeschnürt ist, indem es ein Rohr (13a) mit einem Durchmesser bildet, der etwas kleiner als jener des Rohrs (13) ist.
  5. Verpackungsvorrichtung nach einem der Ansprüche 1 bis 4, dadurch gekennzeichnet, dass die elastischen Rückhaltemittel (7, 8) durch einen ununterbrochenen oder unterbrochenen ringförmigen Wulst gebildet sind.
  6. Verpackungsvorrichtung nach einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, dass die elastischen Rückhaltemittel (7, 8) durch Zungen (15, 16) gebildet sind, deren freie Enden in den Innenraum des Rohrs (13) orientiert sind.
  7. Verpackungsvorrichtung nach einem der Ansprüche 1 bis 6, dadurch gekennzeichnet, dass die Basis des Rohrs (13) mit einem Flansch (9) ausgerüstet ist, der eventuell mit Mitteln versehen ist, die dazu bestimmt sind, ein Rollen der Vorrichtung in horizontaler Position zu verhindern.
  8. Verpackungsvorrichtung nach einem der Ansprüche 1 bis 7, dadurch gekennzeichnet, dass die Basis des Rohrs eine oder mehrere Öffnungen (17) aufweist, die dazu bestimmt sind, die Ausübung des Schubs auf den Boden des Fläschchens zu erleichtern.
  9. Verpackungsvorrichtung nach einem der Ansprüche 1 bis 8, dadurch gekennzeichnet, dass der röhrenförmige Körper aus einem stoßfesten und lichtdurchlässigen Kunststoff besteht.
  10. Verpackungsvorrichtung nach einem der Ansprüche 1 bis 9, dadurch gekennzeichnet, dass die Vorrichtung in ihrer Verpackung mit Ethylenoxid, mit Dampf oder durch Bestrahlung sterilisiert wird.
  11. Verpackungsvorrichtung nach einem der Ansprüche 1 bis 10, dadurch gekennzeichnet, dass die Vorrichtung in Blister verpackt ist.
EP20020796303 2001-08-22 2002-08-22 Sicherheitsverpackung für eine flasche für medizinische anwendungen Expired - Lifetime EP1435893B1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR0110982A FR2828802A1 (fr) 2001-08-22 2001-08-22 Conditionnement de securite pour flacon a usage medical
FR0110982 2001-08-22
FR0116379 2001-12-18
FR0116379A FR2828803B1 (fr) 2001-08-22 2001-12-18 Conditionnement de securite pour flacon a usage medical
PCT/FR2002/002920 WO2003017916A1 (fr) 2001-08-22 2002-08-22 Conditionnement de securite pour flacon a usage medical

Publications (2)

Publication Number Publication Date
EP1435893A1 EP1435893A1 (de) 2004-07-14
EP1435893B1 true EP1435893B1 (de) 2008-02-06

Family

ID=26213151

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20020796303 Expired - Lifetime EP1435893B1 (de) 2001-08-22 2002-08-22 Sicherheitsverpackung für eine flasche für medizinische anwendungen

Country Status (8)

Country Link
EP (1) EP1435893B1 (de)
AT (1) ATE385418T1 (de)
DE (1) DE60224940T2 (de)
DK (1) DK1435893T3 (de)
ES (1) ES2300504T3 (de)
FR (2) FR2828802A1 (de)
PT (1) PT1435893E (de)
WO (1) WO2003017916A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2863161B1 (fr) 2003-12-05 2006-09-01 Map France Capuchon pour conditionnement de securite pour flacon a usage medical
US7615041B2 (en) 2004-07-29 2009-11-10 Boston Scientific Scimed, Inc. Vial adaptor
FR2878737B1 (fr) 2004-12-07 2007-03-16 Maptech Soc Par Actions Simpli Dispositif de securite pour flacon a usage medical
AU2010294420B2 (en) * 2009-09-14 2015-08-13 Société des Produits Nestlé S.A. Package with foil seals and penetrating means
US20160039546A1 (en) * 2014-08-07 2016-02-11 Greg Gardner Condiment transfer device and method
ITUB20153260A1 (it) * 2015-08-27 2017-02-27 Paolo Gobbi Frattini S R L Tappo di chiusura ermetica per flacone sterile sigillato di contenimento di sostanze attive medicinali o nutrizionali, idoneo per la connessione sterile con un contenitore di soluzione liquida diluente, e sistema di connessione sterile utilizzante detto tappo di chiusura.
US20220087901A1 (en) * 2019-02-12 2022-03-24 Amgen Inc. Systems and approaches for drug delivery device reconstitution
CH716516A1 (fr) * 2019-08-22 2021-02-26 Mpi Int Sa Procédé de préparation d'au moins une solution injectable en poche, unité pour la préparation de ladite solution injectable et poche contenant ladite solution injectable.
CH716733A1 (fr) * 2019-10-29 2021-04-30 Mpi Int Sa Procédé de préparation d'au moins une solution injectable en ampoule, unité pour la préparation de ladite solution injectable et ampoule contenant ladite solution injectable.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1380706A (fr) 1963-10-23 1964-12-04 Dispositif pour le transvasement d'un fluide d'un récipient à un autre
FR1545963A (fr) 1967-11-07 1968-11-15 Abc Ist Biolog Chem Spa Emballage de deux substances séparées et miscibles, dont une au moins liquide, avec dispositif de transvasement
FR2302134A1 (fr) 1975-02-28 1976-09-24 Merieux Inst Dispo
US4607671A (en) 1984-08-21 1986-08-26 Baxter Travenol Laboratories, Inc. Reconstitution device
US4759756A (en) 1984-09-14 1988-07-26 Baxter Travenol Laboratories, Inc. Reconstitution device
WO1988007358A1 (en) * 1987-04-02 1988-10-06 Drg (Uk) Limited Apparatus for contacting material such as a drug with a fluid
DE19513666C1 (de) * 1995-04-11 1996-11-28 Behringwerke Ag Vorrichtung zum Zusammenführen einer ersten flüssigen und einer zweiten festen oder flüssigen Komponente mittels Unterdruck unter sterilen Bedingungen
FR2738550B1 (fr) 1995-09-11 1997-11-07 Biodome Dispositif d'obturation d'un recipient lui-meme ferme, ensemble pour dispenser un produit comprenant un tel recipient et un tel dispositif d'obturation
WO1997020536A1 (fr) * 1995-12-06 1997-06-12 Gabriel Meyer Dispositif pour la preparation d'une solution medicamenteuse reconstituee a partir de deux composants
FR2753624B1 (fr) 1996-09-25 1999-04-16 Biodome Dispositif de connexion, en particulier entre un recipient avec bouchon perforable et une seringue
FR2780878B1 (fr) 1998-07-10 2000-09-29 Frederic Senaux Capuchon de transfert encliquetable
FR2790749B1 (fr) * 1999-03-10 2001-05-18 Maco Pharma Sa Dispositif de transfert d'une substance contenue dans un flacon dans une poche de solute

Also Published As

Publication number Publication date
WO2003017916A1 (fr) 2003-03-06
FR2828802A1 (fr) 2003-02-28
FR2828803A1 (fr) 2003-02-28
DE60224940D1 (de) 2008-03-20
FR2828803B1 (fr) 2004-10-22
ATE385418T1 (de) 2008-02-15
DK1435893T3 (da) 2008-06-09
ES2300504T3 (es) 2008-06-16
PT1435893E (pt) 2008-05-09
EP1435893A1 (de) 2004-07-14
DE60224940T2 (de) 2008-08-21

Similar Documents

Publication Publication Date Title
EP1827353B1 (de) Sicherheitsvorrichtung zur medizinischen anwendung
EP1694269B1 (de) Kappe für die sichere verpackng einer medizinflasche
EP0403626B1 (de) Aufbewahrungs- und umfüllflasche zum aufbewahren von zwei bestandteilen einer heilkräftigen substanz
CA2986962C (en) Medical vial access device with pressure equalization and closed drug transfer system and method utilizing same
EP1226077B1 (de) Einsatzbereite verbindungsvorrichtung
EP1079789B1 (de) Ampulle zur aufnahme einer medizinischen flüssigkeit
EP0717611B1 (de) Spritzenvorrichtung zum mischen von zwei präparaten
EP0406374B1 (de) Aufbewahrungs- und umfüllflasche zum aufbewahren von zwei bestandteilen einer heilkräftigen substanz
WO2002053086A1 (fr) Ampoule pour le conditionnement et le transfert d'un liquide ou d'une poudre a usage medical
EP1008337A1 (de) Verschluss für Artzneimittelbehälter mit versenktem Zugangsmittel für Einstechdorn
FR2717086A1 (fr) Dispositif de seringue pour le mélange de deux composés.
WO1991007160A1 (fr) Flacon de stockage contenant un composant d'une solution medicamenteuse
US20140318995A1 (en) Barrier Element Removal
EP1949883B1 (de) Flüssigkeitsumfüllungsverfahren und -set zwischen zwei Behältern
EP1435893B1 (de) Sicherheitsverpackung für eine flasche für medizinische anwendungen
EP1034772B1 (de) Vorrichtung zum Übertragen einer in einem Flacon enthaltenen Substanz in einen Beutel der eine Lösung enthält
WO1999010245A1 (fr) Flacon melangeur mettant en contact deux composants isoles avant leur prelevement et leur injection a l'aide d'une seringue
EP3496695B1 (de) Phiolenanordnung mit luer-anschluss
FR2708469A1 (fr) Dispositif de seringue pour le mélange de deux composés.
FR2715311A1 (fr) Dispositif de seringue pour le mélange de deux composés.
FR2714294A1 (fr) Dispositif de seringue pour le mélange de deux composés.

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20040319

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: MAPTECH

17Q First examination report despatched

Effective date: 20060728

17Q First examination report despatched

Effective date: 20060728

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: LANGUAGE OF EP DOCUMENT: FRENCH

REF Corresponds to:

Ref document number: 60224940

Country of ref document: DE

Date of ref document: 20080320

Kind code of ref document: P

REG Reference to a national code

Ref country code: PT

Ref legal event code: SC4A

Free format text: AVAILABILITY OF NATIONAL TRANSLATION

Effective date: 20080428

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2300504

Country of ref document: ES

Kind code of ref document: T3

REG Reference to a national code

Ref country code: GR

Ref legal event code: EP

Ref document number: 20080401154

Country of ref document: GR

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20080206

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20080206

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20080206

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20081107

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20080831

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20080506

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20080206

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20080206

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20080822

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20080206

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20110901

Year of fee payment: 10

Ref country code: DK

Payment date: 20110830

Year of fee payment: 10

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IE

Payment date: 20120829

Year of fee payment: 11

Ref country code: GB

Payment date: 20120903

Year of fee payment: 11

Ref country code: SE

Payment date: 20120829

Year of fee payment: 11

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GR

Payment date: 20120831

Year of fee payment: 11

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20120831

Year of fee payment: 11

Ref country code: DE

Payment date: 20120831

Year of fee payment: 11

Ref country code: IT

Payment date: 20120827

Year of fee payment: 11

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: PT

Payment date: 20120222

Year of fee payment: 11

Ref country code: NL

Payment date: 20120831

Year of fee payment: 11

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20120831

Year of fee payment: 11

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: AT

Payment date: 20120831

Year of fee payment: 11

BERE Be: lapsed

Owner name: MAPTECH

Effective date: 20130831

REG Reference to a national code

Ref country code: PT

Ref legal event code: MM4A

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20140224

REG Reference to a national code

Ref country code: NL

Ref legal event code: V1

Effective date: 20140301

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

Ref country code: DK

Ref legal event code: EBP

Effective date: 20130831

REG Reference to a national code

Ref country code: SE

Ref legal event code: EUG

REG Reference to a national code

Ref country code: AT

Ref legal event code: MM01

Ref document number: 385418

Country of ref document: AT

Kind code of ref document: T

Effective date: 20130822

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20130822

REG Reference to a national code

Ref country code: GR

Ref legal event code: ML

Ref document number: 20080401154

Country of ref document: GR

Effective date: 20140305

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140301

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140301

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130823

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130831

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130831

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 60224940

Country of ref document: DE

Effective date: 20140301

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130831

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130822

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130822

Ref country code: GR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140305

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140224

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130822

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130822

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130831

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20150710

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20130823

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 15

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 16

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20170828

Year of fee payment: 16

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180831