EP1034772B1 - Vorrichtung zum Übertragen einer in einem Flacon enthaltenen Substanz in einen Beutel der eine Lösung enthält - Google Patents

Vorrichtung zum Übertragen einer in einem Flacon enthaltenen Substanz in einen Beutel der eine Lösung enthält Download PDF

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Publication number
EP1034772B1
EP1034772B1 EP20000400612 EP00400612A EP1034772B1 EP 1034772 B1 EP1034772 B1 EP 1034772B1 EP 20000400612 EP20000400612 EP 20000400612 EP 00400612 A EP00400612 A EP 00400612A EP 1034772 B1 EP1034772 B1 EP 1034772B1
Authority
EP
European Patent Office
Prior art keywords
guide
flask
needle
bottle
closed end
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP20000400612
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English (en)
French (fr)
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EP1034772A1 (de
Inventor
Thierry Verpoort
Francis Goudaliez
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Maco Pharma SAS
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Maco Pharma SAS
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Publication date
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Publication of EP1034772A1 publication Critical patent/EP1034772A1/de
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Publication of EP1034772B1 publication Critical patent/EP1034772B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2065—Connecting means having aligning and guiding means

Definitions

  • the invention relates to a device for transferring a substance, for example a medicine, into a pocket.
  • the contents of the solute bag e.g. glucose to which the drug is added, is then administered to the patient in a continuous manner, for example using a conventional infusion device.
  • a transfer device comprising a first part, intended to be mounted on the inlet port of a bag, and a second part, intended to receive the end of a bottle.
  • the first and second parts are provided with a coaxial hollow needle allowing one hand to pierce the cap of the bottle, generally made of rubber, as well as the inlet port of the bag, then to transfer the contents of the bottle into the pocket on the other hand.
  • the first part of the device is mounted on the inlet port of the solute bag by piercing the inlet port of the bag, the needle is found in the airlock of the injection site then the vial is mounted on the second part of the device, the needle also piercing the rubber stopper of the vial.
  • the vial and the transfer device are generally removed from the bag.
  • the solute bag containing the drug can then be administered to the patient.
  • drug transfers can be made to the patient's bed, and hospital staff must assemble on-site bags of solute, transfer devices and vials.
  • Document FR-2 473 017 discloses an apparatus for mixing and dispensing two substances under sterile conditions.
  • such an apparatus has the particular disadvantage of ensuring insufficient stability of the bottle when associated on the bottle.
  • the invention aims to remedy these drawbacks, by proposing a transfer device that makes it possible to control the nature of the product transferred and the successful completion of this transfer.
  • the device for transferring, in a solute bag, a substance, for example a medicinal substance, contained in a receptacle, such as a vial comprises a first guide, of generally cylindrical general shape, open to the patient. one of its ends and closed at its other end opposite the open end.
  • the first guide is adapted to receive at least the neck and the upper part of the body of the bottle, the bottle being capable of sliding at least partially in the first guide.
  • the first guide further comprises means adapted to prevent the total withdrawal of the bottle from the first guide after its introduction therein, said means being arranged so as to allow at least partial sliding of said bottle in the first guide.
  • the device according to the invention further comprises a second guide, of substantially cylindrical general shape, extending the first guide side of the closed end thereof and mounted coaxially with the first guide.
  • the end of the second guide opposite the first guide is open and adapted to receive the inlet of the solute bag.
  • the device according to the invention also comprises a means for piercing the means for closing the bottle and the solute bag, respectively, and for transferring the substance contained in the bottle into the solute bag, the piercing means being arranged coaxial with the first and second guides.
  • the first guide is able to receive not only the neck but also the upper part of the body of the bottle, and the means able to prevent the total withdrawal of the bottle are elastic and are arranged on the inner face of the first guide so to allow at least partial sliding of said bottle in the first guide.
  • the means preventing the withdrawal of the bottle comprise at least one elastic tab formed on the inner face of the first guide, for example at the open end of the first guide.
  • the tab projects from one of its ends towards the interior of the first guide being directed towards the closed end of the first guide.
  • the inner face of the first guide may comprise three elastic tabs arranged substantially uniformly with each other and substantially at the same level on the inner face of the first guide.
  • the means preventing the removal of the bottle comprise at least one elastic annular lip disposed on the inner face of the first guide, for example at the open end of the first guide.
  • the annular lip is disposed projecting inwardly of the first guide, substantially perpendicular to the longitudinal axis of the first guide.
  • the second guide can be fixed rigidly on the first guide.
  • the second guide is slidably mounted on the first guide.
  • the second guide comprises a region of smaller external diameter, located towards the end of the second guide opposite to the open end of the second guide and intended to slide in an opening of corresponding diameter formed in the end closed of the first guide.
  • the end portion of the smaller diameter region located on the side of the first guide is provided with an annular lip forming a bearing surface against the closed end of the first guide, inside thereof, so as to block the sliding of the second guide in the first guide.
  • the piercing means of the closure means of the bottle and the inlet port of the bag comprise a hollow needle along its entire length, coaxial with the first and second guides.
  • the two ends of the needle are shaped beveled tips, opening for one in the first guide and the other in the second guide.
  • the needle is held in place at the closed end of the first guide.
  • the needle is held in place at the region of smaller diameter of the second guide.
  • the tip of the needle opening into the first guide and / or the tip of the needle opening into the second guide is protected by a flexible envelope, for example latex.
  • the transfer device according to the invention may be independent of the solute bag and the bottle, the various elements being assembled before the transfer.
  • the second guide may comprise means able to prevent the total withdrawal of the inlet orifice of the solute bag from the second guide after it has been inserted into it.
  • said means have a structure identical to those arranged in the first guide and are arranged to allow at least partial sliding of the inlet port in the second guide.
  • the transfer device according to the invention can be integrated, permanently and not detachable, to a solute bag.
  • the transfer device of the invention may be fixedly mounted on the inlet port of a solute bag, at the open end of the second guide.
  • the user only has to introduce the bottle in the first guide, before proceeding with the transfer.
  • the tip of the needle on the side of the solute bag does not need to be protected by a flexible envelope, since it is no longer in contact with the outside.
  • the tip of the needle on the side of the solute bag does not need to be beveled, since it no longer pierces the inlet port of the solute bag.
  • the transfer device mounted on the solute bag can be protected, in addition to the flexible envelope covering the needle on the side of the first guide, by a lid resting on the longitudinal walls of the first guide.
  • the transfer device 1 comprises a first guide 2 adapted to receive, at least partially, a bottle 3.
  • the first guide 2 is of generally cylindrical shape, the shape of the first guide depending on that of the bottle.
  • the first guide may be of a shape other than cylindrical, for example parallelepiped, to fit bottles of a corresponding shape.
  • the first guide 2 comprises a longitudinal wall 4 open at one of its ends 6 and closed at its opposite end 5.
  • the first guide 2 is provided with means preventing the withdrawal of the bottle 3 from the first guide 2. These means also allow at least partial sliding of the bottle 3 in the first guide 2.
  • the means preventing the withdrawal comprise two elastic tabs 7 arranged on the internal face 8 of the longitudinal wall 4 of the first guide 2.
  • the two tabs 7 are arranged to allow the introduction of the bottle 3 into the first guide 2 and prevent its total withdrawal from it while allowing the sliding of said bottle 3 in the first guide 2.
  • the tabs 7 deviate towards the inner face 8 of the first guide 2 under the action exerted by the neck 9 of the bottle 3.
  • the neck 9 of the bottle 3 can then be introduced into the first guide 2.
  • the lugs 7 can then again deviate towards the inner face 8 of the first guide 2, to allow said vial to slide so as to effect the passage of the body 11 of the vial 3.
  • the tabs 7 are fixed to the inner face 8 of the first guide 2 by one of their ends 12, the other free end 13 of the tabs 7 being directed towards the closed end of the first guide 2, so as to block the withdrawal of the bottle 3 out of the first guide 2, at the neck 10 of the bottle 3.
  • the number of tabs 7 may vary depending in particular on the shrink resistance that it is desired to confer on the transfer device 1 of the invention.
  • the transfer device 1 comprises three tabs 7 arranged substantially at the same level of the inner face 8 of the first guide 2 and spaced substantially evenly between them.
  • the first guide 2 is extended towards the closed end 5 by a second guide 14.
  • the second guide 14 is fixedly arranged and coaxial, with respect to the median longitudinal axis X of the device 1, with the first guide 2.
  • the second guide 14 is hollow and intended to receive the inlet 15 of a solute bag 16.
  • the inlet orifice 15 comprises a bushing 28 made of elastomer that can be traversed by the U-shaped needle 17 and autorecleant and which is closed by a cover 23.
  • introduction of the needle 17 into the inlet orifice which first passes through the lid 23 to be in the lock chamber 29 formed inside the U and an additional sliding brings the needle 17 into position. contact with the bottom 30 of the U so that it can pass through and thus bring the interior of the solute bag into contact with the outside.
  • the second guide comprises means preventing the total withdrawal of the inlet orifice 15 from the second guide 14 after its insertion therein.
  • the means preventing the total withdrawal have a structure identical to that of the means preventing the withdrawal of the bottle 3 and therefore comprise two elastic tabs disposed on the inner face of the longitudinal wall of the second guide 14.
  • the tabs 25 deviate towards the inner face of the second guide 14 under the action exerted.
  • the locking of the withdrawal of the inlet orifice 15 is then made between the free end 26 of the tabs 25 and a circular flattened portion 27 formed on said orifice.
  • the assembly formed by the solute bag 16 and the device 1 is then in a first position (see FIG. 2) in which, although associated with each other, the needle 17 has not passed through the 23.
  • the inlet orifice 15 can then slide so that the needle is in the chamber 29 (second position shown in particular in Figure 1) and then crosses the bottom 30 to bring the interior of the solute bag 16 into contact with the inside of the bottle 3 (third position shown in particular in FIG. 6).
  • the second guide 14 comprises a hollow needle 17, substantially parallel to the median longitudinal axis X.
  • the needle 17 is provided with two ends forming beveled tips 18 for piercing the inlet 15 of the solute bag 16 on the one hand and the bottle cap 3 on the other hand.
  • the needle 17 is held in place at the closed end 5 of the first guide 2, the two tips 18 of the needle 17 opening for one in the first guide 2 and for the other in the second guide 14 .
  • a base region 19 may be provided on the closed end 5 side of the first guide 2 (or, alternatively, on the side of the second guide 14) to reinforce the rigidity of the needle 17.
  • the base region 19 makes it possible to prevent the needle 17 from twisting when piercing the cap of the vial 3 or of the inlet 15 of the solute bag 16.
  • the transfer device 1 may be made of an injectable plastic material.
  • the plastic used must also be able to withstand the conditions of sterilization.
  • the transfer device may be made of a polymer based on polyethylene, polycarbonate, polypropylene, polystyrene, and the derivatives and / or mixtures of these products.
  • the transfer device shown in FIG. 1 is made by injection from the raw materials indicated above, the first and second guides being formed in one piece and the over-molded needle.
  • FIG. 1 Another embodiment of the transfer device 1 is shown in FIG. 1
  • the transfer device 1 comprises a first guide 2 and a second guide 14 into which the tips 18 of a needle 17 open.
  • the second guide 14 is slidably mounted on the first guide 2.
  • the second guide 14 comprises a region of smaller outer diameter 20, located at the end of the second guide 14 located on the side of the first guide 2.
  • This region of smaller outer diameter 20 is slidably mounted in a corresponding opening formed on the closed end 5 of the first guide 2.
  • a more or less easy sliding of the second guide 14 can be obtained depending on the choice of plastic materials used for the first and second guides and the outer diameter of the region 20 relative to the opening on the closed end 5 of the first guide 2.
  • Sliding can be further facilitated by the deposition of a silicone material on the region of smaller outer diameter 20.
  • the sliding of the second guide 14 is limited in one direction by an annular lip 21 forming a bearing surface against the closed end 5 of the first guide 2, inside the first guide 2.
  • the sliding of the second guide 14 is limited in the other direction by the return of the second guide 14 to its normal diameter, at the region 22.
  • the embodiment of the transfer device 1 according to the invention as illustrated in Figure 2 involves the separate manufacture of two parts corresponding to the first and second guides.
  • FIGS 3, 4, 5 and 6 illustrate the operation of the transfer device according to the invention.
  • FIGS. 3 to 6 the same reference numerals designate the same elements as in FIGS. 1 and 2.
  • a transfer device 1 according to the invention is mounted, via the second guide 14, on the inlet 15 of a solute bag 16 so as to make the device 1 and the solute bag 16.
  • the other point 18 of the needle 17 located on the side of the first guide 2 is protected by a flexible envelope that is self-climbing 24, for example made of latex, in order to guarantee the sterility of the transfer device 1.
  • Such an envelope 24 may also be provided on the side of the tip 18 of the needle 17 located on the side of the second guide 14.
  • a bottle 3 containing for example a drug is introduced into the first guide 2 ( Figures 4 and 5).
  • the bottle 3 is associated with the solute bag 16 via the transfer device 1 to form a unitary assembly in which the inside of the bottle 3 and the inside of the bag 16 are not in communication .
  • the solute bag 16, the device 1 and the bottle 3 are associated with each other irreversibly.
  • unitary unit it is understood that it can be stored, sold, manipulated and used together.
  • the cap of the bottle 3 then comes into contact with the tip 18 of the needle 17 protected by the envelope 24.
  • the operator can then exert a force on the solute bag 16 and on the bottle 3 so as simultaneously to cause on the one hand an additional sliding of the bottle 3 which leads to the piercing of the cap and the envelope 24 by the needle 17 and on the other hand an additional sliding of the inlet 15 which leads to the drilling of the bottom 30 by the other end 18 of the needle 17.
  • This action communicates the interior of the bottle 3 with the interior of the solute bag 16, through the hollow needle 17 ( Figure 6).
  • the solute bag 16 is positioned with the inlet port 15 directed downwards to introduce, by exerting manual pressure on the solute bag 16, a small amount of solute inside the bottle 3 to dissolve the medicine it contains. After dissolution, the whole bag of solute 16 and bottle 3 is turned over in order to transfer the contents of the bottle 3 into the solute bag 16, the sterile air of the solute bag 16 replacing the liquid contained in the bottle 3.
  • the bottle 3 remains on the device 1 according to the invention, its removal being prevented by the tabs 7 which block the passage of the neck 9 out of the first guide 2.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (24)

  1. Vorrichtung (1) für den Transfer in einen Lösungsbeutel (16) einer beispielsweise pharmazeutischen Substanz, die in einem Flakon (3) bestehend aus einem Körper (11), einem Kragen (10) und einem Hals (9) enthalten ist, wobei die genannte Vorrichtung folgendes umfasst:
    - eine erste, etwa zylindrische Führung (2), die an einem ihrer Enden (6) offen und an ihrem anderen, dem offenen Ende (6) gegenüber liegenden Ende (5) geschlossen ist, wobei die erste Führung (2) ausgebildet ist, um nicht nur den Kragen (10) sondern ebenfalls das obere Teil des Körpers (11) des Flakons (3) aufzunehmen;
    - eine zweite, etwa zylindrische Führung (14), die sich an die erste Führung (2) an deren geschlossenem Ende (5) anschließt und koaxial zu der ersten Führung (2) montiert ist, wobei das Ende der zweiten Führung (14), das der ersten Führung (2) gegenüber liegt, geöffnet und dazu geeignet ist, die Eintrittsöffnung (15) des Lösungsbeutels (16) aufzunehmen;
    - ein Durchlöcherungsmittel jeweils der Verschlussmittel des Flakons (3) und des Lösungsbeutels (16) und zum Transferieren der in dem Flakon (3) enthaltenen Substanz in den Lösungsbeutel (16), wobei die Durchlöcherungsmittel koaxial zu der ersten (2) und zweiten (14) Führung angeordnet sind;
    - wobei die Innenseite (8) der ersten Führung (2) elastische Mittel aufweist, um eine zumindest teilweise Verschiebung des Flakons (3) in der ersten Führung (2) zu ermöglichen, dadurch gekennzeichnet, dass die genannten elastischen Mittel nicht nur mit dem Kragen (10) in Kontakt stehen, sondern ebenfalls mit dem oberen Teil des Körpers (11) des Flakons (3), und geeignet sind, den völligen Rückzug des Flakons (3) aus der ersten Führung (2) zu verhindern, nachdem er in diese eingeführt wurde.
  2. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass die den Rückzug des Flakons (3) verhindernden Mittel mindestens eine elastische Lasche (7) aufweisen, die an der Innenseite (8) der ersten Führung (2), beispielsweise an dem offenen Ende (6) der ersten Führung (2) angeordnet ist, wobei die Lasche (7) in die erste Führung (2) hinein ragt mit einem ihrer Enden (13), das zu dem geschlossenen Ende (5) der ersten Führung (2) hin gerichtet ist.
  3. Vorrichtung nach Anspruch 2, dadurch gekennzeichnet, dass die Laschen (7) mit einem ihrer Enden (12) an der Innenseite (8) der ersten Führung (2) befestigt sind, wobei das andere Ende (13) der Laschen (7) zu dem geschlossenen Ende (5) der ersten Führung (2) hin gerichtet ist.
  4. Vorrichtung nach Anspruch 2 oder 3, dadurch gekennzeichnet, dass sie drei elastische Laschen (7) aufweist, die etwa regelmäßig zueinander und etwa in der gleichen Höhe an der Innenseite (8) der ersten Führung (2) angeordnet sind.
  5. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass die den Rückzug des Flakons (3) verhindernden Mittel mindestens eine ringförmige elastische Lippe aufweisen, die an der Innenseite (8) der ersten Führung (2), beispielsweise am offenen Ende (6) der ersten Führung (2), angeordnet ist und in die erste Führung (2) hinein ragt, und zwar etwa senkrecht zur Längsachse (X) der ersten Führung (2).
  6. Vorrichtung nach einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, dass die zweite Führung (14) starr an der ersten Führung (2) befestigt ist.
  7. Vorrichtung nach einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, dass die zweite Führung (14) gleitend an der ersten Führung (2) montiert ist.
  8. Vorrichtung nach Anspruch 7, dadurch gekennzeichnet, dass die zweite Führung (14) einen Bereich mit einem kleineren Außendurchmesser (20) aufweist, der sich etwa am Ende der dem offenen Ende der zweiten Führung (14) gegenüber liegenden Ende der zweiten Führung (14) befindet und dazu bestimmt ist, in eine einen entsprechenden Durchmesser aufweisende Öffnung zu gleiten, die in dem geschlossenen Ende (5) der ersten Führung (2) vorgesehen ist.
  9. Vorrichtung nach Anspruch 8, dadurch gekennzeichnet, dass das Endteil des Bereichs mit dem kleineren Durchmesser (20), das auf der Seite der ersten Führung (2) liegt, eine ringförmige Lippe (21) aufweist, die eine Stützfläche gegen das geschlossene Ende (5) der ersten Führung (2) innerhalb derselben bildet, um so das Gleiten der zweiten Führung (14) in der ersten Führung (2) zu blockieren.
  10. Vorrichtung nach Anspruch 8 oder 9, dadurch gekennzeichnet, dass der Bereich mit dem kleineren Durchmesser (20) mit einem Silikon-Werkstoff beschichtet ist.
  11. Vorrichtung nach einem der Ansprüche 1 bis 10, dadurch gekennzeichnet, dass die Durchlöcherungsmittel der Verschlussmittel des Flakons (3) und der Eintrittsöffnung (15) des Beutels (16) eine über ihre gesamte Länge hohle Nadel (17) aufweisen, die koaxial zu der ersten (2) und der zweiten (14) Führung verläuft, wobei die beiden Enden der Nadel (17) abgeschrägte Spitzen (18) bilden, von denen eine in die erste Führung (2) und die andere in die zweite Führung (14) mündet.
  12. Vorrichtung nach Anspruch 11, dadurch gekennzeichnet, dass die Nadel (17) an dem geschlossenen Ende (5) der ersten Führung (2) festgehalten wird.
  13. Vorrichtung nach Anspruch 12, dadurch gekennzeichnet, dass sie einen Bereich umfasst, der auf der Seite des geschlossenen Endes (5) der ersten Führung (2) bzw., als Alternative, auf der Seite der zweiten Führung (14), einen Sockel (19) bildet, um die Steifigkeit der Nadel (17) zu erhöhen.
  14. Vorrichtung nach Anspruch 11, wenn er von den Ansprüchen 8 bis 10 abhängig ist, dadurch gekennzeichnet, dass die Nadel (17) in dem Bereich mit dem kleineren Durchmesser (20) der zweiten Führung (14) festgehalten wird.
  15. Vorrichtung nach einem der Ansprüche 11 bis 14, dadurch gekennzeichnet, dass die in die erste Führung (2) mündende Spitze (18) der Nadel (17) durch einen flexiblen Mantel (24), beispielsweise aus Latex, geschützt wird.
  16. Vorrichtung nach einem der Ansprüche 11 bis 15, dadurch gekennzeichnet, dass die in die zweite Führung (14) mündende Spitze (18) der Nadel (17) durch einen flexiblen, sich selbst verschließenden Mantel (24), beispielsweise aus Latex, geschützt wird.
  17. Vorrichtung nach einem der Ansprüche 1 bis 16, dadurch gekennzeichnet, dass sie unabhängig ist von dem Lösungsbeutel (16) und von dem Flakon (3).
  18. Vorrichtung nach Anspruch 17, dadurch gekennzeichnet, dass die zweite Führung (14) Mittel umfasst, die den kompletten Rückzug der Eintrittsöffnung (15) des Lösungsbeutels (16) aus der zweiten Führung (14) nach ihrer Einführung in diese verhindern.
  19. Vorrichtung nach Anspruch 18, dadurch gekennzeichnet, dass die den Rückzug der Eintrittsöffnung (15) verhindernden Mittel eine identische Struktur mit derjenigen der den Rückzug des Flakons (3) aus der ersten Führung (2) verhindernden Mittel aufweisen und so angeordnet sind, dass sie das zumindest teilweise Gleiten der genannten Eintrittsöffnung (15) in der zweiten Führung (14) ermöglichen.
  20. Vorrichtung nach einem der Ansprüche 1 bis 16, dadurch gekennzeichnet, dass sie permanent und unlösbar in dem Lösungsbeutel (16) angebracht sind.
  21. Vorrichtung nach Anspruch 20, dadurch gekennzeichnet, dass sie fest an der Eintrittsöffnung (15) des Lösungsbeutels (16), an dem offenen Ende der zweiten Führung (14), befestigt ist.
  22. Vorrichtung nach Anspruch 20 oder 21, dadurch gekennzeichnet, dass sie ferner von einem Verschluss geschützt ist, der an den Längswänden (4) der ersten Führung (2) ruht.
  23. Vorrichtung nach einem der Ansprüche 1 bis 22, dadurch gekennzeichnet, dass sie aus einem einspritzbaren und sterilisierbaren Kunststoff hergestellt ist.
  24. Vorrichtung nach Anspruch 23, dadurch gekennzeichnet, das sie aus einem Polymer auf der Basis von Polyethylen, Polycarbonat, Polypropylen, Polystyrol oder Derivaten und/oder Mischungen dieser Produkte hergestellt ist.
EP20000400612 1999-03-10 2000-03-07 Vorrichtung zum Übertragen einer in einem Flacon enthaltenen Substanz in einen Beutel der eine Lösung enthält Expired - Lifetime EP1034772B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9902963 1999-03-10
FR9902963A FR2790749B1 (fr) 1999-03-10 1999-03-10 Dispositif de transfert d'une substance contenue dans un flacon dans une poche de solute

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EP1034772A1 EP1034772A1 (de) 2000-09-13
EP1034772B1 true EP1034772B1 (de) 2007-01-24

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EP (1) EP1034772B1 (de)
AT (1) ATE352274T1 (de)
DE (1) DE60033074D1 (de)
FR (1) FR2790749B1 (de)

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FR2828802A1 (fr) * 2001-08-22 2003-02-28 Map France Conditionnement de securite pour flacon a usage medical
US6875205B2 (en) 2002-02-08 2005-04-05 Alaris Medical Systems, Inc. Vial adapter having a needle-free valve for use with vial closures of different sizes
FR2863161B1 (fr) * 2003-12-05 2006-09-01 Map France Capuchon pour conditionnement de securite pour flacon a usage medical
FR2878737B1 (fr) 2004-12-07 2007-03-16 Maptech Soc Par Actions Simpli Dispositif de securite pour flacon a usage medical
FR2907769B1 (fr) 2006-10-31 2009-02-06 Maco Pharma Sa Recipient equipe d'un systeme de transfert aseptique
BR112012025861A2 (pt) 2010-04-09 2016-06-28 Sanofi Aventis Deutschland elemento de conexão de reservatório de fármaco codificado com elementos de travamento encurváveis
ES2655593T3 (es) * 2010-04-09 2018-02-20 Sanofi-Aventis Deutschland Gmbh Elemento codificado de conexión de depósito de fármaco con brida articulada
CN107468520A (zh) 2012-02-02 2017-12-15 碧迪股份有限公司 用于与医用容器相联接的适配器
SG192312A1 (en) 2012-02-02 2013-08-30 Becton Dickinson Holdings Pte Ltd Adaptor for coupling to a medical container
SG192310A1 (en) 2012-02-02 2013-08-30 Becton Dickinson Holdings Pte Ltd Adaptor for coupling to a medical container
EP2692328A1 (de) 2012-08-03 2014-02-05 Becton Dickinson France Dosierungszählvorrichtung zur Kopplung an einen medizinischen Behälter
EP2735300A1 (de) 2012-11-26 2014-05-28 Becton Dickinson France Adapter für Multidosierungs-Medizinbehälter
CN111474375A (zh) * 2013-07-26 2020-07-31 积水医疗株式会社 试剂供给装置
JP1526207S (de) 2013-08-05 2015-06-15
IT201900002745A1 (it) * 2019-02-26 2020-08-26 Adienne Pharma & Biotech Sa “Confezione sterile o sterilizzata per l’erogazione di sostanze medicinali o nutrizionali”
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Publication number Publication date
ATE352274T1 (de) 2007-02-15
DE60033074D1 (de) 2007-03-15
FR2790749A1 (fr) 2000-09-15
FR2790749B1 (fr) 2001-05-18
EP1034772A1 (de) 2000-09-13

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