EP1363638A4 - USE OF GAL3 RECEPTOR ANTAGONISTS IN THE TREATMENT OF DEPRESSION AND / OR ANXIETY AND COMPOUNDS USEFUL IN SUCH METHODS - Google Patents

USE OF GAL3 RECEPTOR ANTAGONISTS IN THE TREATMENT OF DEPRESSION AND / OR ANXIETY AND COMPOUNDS USEFUL IN SUCH METHODS

Info

Publication number
EP1363638A4
EP1363638A4 EP02714918A EP02714918A EP1363638A4 EP 1363638 A4 EP1363638 A4 EP 1363638A4 EP 02714918 A EP02714918 A EP 02714918A EP 02714918 A EP02714918 A EP 02714918A EP 1363638 A4 EP1363638 A4 EP 1363638A4
Authority
EP
European Patent Office
Prior art keywords
anxiety
depression
treatment
methods
receptor antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02714918A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1363638A2 (en
Inventor
Thomas P Blackburn
Michael Konkel
Lakmal W Boteju
Ian Jamie Talisman
John M Wetzel
Mathivanan Packiarajan
Heidi Chen
Hermo Jimenez
Bharat Lagu
Kitae Lim
Stewart Noble
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Priority to EP09010004A priority Critical patent/EP2140862A3/en
Priority to EP09010003A priority patent/EP2140864A3/en
Priority claimed from PCT/US2002/004608 external-priority patent/WO2002060392A2/en
Publication of EP1363638A2 publication Critical patent/EP1363638A2/en
Publication of EP1363638A4 publication Critical patent/EP1363638A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EP02714918A 2001-01-31 2002-01-31 USE OF GAL3 RECEPTOR ANTAGONISTS IN THE TREATMENT OF DEPRESSION AND / OR ANXIETY AND COMPOUNDS USEFUL IN SUCH METHODS Withdrawn EP1363638A4 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP09010004A EP2140862A3 (en) 2001-01-31 2002-01-31 Use of GAL 3 receptor antagonists for the treatment of depression and /or anxiety and compounds useful in such methods
EP09010003A EP2140864A3 (en) 2001-01-31 2002-01-31 Use of GAL3 receptor antagonists for the treatment of depression and / or anxiety and compounds useful in such methods

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77534101A 2001-01-31 2001-01-31
US775341 2001-01-31
PCT/US2002/004608 WO2002060392A2 (en) 2001-01-31 2002-01-31 Use of gal3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP09010003A Division EP2140864A3 (en) 2001-01-31 2002-01-31 Use of GAL3 receptor antagonists for the treatment of depression and / or anxiety and compounds useful in such methods
EP09010004A Division EP2140862A3 (en) 2001-01-31 2002-01-31 Use of GAL 3 receptor antagonists for the treatment of depression and /or anxiety and compounds useful in such methods

Publications (2)

Publication Number Publication Date
EP1363638A2 EP1363638A2 (en) 2003-11-26
EP1363638A4 true EP1363638A4 (en) 2010-01-06

Family

ID=25104097

Family Applications (3)

Application Number Title Priority Date Filing Date
EP09010003A Withdrawn EP2140864A3 (en) 2001-01-31 2002-01-31 Use of GAL3 receptor antagonists for the treatment of depression and / or anxiety and compounds useful in such methods
EP09010004A Withdrawn EP2140862A3 (en) 2001-01-31 2002-01-31 Use of GAL 3 receptor antagonists for the treatment of depression and /or anxiety and compounds useful in such methods
EP02714918A Withdrawn EP1363638A4 (en) 2001-01-31 2002-01-31 USE OF GAL3 RECEPTOR ANTAGONISTS IN THE TREATMENT OF DEPRESSION AND / OR ANXIETY AND COMPOUNDS USEFUL IN SUCH METHODS

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EP09010003A Withdrawn EP2140864A3 (en) 2001-01-31 2002-01-31 Use of GAL3 receptor antagonists for the treatment of depression and / or anxiety and compounds useful in such methods
EP09010004A Withdrawn EP2140862A3 (en) 2001-01-31 2002-01-31 Use of GAL 3 receptor antagonists for the treatment of depression and /or anxiety and compounds useful in such methods

Country Status (22)

Country Link
EP (3) EP2140864A3 (sk)
JP (3) JP4739650B2 (sk)
KR (1) KR20040041092A (sk)
CN (2) CN100446767C (sk)
AU (2) AU2002247149B2 (sk)
BG (1) BG108114A (sk)
BR (1) BR0206844A (sk)
CA (3) CA2672805A1 (sk)
CZ (1) CZ20032341A3 (sk)
EA (1) EA006486B1 (sk)
HR (1) HRP20030608A2 (sk)
HU (1) HUP0401858A3 (sk)
IL (2) IL157102A0 (sk)
IS (1) IS6880A (sk)
MX (1) MXPA03006812A (sk)
NO (1) NO20033388L (sk)
NZ (1) NZ527163A (sk)
PL (1) PL369270A1 (sk)
SK (1) SK9562003A3 (sk)
UA (1) UA74421C2 (sk)
YU (1) YU60803A (sk)
ZA (1) ZA200305686B (sk)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2672805A1 (en) * 2001-01-31 2002-08-08 H. Lundbeck A/S Pyrimidine derivatives
EP1474401A2 (en) * 2002-02-05 2004-11-10 Novo Nordisk A/S Novel aryl- and heteroarylpiperazines
CN101973925B (zh) * 2010-10-15 2012-03-28 中国药科大学 具有抗炎活性的2-吲哚酮类化合物、其制备方法及医药用途
WO2015054317A1 (en) * 2013-10-07 2015-04-16 Kadmon Corporation, Llc Rho kinase inhibitors
AU2017388466B2 (en) 2016-12-29 2022-04-28 Minoryx Therapeutics S.L. Heteroaryl compounds and their use
AU2020214796A1 (en) * 2019-01-30 2021-07-29 Truebinding, Inc. Anti-Gal3 antibodies and uses thereof
CN113317221B (zh) * 2021-06-18 2023-01-31 青岛百宜电器有限公司 自动梳毛机

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50140441A (sk) * 1974-04-23 1975-11-11

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1477349A (en) * 1975-09-24 1977-06-22 Ciba Geigy Ag Azo pigments
MA18829A1 (fr) * 1979-05-18 1980-12-31 Ciba Geigy Ag Derives de la pyrimidine,procedes pour leur preparation,compositions pharmaceutiques contenant ces composes et leur utilisation therapeutique
US4946956A (en) * 1988-09-21 1990-08-07 Uniroyal Chemical Company, Inc. Arylenediamine substituted pyrimidines
JPH02300264A (ja) * 1989-05-16 1990-12-12 Fuji Photo Film Co Ltd アミノピリミジンアゾメチン色素とその製造方法
JPH02308248A (ja) * 1989-05-24 1990-12-21 Fuji Photo Film Co Ltd アミノピリミジン系色素形成カプラーおよび該カプラーを含有するハロゲン化銀カラー写真感光材料
HUT64323A (en) * 1992-06-09 1993-12-28 Richter Gedeon Vegyeszet Process for production new piperazinyl-bis(alkyl-amino)-pyrimidine derivatives
DK69693D0 (da) * 1993-06-14 1993-06-14 Neurosearch As Farven lilla
CN100384825C (zh) * 1994-06-15 2008-04-30 大塚制药株式会社 苯并杂环衍生物
DE4435477A1 (de) * 1994-10-04 1996-04-11 Bayer Ag Cycloalkano-indol- und -azaindol-derivate
WO1996032366A1 (fr) * 1995-04-12 1996-10-17 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Derives du naphtol et procede de fabrication
KR100457502B1 (ko) * 1995-06-02 2005-09-05 사노피-신델라보 옥사졸리디논유도체,그것의제법및치료학적사용
EP1000025B1 (en) * 1995-10-13 2007-02-21 Transitions Optical, Inc. Substituted naphthopyrans
FR2741072B1 (fr) * 1995-11-09 1997-12-12 Synthelabo Derives d'oxazolidin-2-one, leur preparation et leur application en therapeutique
US6329197B2 (en) 1996-10-09 2001-12-11 Synaptic Pharmaceutical Corporation DNA encoding galanin GALR3 receptors and uses thereof
ATE214704T1 (de) * 1997-07-18 2002-04-15 Hoffmann La Roche 5h-thiazolo(3,2-a)pyrimidinderivate
JPH11158073A (ja) * 1997-09-26 1999-06-15 Takeda Chem Ind Ltd アデノシンａ３拮抗剤
CN1240210A (zh) * 1998-04-17 2000-01-05 伊莱利利公司 取代的三环化合物
AU770309B2 (en) * 1998-06-05 2004-02-19 Regent Court Technologies Monoamine oxidase (MAO) inhibitors and uses thereof
PE20001236A1 (es) * 1998-11-13 2000-11-10 Lilly Co Eli Moduladores del receptor de aminoacidos excitadores
CH1196397H1 (de) * 1999-06-02 2007-05-31 Nps Pharma Inc Metabotrope Glutamatrezeptorantagonisten zur Behandlung von Krankheiten des zentralen Nervensystems.
AU5108000A (en) * 1999-06-10 2001-01-02 Yamanouchi Pharmaceutical Co., Ltd. Novel nitrogen-contaiing heterocyclic derivatives or salts thereof
WO2001047921A1 (en) * 1999-12-28 2001-07-05 Pharmacopeia, Inc. Pyrimidine and triazine kinase inhibitors
CA2672805A1 (en) * 2001-01-31 2002-08-08 H. Lundbeck A/S Pyrimidine derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50140441A (sk) * 1974-04-23 1975-11-11

Non-Patent Citations (18)

* Cited by examiner, † Cited by third party
Title
ABDEL-RAHMAN, R. M. ET AL: "Synthesis of some 1,2,4-triazino[4,3-a]indole derivatives", JOURNAL OF THE INDIAN CHEMICAL SOCIETY ( 1991 ), 68(11), 621-4 CODEN: JICSAH; ISSN: 0019-4522, 1991, XP008115404 *
BAIOCCHI L ET AL: "SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW INDOLOÄ2,1-BÜQUINAZOLIN-6(12H)ONES", FARMACO, SOCIETA CHIMICA ITALIANA, PAVIA, IT, vol. 48, no. 4, 1 January 1993 (1993-01-01), pages 487 - 501, XP009063144, ISSN: 0014-827X *
CURRENT SCIENCE , 51(23), 1100-3 CODEN: CUSCAM; ISSN: 0011-3891, 1982 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; OTOMASU, HIROTAKA ET AL: "Spiro[indoline-3,2'-thiazolidine]-2,4'-diones", XP002557734, retrieved from STN Database accession no. 1976:432991 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SEN GUPTA, A. K. ET AL: "Synthesis of indole derivatives as potential biodynamic agents: Part II: 1,5-Disubstituted 3-(5-aryl-1,3,4-oxadiazol-2-yl)-iminoindolin-2-ones as possible antibacterial and CNS active agents", XP002557738, retrieved from STN Database accession no. 1983:83236 *
DATABASE REGISTRY 16 November 1984 (1984-11-16), XP002557735, retrieved from STN Database accession no. 59618-76-7 *
DATABASE REGISTRY 17 November 2000 (2000-11-17), XP002557739, retrieved from STN Database accession no. 303149-06-6 *
DATABASE REGISTRY 17 November 2000 (2000-11-17), XP002557741, retrieved from STN Database accession no. 303149-14-6 *
DATABASE REGISTRY 17 November 2000 (2000-11-17), XP002557742, retrieved from STN Database accession no. 303149-12-4 *
DATABASE REGISTRY 18 December 2000 (2000-12-18), XP002557736, retrieved from STN Database accession no. 309271-04-3 *
DATABASE REGISTRY 19 December 2000 (2000-12-19), XP002557737, retrieved from STN Database accession no. 309744-91-0 *
DATABASE REGISTRY 22 November 2000 (2000-11-22), XP002557740, retrieved from STN Database accession no. 303984-51-2 *
JOSHI, K. C. ET AL: "Possible psychopharmacological agents. X. Synthesis of some fluorine-containing indole-2,3-dione derivatives", JOURNAL FUER PRAKTISCHE CHEMIE (LEIPZIG) ( 1980 ), 322(2), 314-20 CODEN: JPCEAO; ISSN: 0021-8383, 1980, XP002557733 *
KNOTZ, FLORIAN: "Preparation of antiviral and antimicrobial substances. 2. Acyl hydrazones and thiosemicarbazones of 1-isatin acetic acid derivatives", SCIENTIA PHARMACEUTICA ( 1970 ), 38(3), 163-72 CODEN: SCPHA4; ISSN: 0036-8709, 1970, XP008115405 *
See also references of WO02060392A2 *
SEN GUPTA A K ET AL: "Synthesis of indole derivatives as potential biodynamic agents: Part II: 1,5-Disubstituted 3-(5-aryl-1,3,4-oxadiazol-2-yl)-iminoindolin-2 ones as possible antibacterial and CNS active agents", CURRENT SCIENCE, INDIAN ACADEMY OF SCIENCES, IN, vol. 51, no. 23, 5 December 1982 (1982-12-05), pages 1100 - 1103, XP008115354, ISSN: 0011-3891 *
VARMA, RAJENDRA S. ET AL: "Potential biologically active agents. Part XLIII. Synthesis of substituted 2-phenylbenzoxazoles as CNS active agents", INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY ( 1985 ), 24B(3), 280-5 CODEN: IJSBDB; ISSN: 0376-4699, 1985, XP008115349 *
ZAM A ET AL: "Synthesis and pharmacological activities of Mannich bases using indole-2,3-dione/3-phenylimino-2-indolinone as amine moiety", JOURNAL OF THE INSTITUTION OF CHEMISTS (INDIA), CALCUTTA, IN, vol. 68, no. 4, 1 January 1996 (1996-01-01), pages 114 - 116, XP008115350, ISSN: 0020-3254 *

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