EP1361917B1 - Vorrichtung zum mischen und homogenisieren von materialien in einem labortestgefäss mit einem rührelement - Google Patents

Vorrichtung zum mischen und homogenisieren von materialien in einem labortestgefäss mit einem rührelement Download PDF

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Publication number
EP1361917B1
EP1361917B1 EP01969125A EP01969125A EP1361917B1 EP 1361917 B1 EP1361917 B1 EP 1361917B1 EP 01969125 A EP01969125 A EP 01969125A EP 01969125 A EP01969125 A EP 01969125A EP 1361917 B1 EP1361917 B1 EP 1361917B1
Authority
EP
European Patent Office
Prior art keywords
laboratory test
test container
lid
cutting edges
stirring element
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP01969125A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1361917A1 (de
Inventor
Franz G. Bucher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Miltenyi Biotec Swiss AG
Original Assignee
Medic Tools AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medic Tools AG filed Critical Medic Tools AG
Publication of EP1361917A1 publication Critical patent/EP1361917A1/de
Application granted granted Critical
Publication of EP1361917B1 publication Critical patent/EP1361917B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
    • B01F27/86—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis co-operating with deflectors or baffles fixed to the receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • B01F33/4534—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements using a rod for supporting the stirring element, e.g. stirrer sliding on a rod or mounted on a rod sliding in a tube
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/83—Mixing plants specially adapted for mixing in combination with disintegrating operations
    • B01F33/8305—Devices with one shaft, provided with mixing and milling tools, e.g. using balls or rollers as working tools; Devices with two or more tools rotating about the same axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/60—Safety arrangements
    • B01F35/605—Safety devices concerning the operation of the mixer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
    • B01F2035/35—Use of other general mechanical engineering elements in mixing devices
    • B01F2035/351—Sealings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/836—Mixing plants; Combinations of mixers combining mixing with other treatments
    • B01F33/8361—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating
    • B01F33/83611—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating by cutting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
    • B01F35/32—Driving arrangements
    • B01F35/321—Disposition of the drive
    • B01F35/3213—Disposition of the drive at the lower side of the axis, e.g. driving the stirrer from the bottom of a receptacle

Definitions

  • the invention relates to a device for mixing and homogenizing of materials, especially infectious or chemical aggressive materials, in a laboratory test vessel.
  • Such Devices are known from DE-9-3 638 656 and GB-A-820574 known.
  • Magnetic stirrers and mechanical stirrers are common in the laboratory known and in use. In the crushing of infectious or chemically aggressive materials in non-hermetic Closed vessels there is a large infection and / or Contamination risk due to uncontrolled splashes, which penetrate through the opening of the laboratory test tube to the outside can, by unintentional tipping over the laboratory test vessel and through the use of reusable mixers. This is special in the case of test tubes and mixers known for this purpose.
  • the lid is designed as a disposable lid, so that it is disposed of immediately after use and thus a Contamination during further work in the laboratory safely avoided becomes.
  • Fig. 1 shows a schematic partially sectioned side View of a first embodiment of the invention.
  • a laboratory test vessel is provided with the reference numeral 20. there this is a cylindrical tube 18 with conical tapered tip 21.
  • the interior 17 of the laboratory test tube 20 is filled with the materials to be mixed 37. Subsequently the laboratory test tube 20 is in use the disposable screw cap 10 with this closed and then on upside down.
  • disposable screw cap or disposable snap cap (Snap-cap) 10 of the hermetically sealable laboratory test tube 20 is a sunken, four-sided, with radial and axial Cutting edges 29 provided plastic or metal beams 11th provided at the cutting edges 28 of the cutting ribs 12 is passed.
  • This bar 11 is using the axis 13 from outside the laboratory test vessel 20 from a six-point quick release ring 14 driven.
  • the laboratory test vessel 20 with the mixing and homogenizing Materials will be appropriate for inverted vessel position Fig. 1 frictionally via the coupling ring 14 on a external drive provided.
  • the transmitted rotary motion are located in the interior 17 of the vessel 20 Substances and liquids through the beam 11 axially, that is along the longitudinal axis 22 of the laboratory test vessel 20, aspirated and thrown radially. They are under Cutting action on the peripheral cutting ribs 12 through the Slits ejected. As a result, the mix is crushed, mixed, homogenized and then at the mixer wall 15, extending respectively between the cutting ribs 12, after upside down.
  • the set around the axis 13 sealing ring 16th prevents the leakage of the liquid.
  • the rotational energy is mechanically from the outside on the coupling ring 14 and the axis 13 transferred to the beam 11.
  • the speed is material specific set for optimal homogenization.
  • Of the Seal ring 16 may be realized by a sealing lip.
  • Fig. 2 shows a schematic plan view of the disposable lid 10 of the first embodiment of FIG. 1. Same Features are provided in all figures with the same reference numerals.
  • the cutting lips 12 are by a wave on the circumference arranged element formed, which here nine lips includes.
  • the bar 11 may, for example, be U-shaped, downwards open, be trained, so that on both sides of the beam 11 two vertical cutting edges 29 exist. These two each Cutting edges 29 are at a short distance here eighteen (two times nine) cutting edges 28 of the cutting lips 12 opposite.
  • FIG. 3 shows an isolated view of the disposable lid 10 from Fig. 1, in which all for the transmission of the rotational movement essential elements are inserted into the body 3.
  • the Fig. 4 shows an exploded view of the one-way lid 10 used drive of FIG. 1, consisting of the beam eleventh with integrally connected axle 13, the sealing ring 16 and the coupling ring 14, all about the longitudinal axis 22 of the device are arranged.
  • Fig. 5 shows a schematic partially cut side View of a second embodiment of the invention.
  • the disposable lid 10 has a body 3 having a circumferential groove 24, in which the laboratory test vessel 20 can be inserted or is screwed.
  • a sealing element 1 is used, which at the same time the interior 9 of the laboratory test tube 20 hermetically opposite the outside space concludes.
  • the sealing element 1 has at the same time via a transversely to the longitudinal axis 22 arranged, perforated Disc, which forms a cavity 30 with respect to the body 3, which forms a cylindrical cage.
  • a turnstile 2 is arranged in this cavity 30.
  • the turnstile 2 has radial 39 and peripheral 38 cutting edges attached to the corresponding cutting edges 31 of the inlet holes 25 are passed.
  • a sealing lip 5 prevents the leakage of the liquid.
  • the rotational energy becomes mechanical transferred from the outside to the hexagon socket 6 and the axis 4.
  • the speed is also material specific for a optimal homogenization.
  • Fig. 6 shows a schematic plan view of the disposable lid of the second embodiment of FIG. 5.
  • the sealing element 1 has four openings 25 in the disk area here on, which are at a radial distance from the axis 22 and are arranged at an angular distance of 90 degrees to each other.
  • the cutting element is a turnstile 2 with four arms 32. Instead of four breakthroughs 25 and a turnstile 2 with four Poor 32 are also corresponding elements with three or example five breakthroughs / arms possible.
  • the turnstile 2 can be a four-sided plastic cross.
  • FIG. 7 shows a representation of the disposable lid from FIG. 5.
  • Fig. 8 shows an exploded view of the one-way lid 10 used drive of FIG. 5, from the four Elements exists. It is indicated here by the reference numeral, the laboratory test vessel 20 is screwed into the circumferential groove which is on its outside over a corresponding thread 33 features.
  • the drive axle 4 can be thermally conductive, so that 4 heat energy into the laboratory test vessel via this drive axle 20 insertable or can be derived from this to the outside. It can be provided that in the laboratory test vessel 20 electrical Energy is introduced via the drive axle 4 and / or the electrochemical sensors are used.
  • Fig. 9 shows a schematic partially sectioned lateral View of a third embodiment of the invention.
  • the lid 10 is a rotary wing or rotor 13 in a cylindrical Cage 42 integrated.
  • the cylindrical cage 12 is used in a body 41 of the lid 10 and has four radially aligned, oval openings 26, through which the material to be homogenized into the cavity 30 in the cage 42 guided and cut off there by the rotor 13.
  • the laboratory test vessel 20 with the tissue material 27 is placed on the cover standing in the drive, so that there is a filling level 37 and the material with the cage 42 and the rotor 13 is in contact.
  • the in the Drawings not shown known drive comprises a another magnetic rotor, with which the rotational energy magnetic or transmitted electromagnetically.
  • the magnetic Field strength is dimensioned such that one for homogenization optimum torque is transmitted.
  • Fig. 10 shows a schematic plan view of the disposable lid 10 of the third embodiment of FIG. 9 and the Fig. 11 shows a representation of the disposable lid of Fig. 9.
  • the circular groove 24 allows one via a positive Seat passing passport of the laboratory test tube 20 in the lid 11.
  • the magnetic bar 13 is constructed asymmetrically, so that through the aerodynamically optimized design in one Direction of rotation a central liquid flow from top to bottom and in the other direction of rotation a lateral fluid flow along the wall of the laboratory test vessel 20 from top to bottom generated. By reversing the direction of rotation is thus the Ansaugund Output changed.
  • Fig. 12 shows a schematic sectional side view a disposable lid according to a fourth embodiment of the invention
  • Fig. 13 is a plan view of the disposable lid from Fig. 12.
  • the differences from the embodiment Fig. 1 is particularly as follows.
  • the quick coupling ring 14 has teeth on its underside, teeth 53 in one Drive shaft 54 engage.
  • the lower edge 55 of the body 3 is in particular pulled so far down that the lid 10th can be placed flat without the teeth of the quick coupling ring 14 survive.
  • the reference numeral 59 denotes a ball bearing for the shaft 13.
  • a ball bearing is for a cost-effective Manufacture of the device as a disposable lid 10 is not required. It can not in particular by a in the drawings shown slide bearing of the drive shaft 13 are replaced the seal provided by an inserted O-ring becomes. This is particularly advantageous because at a Disposable lid 10 the bearing only once and then for only one burdened for a short time and must withstand this load.
  • the cage 52 forms here simultaneously cutting edges, the not from breakthroughs as in the second embodiment and also not from a purely lateral element as in the first embodiment consist.
  • the cage 52 has down drawn lugs 56, which embrace the beam 11. This one is with equipped with two arms, but it can also be a turnstile 2 with be provided more poor.
  • the cutting edges 57 are in particular can be seen in the plan view of FIG. 13, wherein cavities 58 are adjacent lugs 56 record material to it then to cut off with the bar 11.
  • sensor lines through the Body 3 are performed on the outward-facing Page have electrical connections.
  • a sensor while mixing near the ground be arranged processing material.
  • sensor cables can also be performed a light guide or a Supply line, which in the interior 60 a radiator or a Peltier element forms.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EP01969125A 2001-02-22 2001-10-04 Vorrichtung zum mischen und homogenisieren von materialien in einem labortestgefäss mit einem rührelement Expired - Lifetime EP1361917B1 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CH3242001 2001-02-22
CH324012001 2001-02-22
CH3512001 2001-02-27
CH351012001 2001-02-27
CH113901 2001-06-23
CH11392001 2001-06-23
PCT/CH2001/000597 WO2002066147A1 (de) 2001-02-22 2001-10-04 Vorrichtung zum mischen und homogenisieren von materialien in einem labortestgefäss mit einem rührelement

Publications (2)

Publication Number Publication Date
EP1361917A1 EP1361917A1 (de) 2003-11-19
EP1361917B1 true EP1361917B1 (de) 2004-08-04

Family

ID=27178356

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01969125A Expired - Lifetime EP1361917B1 (de) 2001-02-22 2001-10-04 Vorrichtung zum mischen und homogenisieren von materialien in einem labortestgefäss mit einem rührelement

Country Status (12)

Country Link
US (1) US7165734B2 (es)
EP (1) EP1361917B1 (es)
JP (1) JP4261188B2 (es)
AT (1) ATE272439T1 (es)
AU (1) AU2001289471B2 (es)
CA (1) CA2438342C (es)
DE (1) DE50103166D1 (es)
DK (1) DK1361917T3 (es)
ES (1) ES2225601T3 (es)
NZ (1) NZ527657A (es)
PT (1) PT1361917E (es)
WO (1) WO2002066147A1 (es)

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US8182137B2 (en) 2000-10-09 2012-05-22 Atmi Packaging, Inc. Mixing bag or vessel with a fluid-agitating element
US7086778B2 (en) * 2000-10-09 2006-08-08 Levtech, Inc. System using a levitating, rotating pumping or mixing element and related methods
CA2462309C (en) * 2001-10-03 2010-12-14 Levtech, Inc. Mixing bag or vessel having a receiver for a fluid-agitating element
EP1701780B8 (en) * 2004-01-07 2014-09-24 Pall Technology UK limited Bioprocessing vessel with integral sparger, and method of its manufacture
EP1839027B1 (de) * 2005-01-21 2016-10-19 Medic Tools AG Einwegmischer, -homogenisator, -extrahierer, -fraktionierer oder -aufschlämmer
EP1748201B1 (de) * 2005-07-29 2010-12-29 Zeta Biopharma GmbH Magnetrührer
WO2008040567A1 (en) * 2006-10-03 2008-04-10 Artelis Flexible mixing bag, mixing device and mixing system
CA2627654C (en) * 2005-10-26 2012-02-07 Levtech, Inc. Bioreactor with mixer and sparger
CN101460605B (zh) 2006-05-13 2017-09-08 Atmi有限责任公司 一次性生物反应器
JP2008096256A (ja) * 2006-10-11 2008-04-24 Onsui:Kk 気体成分の分析方法及び気体成分の分離装置並びに判別方法
JP5663311B2 (ja) * 2008-01-09 2015-02-04 ケック グラデュエイト インスティテュート 物質の調整及び／又は取扱システム、装置及び方法
US8480292B2 (en) * 2010-06-01 2013-07-09 Boris Dushine Systems, apparatus and methods to reconstitute dehydrated drinks
EP2478962A1 (en) 2011-01-24 2012-07-25 Miltenyi Biotec GmbH Heating device for cylindrical laboratory vessels
US8596566B2 (en) 2012-01-16 2013-12-03 Yang-Te Hsu Biomedical homogenizing device
JP2013217882A (ja) * 2012-04-12 2013-10-24 Hitachi High-Technologies Corp 試薬撹拌機構および自動分析装置
US9339026B2 (en) 2012-06-14 2016-05-17 Therapeutic Proteins International, LLC Pneumatically agitated and aerated single-use bioreactor
US9452206B2 (en) 2012-08-24 2016-09-27 Children's Hospital Of Orange County Isolation of lymphocytes and delivery to splenectomy patients
US9880067B2 (en) * 2013-12-03 2018-01-30 Pall Corporation Mechanical agitator with seal housing assembly
CN203862180U (zh) * 2014-05-21 2014-10-08 厦门信道生物技术有限公司 一种标本的混均过滤一体处理机构
SE540903C2 (en) * 2017-03-06 2018-12-18 Spinchem Ab Flow-promoting device, a reactor arrangement and the use of such flow-promoting device
IT201900006854A1 (it) 2019-05-15 2020-11-15 Fidia Farm Spa Dispositivo per disgregare materiale biologico e relativo metodo di disgregazione e preparazioni cellulari

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Also Published As

Publication number Publication date
DK1361917T3 (da) 2004-12-06
JP4261188B2 (ja) 2009-04-30
WO2002066147A1 (de) 2002-08-29
US7165734B2 (en) 2007-01-23
AU2001289471B2 (en) 2006-05-18
EP1361917A1 (de) 2003-11-19
DE50103166D1 (de) 2004-09-09
ES2225601T3 (es) 2005-03-16
JP2004528960A (ja) 2004-09-24
ATE272439T1 (de) 2004-08-15
NZ527657A (en) 2006-02-24
PT1361917E (pt) 2004-11-30
US20040252582A1 (en) 2004-12-16
CA2438342A1 (en) 2002-08-29
CA2438342C (en) 2009-09-29

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