EP1353857A1 - Primary packaging unit for a plurality of individual film tablets as pharmaceutical forms - Google Patents
Primary packaging unit for a plurality of individual film tablets as pharmaceutical formsInfo
- Publication number
- EP1353857A1 EP1353857A1 EP02702263A EP02702263A EP1353857A1 EP 1353857 A1 EP1353857 A1 EP 1353857A1 EP 02702263 A EP02702263 A EP 02702263A EP 02702263 A EP02702263 A EP 02702263A EP 1353857 A1 EP1353857 A1 EP 1353857A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- compartments
- dosage forms
- primary packaging
- packaging unit
- tear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
- B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
- B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
- B65D75/34—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents and having several recesses to accommodate a series of articles or quantities of material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/52—Details
- B65D75/58—Opening or contents-removing devices added or incorporated during package manufacture
- B65D75/5855—Peelable seals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
- B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
- B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
- B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
- B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/52—Details
- B65D75/527—Tear-lines for separating a package into individual packages
Definitions
- the invention relates to a primary packaging unit for several isolated film plates as dosage forms, which are arranged in compartments formed in several rows, in particular for circular dosage forms.
- This has a lower layer and an upper layer, between which sheet-like film plates are enclosed as forms of administration in co-ordinates (compartments)
- the upper and lower layers are connected to one another by sealing seams or areas, into which perforations are introduced as predetermined breaking lines in the areas between the compartments, which enable the individual compartments to be separated from the primary packaging unit as required
- an unsealed edge can be arranged on at least one side outside the sealing area, or upper and lower layer can be shifted from each other: and connected to each other so that a protruding edge of one of the two layers is formed.
- DE 100 08 165 also relates to a primary packaging unit with a lower layer and an upper layer.
- the two layers are not connected to one another in predetermined areas and thereby form a tear-open aid.
- the invention consists in the fact that in a primary packaging unit for several individual dosage forms in the form of film plates, which is formed from a lower layer and an upper layer sealed with this, between which individual compartments for the dosage forms surrounded by sealing areas are formed, in the area of which rich, the top and bottom layers are unsealed, at least two rows of compartments are formed, and the compartments and dosage forms of the adjacent rows are arranged offset from one another, or, alternatively, that the compartments are arranged in a ring.
- the multi-row positioning with an offset of the compartments or the ring-shaped positioning of the dosage forms leads to a denser packing per unit area and thus also to smaller primary packaging units.
- the primary packaging unit is preferably provided as a dosage form for round, platelet-shaped film plates, in which the compartments are arranged in such a way that the offset of the dosage forms included in this corresponds to half the distance between the centers of two adjacent dosage forms, and that all adjacent dosage forms correspond to that have the same distance from each other.
- a distance A between two adjacent dosage forms of a row this means that a dosage form of the adjacent row is offset by 0.5 A to these.
- the connecting lines of the middle points of the dosage forms isosceles triangles.
- the offset can also be selected differently.
- the distance between the edges of two adjacent dosage forms is between 3 mm and 50 mm, preferably between 6 mm and 20 mm.
- the dosage forms are preferably circular dosage forms with a diameter between 0.5 and 3 cm and with a thickness between 50 and 700 ⁇ m.
- the primary packaging has tear tabs assigned to the compartments, which are formed in that the upper layer is not connected to the lower layer in its area and the upper layer in the area facing away from the compartments is separated from the upper layer sealed with the lower layer.
- the tear tabs border on predetermined tear lines, which are arranged in the sealed upper layer of the areas surrounding the compartments. With the help of a pull tab, the upper layer is separated from the lower layer along the predetermined tear line surrounding a compartment, and the respective compartment is opened. The dosage form inside is accessible.
- the tear-open tabs are advantageously arranged such that they protrude into the spaces between the compartments of an adjacent row.
- Polyethylene (PE), polyethylene terephthalate (PET), polypropylene (PP) and ethylene-vinyl acetate copolymer (EVA) are particularly suitable as materials for the two layers, but also paper, aluminum or composites of these materials.
- the top layer and the bottom layer can consist of different materials. It can also be advantageous to use a transparent material for one of the two layers or only for the top layer.
- the primary packaging unit is produced by pulling a web-shaped pharmaceutical form from a supply roll and feeding it from the material of the lower layer, which is also drawn from such a web, and punching out or cutting out the dosage forms, in particular circular dosage forms, in accordance with the predetermined arrangement in the primary packaging, from the pharmaceutical path and the residual material is separated by passing the residual material web over a separating edge at which the dosage forms released from the dressing remain on the web of the material of the lower layer and are advanced with it.
- a web made of the material of the upper layer is fed onto the lower web and the dosage forms positioned thereon and sealed with the material of the lower layer in predetermined areas. Then the top web is punched through and punched to form tear tabs and predetermined tear lines. Finally, the sealed composite with the dosage forms positioned according to the sample is separated from the subsequent sheets.
- FIG. 1 shows in connection with FIG. 1 a a primary packaging unit with five circular film plates arranged in two rows I and II as dosage forms 1 with a diameter of 1.9 cm and a thickness of 200 ⁇ m.
- three adjacent dosage forms 1 are positioned so that they form an isosceles triangle, so that the adjacent dosage forms 1 of both rows I and II are at a distance S from one another. The distance between their edges is 1.7 cm.
- the compartments 4 are assigned tongue-shaped regions 6 of the upper layer 3 which are not associated with the Underlayer 2 are sealed and the tip facing away from the respective compartment 4 is separated from the rest of the upper layer 3 in the region and serves as gripping and tear-open tabs. In addition, they border on their side facing the respective compartment 4 at predetermined tear lines 7, which are formed on both sides of a compartment 4 in the top layer 3 sealed with the underlayer 2.
- the tongue-shaped tear tabs (6) each protrude into the spaces between the compartments 4 of the other row I or II.
- FIG. 3 shows a primary packaging made of a lower layer 11 made of a composite of paper, aluminum and polyethylene with a thickness of 5.00 ⁇ m and an upper layer 12 sealed therewith made of a composite of polyethylene terephthalate, polypropylene and polyethylene with a thickness of 70 um and with seven compartments 13 arranged in a ring between them and seven dosage forms 1 accommodated therein.
- This primary packaging represents a weekly pack from which a dosage form 1 is to be taken every day.
- the arrangement of the compartments 13 is such that they lie with their centers on a circle with a diameter of 9.5 cm and have a regular distance S 3 of 3.5 cm from one another.
- the upper layer 12 is in the area through the A predetermined number of dosage forms and the dimensioning given the gap 14 are left out and sealed with the underlayer 11 in the shaded areas 15.
- This primary packaging is also provided with tongue-shaped tear-open tabs (16) formed by unsealed areas 16 of the top layer 12, which are separated from one another and all point towards the center. Between the compartments 13, predetermined tear lines 17 are formed in the sealed area.
- FIG. 4 shows the process sequence for producing a primary packaging unit.
- web-like material of the drug is stored on rolls, to form the lower layer 2 (11) and the upper layer 3 (12).
- the medicament web 20 is fed to a punching station 21 intermittently at a predetermined rate and before it is brought together with the web-like material of the lower layer 2, in the (21) circular dosage forms 1, according to the predetermined packaging pattern of the primary packaging unit according to FIG. 1, FIG. 2 or FIG. 3, are punched out on the material web of the lower layer 2.
- the material web of the lower layer 2 is moved forward in time by a transport mechanism 22, not shown.
- the dosage forms 1 are separated and lie in the predetermined packaging position on the material web of the underlayer 2.
- the material web of the upper layer 3 is fed onto this as a cover layer and sealed with the material web of the underlayer 2 in a sealing station 25 according to a predetermined pattern, both the areas for forming the compartments 4 (13) and the areas in which the tear-open tabs 6 (16) are formed remain unsealed.
- the upper layer is in one Punching station 26 punched out according to a predetermined pattern to form predetermined tear lines 7 (10, 17) and punched through to separate the tear-open tabs (16).
- the primary packaging unit P designed in this way is separated from the subsequent one.
Abstract
Description
Claims
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10102818 | 2001-01-23 | ||
DE10102818A DE10102818A1 (en) | 2001-01-23 | 2001-01-23 | Primary packaging unit for several isolated film platelets as dosage forms |
PCT/EP2002/000287 WO2002059012A1 (en) | 2001-01-23 | 2002-01-14 | Primary packaging unit for a plurality of individual film tablets as pharmaceutical forms |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1353857A1 true EP1353857A1 (en) | 2003-10-22 |
EP1353857B1 EP1353857B1 (en) | 2004-08-18 |
Family
ID=7671412
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02702263A Expired - Lifetime EP1353857B1 (en) | 2001-01-23 | 2002-01-14 | Primary packaging unit for a plurality of individual film tablets as pharmaceutical forms |
Country Status (10)
Country | Link |
---|---|
US (1) | US7293653B2 (en) |
EP (1) | EP1353857B1 (en) |
JP (1) | JP2004517011A (en) |
KR (1) | KR100808612B1 (en) |
AT (1) | ATE273869T1 (en) |
DE (2) | DE10102818A1 (en) |
DK (1) | DK1353857T3 (en) |
ES (1) | ES2227425T3 (en) |
PT (1) | PT1353857E (en) |
WO (1) | WO2002059012A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2248519A2 (en) | 2006-10-02 | 2010-11-10 | Labtec GmbH | Non-mucoadhesive film dosage forms |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1589513A (en) * | 2001-09-20 | 2005-03-02 | 阿拉巴玛州立大学伯明翰研究基金会 | Mid-ir microchip laser: ZnS:Cr2+ laser with saturable absorber material |
US7770732B2 (en) | 2002-10-04 | 2010-08-10 | Alpex Pharma Sa | Blister packaging |
US20060169601A1 (en) * | 2003-12-23 | 2006-08-03 | Lyon Stephen C | Medicinal container |
DE102004017030A1 (en) * | 2004-04-02 | 2005-10-20 | Schering Ag | Flat system for use in the oral cavity, e.g. for transmucosal drug delivery, comprises an intermediate, active agent-containing layer sealed between two covering layers of higher surface area |
US20060207911A1 (en) * | 2005-03-15 | 2006-09-21 | Bullock John D | Emergency medical treatment system |
US20060254949A1 (en) * | 2005-05-12 | 2006-11-16 | Staggs William B Jr | Credit card-shaped drug delivery system |
US7758484B2 (en) * | 2005-12-30 | 2010-07-20 | 3M Innovative Properties Company | Packaging and method for making the same |
DE102006041921A1 (en) * | 2006-09-07 | 2008-03-27 | Lts Lohmann Therapie-Systeme Ag | Packaging for active substance-containing films and process for their preparation |
JP5184925B2 (en) * | 2007-03-15 | 2013-04-17 | 株式会社シード | Contact lens shipping container and connection structure thereof |
US20110198261A1 (en) * | 2008-08-11 | 2011-08-18 | Boehringer Ingelheim International Gmbh | Blister pack |
DE102010028351A1 (en) | 2010-04-29 | 2011-11-03 | Bayer Schering Pharma Aktiengesellschaft | wafer pocket |
US20120305584A1 (en) * | 2011-06-06 | 2012-12-06 | Omnicare Inc. | Administration methods and packagings for oral medications |
JP6209971B2 (en) * | 2014-01-16 | 2017-10-11 | 大日本印刷株式会社 | Blister container |
WO2016077439A2 (en) * | 2014-11-11 | 2016-05-19 | Dufour Brian | Layered multiple single-dose medication systems and assemblies |
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US3503493A (en) * | 1968-01-08 | 1970-03-31 | Hoffmann La Roche | Medicament packaging device |
US3743084A (en) * | 1970-11-09 | 1973-07-03 | Colgate Palmolive Co | Carrier-dispenser package |
DE2322055A1 (en) * | 1973-05-02 | 1975-01-30 | Bosch Gmbh Robert | CHILD RESISTANT TABLET PACK |
CA1097233A (en) * | 1977-07-20 | 1981-03-10 | George K. E. Gregory | Packages |
DE2919713A1 (en) * | 1979-05-16 | 1980-11-20 | Helmut Zanker | Childproof blister pack - with safety foil forming detents around deep drawn pill cups |
US4398634A (en) * | 1981-11-12 | 1983-08-16 | Wrapade Machine Company, Inc. | Child-proof package system |
CH655913A5 (en) * | 1982-04-16 | 1986-05-30 | Ernst Ramseier | Packaging unit |
DE8902268U1 (en) * | 1989-02-25 | 1989-04-06 | Bayer Ag, 5090 Leverkusen, De | |
US4911304A (en) * | 1989-03-20 | 1990-03-27 | Merck & Co., Inc. | Sandwich blister package for tablets and similar articles |
US4955165A (en) * | 1989-05-04 | 1990-09-11 | Brooks Harvey L | Pipe tapering device |
US5046618A (en) * | 1990-11-19 | 1991-09-10 | R. P. Scherer Corporation | Child-resistant blister pack |
CA2144538C (en) * | 1992-09-30 | 2003-12-23 | Andrew Roy Thompson | Stepped-edge blister pack and use of steps |
US5325968A (en) * | 1993-07-14 | 1994-07-05 | Mcneil-Ppc, Inc. | Package for holding tablets |
US5620088A (en) * | 1993-11-02 | 1997-04-15 | Johnson & Johnson Vision Products, Inc. | Packaging arrangement for contact lenses |
JP3892056B2 (en) * | 1994-06-10 | 2007-03-14 | ジョンソン・アンド・ジョンソン・ビジョン・ケア・インコーポレイテッド | Contact lens packaging container and synthesized packaging means |
US5775505A (en) * | 1996-02-27 | 1998-07-07 | Vasquez; William M. | Blister card package |
FR2760436B1 (en) | 1997-03-06 | 1999-04-16 | Oreal | MULTI-COMPARTMENT BAG |
DE69838393T2 (en) * | 1997-04-01 | 2008-01-17 | Cima Labs Inc., Eden Prairie | BLISTER PACKAGING FOR TABLETS |
US5899335A (en) * | 1997-07-07 | 1999-05-04 | Boyer; Mildred E. | Medication container and method of using |
DE19800682B4 (en) | 1998-01-10 | 2004-07-08 | Lts Lohmann Therapie-Systeme Ag | Process for producing a primary packaging for film or wafer-shaped administration forms |
US6036016A (en) * | 1998-04-20 | 2000-03-14 | Pinnacle Intellectual Property Services, Inc. | Blister package with easy tear blister |
FR2778893B1 (en) * | 1998-05-19 | 2000-08-04 | Danisco Flexible France | MULTI-COMPARTMENT PACKAGING |
US6375956B1 (en) * | 1999-07-22 | 2002-04-23 | Drugtech Corporation | Strip pack |
DE10008165A1 (en) | 2000-02-23 | 2001-08-30 | Lohmann Therapie Syst Lts | Packaging of sheet-like objects with improved tear properties |
-
2001
- 2001-01-23 DE DE10102818A patent/DE10102818A1/en not_active Ceased
-
2002
- 2002-01-14 EP EP02702263A patent/EP1353857B1/en not_active Expired - Lifetime
- 2002-01-14 PT PT02702263T patent/PT1353857E/en unknown
- 2002-01-14 US US10/466,905 patent/US7293653B2/en not_active Expired - Lifetime
- 2002-01-14 AT AT02702263T patent/ATE273869T1/en active
- 2002-01-14 KR KR1020037009742A patent/KR100808612B1/en active IP Right Grant
- 2002-01-14 DE DE50200857T patent/DE50200857D1/en not_active Expired - Lifetime
- 2002-01-14 JP JP2002559320A patent/JP2004517011A/en active Pending
- 2002-01-14 WO PCT/EP2002/000287 patent/WO2002059012A1/en active IP Right Grant
- 2002-01-14 ES ES02702263T patent/ES2227425T3/en not_active Expired - Lifetime
- 2002-01-14 DK DK02702263T patent/DK1353857T3/en active
Non-Patent Citations (1)
Title |
---|
See references of WO02059012A1 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2248519A2 (en) | 2006-10-02 | 2010-11-10 | Labtec GmbH | Non-mucoadhesive film dosage forms |
EP2444072A2 (en) | 2006-10-02 | 2012-04-25 | Labtec GmbH | Non-mucoadhesive film dosage forms |
DE202007019476U1 (en) | 2006-10-02 | 2013-01-25 | Labtec Gmbh | Non-mucoadhesive film dosage forms |
US8580830B2 (en) | 2006-10-02 | 2013-11-12 | Labtec Gmbh | Non-mucoadhesive film dosage forms |
US9682037B2 (en) | 2006-10-02 | 2017-06-20 | Apr Applied Pharma Research Sa | Non-mucoadhesive film dosage forms |
Also Published As
Publication number | Publication date |
---|---|
DK1353857T3 (en) | 2004-12-27 |
ES2227425T3 (en) | 2005-04-01 |
KR20030093201A (en) | 2003-12-06 |
EP1353857B1 (en) | 2004-08-18 |
JP2004517011A (en) | 2004-06-10 |
KR100808612B1 (en) | 2008-02-28 |
US7293653B2 (en) | 2007-11-13 |
DE10102818A1 (en) | 2002-08-08 |
US20040050749A1 (en) | 2004-03-18 |
WO2002059012A1 (en) | 2002-08-01 |
PT1353857E (en) | 2004-12-31 |
DE50200857D1 (en) | 2004-09-23 |
ATE273869T1 (en) | 2004-09-15 |
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