Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/11—Encapsulated compositions
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/31—Hydrocarbons
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
  • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/67—Vitamins
  • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
  • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
  • A61L15/42—Use of materials characterised by their function or physical properties
  • A61L15/44—Medicaments
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
  • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
  • A61L27/60—Materials for use in artificial skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
  • A61K2800/41—Particular ingredients further characterized by their size
  • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
  • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
  • A61L2300/21—Acids
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
  • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
  • A61L2300/412—Tissue-regenerating or healing or proliferative agents
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
  • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
  • A61L2300/428—Vitamins, e.g. tocopherol, riboflavin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
  • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
  • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures

Definitions

• the invention relates to the cosmetic use of a composition
• a composition comprising, in a physiologically acceptable medium, from 0.001% to 1% by weight of aceamic acid and / or one of its salts, and from 0.00001% to 0.1% by weight of at least one compound chosen from retinoids and carotenoids to prevent or combat chapped skin, tightness and / or redness.
• composition relates to the dermatological uses of this composition, in particular for promote re-epithelialization of the skin or mucous membranes.
• the skin disorders resulting from these environmental aggressions are due to a alteration, even rupture, in the continuity of the dermal cover by the cells epidermis normally forming a continuous and multi-layered protective "mat".
• a composition would also be of interest to people with traumatic alterations such as large wounds and burns.
• a factor limiting the vital prognosis is that a minimum area of skin should retain, at best, the characteristics of a skin so-called normal in terms of the number of epidermal cell layers and the integrity of the barrier function.
• hand creams usually contain compounds for protecting the skin by forming a protective film thereon (petroleum jelly, collagen, waxes, vegetable oils, silicone oils), by moistening it (allantoin, urea, glycerol, sorbitol, ammonium lactate), soothing or promoting healing (aloe, bisabolol, vitamins A, E, F and B5, allantoin), by filtering out UVA radiation and / or UVB, and / or by nourishing it (essential fatty acids, shea butter).
• retinoids including retinol
• retinoids are able to accelerate re-epithelialization damaged skin by activating epidermal proliferation (M. Verschoore and al., Topical Retinoids - Their Uses in Dermatology, Dermatologic Clinics, Vol. 11, No. 1, January 1993).
• the Applicant has demonstrated that the epidermis thus obtained is not not thick enough and well differentiated.
• the present invention therefore relates to the cosmetic use of a composition
• a composition comprising, in a physiologically acceptable medium, from 0.001% to 1% by weight of acid aceamic and / or one of its salts, and from 0.00001% to 0.1% by weight of at least one compound chosen from retinoids and carotenoids to prevent or combat chapped skin, tightness and / or redness.
• composition is thus advantageously applied to the hands, in particular the hands withered and / or damaged. Alternatively, it can be applied to the lips.
• composition according to the invention protects the skin or the mucous membranes against attack by the environment. It provides a lasting result without offering a greasy touch or tights.
• the retinoids which can be used in the composition according to the invention can be chosen from: retinol, retinal, 13-cis retinoic acid, all-trans retinoic acid and retinyl esters such as retinyl acetate, retinyl propionate and retinyl palmitate. Palmitate Retinyl is preferred for use in the present invention.
• carotenoids there may be mentioned those with or without vitamin A activity, of which some are precursors of retinoids, and in particular ⁇ -carotene, ⁇ -carotene, lycopene, zeaxanthin, lutein, ataxanthin, canthaxanthin and cryptoxanthin.
• the carotenoid used according to the invention can be of natural or synthetic origin.
• origin natural means the carotenoid, in its pure state or in solution whatever its concentration in said solution, obtained from a natural element.
• origin synthetic means the carotenoid, in its pure state or in solution whatever its concentration in said solution, obtained by chemical synthesis.
• the carotenoid When the carotenoid is of natural origin, it can be obtained from plant material from a whole plant grown in vivo or from in vitro culture.
• in vivo culture means any culture of the conventional type, that is to say in soil in the open air or in a greenhouse, or even above ground.
• in vitro culture means all of the techniques known to those skilled in the art which artificially make it possible to obtain a plant or part of a plant. The selection pressure imposed by the physico-chemical conditions during the growth of plant cells in vitro makes it possible to obtain standardized plant material which is available throughout the year unlike plants cultivated in vivo .
• a plant derived from culture in vivo is used .
• the preferred carotenoids according to the invention are ⁇ -carotene and lycopene.
• Lycopene is a natural pigment found in ripe fruit, especially in the tomato. Its structure is close to that of ⁇ -carotene. It can be in cis or trans form.
• an extract of tomato rich in lycopene is used, prepared by the company Métaphar, marketed under the name LycOMato® consisting of oleoresin extract (fatty phase) containing 6% pure lycopene.
• acexamic acid salts mention may be made of organic and inorganic salts preferably having an activating effect on urokinase (which is an intervening enzyme, especially in elderly or stressed people, in the regeneration of the epidermis but also in the phenomena of re-epithelialization and scarring) and in particular the salts of alkaline earth metals and the transition metal salts of acexamic acid, such as zinc, calcium and / or magnesium salts of acexamic acid.
• urokinase which is an intervening enzyme, especially in elderly or stressed people, in the regeneration of the epidermis but also in the phenomena of re-epithelialization and scarring
• the salts of alkaline earth metals and the transition metal salts of acexamic acid such as zinc, calcium and / or magnesium salts of acexamic acid.
• Free acexamic acid is preferably used, advantageously in powder form, marketed by SANOFI CHIMIE under the trade name Acide Acexamic N.
• the composition according to the invention generally contains an effective amount of retinoid or carotenoid and acexamic acid to obtain the desired effect, that is to say from 0.001% to 1% by weight, better still, from 0.01% to 0.1% by weight, of acexamic acid and / or its salt, and 0.00001% to 0.1% by weight, better still, from 0.001% to 0.01% by weight, retinoid or carotenoid, relative to the total weight of the composition.
• composition according to the invention is advantageously suitable for topical application to the skin or mucous membranes.
• skin is meant both the skin of the face and that of the body, especially the hands.
• mucous membranes is meant in particular the lips.
• physiologically acceptable medium means a medium compatible with the skin and / or the mucous membranes.
• acexamic acid and retinoid or carotenoid also finds an interest in the field dermatology.
• the invention therefore also relates to the use of at least a first chosen compound among acexamic acid and its salts, and at least one second compound chosen from retinoids and carotenoids, to make a first and a second respectively dermatological preparations intended to be administered successively to promote the re-epithelialization of the skin or mucous membranes.
• These first and second preparations can be more particularly intended for promote healing of wounds or burns.
• the first preparation can be applied topically on the skin or mucous membranes and the second preparation administered orally or by parenteral route.
• the first preparation and the second preparation can be applied topically to the skin or mucous membranes.
• the first and second preparations can be administered by the oral.
• the successive administration of the two compounds according to the invention can, according to another form of execution, be used in the manufacture of reconstructed or artificial skin.
• the invention therefore also extends its scope to a method for manufacturing a skin. reconstructed or artificial, comprising the successive stages (a) of application to a dermal equivalent of a first composition comprising at least a first compound chosen from acexamic acid and its salts, (b) of application to said dermal equivalent a second composition comprising at least one second compound chosen from retinoids and carotenoids.
• tissue equivalent any support of biological origin (that is to say of origin cell, preferably comprising fibroblasts and / or endothelial cells) and / or biochemical (i.e. of protein origin, preferably comprising collagen and / or fibronectin, and / or based on mucopolysaccharides, preferably comprising hyaluronic acid), the support can also comprise a synthetic portion.
• biological origin that is to say of origin cell, preferably comprising fibroblasts and / or endothelial cells
• biochemical i.e. of protein origin, preferably comprising collagen and / or fibronectin, and / or based on mucopolysaccharides, preferably comprising hyaluronic acid
• compositions and the preparations according to the invention can be presented in all dosage forms normally used in the cosmetic and dermatological fields, and they can in particular be in the form of an oily solution which may be gelled, of an emulsion obtained by dispersion of a fatty phase in an aqueous phase (O / W) or vice versa (W / O), of a triple emulsion (W / O / W or O / W / O), of a vesicular dispersion of ionic (liposomes or oleosomes) and / or nonionic (niosomes) type and / or a dispersion nanocapsules or nanospheres.
• composition according to the invention is preferably in the form of a water-in-oil emulsion (E / H).
• the retinoid or carotenoid used in the composition according to the invention is of preferably encapsulated, advantageously in nanocapsules, so as to delay its release and thus obtain a sequential effect of acexamic acid then of the retinoid and / or of the carotenoid after application of the composition to the skin.
• the Applicant has indeed highlighted, as emerges from Example 1 below, that the sequential application of these compounds allowed optimal re-epithelialization of the skin.
• compositions and the preparations according to the invention can be more or less fluid and have the appearance of a white or colored cream, an ointment, a milk, a lotion, a serum, paste, foam. It can optionally be applied to the skin in aerosol or patch form. They can also be presented in solid form, in especially in the form of a lip stick or lipstick. They can be used as a care product and / or as a make-up product for the skin or the lips and / or as a shaving product.
• composition and the preparations according to the invention can contain also the usual adjuvants in the cosmetic and dermatological fields, such as hydrophilic or lipophilic gelling agents, hydrophilic or lipophilic active agents, preservatives, antioxidants, solvents, perfumes, fillers, filters, pigments, odor absorbers and coloring matters.
• the quantities of these various adjuvants are those conventionally used in the field under consideration, and for example from 0.01 to 20% of the total weight of the composition.
• These adjuvants depending on their nature, can be introduced into the fatty phase or in the aqueous phase. In any event, these adjuvants, as well as their proportions, will be chosen so as not to harm the desired properties of the combination of active ingredients according to the invention.
• the proportion of the fatty phase can range from 5 to 80% by weight, and preferably from 5 to 50% by weight relative to the total weight of composition.
• the oils, emulsifiers and coemulsifiers used in the composition in the form of an emulsion are chosen from those conventionally used in the domain considered.
• the emulsifier and co-emulsifier are generally present, in the composition, in a proportion ranging from 0.3 to 30% by weight, and preferably from 0.5 to 20 % by weight relative to the total weight of the composition.
• O / W emulsifiers such as fatty acid and polyethylene glycol esters, in particular PEG-100 stearate, and fatty acid and glycerin esters such as glyceryl stearate
• W / O emulsifiers such as oxyethylenated poly (methylketyl) (dimethyl) methylsiloxane available under the name commercial ABIL WE09 with Degussa Goldschmidt or the mixture of ethylene glycol acetyl stearate and glyceryl tristearate sold by the company Guardian under the trade name UNITWIX.
• hydrophilic gelling agents mention may in particular be made of carboxyvinyl polymers (carbomer), acrylic copolymers such as acrylate / alkylacrylate copolymers, polyacrylamides, polysaccharides, natural gums and clays, and, as lipophilic gelling agents, mention may be made of modified clays such as bentones, salts metallic fatty acids, hydrophobic silica and polyethylenes.
• fillers which can be used in the composition of the invention, mention may be made of for example, in addition to pigments, silica powder; talc; starch crosslinked with anhydride octenylsuccinique marketed by the company National Starch under the name DRY FLO PLUS (28-1160); polyamide particles and in particular those sold under the name ORGASOL by the company Atochem; polyethylene powders; microspheres based on acrylic copolymers, such as those in dimethacrylate copolymer ethylene glycol / lauryl methacrylate sold by the company Dow Corning under the name of POLYTRAP; expanded powders such as hollow microspheres and in particular, the microspheres marketed under the name EXPANCEL by the Kemanord Plast or under the name MICROPEARL F 80 ED by the company Matsumoto; silicone resin microbeads such as those sold under the name TOSPEARL by the company Toshiba Silicone; and their mixtures. These charges may be present in amounts ranging from 0 to
• active agents which can be used in the composition or the preparations according to the invention: collagen, allantoin, urea, glycerol, sorbitol, ammonium lactate, aloe extracts, bisabolol, and vitamins E, F and B5.
• active agents which can be used in the composition or the preparations according to the invention: collagen, allantoin, urea, glycerol, sorbitol, ammonium lactate, aloe extracts, bisabolol, and vitamins E, F and B5.
• spherules in particular ionic or nonionic vesicles and / or nanoparticles (nanocapsules and / or nanospheres).
• UVA and / or UVB filters chosen from organic filters and mineral filters possibly coated to make them hydrophobic.
• the acexamic acid can be compatibilized in the fatty phase of the compositions or preparations according to the invention, in particular when it is an anhydrous phase, by means of at least one liquid polyol with ambient temperature, having a BIO index of between 1 and 7.
• the Applicant has discovered effect that these polyols constituted very good solvents of acexamic acid.
• the IOB parameter is known to those skilled in the art from a number of publications such as the article by A. FUJITA Pharm. Bull 2 , 163-173 (1954) and documents J0 9/151109, J08 / 217639 or J09 / 175925.
• alkylene glycols such as propylene glycol, butylene glycol, pentylene glycol and hexylene glycol
• PEG polyethylene glycols
• glycerol glycerol
• first and / or the second preparation are administered orally, they can be in any dosage form suitable for this mode of administration, for example in the form of breakable tablets or not, granules, capsules, capsules, solutes, suspensions or solutions comprising a suitable excipient.
• excipients suitable for this mode of administration include a mixture of dextrose and cellulose possibly reinforced with magnesium stearate as bonding agent and lubricant.
• the first preparation when administered orally, contains an amount sufficient acexamic acid or its salt to achieve the desired effect, for example a quantity allowing administration, in one or more doses, of 300 to 600 mg per day acexamic acid.
• the second preparation when administered orally, contains an amount sufficient retinoid or carotenoid to achieve the desired effect, so for example provide a dose of carotene corresponding to 400 ⁇ g of vitamin A, i.e. approximately 3 mg of carotene, or to provide a dose of other carotenoids such as lycopene, zeaxanthin, cryptoxanthin or lutein, corresponding to 1.6 mg per day.
• an amount sufficient retinoid or carotenoid to achieve the desired effect, so for example provide a dose of carotene corresponding to 400 ⁇ g of vitamin A, i.e. approximately 3 mg of carotene, or to provide a dose of other carotenoids such as lycopene, zeaxanthin, cryptoxanthin or lutein, corresponding to 1.6 mg per day.
• Example 1 re-epithelialization test and epithelial proliferation
• the dermal equivalent was formed by polymerization in an oven at 37 ° C, under an atmosphere of 5% carbon dioxide.
• Composition A consisted of 4% by weight of acexamic acid in water.
• Composition B consisted of a dispersion of 30% by weight of nanocapsules, containing 2.5% by weight of retinyl palmitate, in 70% by weight of water.
• the medium was changed every two days for 20 days.
• the reconstructed skins were taken on the twentieth day to be tested as described below.
• the number of cell layers in the neoformed epithelium has been measured.
• condition 4 We thus highlighted a better histological quality of condition 4, compared other conditions. This results in the formation of a very thick newly formed epithelium (from 1 to 5 cell layers) associated with good differentiation and the presence of layer of basal cells of cubic appearance, generally contiguous.
• condition 1 which were not treated with composition B, most often contiguous, but spindle-shaped cells, while the condition 2 has a lower number of layers than condition 4.
• a count of the number of labeled cells in the epithelium was carried out. A percentage of cells in mitosis was thus calculated.
• condition 4 allows a very high proliferation rate to be obtained satisfactory.
• condition 4 which corresponds to a pre-treated skin sample (before epidermis) with acexamic acid and treated (after formation of the reconstituted skin) by retinyl palmitate, gives the best results, whether in terms of modulation of proliferation (quantitative assessment) or modulation of epithelialization (assessment qualitative).
• Example 2 re-epithelialization and epithelial proliferation test
• Example 2 A test similar to that described in Example 1 was carried out, except that the skins reconstituted were treated after epidermisation only, by introduction into the medium of culture, on the seventh day, of a composition made up, in percentage by weight: of 4% acexamic acid; 30% of nanocapsules containing 3.5% by weight of palmitate retinyl; 0.075% preservative and 0.075% antioxidant in water.
• Histological analysis shows that on the twenty-fifth day, the five series of samples all have a neo-epithelium formed of a basal layer and one to four layers of mucous body. By comparison, the neo-formed epithelium of the same skins reconstituted untreated has only one basal layer and appears with five to ten days late compared to the series treated.
• Immunohistochemical analysis reveals significant cell division, corresponding to the cell proliferation, while the cell proliferation phase of the skins reconstructed untreated appears, again, with delay.
• This cream can be applied to the hands as often as necessary to soothe the redness and tightness and close the cracks.
• composition is prepared, in a conventional manner, for a person skilled in the art: octyldodecanol 4% Magnesium sulfate 0.7% Mineral oil 18% conservatives 0.75% Glycerin 7% Cetyl dimethicone copolyol 2% Retinyl palmitate nanocapsules (2.5% active ingredient) 0.3% lycopene 0.0013% Acexamic acid 0.04% Water qs. 100%
• Example 5 preparations for sequential administration
• compositions A and B are prepared, in a conventional manner, for a person skilled in the art.
• Composition A skin cream octyldodecanol 4% Magnesium sulfate 0.7% Mineral oil 18% conservatives 0.75% Glycerin 7% Cetyl dimethicone copolyol 2% Retinyl palmitate nanocapsules (2.5% active ingredient) 0.3% Acexamic acid 0.04% Water qs. 100%
• Composition B capsules Beta carotene 5 mg lycopene 2.6 mg maltodextrin 300 mg
• composition for the skin is intended to be applied in the morning to the exposed parts of the body, while the capsules will be ingested at the end of the day. This protocol will be repeated for several days or even weeks.
• compositions A and B are prepared, in a conventional manner, for a person skilled in the art.
• Composition A skin cream octyldodecanol 4% Magnesium sulfate 0.7% Mineral oil 18% conservatives 0.75% Glycerin 7% Cetyl dimethicone copolyol 2% Retinyl palmitate nanocapsules (2.5% active ingredient) 0.3% Acexamic acid 0.04% Water qs. 100%
• Composition B nutritional supplement - soft capsules Beta carotene 5 mg lycopene 2.6 mg Hydrogenated soybean oil 40 mg Wheat oil 95 mg Soy lecithin 20 mg Natural tocopherols 5 mg Ascorbic acid 30 mg
• the above skin composition is intended to be applied to the exposed parts of the body substantially simultaneously with the ingestion of the nutritional supplement, including use may be extended for a few days.
• the absorption kinetics of nutrients being slower than the percutaneous absorption of acexamic acid, we will obtain thus a sequential effect of acexamic acid and carotenoids which makes it possible to offer a maximum benefit to the skin.

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• 2001
  • 2001-11-30 FR FR0115518A patent/FR2832926B1/fr not_active Expired - Fee Related
• 2002
  • 2002-10-29 EP EP02292680A patent/EP1316301A1/de not_active Withdrawn
  • 2002-11-29 JP JP2002348941A patent/JP2003183159A/ja not_active Withdrawn

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