EP1315459A1 - Methode d'echantillonnage d'acide nucleique transdermique - Google Patents
Methode d'echantillonnage d'acide nucleique transdermiqueInfo
- Publication number
- EP1315459A1 EP1315459A1 EP01962273A EP01962273A EP1315459A1 EP 1315459 A1 EP1315459 A1 EP 1315459A1 EP 01962273 A EP01962273 A EP 01962273A EP 01962273 A EP01962273 A EP 01962273A EP 1315459 A1 EP1315459 A1 EP 1315459A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- skin
- nucleic acid
- microprojections
- microprojection
- piercing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B2010/008—Interstitial fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
L'invention concerne une méthode d'échantillonnage d'acide nucléique transdermique peu invasive, qui consiste à percer la couche supérieure de la peau (20) pour atteindre l'épiderme sous-jacent, à l'aide de plusieurs microprojections (4). Des cellules cutanées vivantes de l'épiderme sous-jacent sont désorganisées, ce qui les amène à libérer leurs contenus, notamment leurs acides nucléiques (c.-à-d. l'ADN, l'ARN, leurs fragments ou autres matières d'acide polynucléique trouvés dans les noyaux et/ou les mitochondries de cellules). L'acide nucléique est recueilli sur les surfaces des microprojections et/ou dans un réservoir de collecte d'acide nucléique séparé. L'acide nucléique recueilli est ensuite analysé par des techniques de réaction en chaîne de la polymérase (PCR). Facultativement, un dispositif d'aspiration (10) opère une dépression partielle à travers des ouvertures (8) ménagés dans l'élément à microprojections (6), jusqu'aux microcoupures pratiquées dans la peau (20), afin d'améliorer l'écoulement de liquides (c.-à-d. organiques) intracellulaires et extracellulaires contenant l'acide nucléique.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22767500P | 2000-08-24 | 2000-08-24 | |
US227675P | 2000-08-24 | ||
PCT/US2001/026102 WO2002015800A1 (fr) | 2000-08-24 | 2001-08-20 | Methode d'echantillonnage d'acide nucleique transdermique |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1315459A1 true EP1315459A1 (fr) | 2003-06-04 |
Family
ID=22854028
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01962273A Withdrawn EP1315459A1 (fr) | 2000-08-24 | 2001-08-20 | Methode d'echantillonnage d'acide nucleique transdermique |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1315459A1 (fr) |
JP (1) | JP2004506914A (fr) |
KR (1) | KR20030068127A (fr) |
CN (1) | CN1471378A (fr) |
AU (2) | AU2001283469B2 (fr) |
CA (1) | CA2420343A1 (fr) |
MX (1) | MXPA03001694A (fr) |
WO (1) | WO2002015800A1 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050025778A1 (en) * | 2003-07-02 | 2005-02-03 | Cormier Michel J.N. | Microprojection array immunization patch and method |
CN100367906C (zh) * | 2004-12-08 | 2008-02-13 | 圣美迪诺医疗科技(湖州)有限公司 | 皮下植入式生物传感器 |
US8389215B2 (en) | 2007-07-26 | 2013-03-05 | University Of Utah Research Foundation | Non-invasive recovery of RNA and analysis of gene expression in skin |
KR101032978B1 (ko) * | 2009-04-29 | 2011-05-09 | 한국과학기술원 | 모션센서를 이용한 운동 피드백 기능과 운동기록이 가능한 아령세트 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5250067A (en) * | 1992-11-30 | 1993-10-05 | Ala Gelfer | Body treatment pad having a multiple number of sharpened skin-penetration protuberances |
US6063082A (en) * | 1997-11-04 | 2000-05-16 | Scimed Life Systems, Inc. | Percutaneous myocardial revascularization basket delivery system and radiofrequency therapeutic device |
US6551338B1 (en) * | 1999-09-01 | 2003-04-22 | Mcgill University | Method and device for myogenesis and angiogenesis of the heart |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
EP0429842B1 (fr) | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Dispositif d'administration transcutanée de médicaments à base de protéine ou de peptide |
US5161532A (en) | 1990-04-19 | 1992-11-10 | Teknekron Sensor Development Corporation | Integral interstitial fluid sensor |
US5279544A (en) | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
JP2572823Y2 (ja) | 1992-02-13 | 1998-05-25 | 株式会社アドバンス | 簡易採血器 |
US5582184A (en) | 1993-10-13 | 1996-12-10 | Integ Incorporated | Interstitial fluid collection and constituent measurement |
US5682233A (en) | 1995-09-08 | 1997-10-28 | Integ, Inc. | Interstitial fluid sampler |
AU3399197A (en) | 1996-06-18 | 1998-01-07 | Alza Corporation | Device for enhancing transdermal agent delivery or sampling |
DE69720057T2 (de) * | 1996-12-20 | 2003-09-25 | Alza Corp | Vorrichtung und verfahren zur erhöhung des transdermalen wirkstoffeflusses |
JP3097600B2 (ja) * | 1997-05-30 | 2000-10-10 | 日本電気株式会社 | 角質層穿刺装置 |
US6091975A (en) | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
WO2000035530A1 (fr) * | 1998-12-18 | 2000-06-22 | Minimed Inc. | Ensembles d'injection pourvus d'elements de micro-perforation, utilises avec des dispositifs medicaux, et leurs procedes d'utilisation |
WO2001041863A1 (fr) | 1999-12-10 | 2001-06-14 | Alza Corporation | Dispositif et procede d'amelioration de percage de peau par micro-protuberances |
-
2001
- 2001-08-20 AU AU2001283469A patent/AU2001283469B2/en not_active Ceased
- 2001-08-20 WO PCT/US2001/026102 patent/WO2002015800A1/fr active Application Filing
- 2001-08-20 AU AU8346901A patent/AU8346901A/xx active Pending
- 2001-08-20 EP EP01962273A patent/EP1315459A1/fr not_active Withdrawn
- 2001-08-20 CA CA002420343A patent/CA2420343A1/fr not_active Abandoned
- 2001-08-20 MX MXPA03001694A patent/MXPA03001694A/es unknown
- 2001-08-20 CN CNA018178731A patent/CN1471378A/zh active Pending
- 2001-08-20 JP JP2002520715A patent/JP2004506914A/ja active Pending
- 2001-08-20 KR KR10-2003-7002654A patent/KR20030068127A/ko not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5250067A (en) * | 1992-11-30 | 1993-10-05 | Ala Gelfer | Body treatment pad having a multiple number of sharpened skin-penetration protuberances |
US6063082A (en) * | 1997-11-04 | 2000-05-16 | Scimed Life Systems, Inc. | Percutaneous myocardial revascularization basket delivery system and radiofrequency therapeutic device |
US6551338B1 (en) * | 1999-09-01 | 2003-04-22 | Mcgill University | Method and device for myogenesis and angiogenesis of the heart |
Non-Patent Citations (1)
Title |
---|
See also references of WO0215800A1 * |
Also Published As
Publication number | Publication date |
---|---|
CN1471378A (zh) | 2004-01-28 |
KR20030068127A (ko) | 2003-08-19 |
WO2002015800A1 (fr) | 2002-02-28 |
AU8346901A (en) | 2002-03-04 |
JP2004506914A (ja) | 2004-03-04 |
MXPA03001694A (es) | 2004-11-01 |
AU2001283469B2 (en) | 2006-07-06 |
CA2420343A1 (fr) | 2002-02-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20030321 |
|
AK | Designated contracting states |
Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
17Q | First examination report despatched |
Effective date: 20050602 |
|
17Q | First examination report despatched |
Effective date: 20050602 |
|
17Q | First examination report despatched |
Effective date: 20050602 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20090303 |