CA2420343A1 - Methode d'echantillonnage d'acide nucleique transdermique - Google Patents

Methode d'echantillonnage d'acide nucleique transdermique Download PDF

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Publication number
CA2420343A1
CA2420343A1 CA002420343A CA2420343A CA2420343A1 CA 2420343 A1 CA2420343 A1 CA 2420343A1 CA 002420343 A CA002420343 A CA 002420343A CA 2420343 A CA2420343 A CA 2420343A CA 2420343 A1 CA2420343 A1 CA 2420343A1
Authority
CA
Canada
Prior art keywords
skin
nucleic acid
microprojections
microprojection
piercing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002420343A
Other languages
English (en)
Inventor
James A. Matriano
Michel J.N. Cormier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2420343A1 publication Critical patent/CA2420343A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/008—Interstitial fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

L'invention concerne une méthode d'échantillonnage d'acide nucléique transdermique peu invasive, qui consiste à percer la couche supérieure de la peau (20) pour atteindre l'épiderme sous-jacent, à l'aide de plusieurs microprojections (4). Des cellules cutanées vivantes de l'épiderme sous-jacent sont désorganisées, ce qui les amène à libérer leurs contenus, notamment leurs acides nucléiques (c.-à-d. l'ADN, l'ARN, leurs fragments ou autres matières d'acide polynucléique trouvés dans les noyaux et/ou les mitochondries de cellules). L'acide nucléique est recueilli sur les surfaces des microprojections et/ou dans un réservoir de collecte d'acide nucléique séparé. L'acide nucléique recueilli est ensuite analysé par des techniques de réaction en chaîne de la polymérase (PCR). Facultativement, un dispositif d'aspiration (10) opère une dépression partielle à travers des ouvertures (8) ménagés dans l'élément à microprojections (6), jusqu'aux microcoupures pratiquées dans la peau (20), afin d'améliorer l'écoulement de liquides (c.-à-d. organiques) intracellulaires et extracellulaires contenant l'acide nucléique.
CA002420343A 2000-08-24 2001-08-20 Methode d'echantillonnage d'acide nucleique transdermique Abandoned CA2420343A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22767500P 2000-08-24 2000-08-24
US60/227,675 2000-08-24
PCT/US2001/026102 WO2002015800A1 (fr) 2000-08-24 2001-08-20 Methode d'echantillonnage d'acide nucleique transdermique

Publications (1)

Publication Number Publication Date
CA2420343A1 true CA2420343A1 (fr) 2002-02-28

Family

ID=22854028

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002420343A Abandoned CA2420343A1 (fr) 2000-08-24 2001-08-20 Methode d'echantillonnage d'acide nucleique transdermique

Country Status (8)

Country Link
EP (1) EP1315459A1 (fr)
JP (1) JP2004506914A (fr)
KR (1) KR20030068127A (fr)
CN (1) CN1471378A (fr)
AU (2) AU8346901A (fr)
CA (1) CA2420343A1 (fr)
MX (1) MXPA03001694A (fr)
WO (1) WO2002015800A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0412202A (pt) * 2003-07-02 2006-08-22 Alza Corp emplastro para imunização tendo um arranjo de microprojeções, e método
CN100367906C (zh) * 2004-12-08 2008-02-13 圣美迪诺医疗科技(湖州)有限公司 皮下植入式生物传感器
US8389215B2 (en) 2007-07-26 2013-03-05 University Of Utah Research Foundation Non-invasive recovery of RNA and analysis of gene expression in skin
KR101032978B1 (ko) * 2009-04-29 2011-05-09 한국과학기술원 모션센서를 이용한 운동 피드백 기능과 운동기록이 가능한 아령세트

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
EP0429842B1 (fr) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Dispositif d'administration transcutanée de médicaments à base de protéine ou de peptide
US5161532A (en) 1990-04-19 1992-11-10 Teknekron Sensor Development Corporation Integral interstitial fluid sensor
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
JP2572823Y2 (ja) 1992-02-13 1998-05-25 株式会社アドバンス 簡易採血器
US5250067A (en) * 1992-11-30 1993-10-05 Ala Gelfer Body treatment pad having a multiple number of sharpened skin-penetration protuberances
US5582184A (en) 1993-10-13 1996-12-10 Integ Incorporated Interstitial fluid collection and constituent measurement
US5682233A (en) 1995-09-08 1997-10-28 Integ, Inc. Interstitial fluid sampler
CA2253549C (fr) 1996-06-18 2005-10-25 Alza Corporation Dispositif d'amelioration d'apport ou d'echantillonnage d'agents transdermiques
AU722574B2 (en) * 1996-12-20 2000-08-10 Alza Corporation Device and method for enhancing transdermal agent flux
JP3097600B2 (ja) * 1997-05-30 2000-10-10 日本電気株式会社 角質層穿刺装置
US6063082A (en) * 1997-11-04 2000-05-16 Scimed Life Systems, Inc. Percutaneous myocardial revascularization basket delivery system and radiofrequency therapeutic device
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
EP1140275A1 (fr) * 1998-12-18 2001-10-10 Minimed Inc. Ensembles d'injection pourvus d'elements de micro-perforation, utilises avec des dispositifs medicaux, et leurs procedes d'utilisation
US6551338B1 (en) * 1999-09-01 2003-04-22 Mcgill University Method and device for myogenesis and angiogenesis of the heart
ATE310561T1 (de) 1999-12-10 2005-12-15 Alza Corp Vorrichtung und verfahren zur verbesserung des mikronadel-haut-piercing

Also Published As

Publication number Publication date
JP2004506914A (ja) 2004-03-04
AU2001283469B2 (en) 2006-07-06
KR20030068127A (ko) 2003-08-19
AU8346901A (en) 2002-03-04
CN1471378A (zh) 2004-01-28
WO2002015800A1 (fr) 2002-02-28
EP1315459A1 (fr) 2003-06-04
MXPA03001694A (es) 2004-11-01

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Legal Events

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EEER Examination request
FZDE Dead