EP1294376A2 - Medicament pour lutter contre la depression respiratoire - Google Patents

Medicament pour lutter contre la depression respiratoire

Info

Publication number
EP1294376A2
EP1294376A2 EP01933937A EP01933937A EP1294376A2 EP 1294376 A2 EP1294376 A2 EP 1294376A2 EP 01933937 A EP01933937 A EP 01933937A EP 01933937 A EP01933937 A EP 01933937A EP 1294376 A2 EP1294376 A2 EP 1294376A2
Authority
EP
European Patent Office
Prior art keywords
use according
radical
general formula
compound
respiratory depression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01933937A
Other languages
German (de)
English (en)
Inventor
Thomas Christoph
Boris Chizh
Oswald Zimmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Publication of EP1294376A2 publication Critical patent/EP1294376A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Definitions

  • the present invention relates to the use of at least one compound of the general formula I and / or one of its diastereomers and / or one of its enantiomers and / or one of the corresponding physiologically tolerable salts for the preparation of a medicament for combating respiratory depression with the exception of medicaments for combating respiratory depression as the cause of sleep apnea.
  • the object on which the invention is based was therefore to provide medicaments which are suitable for combating respiratory depression, in particular for combating respiratory depression when administering compounds with opioid activity, in shock conditions, when administering psychotropic drugs or in the case of central respiratory regulation disorders.
  • the present invention therefore relates to the use of at least one compound of the general formula I,
  • radical R is one of the following groups a) to f)
  • radicals R ⁇ , R ⁇ , R3 ( identical or different, mean an H or a CH radical and / or at least one of their enantiomers and / or one of their diasteromers and / or at least one corresponding physiologically tolerable salt for the preparation of a medicament for combating respiratory depression, preferably for the manufacture of a medicament for combating respiratory depression when administering compounds with opioid activity and / or in shock states and / or when administering psychotropic drugs and / or in the case of central respiratory regulation disorders with the exception of medicaments for combating respiratory depression as the cause of sleep apnea.
  • the compounds of general formula I, their enantiomers, diastereomers and the corresponding physiologically tolerable salts can be used individually or in mixtures of at least two of these compounds to prepare a medicament for combating respiratory depression.
  • Enantiomers one of their diastereomers or one of the corresponding physiologically acceptable salts used for the preparation of the drug.
  • At least one compound of the general formula I is used in which the radical R is group f), R 1 is a CH 3 radical and R 2 is an H radical and / or at least one of their enantiomers and / or one of their diastereomers and / or at least one of their physiologically tolerable salts.
  • a compound of the general formula I in which the radical R represents group a), the radicals R ', R ⁇ and R ⁇ each mean H and / or at least one of their enantiomers and / or one of their diastereomers and / or at least one of their corresponding physiologically acceptable salts.
  • a compound of the general formula I is also preferably used, in which the radical R is group c), the radical R ⁇ is one
  • CH3 radical is and the radical R ⁇ is an H radical and / or at least one of their enantiomers and / or one of their diastereomers and / or at least one of their corresponding physiologically acceptable salts.
  • the compound of the general formula I is used in which the radical R is group f), R 1 is a CH 3 radical and R 2 is an H radical (montirelin) and / or at least one of their physiologically compatible salts.
  • the physiologically compatible salt of the compounds of the general formula I and / or their enantiomers and / or their diastereomers the hydrochloride, hydrobromide, sulfate, sulfonate,
  • the above-mentioned medicaments are preferably in the form of tablets, chewable tablets, chewing gums, dragées, capsules, drops, juices, syrups, suppositories, solutions, emulsions, suspensions, powders or sprays.
  • the medicaments are particularly preferably in the form of tablets, capsules, drops or solutions.
  • the above-mentioned medicaments for combating respiratory depression are likewise preferably in multiparticulate form, preferably as microtablets, microcapsules, spheroids, ion exchange resinates, granules, active substance crystals or pellets, particularly preferably as
  • Pellets in the sense of the present invention also include pellets or build-up pellets produced by extrusion and spheronization.
  • the medicaments are preferably suitable for oral, intravenous, intramuscular, subcutaneous, intrathecal, epidural, buccal, sublingual, pulmonary, rectal, transdermal, nasal or intracerebroventricular administration, with medicaments for oral or intravenous administration being particularly preferred.
  • Preparations in the form of tablets, chewable tablets, chewing gums, dragées, capsules, granules, drops, juices and syrups are preferably suitable for oral administration.
  • a transmucal therapeutic system is preferably suitable for buccal application.
  • Solutions, suspensions, emulsions, easily reconstitutable dry preparations, microspheroids, sprays, suppositories or plasters are preferably suitable for parenteral, topical and inhalative application. Suppositories or solutions are particularly preferably used for parenteral administration, transdermal therapeutic systems for topical administration and powders or solutions for inhalation for inhalation administration.
  • Colorants, flavors, binders or mixtures of at least two of these materials can be used.
  • the selection of these auxiliaries and their amounts depend on the manner in which the medicament is to be applied. The person skilled in the art is aware of the auxiliaries suitable for the particular form of application and their amounts.
  • the pharmaceuticals can be produced by the customary methods known to the person skilled in the art.
  • the abovementioned medicaments for combating respiratory depression can also contain at least one compound of the general formula I, one of its enantiomers, one of its diastereomers and / or one of the corresponding physiologically tolerable salts in retarded form.
  • the respective active substance is preferably retarded by a retarding coating, by fixation to an ion exchange resin, by embedding in a retarding matrix or by a combination of these retardations.
  • Suitable retarding coatings include water-insoluble waxes or polymers such as acrylic resins, preferably poly (meth) acrylates, or water-insoluble celluloses, preferably ethyl cellulose. These materials are known from the prior art, for example Bauer, Lehmann, Osterwald, Rothgang “Coated Pharmaceutical Forms", Erasmusliche Verlagsgesellschaft mbH Stuttgart, 1988, page 69 ff. They are hereby introduced as a reference and are therefore considered part of the disclosure.
  • the retarding coatings can optionally also be used in order to adjust the release rate of the respective active ingredient, preferably water-soluble polymers in amounts of up to 30% by weight, such as polyvinylpyrrolidone or water-soluble celluloses, preferably
  • the respective pharmaceutical formulation can, if necessary, have more
  • Coatings that dissolve depending on the pH can also be present as coatings. It can thus be achieved that the pharmaceutical formulation passes through the gastrointestinal tract undissolved and the respective active ingredient is only released in the intestinal tract. Coatings can also be used to improve the taste.
  • Cation exchange resins preferably polystyrene sulfonates, are used to retard these active ingredients.
  • the respective active ingredient can also be present in a retarding matrix, preferably evenly distributed.
  • Physiologically compatible, hydrophilic materials which are known to the person skilled in the art can be used as matrix materials.
  • Polymers particularly preferably cellulose ethers, cellulose esters and / or acrylic resins, are preferably used as the hydrophilic matrix materials.
  • Particularly preferred matrix materials are ethyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose,
  • Hydroxymethyl cellulose poly (meth) acrylic acid and / or their derivatives, such as their salts, amides or esters.
  • Matrix materials made from hydrophobic materials such as hydrophobic polymers, waxes, fats, long-chain fatty acids, fatty alcohols or corresponding esters or ethers or mixtures thereof, are also preferred.
  • Mono- or diglycerides of C 2 -C 3 o-fatty acids and / or Ci 2 -C 3 o-fatty alcohols and / or waxes or mixtures thereof are particularly preferably used as hydrophobic materials.
  • the above-mentioned medicament contains at least one compound of the general formula I and / or one of its enantiomers and / or one of its diastereomers and / or one of the corresponding physiologically tolerable salts in addition to the retarded form and also in the unretarded form , Combined with the immediately released active ingredient, a high initial dose can be achieved to combat respiratory depression immediately. The slow release from the retarded form then prevents respiratory depression from occurring again.
  • the amount of active ingredient to be administered to the patient varies e.g. depending on the weight of the patient, the type of application, the indication and the severity of respiratory depression.
  • the amount to be administered and the
  • the patient is preferably 0.1 to 100 mg, particularly preferably 0.5 to 50 mg of a compound of general formula I and / or one of its diastereomers and / or one of its enantiomers and / or one of the corresponding physiological tolerated salts administered.
  • the patient When administered twice a day, the patient is preferably given 0.05 to 50 mg, particularly preferably 0.25 to 25 mg, of a compound of the general formula I and / or one of its diastereomers and / or one of its enantiomers and / or one of the corresponding administered physiologically acceptable salts.
  • the compounds of general formula I, their enantiomers, their diastereomers and the corresponding physiologically tolerable salts surprisingly show a very good action in combating respiratory depression, in particular in combating respiratory depression when administering compounds with opioid activity and / or in shock conditions and / or with the administration of psychotropic drugs and / or with central respiratory regulation disorders.
  • Balloon catheter was equipped with a pressure transducer and a
  • a third group of 8 rats was given a 0.9% saline solution containing only 10 mg morphine per kg body weight of the rat intravenously.
  • a fourth group of 8 rats was given a 0.9% saline solution in a volume of 1 ml per kg body weight of the rat intravenously.
  • FIGS. 1 and 2 The results of these investigations are shown in FIGS. 1 and 2.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne l'utilisation d'au moins un composé de formule générale (I), d'un de ses diastéréoisomères, d'un de ses énantiomères ou d'un des sels correspondants physiologiquement acceptables pour la production d'un médicament servant à lutter contre la dépression respiratoire, à l'exception de médicaments servant à lutter contre la dépression respiratoire à l'origine de l'apnée du sommeil.
EP01933937A 2000-05-26 2001-05-05 Medicament pour lutter contre la depression respiratoire Withdrawn EP1294376A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10025949A DE10025949A1 (de) 2000-05-26 2000-05-26 Arzneimittel zur Bekämpfung von Atemdepression
DE10025949 2000-05-26
PCT/EP2001/005110 WO2001091732A2 (fr) 2000-05-26 2001-05-05 Medicament pour lutter contre la depression respiratoire

Publications (1)

Publication Number Publication Date
EP1294376A2 true EP1294376A2 (fr) 2003-03-26

Family

ID=7643553

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01933937A Withdrawn EP1294376A2 (fr) 2000-05-26 2001-05-05 Medicament pour lutter contre la depression respiratoire

Country Status (12)

Country Link
US (1) US20030130203A1 (fr)
EP (1) EP1294376A2 (fr)
JP (1) JP2003534372A (fr)
AR (1) AR031584A1 (fr)
AU (2) AU2001260281B2 (fr)
CA (1) CA2410650A1 (fr)
DE (1) DE10025949A1 (fr)
HU (1) HUP0301873A2 (fr)
MX (1) MXPA02011535A (fr)
NZ (1) NZ521440A (fr)
PE (1) PE20011327A1 (fr)
WO (1) WO2001091732A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
US7591999B2 (en) 2003-03-04 2009-09-22 Mitsubishi Tanabe Pharma Corporation Powdery preparation for nasal administration
JP2008538547A (ja) * 2005-03-09 2008-10-30 ロジャー・ウィリアムズ・ホスピタル 甲状腺刺激ホルモン放出ホルモン類縁体及び使用方法
US8343546B2 (en) * 2005-09-13 2013-01-01 Coating Place, Inc. Ion exchange resin treated to control swelling

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2449167C2 (de) * 1974-10-16 1984-05-24 Grünenthal GmbH, 5190 Stolberg N-Acyl-L-histidyl-L-prolinamide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
NL183764C (nl) * 1974-10-16 1989-01-16 Gruenenthal Gmbh Werkwijze voor de bereiding van een geneesmiddel met psychotrope of neurotrope werking en werkwijze voor de bereiding van een histidylprolineamide-derivaat.
EP0429245B1 (fr) * 1989-11-17 1996-02-07 Takeda Chemical Industries, Ltd. Agent thérapeutique pour les maladies du système central nerveux
DE69636393T2 (de) * 1995-10-24 2006-12-07 Grünenthal GmbH Montirelin zur verhinderung der schlafapnoe
AU7388898A (en) * 1997-05-16 1998-12-08 Trustees Of The University Of Pennsylvania, The Use of serotonin agonists to alleviate disordered breathing episodes in a mammal

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0191732A2 *

Also Published As

Publication number Publication date
US20030130203A1 (en) 2003-07-10
JP2003534372A (ja) 2003-11-18
NZ521440A (en) 2004-09-24
AU6028101A (en) 2001-12-11
AU2001260281B2 (en) 2005-01-27
CA2410650A1 (fr) 2001-12-06
MXPA02011535A (es) 2003-06-06
WO2001091732A2 (fr) 2001-12-06
WO2001091732A3 (fr) 2002-04-18
DE10025949A1 (de) 2001-11-29
AR031584A1 (es) 2003-09-24
PE20011327A1 (es) 2002-01-26
HUP0301873A2 (hu) 2003-09-29

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