Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
  • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
  • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
  • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
  • A61K8/9755—Gymnosperms [Coniferophyta]
  • A61K8/9761—Cupressaceae [Cypress family], e.g. juniper or cypress
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
  • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
  • A61K8/9783—Angiosperms [Magnoliophyta]
  • A61K8/9789—Magnoliopsida [dicotyledons]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
  • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
  • A61K8/9783—Angiosperms [Magnoliophyta]
  • A61K8/9794—Liliopsida [monocotyledons]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings

Definitions

• Anti-pollution compositions based on anthocyanins.
• the present invention relates to anti-pollution compositions based on anthocyanins, the use in topical application of anthocyanins or extracts containing anthocyanins as anti-pollution cosmetic agents as well as a cosmetic treatment process using said compositions.
• the skin is directly and frequently exposed to the pro-oxidant environment.
• Sources of environmental oxidants include oxygen, UV solar irradiation as well as in polluted air, ozone and oxides of nitrogen and sulfur.
• Air pollutants represented by the primary and secondary products of domestic and industrial combustion such as mono- and polycyclic aromatic hydrocarbons are also an important source of oxidative stress.
• the skin is particularly sensitive to the action of oxidative stress and the outermost layer acts as a barrier against oxidative damage. In most circumstances, the oxidant is likely to be neutralized after reaction with eratin materials, but the reaction products formed can be responsible for cell and tissue damage.
• the stratum corneum is the contact site between air and skin tissue.
• the biphasic lipid / protein structure is a crucial determinant of this barrier function of the skin. These elements can react with oxidants and be altered which will promote the phenomena of scaling. Ozone-induced lipid peroxidation can affect the skin in two ways:
• UV can cause synergistic oxidative stress.
• toxic gases such as ozone, carbon monoxide carbon, nitrogen oxides or sulfur oxides, are major constituents of pollutants.
• compositions making it possible to avoid the harmful effects due to these pollutants, thus making it possible to protect keratin materials.
• US Pat. No. 4,503,037 describes therapeutic compositions containing inter alia anthocyanins, used for therapeutic purposes to treat burns of the skin.
• Anthocyanins are found in plants as a heteroside, anthocyanosides, whose acid hydrolysis releases genes (or aglycone called anthocyanidole). These pigments are more or less dark red in acid solution and turn blue or purplish blue in the presence of alkali.
• anthocyanins used can be pure, for example obtained by biotechnology.
• the main object of the invention is the use in topical application of at least one anthocyanin as defined above, as an anti-pollution cosmetic agent.
• Cosmetic anti-pollution agent is understood to mean an agent which protects the skin and keratin materials so as to prevent, attenuate and / or eliminate the deleterious effects of toxic gases such as ozone.
• R and R ' represent, independently of one another, a hydrogen atom, a hydroxyl radical, a C1-C6 alkoxy or oside group; X- representing a monovalent counter-anion.
• R and R ' represent a hydrogen atom, a hydroxyl, a methoxy or a glucoside and X- a halogen atom.
• the plant extract containing at least one anthocyanin as defined above can also be used in topical application as a topical anti-pollution agent.
• the anthocyanin or the extract containing at least one anthocyanin as defined above are used in particular to protect keratin materials from the effects of toxic gases.
• keratinous material means the skin, the scalp, the hair, the eyelashes, the eyebrows, the nails and the mucous membranes.
• the anthocyanins and / or the extract containing the anthocyanins can also be used in order to improve cellular respiration and / or to reduce flaking and / or to avoid tarnishing or dirtying the keratin materials.
• the subject of the invention is also a cosmetic composition for non-polluting topical application which may be in the dosage forms normally used for a topical application, in particular in the form of an oil-in-water, water-in-oil or multiple emulsion, an aqueous or oily gel, an oil dispersion in an aqueous phase using spherules, lipid vesicles of ionic and / or nonionic type.
• the compositions according to the invention contain, in a cosmetically acceptable medium, at least one anthocyanin or an anthocyanin extract as defined above,
• This cosmetic composition may in particular contain from 0.005% to 10% and preferably from 0.1 to 5% by weight of anthocyanin active material relative to the total weight of the composition.
• This composition can also contain at least one anti-pollution compound.
• This can in particular be chosen from compounds containing a thioether, sulfoxide or sulfone function, ergothionein and / or its derivatives, metal chelators such as, for example, N, N'-dibenzyl ethylene acid derivatives diamine N, N'-diacetic, ellagic acid, a cellular extract of plant from the family Pontederiaceae.
• the cosmetically acceptable medium of the compositions according to the invention more particularly consists of water and / or optionally of cosmetically acceptable organic solvent.
• the organic solvents can represent from 5 to 98% of the total weight of the composition. They can be chosen from the group consisting of hydrophilic organic solvents, lipophilic organic solvents, amphiphilic solvents or their mixtures.
• hydrophilic organic substances there may be mentioned, for example, monofunctional or polyfunctional alcohols such as lower, linear or branched monoalcohols having from 1 to 8 carbon atoms such as ethanol, propanol, butanol, isopropanol , isobutanol; optionally oxyethylenated polyethylene glycols having from 6 to 80 ethylene oxides, polyols such as propylene glycol, isoprene glycol, butylene glycol, glycerol, sorbitol and its derivatives, iso- or dialkyls of isosorbide, the groups of which alkyl have from 1 to 5 carbon atoms such as dimethyl isosorbide, glycol ethers such as diethylene glycol mono-methyl or mono
• polyols such as propylene glycol derivatives (PPG), such as polypropylene glycol esters and in particular esters of polypropylene glycol and fatty acids, PPG and fatty alcohols such as PPG-23 oleyl ether and PPG-36 oleate.
• PPG propylene glycol derivatives
• PPG polypropylene glycol esters and in particular esters of polypropylene glycol and fatty acids
• PPG and fatty alcohols such as PPG-23 oleyl ether and PPG-36 oleate.
• fatty esters such as diisopropyl adipate, dioctyl adipate, alkyl benzoates.
• fatty esters such as diisopropyl adipate, dioctyl adipate, alkyl benzoates.
• the fatty phase preferably represents from 0 to 50% by total weight of the composition.
• This fatty phase can comprise one or more oils preferably chosen from the group consisting of:
• oils of animal origin such as perhydrosqualene
• oils of vegetable origin such as sweet almond oil, avocado oil, castor oil, olive oil, jojoba oil, sesame oil, peanut oil, macadamia oil, grape seed oil, rapeseed oil, coconut oil,
• oils such as Purcellin oil, isoparaffins, - fluorinated and perfluorinated oils,
• compositions of the invention may also contain adjuvants customary in the cosmetic and dermatological field such as gelling agents and / or thickening agents, aqueous or lipophilic, hydrophilic or lipophilic active agents, preservatives, antioxidants, perfumes, emulsifiers, hydrating agents, pigmenting agents, depigmenting agents, keratolytic agents, vitamins, emollients, sequestrants, surfactants, polymers, alkalizing or acidifying agents, fillers, anti-aging agents free radicals, ceramides, sun filters, especially ultraviolet filters, insect repellents, slimming agents, coloring matters, bactericides, anti-dandruff.
• adjuvants customary in the cosmetic and dermatological field such as gelling agents and / or thickening agents, aqueous or lipophilic, hydrophilic or lipophilic active agents, preservatives, antioxidants, perfumes, emulsifiers, hydrating agents, pigmenting agents, depigmenting agents, ker
• compositions according to the invention may be more or less fluid and have the appearance of a white or colored cream, an ointment, a milk, a lotion, a serum, a paste, of a foam.
• They can optionally be applied to the skin in the form of an aerosol. They can also be in solid form, and for example in the form of a stick.
• compositions according to the invention can have a pH of between 3 and 8, and preferably between 5 and 7.
• Another subject of the invention is the use of at least one anthocyanin or of an extract as defined above, in or for the preparation of a composition for topical anti-pollutant application.
• the invention also relates to the use of at least one anthocyanin or of an extract as defined above as a dye in or for the preparation of a makeup composition with topical anti-pollutant application.
• Another subject of the invention consists in a cosmetic treatment process intended to obtain protection of the body against the effects of pollution, consisting in applying to keratin materials a cosmetically effective amount of at least one anthocyanin or of an extract containing an anthocyanin as defined above.
• Another cosmetic treatment method according to the invention intended to obtain protection of the organism against the effects of pollution, consists in applying to the keratin material a composition according to the invention as defined above.
• a 125 ⁇ g / ml solution of the extract is prepared extemporaneously in the culture medium.
• the cells are brought into contact (500 ⁇ l / well for 24 hours).
• DGF 2,1 2,7-dichlorofluorescine
• the anthocyanin-based extract significantly reduces the effects induced by ozone. This protection is maximum after 5 minutes of exposure (54.9% drop in induced stress). It is still significant after 20 minutes of exposure (23.5% drop in induced stress).
• Example 1 According to the usual preparation techniques, the constituents below are mixed to prepare an emulsion.
• Example 2 In the same way, an emulsion is prepared according to a conventional technique, from the following compounds:
• delphinidol 1 g jojoba oil 13 g parabenzoxy benzoate 0.05 g methyl and isopropyl potassium sorbate 0.3 g cyclopentadimethylsiloxane 10 g ellagic acid 0, 1 g stearyl alcohol 1 g stearic acid 4 g polyethylene glycol stearate 3 g vitamin E 1 g glycerol 3 g water qs 00 g
• Example 4 From the constituents below, the following composition is formulated:
• oenoside 0.1 g jojoba oil 13 g parabenzoxy benzoate 0.05 g methyl and isopropyl potassium sorbate 0.3 g cyclopentadimethylsiloxane 10 g N, N'-di- (3-hydroxybenzyl) acid - 0, 1 ethylene diamine N, N'-diacetic stearyl alcohol 1 g stearic acid 4 g polyethylene glycol stearate 3 g vitamin E 1 g glycerol 3 g water qs 00 g

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• Life Sciences & Earth Sciences (AREA)
• Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Epidemiology (AREA)
• Birds (AREA)
• Engineering & Computer Science (AREA)
• Biotechnology (AREA)
• Botany (AREA)
• Microbiology (AREA)
• Mycology (AREA)
• Dermatology (AREA)
• Cosmetics (AREA)

Applications Claiming Priority (3)

Publications (1)

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ID=8850382

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Family Cites Families (14)

• 2000
  • 2000-05-18 FR FR0006382A patent/FR2809003B1/fr not_active Expired - Fee Related
• 2001
  • 2001-05-07 EP EP01931810A patent/EP1282396A1/de not_active Withdrawn
  • 2001-05-07 US US10/276,544 patent/US20040037857A1/en not_active Abandoned
  • 2001-05-07 WO PCT/FR2001/001382 patent/WO2001087259A1/fr not_active Application Discontinuation
  • 2001-05-07 AU AU2001258503A patent/AU2001258503A1/en not_active Abandoned
  • 2001-05-07 JP JP2001583728A patent/JP2003533461A/ja active Pending

Non-Patent Citations (1)

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