EP1274862A4 - Regulation eines gens welches durch oxidierte lipide in menschlichen arterien wandzellen induziert wird - Google Patents

Regulation eines gens welches durch oxidierte lipide in menschlichen arterien wandzellen induziert wird

Info

Publication number
EP1274862A4
EP1274862A4 EP01923022A EP01923022A EP1274862A4 EP 1274862 A4 EP1274862 A4 EP 1274862A4 EP 01923022 A EP01923022 A EP 01923022A EP 01923022 A EP01923022 A EP 01923022A EP 1274862 A4 EP1274862 A4 EP 1274862A4
Authority
EP
European Patent Office
Prior art keywords
oxidised
phospholipid
mammal
atherosclerosis
risk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01923022A
Other languages
English (en)
French (fr)
Other versions
EP1274862A1 (de
Inventor
Alan M Fogelman
Mohamad Navab
Susan Hama
Srinivasa T Reddy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/541,468 external-priority patent/US6596544B1/en
Application filed by University of California filed Critical University of California
Publication of EP1274862A1 publication Critical patent/EP1274862A1/de
Publication of EP1274862A4 publication Critical patent/EP1274862A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
EP01923022A 2000-03-31 2001-03-29 Regulation eines gens welches durch oxidierte lipide in menschlichen arterien wandzellen induziert wird Withdrawn EP1274862A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US541468 1983-10-13
US53956900A 2000-03-31 2000-03-31
US539569 2000-03-31
US09/541,468 US6596544B1 (en) 2000-03-31 2000-03-31 Functional assay of high-density lipoprotein
PCT/US2001/010590 WO2001075168A1 (en) 2000-03-31 2001-03-29 Control of a gene induced by oxidized lipids in human artery wall cells

Publications (2)

Publication Number Publication Date
EP1274862A1 EP1274862A1 (de) 2003-01-15
EP1274862A4 true EP1274862A4 (de) 2005-06-22

Family

ID=27066136

Family Applications (3)

Application Number Title Priority Date Filing Date
EP01923022A Withdrawn EP1274862A4 (de) 2000-03-31 2001-03-29 Regulation eines gens welches durch oxidierte lipide in menschlichen arterien wandzellen induziert wird
EP01923023A Expired - Lifetime EP1272666B1 (de) 2000-03-31 2001-03-29 Funktionaler nachweis von lipoprotein mit hoher dichte
EP05022081A Withdrawn EP1650312A3 (de) 2000-03-31 2001-03-29 Funktionaler Nachweis von Lipoprotein mit hoher Dichte

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP01923023A Expired - Lifetime EP1272666B1 (de) 2000-03-31 2001-03-29 Funktionaler nachweis von lipoprotein mit hoher dichte
EP05022081A Withdrawn EP1650312A3 (de) 2000-03-31 2001-03-29 Funktionaler Nachweis von Lipoprotein mit hoher Dichte

Country Status (9)

Country Link
EP (3) EP1274862A4 (de)
JP (2) JP4675539B2 (de)
AT (1) ATE306563T1 (de)
AU (3) AU4976101A (de)
CA (2) CA2404350A1 (de)
DE (1) DE60113976T2 (de)
DK (1) DK1272666T3 (de)
ES (1) ES2250378T3 (de)
WO (2) WO2001075168A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6838452B2 (en) * 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
US7807847B2 (en) 2004-07-09 2010-10-05 Vascular Biogenics Ltd. Process for the preparation of oxidized phospholipids
GB0421176D0 (en) * 2004-09-23 2004-10-27 Poston Robin Treatment of atherosclerosis
EP2218736A1 (de) 2004-10-15 2010-08-18 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Implantate, die mit amphipathischen helikalen Peptiden beschichtet sind, die mehrere Domaenen enthalten, und Verfahren zu ihrer Verwendung
AU2006274477B2 (en) * 2005-07-27 2011-05-12 Technische Universitat Graz Oxidised phospholipids comprising a fluorophore moiety and use in the determination of the presence of enzymes having antiatherogenetic activity
AU2007284801A1 (en) 2006-08-08 2008-02-21 The Regents Of The University Of Californina Salicylanilides enhance oral delivery of therapeutic peptides
US8569529B2 (en) 2007-01-09 2013-10-29 Vascular Biogenics Ltd. High-purity phospholipids
US9006217B2 (en) 2007-01-09 2015-04-14 Vascular Biogenics Ltd. High-purity phospholipids
DK2682400T5 (da) 2007-08-28 2017-11-27 Uab Research Foundation Syntetiske apolipoprotein E-efterlignende polypeptider og fremgangsmåder til anvendelse
RU2532546C2 (ru) 2008-11-06 2014-11-10 Васкьюлар Байодженикс Лтд. Окисленные соединения липидов и их применение
AU2015298263B2 (en) 2014-07-31 2020-05-14 Anji Pharmaceuticals, Inc. ApoE mimetic peptides and higher potency to clear plasma cholesterol
US9771385B2 (en) 2014-11-26 2017-09-26 Vascular Biogenics Ltd. Oxidized lipids
WO2016084023A1 (en) 2014-11-26 2016-06-02 Vascular Biogenics Ltd. Oxidized lipids and treatment or prevention of fibrosis
US10905736B2 (en) 2016-09-28 2021-02-02 The Regents Of The University Of California Ezetimibe-associated ApoA-I mimetic peptides showing enhanced synergism
JP7084590B2 (ja) * 2016-10-31 2022-06-15 国立大学法人大阪大学 脂質異常症治療が必要な被検者の選別方法及び選別用試薬
WO2018165574A1 (en) * 2017-03-10 2018-09-13 The Regents Of The University Of California Method for diagnosing risk for inflammatory disease through glycan profiling
WO2021172380A1 (ja) * 2020-02-25 2021-09-02 株式会社Ｌｓｉメディエンス 核酸医薬品等の分析方法

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO1998020897A1 (en) * 1996-11-15 1998-05-22 President And Fellows Of Harvard College Modulation of map kinase phosphatase 1 (mkp-1)

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JPS56117798A (en) * 1980-02-21 1981-09-16 Toyo Jozo Co Ltd Kit for measuring lipoid peroxide
JPS60133368A (ja) * 1983-12-19 1985-07-16 Dai Ichi Pure Chem Co Ltd 免疫測定方法
JPH01231897A (ja) * 1988-03-11 1989-09-18 Fuji Photo Film Co Ltd 乾式グルコース分析要素
US5135716A (en) * 1989-07-12 1992-08-04 Kingston Diagnostics, L.P. Direct measurement of HDL cholesterol via dry chemistry strips
WO1994023302A1 (en) * 1993-04-07 1994-10-13 The Australian National University Immunological assay of oxidatively modified human low density lipoproteins in plasma
RU94044169A (ru) * 1994-12-16 1996-10-20 И.А. Кочетов Многослойный аналитический элемент
US5958714A (en) * 1996-10-02 1999-09-28 Safety Associates, Inc. Test kits for determining at least two specific analytes in foods and other complex matrices
JP3428853B2 (ja) * 1997-04-02 2003-07-22 東北電子産業株式会社 液体試料の抗酸化力を測定するための方法および装置
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WO1998020897A1 (en) * 1996-11-15 1998-05-22 President And Fellows Of Harvard College Modulation of map kinase phosphatase 1 (mkp-1)

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DUFF JENNIFER L ET AL: "Mitogen-activated protein (MAP) kinase is regulated by the MAP kinase phosphatase (MKP-1) in vascular smooth muscle cells: Effect of actinomycin D and antisense oligonucleotides", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 13, 1995, pages 7161 - 7166, XP002325494, ISSN: 0021-9258 *
HUANG Y ET AL: "Oxidized LDL-containing immune complexes induce Fc gamma receptor I-mediated mitogen-activated protein kinase activation in THP-1 macrophages.", ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. JUL 1999, vol. 19, no. 7, July 1999 (1999-07-01), pages 1600 - 1607, XP002325496, ISSN: 1079-5642 *
LAI K ET AL: "MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASE-1 IN RAT ARTERIAL SMOOTH MUSCLE CELL PROLIFERATION", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 98, no. 7, October 1996 (1996-10-01), pages 1560 - 1567, XP002058893, ISSN: 0021-9738 *
METZLER B ET AL: "Induction of mitogen-activated protein kinase phosphatase-1 by arachidonic acid in vascular smooth muscle cells.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 11 DEC 1998, vol. 273, no. 50, 11 December 1998 (1998-12-11), pages 33320 - 33326, XP002325495, ISSN: 0021-9258 *
REDDY SRINIVASA ET AL: "Mitogen-activated protein kinase phosphatase 1 activity is necessary for oxidized phospholipids to induce monocyte chemotactic activity in human aortic endothelial cells", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 20, 18 May 2001 (2001-05-18), pages 17030 - 17035, XP002325497, ISSN: 0021-9258 *
SUBBANAGOUNDER ET AL.: "EVIDENCE THAT PHOSPHOLIPID OXIDATION PRODUCTS AND/OR PLATELET-ACTIVATING FACTOR PLAY AN IMPORTANT ROLE IN EARLY ATHEROGENESIS IN VITRO AND IN VIVO INHIBITION BY WEB 2086", CIRCULATION RESEARCH, GRUNE AND STRATTON, BALTIMORE, US, no. 85, 20 August 1999 (1999-08-20), pages 311 - 318, XP002951988, ISSN: 0009-7330 *

Also Published As

Publication number Publication date
EP1650312A2 (de) 2006-04-26
EP1272666B1 (de) 2005-10-12
DE60113976T2 (de) 2006-07-27
AU4976201A (en) 2001-10-15
JP2003529375A (ja) 2003-10-07
AU4976101A (en) 2001-10-15
AU2001249762B2 (en) 2006-03-30
ES2250378T3 (es) 2006-04-16
DK1272666T3 (da) 2006-02-27
EP1272666A4 (de) 2004-09-22
JP2003529775A (ja) 2003-10-07
CA2404000A1 (en) 2001-10-11
JP4675539B2 (ja) 2011-04-27
ATE306563T1 (de) 2005-10-15
DE60113976D1 (de) 2006-02-23
EP1272666A1 (de) 2003-01-08
EP1274862A1 (de) 2003-01-15
CA2404000C (en) 2010-07-27
CA2404350A1 (en) 2001-10-11
EP1650312A3 (de) 2006-05-17
WO2001075170A1 (en) 2001-10-11
WO2001075168A1 (en) 2001-10-11

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