EP1270578A4 - Nouveau procede de production de derive d'imidazopyridine fondu et nouvelle forme cristalline - Google Patents

Nouveau procede de production de derive d'imidazopyridine fondu et nouvelle forme cristalline

Info

Publication number
EP1270578A4
EP1270578A4 EP01917588A EP01917588A EP1270578A4 EP 1270578 A4 EP1270578 A4 EP 1270578A4 EP 01917588 A EP01917588 A EP 01917588A EP 01917588 A EP01917588 A EP 01917588A EP 1270578 A4 EP1270578 A4 EP 1270578A4
Authority
EP
European Patent Office
Prior art keywords
novel
crystal form
producing fused
imidazopyridine derivative
novel crystal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01917588A
Other languages
German (de)
English (en)
Other versions
EP1270578A1 (fr
Inventor
Fumihiko Matsubara
Takashi Ohya
Masaaki Uenaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of EP1270578A1 publication Critical patent/EP1270578A1/fr
Publication of EP1270578A4 publication Critical patent/EP1270578A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La présente invention concerne un procédé de production d'un composé représenté par la formule (I), dans laquelle R représente un hétérocycle aromatique, etc., et A représente un groupe hétéroalicyclique, etc. Ce composé est caractérisé en ce qu'il fait réagir un composé de formule (II), dans laquelle Hal représente halogéno et R et A ont les mêmes significations que celles susmentionnées, en présence d'un sel d'acide sulfinique et d'un sel d'un acide ou d'une base organique. La présente invention concerne également un nouveau cristal de monohydrate de 2-(3-isooxazolyl)-3,6,7,9-tétrahydroimidazo[4,5-d]pyrano[4,3-b]pyridine phosphate.
EP01917588A 2000-03-30 2001-03-29 Nouveau procede de production de derive d'imidazopyridine fondu et nouvelle forme cristalline Withdrawn EP1270578A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000092565 2000-03-30
JP2000092565 2000-03-30
PCT/JP2001/002620 WO2001074821A1 (fr) 2000-03-30 2001-03-29 Nouveau procede de production de derive d'imidazopyridine fondu et nouvelle forme cristalline

Publications (2)

Publication Number Publication Date
EP1270578A1 EP1270578A1 (fr) 2003-01-02
EP1270578A4 true EP1270578A4 (fr) 2004-11-03

Family

ID=18607880

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01917588A Withdrawn EP1270578A4 (fr) 2000-03-30 2001-03-29 Nouveau procede de production de derive d'imidazopyridine fondu et nouvelle forme cristalline

Country Status (17)

Country Link
US (1) US7049437B2 (fr)
EP (1) EP1270578A4 (fr)
JP (1) JP3481930B2 (fr)
KR (1) KR20020082898A (fr)
CN (1) CN1203073C (fr)
AU (1) AU2001244613A1 (fr)
BR (1) BR0109643A (fr)
CA (1) CA2403131A1 (fr)
CZ (1) CZ20023276A3 (fr)
HK (1) HK1054387A1 (fr)
HU (1) HUP0300580A3 (fr)
IL (1) IL151877A0 (fr)
MX (1) MXPA02009460A (fr)
NO (1) NO20024623L (fr)
PL (1) PL357672A1 (fr)
WO (1) WO2001074821A1 (fr)
ZA (1) ZA200207295B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003008421A1 (fr) * 2001-07-16 2003-01-30 Shionogi & Co., Ltd. Procede de preparation de derives amidine
JPWO2004078173A1 (ja) * 2003-02-05 2006-06-08 塩野義製薬株式会社 溶出性の改善された錠剤
WO2005018556A2 (fr) 2003-08-12 2005-03-03 3M Innovative Properties Company Composes contenant une structure imidazo a substitution hydroxylamine
ES2406730T3 (es) 2003-08-27 2013-06-07 3M Innovative Properties Company Imidazoquinolinas sustituidas con ariloxi y arilalquilenoxi
AU2004270201A1 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for CD5+ B cell lymphoma
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
CA2540541C (fr) 2003-10-03 2012-03-27 3M Innovative Properties Company Imidazoquinolines a substitution alcoxy
WO2005048945A2 (fr) * 2003-11-14 2005-06-02 3M Innovative Properties Company Composes d'un anneau d'imidazo substitue par hydroxylamine
EP1685129A4 (fr) 2003-11-14 2008-10-22 3M Innovative Properties Co Composes d'un anneau d'imidazo substitues par oxime
JP4891088B2 (ja) 2003-11-25 2012-03-07 スリーエム イノベイティブ プロパティズ カンパニー 置換されたイミダゾ環系および方法
JP2007517035A (ja) 2003-12-29 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン
CA2551399A1 (fr) 2003-12-30 2005-07-21 3M Innovative Properties Company Sulfonamides d'imidazoquinolinyle, d'imidazopyridinyle et d'imidazonaphtyridinyle
CA2559863A1 (fr) 2004-03-24 2005-10-13 3M Innovative Properties Company Imidazopyridines, imidazoquinolines, et imidazonaphthyridines a substitution amide
WO2005094770A1 (fr) * 2004-03-30 2005-10-13 Unilever Plc Compositions pour eclaircir la peau comprenant des vitamines et des flavonoides
US8017779B2 (en) 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
WO2006009832A1 (fr) * 2004-06-18 2006-01-26 3M Innovative Properties Company Systemes cycliques imidazo substitues, et procedes correspondants
US7915281B2 (en) 2004-06-18 2011-03-29 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method
WO2006038923A2 (fr) 2004-06-18 2006-04-13 3M Innovative Properties Company Imidazonaphthyridines substituees par aryle
AU2005322898B2 (en) 2004-12-30 2011-11-24 3M Innovative Properties Company Chiral fused (1,2)imidazo(4,5-c) ring compounds
AU2005326708C1 (en) 2004-12-30 2012-08-30 3M Innovative Properties Company Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
CA2597092A1 (fr) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Formulations des gel aqueux contenant des modificateurs de reponse immunitaire
WO2006086634A2 (fr) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Composes cycliques imidazo[4,5-c] substitues par oxime et hydroxylamine et procedes associes
EP1869043A2 (fr) 2005-04-01 2007-12-26 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines et analogues associes
CA2602590A1 (fr) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Composes cycliques 1-pyrazolo[3,4-c] substitues comme modulateurs de la biosynthese de cytokine destines au traitement d'infections virales et de maladies neoplastiques
KR20080048551A (ko) * 2005-09-23 2008-06-02 콜레이 파마시티컬 그룹, 인코포레이티드 1Ｈ-이미다조[4,5-ｃ]피리딘 및 그의 유사체의 제조법
WO2008008432A2 (fr) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Composés à cycle [1,2] imidazo [4,5-c] fusionné chiral substitué et procédés correspondants
FI3856341T3 (fi) 2019-04-12 2023-11-30 Blueprint Medicines Corp (s)-1-(4-fluorifenyyli)-1-(2-(4-(6-(1-metyyli-1h-pyratsol-4-yyli)pyrrolo[2,1-f][1,2,4]triatsin-4-yyli)piperatsinyyli)pyrimidin-5-yyli)etaani-1-amiinin kidemuotoja ja valmistusmenetelmiä

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378848A (en) * 1992-02-12 1995-01-03 Shionogi & Co., Ltd. Condensed imidazopyridine derivatives
IL118544A (en) * 1995-06-07 2001-08-08 Smithkline Beecham Corp History of imidazole, the process for their preparation and the pharmaceutical preparations containing them

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
JP3481930B2 (ja) 2003-12-22
CZ20023276A3 (cs) 2003-02-12
CA2403131A1 (fr) 2001-10-11
HUP0300580A3 (en) 2006-06-28
US20030088102A1 (en) 2003-05-08
PL357672A1 (en) 2004-07-26
AU2001244613A1 (en) 2001-10-15
HK1054387A1 (zh) 2003-11-28
NO20024623D0 (no) 2002-09-26
ZA200207295B (en) 2003-09-11
BR0109643A (pt) 2003-04-22
CN1203073C (zh) 2005-05-25
HUP0300580A2 (hu) 2003-07-28
NO20024623L (no) 2002-11-08
US7049437B2 (en) 2006-05-23
MXPA02009460A (es) 2003-02-12
KR20020082898A (ko) 2002-10-31
CN1419557A (zh) 2003-05-21
EP1270578A1 (fr) 2003-01-02
WO2001074821A1 (fr) 2001-10-11
IL151877A0 (en) 2003-04-10

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