EP1270578A4 - Nouveau procede de production de derive d'imidazopyridine fondu et nouvelle forme cristalline - Google Patents

Nouveau procede de production de derive d'imidazopyridine fondu et nouvelle forme cristalline

Info

Publication number
EP1270578A4
EP1270578A4 EP01917588A EP01917588A EP1270578A4 EP 1270578 A4 EP1270578 A4 EP 1270578A4 EP 01917588 A EP01917588 A EP 01917588A EP 01917588 A EP01917588 A EP 01917588A EP 1270578 A4 EP1270578 A4 EP 1270578A4
Authority
EP
European Patent Office
Prior art keywords
novel
crystal form
producing fused
imidazopyridine derivative
novel crystal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01917588A
Other languages
German (de)
English (en)
Other versions
EP1270578A1 (fr
Inventor
Fumihiko Matsubara
Takashi Ohya
Masaaki Uenaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of EP1270578A1 publication Critical patent/EP1270578A1/fr
Publication of EP1270578A4 publication Critical patent/EP1270578A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La présente invention concerne un procédé de production d'un composé représenté par la formule (I), dans laquelle R représente un hétérocycle aromatique, etc., et A représente un groupe hétéroalicyclique, etc. Ce composé est caractérisé en ce qu'il fait réagir un composé de formule (II), dans laquelle Hal représente halogéno et R et A ont les mêmes significations que celles susmentionnées, en présence d'un sel d'acide sulfinique et d'un sel d'un acide ou d'une base organique. La présente invention concerne également un nouveau cristal de monohydrate de 2-(3-isooxazolyl)-3,6,7,9-tétrahydroimidazo[4,5-d]pyrano[4,3-b]pyridine phosphate.
EP01917588A 2000-03-30 2001-03-29 Nouveau procede de production de derive d'imidazopyridine fondu et nouvelle forme cristalline Withdrawn EP1270578A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000092565 2000-03-30
JP2000092565 2000-03-30
PCT/JP2001/002620 WO2001074821A1 (fr) 2000-03-30 2001-03-29 Nouveau procede de production de derive d'imidazopyridine fondu et nouvelle forme cristalline

Publications (2)

Publication Number Publication Date
EP1270578A1 EP1270578A1 (fr) 2003-01-02
EP1270578A4 true EP1270578A4 (fr) 2004-11-03

Family

ID=18607880

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01917588A Withdrawn EP1270578A4 (fr) 2000-03-30 2001-03-29 Nouveau procede de production de derive d'imidazopyridine fondu et nouvelle forme cristalline

Country Status (17)

Country Link
US (1) US7049437B2 (fr)
EP (1) EP1270578A4 (fr)
JP (1) JP3481930B2 (fr)
KR (1) KR20020082898A (fr)
CN (1) CN1203073C (fr)
AU (1) AU2001244613A1 (fr)
BR (1) BR0109643A (fr)
CA (1) CA2403131A1 (fr)
CZ (1) CZ20023276A3 (fr)
HK (1) HK1054387A1 (fr)
HU (1) HUP0300580A3 (fr)
IL (1) IL151877A0 (fr)
MX (1) MXPA02009460A (fr)
NO (1) NO20024623L (fr)
PL (1) PL357672A1 (fr)
WO (1) WO2001074821A1 (fr)
ZA (1) ZA200207295B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6987187B2 (en) 2001-07-16 2006-01-17 Shionogi & Co., Ltd. Process for preparation of amidine derivatives
JPWO2004078173A1 (ja) * 2003-02-05 2006-06-08 塩野義製薬株式会社 溶出性の改善された錠剤
JP2007502293A (ja) 2003-08-12 2007-02-08 スリーエム イノベイティブ プロパティズ カンパニー ヒドロキシルアミン置換イミダゾ含有化合物
EP1658076B1 (fr) 2003-08-27 2013-03-06 3M Innovative Properties Company Imidazoquinolines substituees par aryloxy et arylalkyleneoxy
CA2537763A1 (fr) 2003-09-05 2005-03-17 3M Innovative Properties Company Traitement pour le lymphome a cellules b cd5<sp>+</sp>
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
AR046046A1 (es) 2003-10-03 2005-11-23 3M Innovative Properties Co Imidazoquinolinas alcoxi sustituidas. composiciones farmaceuticas.
CA2545774A1 (fr) 2003-11-14 2005-06-02 3M Innovative Properties Company Composes d'un anneau d'imidazo substitues par oxime
CA2545825A1 (fr) * 2003-11-14 2005-06-02 3M Innovative Properties Company Composes d'un anneau d'imidazo substitue par hydroxylamine
BRPI0416936A (pt) 2003-11-25 2007-01-16 3M Innovative Properties Co sistemas de anel de imidazo substituìdos e métodos
EP1701955A1 (fr) 2003-12-29 2006-09-20 3M Innovative Properties Company Imidazoquinolines a substitution arylalcenyle et arylalkynyle
EP1699788A2 (fr) 2003-12-30 2006-09-13 3M Innovative Properties Company Sulfonamides d'imidazoquinolinyle, d'imidazopyridinyle et d'imidazonaphtyridinyle
AU2005228150A1 (en) 2004-03-24 2005-10-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US20080058281A1 (en) * 2004-03-30 2008-03-06 Yates Paula R Skin Lightening Compositions Comprising Vitamines and Flavonoids
WO2005123080A2 (fr) 2004-06-15 2005-12-29 3M Innovative Properties Company Imidazoquinolines et imidazonaphthyridines substituees par un heterocyclyle contenant un azote
WO2006065280A2 (fr) 2004-06-18 2006-06-22 3M Innovative Properties Company Composes a noyau imidazo a substitutif d'isoxazole, de dihydroisoxazole et d'oxadiazole
WO2006038923A2 (fr) 2004-06-18 2006-04-13 3M Innovative Properties Company Imidazonaphthyridines substituees par aryle
WO2006009832A1 (fr) * 2004-06-18 2006-01-26 3M Innovative Properties Company Systemes cycliques imidazo substitues, et procedes correspondants
WO2006009826A1 (fr) 2004-06-18 2006-01-26 3M Innovative Properties Company Thiazoloquinolines et thiazolonaphtyridines substitues par aryloxy et arylalkyleneoxy
US8034938B2 (en) 2004-12-30 2011-10-11 3M Innovative Properties Company Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
JP5543068B2 (ja) 2004-12-30 2014-07-09 スリーエム イノベイティブ プロパティズ カンパニー キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
US9248127B2 (en) 2005-02-04 2016-02-02 3M Innovative Properties Company Aqueous gel formulations containing immune response modifiers
EP1846405A2 (fr) 2005-02-11 2007-10-24 3M Innovative Properties Company Composes cycliques imidazo 4,5-c substitues par oxime et hydroxylamine et procedes associes
CA2602590A1 (fr) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Composes cycliques 1-pyrazolo[3,4-c] substitues comme modulateurs de la biosynthese de cytokine destines au traitement d'infections virales et de maladies neoplastiques
US7943610B2 (en) 2005-04-01 2011-05-17 3M Innovative Properties Company Pyrazolopyridine-1,4-diamines and analogs thereof
AU2006292119A1 (en) * 2005-09-23 2007-03-29 3M Innovative Properties Company Method for 1H-imidazo[4,5-c]pyridines and analogs thereof
WO2008008432A2 (fr) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Composés à cycle [1,2] imidazo [4,5-c] fusionné chiral substitué et procédés correspondants

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378848A (en) * 1992-02-12 1995-01-03 Shionogi & Co., Ltd. Condensed imidazopyridine derivatives
US5658903A (en) * 1995-06-07 1997-08-19 Smithkline Beecham Corporation Imidazole compounds, compositions and use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
HUP0300580A3 (en) 2006-06-28
PL357672A1 (en) 2004-07-26
HK1054387A1 (zh) 2003-11-28
CN1419557A (zh) 2003-05-21
IL151877A0 (en) 2003-04-10
AU2001244613A1 (en) 2001-10-15
CN1203073C (zh) 2005-05-25
BR0109643A (pt) 2003-04-22
US20030088102A1 (en) 2003-05-08
NO20024623D0 (no) 2002-09-26
JP3481930B2 (ja) 2003-12-22
KR20020082898A (ko) 2002-10-31
US7049437B2 (en) 2006-05-23
HUP0300580A2 (hu) 2003-07-28
ZA200207295B (en) 2003-09-11
WO2001074821A1 (fr) 2001-10-11
NO20024623L (no) 2002-11-08
CA2403131A1 (fr) 2001-10-11
MXPA02009460A (es) 2003-02-12
EP1270578A1 (fr) 2003-01-02
CZ20023276A3 (cs) 2003-02-12

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