EP1268484A1 - Kondensierte imidazole als histamin h3-rezeptor liganden - Google Patents

Kondensierte imidazole als histamin h3-rezeptor liganden

Info

Publication number
EP1268484A1
EP1268484A1 EP01916934A EP01916934A EP1268484A1 EP 1268484 A1 EP1268484 A1 EP 1268484A1 EP 01916934 A EP01916934 A EP 01916934A EP 01916934 A EP01916934 A EP 01916934A EP 1268484 A1 EP1268484 A1 EP 1268484A1
Authority
EP
European Patent Office
Prior art keywords
alkyl
aryl
hydrogen
substituted
tetrahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01916934A
Other languages
English (en)
French (fr)
Inventor
Knud Erik Andersen
Florencio Zaragoza DÖRWALD
Ulla Grove Sidelmann
Klaus Rudolf
Dirk Stenkamp
Rudolf Hurnaus
Stephan Georg MÜLLER
Bernd Krist
Birgitte Eriksen
Bernd Pesche
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Zentrale GmbH
CH Boehringer Sohn AG and Co KG
Novo Nordisk AS
Original Assignee
Boehringer Ingelheim Zentrale GmbH
CH Boehringer Sohn AG and Co KG
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Zentrale GmbH, CH Boehringer Sohn AG and Co KG, Novo Nordisk AS filed Critical Boehringer Ingelheim Zentrale GmbH
Publication of EP1268484A1 publication Critical patent/EP1268484A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
EP01916934A 2000-03-17 2001-03-16 Kondensierte imidazole als histamin h3-rezeptor liganden Withdrawn EP1268484A1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200000441 2000-03-17
DK200000441 2000-03-17
DK200001016 2000-06-29
DKPA200001016 2000-06-29
PCT/DK2001/000188 WO2001068652A1 (en) 2000-03-17 2001-03-16 Condensed imidazoles as histamine h3 receptor ligands

Publications (1)

Publication Number Publication Date
EP1268484A1 true EP1268484A1 (de) 2003-01-02

Family

ID=26068796

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01916934A Withdrawn EP1268484A1 (de) 2000-03-17 2001-03-16 Kondensierte imidazole als histamin h3-rezeptor liganden

Country Status (4)

Country Link
EP (1) EP1268484A1 (de)
JP (1) JP2003527395A (de)
AU (1) AU2001244088A1 (de)
WO (1) WO2001068652A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108314641A (zh) * 2017-12-27 2018-07-24 阜新龙瑞药业有限责任公司 一种天然产物Norpsilocin的制备方法

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1430032A2 (de) * 2001-09-24 2004-06-23 Elan Pharmaceuticals, Inc. Substituierte amide für die behandlung von neurologischen erkrankungen
EP1780196A3 (de) * 2001-12-10 2007-05-09 Amgen, Inc Pyridin-Derivate zur verwendung als Vanilloid-Rezeptor-Liganden
PL373484A1 (en) 2001-12-10 2005-09-05 Amgen Inc. Vanilloid receptor ligands and their use in treatments
JP2003192587A (ja) * 2001-12-26 2003-07-09 Bayer Ag 尿素誘導体
US7105513B2 (en) 2002-08-07 2006-09-12 Sanofi-Avertis Deutschland Gmbh Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals
EP1388342A1 (de) * 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Acylierte, Heteroaryl-kondensierte Cycloalkenylamine und deren Verwendung als Arzneimittel
EP1585731A2 (de) * 2002-09-18 2005-10-19 Eli Lilly And Company Histamin h3 rezeptor-antagonisten, herstellung und therapeutische verwendung
CN1809544A (zh) * 2003-06-17 2006-07-26 麦克公司 作为二肽基肽酶抑制剂用于治疗或预防糖尿病的环己基甘氨酸衍生物
WO2005009471A1 (en) * 2003-07-28 2005-02-03 Osaka Industrial Promotion Organization Composition for lowering blood-sugar level
RU2617988C2 (ru) 2010-09-03 2017-05-02 ФОРМА ТиЭм, ЭлЭлСИ Новые соединения и композиции для ингибирования nampt
CN102452988B (zh) 2010-10-27 2016-01-27 中国科学院化学研究所 一种喹唑啉衍生物及其制备方法
ME02733B (de) 2011-10-18 2017-10-20 Astellas Pharma Inc Bicyclische heterocyclische verbindung
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
US20140057920A1 (en) 2012-08-23 2014-02-27 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
EP3746422A4 (de) 2018-02-01 2021-06-09 The University Of Sydney Antikrebsverbindungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2004911A1 (en) * 1988-12-22 1990-06-22 Mitsuaki Ohta 4,5,6,7-tetrahydrobenzimidazole derivatives
DE69028934T2 (de) * 1989-02-02 1997-03-20 Yamanouchi Pharma Co Ltd Tetrahydrobenzimidazol-Derivate
JPH049372A (ja) * 1990-04-25 1992-01-14 Yamanouchi Pharmaceut Co Ltd ４，５，６，７―テトラヒドロベンズイミダゾール誘導体
AU7707994A (en) * 1993-09-30 1995-04-18 Tokyo Tanabe Company Limited Indoline derivative and 5-ht3 receptor antagonist containing the same as active ingredient

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0168652A1 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108314641A (zh) * 2017-12-27 2018-07-24 阜新龙瑞药业有限责任公司 一种天然产物Norpsilocin的制备方法

Also Published As

Publication number Publication date
JP2003527395A (ja) 2003-09-16
AU2001244088A1 (en) 2001-09-24
WO2001068652A1 (en) 2001-09-20

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Inventor name: SIDELMANN, ULLA, GROVE

Inventor name: MUELLER, STEPHAN, GEORG

Inventor name: ERIKSEN, BIRGITTE

Inventor name: HURNAUS, RUDOLF

Inventor name: STENKAMP, DIRK

Inventor name: DOERWALD, FLORENCIO, ZARAGOZA

Inventor name: ANDERSEN, KNUD, ERIK

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