EP1268067B1 - Pipette provided with sampling volume adjusting means - Google Patents
Pipette provided with sampling volume adjusting means Download PDFInfo
- Publication number
- EP1268067B1 EP1268067B1 EP01921520A EP01921520A EP1268067B1 EP 1268067 B1 EP1268067 B1 EP 1268067B1 EP 01921520 A EP01921520 A EP 01921520A EP 01921520 A EP01921520 A EP 01921520A EP 1268067 B1 EP1268067 B1 EP 1268067B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- pipette
- blocking element
- pipette according
- way
- adjusting means
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
- B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
- B01L3/0224—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type having mechanical means to set stroke length, e.g. movable stops
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/02—Identification, exchange or storage of information
- B01L2300/025—Displaying results or values with integrated means
- B01L2300/027—Digital display, e.g. LCD, LED
Definitions
- the invention relates to sampling pipettes of liquid.
- a sampling pipette comprising a dial accessible through a window of the body of the pipette to adjust the volume of liquid to be pipetted. This volume is also indicated on a display.
- This pipette has many advantages. The wheel does does not protrude out of the body of the pipette and is therefore unlikely to be activated unintentionally. In addition, the wheel is braked in its maneuver by a friction assembly that further reduces the risks of disturbance. However, it is desirable to perfect again. Indeed, he remains a weak risk of accidental disturbance of the volume to be pipetted by an involuntary maneuver of the wheel.
- US-5,849,248 discloses a pipette comprising a movable locking element between a inactive position in which he makes the means of adjustment not suitable for setting and an active position in which he makes them fit. This element extends to near the volume control knob. No inadvertent adjustment of the volume to be pipetted is therefore not more to fear.
- An object of the invention is to provide a pipette of a different type but also avoiding the maladjustment.
- a sampling pipette comprising means for adjusting a volume of liquid to be sampled comprising at least one adjustment control member, the pipette comprising a movable locking element between an inactive position in which he makes the adjustment means not suitable for adjustment and a position active in which it makes the means of adjustment suitable for adjustment, the locking element being the setting control.
- pipette according to the invention allows use to perform by means of the single element of blocking all successive operations relating to setting, eg unlocking, volume control and lock.
- sampling pipette is of the same type as of document FR-2 696 110. It will therefore be referred to document for some details of the pipette already known from this document. We will describe here in detail only certain aspects of the volume adjustment mechanism.
- the pipette 2 conventionally comprises a body 2 as a handle to be grasped by the hand of the user.
- the pipette comprises a piston illustrated mobile sliding axis longitudinal 10 of the pipette into a cavity bottom of the pipette to suck in it a volume of liquid to be withdrawn or expelled out of this cavity.
- the movement of the piston is controlled in particular by means of a control rod 4 of axis 10 connected in the lower part to the piston by parts of a known type and not illustrated.
- This rod 4 is surmounted at its upper end by a button pusher 6 rigidly attached to the rod, that the user can operate with the thumb of the hand holding the pipette.
- the piston lowers and goes up in function of the same movement of the button.
- the pipette has a return spring adapted to replace the piston and the upper stem at the end of their run towards the bottom for the expulsion of the liquid, and a spring of purge adding its effect to that of the previous spring when the piston stroke continues down for a purge race.
- the volume to be pipetted during a normal race complete piston, out of purge stroke can be adjusted by means of an adjustment knob 8 in the form of ring and push button 6.
- These two buttons are rotatably mounted about the longitudinal axis 10 of the pipette. A rotation of one or other of these buttons causes the rotation of a coaxial adjusting screw 5 to the rod 4 about its axis 10. The way the rotation of the screw 5 causes the variation of the volume to pipeter is known and will not be described. We go now describe in detail the upper part of adjustment mechanism.
- the pipette comprises a coupler 12 slidably mounted on the rod 4 but fixed in rotation relative thereto.
- the coupler has a top orifice central having three engaging radial tabs 14 in three longitudinal grooves 16 of the rod 4.
- This orifice is formed by an upper washer 18 of coupler.
- the coupler has three arms 20 extending downwards parallel to axis 10 from the washer 18.
- Each arm 20 is generally flattened in the radial direction at axis 10 and present on its face 22 opposite the axis an elongated relief 24 next the circumferential direction to the axis 10.
- the adjustment knob 8 is movable to slide along the axis 10 and rotated about this axis. he has a substantially cylindrical shape of axis 10.
- the outer face 26 of this button is accessible to the user for his maneuvering through windows from the body. To this end, it includes reliefs of gripping.
- the button 8 Near its upper circular edge, the button 8 has three forks 30 extending in radial projection in the direction of the axis. These forks have a female "U" shape open in direction of the axis, complementary shape to the profile arms 20 and receiving them respectively.
- button 8 is fixed in rotation to the coupler 12 but is not fixed in sliding.
- Button 8 can occupy on the one hand a low position, or inactive position, or position locked, and on the other hand a high position or active or unlocked. These two positions are independent of the angular position of the knob 8 around the axis.
- the button goes from one to another position by sliding along the axis.
- the coupler 12 has an annular spring 26 of axis 10 requesting radially the arms 20 on their inner face for tend to move them away radially from the axis.
- the arms 20 are received in the forks but not the reliefs 24. It is the same in the high position, as shown in Figure 11.
- the reliefs 24 pass in the forks and cause temporary bending of the arms 20 in the radial direction. This passage produces a click sound and constitutes a hard point during the maneuver who demonstrate to the user the change of high or low position.
- the reliefs 24 hold the button in the up position against of the return spring, unless the action of the the user.
- the pipette has a clutch 32 of generally cylindrical shape having an outer annular peripheral rib 34 about halfway up.
- Button 8 has two cylindrical parts 8a and 8b lower and upper force-fitted externally on dog clutch 32 and in axial support on the rib 34.
- the button 8 is rigidly attached to the dog.
- the dog present on his outer face, illustrated in detail in FIG. reliefs cooperating with complementary reliefs of the button to ensure these rigid links.
- the dog 32 has a toothing 36 extending near its edge superior, projecting radially from its internal face in direction of the axis.
- the pipette comprises a coach 38 having an upper portion 40 of cylindrical shape provided with several teeth 42, for example two in number, extending near its upper edge, protruding radial from its outer face in the opposite direction to axis. These two teeth are able to engage with the teeth 36 of the clutch when they extend to the same height as this along the axis 10.
- the coach 38 can be made mobile relative to the adjusting screw 5. It extends directly opposite of it radially. Unlike the screw of setting 5 which is moving according to a movement helical around the axis 10, the coach 38 is fixed sliding along the axis 10 relative to the body of the pipette. It is blocked for this purpose in part superior by a spacer 44 and partly lower by a piece 46 illustrated in Figure 1.
- the coach 38 has two main legs 48 and two secondary legs 50 extending parallel to the axis 10 down from the top 40.
- the secondary legs 50 are sector-shaped of cylinder axis 10. They are alternated around the axis with the main legs 48.
- the legs main 48 have a cylindrical outer face and have a planar inner surface projecting radially from which extends a rib 52 profiled parallel to the axis 10 and rectangular section.
- the coach 38 has a spring 54 encircling externally the four legs 48, 50 and housed in an external notch of these. The spring tends to bring the legs closer radially from the axis.
- the adjusting screw 5 is hollow and traversed longitudinally by the control rod 4. These two parts are totally independent in their relative motion.
- the adjusting screw 5 has a shape circular general of revolution. However, more precisely, it presents two parallel flats 56 to each other and to axis 10 and opposite of share and else of this axis. These flats extend over a medial portion 58 of the screw extending over a threaded lower portion 60 of the screw serving volume adjustment. These flats 56 are joined one to the other by arcs 61.
- the adjusting screw has two longitudinal pins 62 parallel to the axis 10, extending at the edge of the flats respective ones so as to present a stop when circumferentially travels the outer face of the screw 5 from the flats, but also so as to have an arc of a circle that does not form an abutment from cylindrical areas 61.
- the two lugs 62 are not symmetrical one of the other relative to axis 10 but are relative to at a median plane of the screw parallel to the two flats. In addition, the two lugs 62 do not extend exactly coincidentally with respect to their position along the axis 10. They overlap on a certain section. But one of the spurs extends higher than the other while the latter is stretching down more than the first. Also, are the two spurs partial overlap along the axis 10. The longitudinal position of the second lug, normally hidden in Figure 6, has however been indicated by the line 56.
- the coach 38 can be coupled to the screw 5 in rotation, or uncoupled from it.
- the coach When coupled, as in Figures 12 and 15, the coach is located at a level of the screw on which overlap the two pins 62.
- the legs secondary 48 are supported on the cylindrical areas 61 whose form they follow. They realize with these a surface-to-surface contact.
- the ribs 52 are supported radially on the flats 56 and abutting on the respective lugs 62.
- Spring 54 keeps the four tabs resting on the screw 5 and especially keeps taking the ribs on the pins. Therefore, a rotational movement of the coach 38 can be transmitted to the adjusting screw 5.
- the coach As the coach is slidably fixed along of the axis unlike the screw 5, this rotation produces the sliding of the screw along the axis, the screw having a helical movement.
- the two pieces are thus coupled to rotation about the axis by means of friction forces and especially by means of the lugs and ribs. Transmission of the couple therefore takes place even in presence of a strong resistant torque.
- the lugs 62 are positioned so that neighborhood of each end position high and bottom of the adjusting screw 5, the pin that ensures the transmission of movement towards this stop interrupts, as illustrated in FIGS. 14 to 18. Therefore, over the entire range of motion remaining at to travel to the stop position, the transmission of the couple is done only thanks to friction forces of the legs on the screw. In these conditions, this transmission takes place only if the intensity of the binding forces, and therefore the intensity of the resistant torque, is less than a value predetermined function of the spring 54. This transmission nevertheless takes place, so that the user can continue to maneuver (indirectly as we will see later) coach 38 for drive the screw 5. As soon as the screw 5 arrives at the end of adjustment stroke, the resistant torque becomes infinitely big and interrupts the link by the friction forces.
- the low, inactive, locked position of button is illustrated in Figures 1, 3 and 4.
- the arms 20 are engaged with the button 8.
- the rod 4 is therefore in rotation with the button 8.
- the teeth 36 of the clutch are out of reach with the 42 teeth of the coach 38.
- No movement of the button 8 therefore does not rotate the coach 38 or the screw 5.
- This low position of the 8 button therefore inactivates adjustment means.
- the volume to be pipetted can not be modified voluntarily or involuntarily.
- the the words "locked” or "locked” written on the outer face 26 of the button 8 appear in the window to the user.
- a spring of recall 60 illustrated in Figure 1 taking support axially upwards on the coupler 12 and towards the down button 8 solicits the latter for the keep in this low position.
- the button 8 If the user wants to adjust the volume, he or she slide the button 8 upwards against the spring 60 so the forks 30 crossing the reliefs 24 produce a click and a hard point. The button is then in the upper position, active, unlocked. He is kept in this position by the reliefs 24, unless the user otherwise acts. In this position, the teeth 36 of the clutch are in taken with the 42 teeth of the coach 38. A direct request button 8 or button 6 to rotation exerted by the user is therefore transmitted by the teeth 36, 42 to the coach 38, then to the screw of setting 5 in so far as it is not already at the end of the stroke for the desired direction of adjustment. When the desired sample volume is set, the user makes the button 8 slide again in low position to prevent misalignment untimely.
- FIG. 19 illustrates a variant of realization in which analogous elements have numerical references increased by 100.
- the stem 104 has not been illustrated.
- the ribs 152 have a "V" profile with rounded tip.
- Flats 156 are replaced by grooves 156 with a "V" profile of same angle as that of the ribs to allow the drive of the screw 105 by the coach 138.
- the grooves At the vicinity of the stop positions, the grooves the respective ones widen by accentuating the inclination from one of their two faces. This face forms a ramp.
- the pipette is arranged so that when the end position is reached, the strength of tightening of the spring is insufficient to maintain the ribs 152 in the grooves 156.
- the ramp causes then the output of the ribs out of the grooves and the distance of the main legs 148, so that the coach no longer drives the screw and continues to turn alone.
- the pipette may include means electronic displays (eg crystal of a parameter relating to the operation of the pipette.
- these means may indicate permanently locked or unlocked state of button 8.
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- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Sampling And Sample Adjustment (AREA)
- Devices For Use In Laboratory Experiments (AREA)
- External Artificial Organs (AREA)
- One-Way And Automatic Clutches, And Combinations Of Different Clutches (AREA)
- Steroid Compounds (AREA)
Abstract
Description
L'invention concerne les pipettes de prélèvement de liquide.The invention relates to sampling pipettes of liquid.
On connaít, par exemple du document FR-2 696 110, une pipette de prélèvement comprenant une mollette accessible à travers une fenêtre du corps de la pipette pour régler le volume de liquide à pipeter. Ce volume est par ailleurs indiqué sur un afficheur. Cette pipette présente de nombreux avantages. La mollette ne fait pas saillie hors du corps de la pipette et est donc peu susceptible d'être actionnée involontairement. De plus, la mollette est freinée dans sa manoeuvre par un assemblage à friction qui réduit encore les risques de dérèglement. Toutefois, il est souhaitable de la perfectionner encore. En effet, il demeure un faible risque de dérèglement accidentel du volume à pipeter par une manoeuvre involontaire de la molette.We know, for example from document FR-2,696,110, a sampling pipette comprising a dial accessible through a window of the body of the pipette to adjust the volume of liquid to be pipetted. This volume is also indicated on a display. This pipette has many advantages. The wheel does does not protrude out of the body of the pipette and is therefore unlikely to be activated unintentionally. In addition, the wheel is braked in its maneuver by a friction assembly that further reduces the risks of disturbance. However, it is desirable to perfect again. Indeed, he remains a weak risk of accidental disturbance of the volume to be pipetted by an involuntary maneuver of the wheel.
On souhaite donc éliminer tout risque de dérèglement accidentel du volume à pipeter.We therefore wish to eliminate any risk of accidental disturbance of the volume to be pipetted.
Le document US-5 849 248 divulgue une pipette comprenant un élément de blocage mobile entre une position inactive dans laquelle il rend les moyens de réglage inaptes au réglage et une position active dans laquelle il les y rend aptes. Cet élément s'étend à proximité du bouton de réglage du volume. Aucun déréglage intempestif du volume à pipetter n'est donc plus à craindre.US-5,849,248 discloses a pipette comprising a movable locking element between a inactive position in which he makes the means of adjustment not suitable for setting and an active position in which he makes them fit. This element extends to near the volume control knob. No inadvertent adjustment of the volume to be pipetted is therefore not more to fear.
Un but de l'invention est de fournir une pipette d'un type différent mais évitant elle aussi le déréglage intempéstif. An object of the invention is to provide a pipette of a different type but also avoiding the maladjustment.
En vue de la réalisation de ce but, on prévoit selon l'invention une pipette de prélèvement comportant des moyens de réglage d'un volume de liquide à prélever comprenant au moins un organe de commande de réglage, la pipette comprenant un élément de blocage mobile entre une position inactive dans laquelle il rend les moyens de réglage inaptes au réglage et une position active dans laquelle il rend les moyens de réglage aptes au réglage, l'élément de blocage étant l'organe de commande de réglage.In order to achieve this goal, it is expected that according to the invention a sampling pipette comprising means for adjusting a volume of liquid to be sampled comprising at least one adjustment control member, the pipette comprising a movable locking element between an inactive position in which he makes the adjustment means not suitable for adjustment and a position active in which it makes the means of adjustment suitable for adjustment, the locking element being the setting control.
Ainsi, lorsque l'élément de blocage est en position inactive, aucun dérèglement accidentel du volume à pipeter n'est possible. De plus, cette élimination des risques de dérèglement permet en retour de supprimer ou de réduire le freinage à friction de la mollette, ce qui rend sa manoeuvre plus facile lors d'un réglage volontaire. Cette suppression est d'autant plus agréable qu'il pouvait arriver avec la pipette antérieure du document FR-2 696 110 que le gant du manipulateur se coince entre la mollette et le corps de la pipette lors de l'actionnement de la mollette. Cet inconvénient peut donc être lui aussi éliminé.So, when the blocking element is in inactive position, no accidental volume to be pipetted is not possible. In addition, this elimination of the risks of disruption allows in return to remove or reduce the friction brake of the wheel, making it easier to maneuver voluntary adjustment. This deletion is all the more nice that it could happen with the pipette document FR-2 696 110 that the glove of the manipulator gets stuck between the wheel and the body of the pipette when actuating the knob. This inconvenience can be eliminated.
De plus, la pipette selon l'invention permet à l'utilisation d'effectuer au moyen du seul élément de blocage toutes les opérations successives relatives au réglage, par exemple déverrouillage, réglage du volume et verrouillage.In addition, the pipette according to the invention allows use to perform by means of the single element of blocking all successive operations relating to setting, eg unlocking, volume control and lock.
L'invention pourra en outre présenter au moins l'une quelconque des caractéristiques suivantes :
- l'élément de blocage est mobile à coulissement entre les deux positions;
- l'élément de blocage est agencé pour être directement actionné de l'une à l'autre des deux positions par un utilisateur;
- l'élément de blocage s'étend à l'intérieur d'un corps de la pipette
- la pipette est agencée de sorte que l'élément de blocage est apte à transmettre un mouvement de réglage à un organe des moyens de réglage en position active, et est inapte à cette transmission en position inactive ;
- la pipette est agencée de sorte que l'élément de blocage est apte à transmettre un mouvement de l'un à l'autre de deux organes des moyens de réglage autres que l'élément de blocage en position active et est inapte à cette transmission en position inactive ;
- le mouvement est une rotation ;
- les moyens de réglage comprennent deux organes agencés pour être en crabotage mutuel lorsque l'élément de blocage est en position active et pour être désengagés l'un de l'autre lorsque l'élément de blocage est en position inactive ;
- la pipette comporte deux organes de commande de réglage;
- la pipette comporte un bouton de commande de prélèvement formant un organe de commande de réglage ;
- la pipette comporte des moyens de rappel de l'élément de blocage dans la position inactive;
- la pipette comporte des moyens pour maintenir l'élément de blocage dans la position active à l'encontre des moyens de rappel;
- la pipette est agencée de sorte que l'élément de blocage est apte à passer de la position active à la position inactive avec franchissement d'un point dur, et inversement, et
- les moyens de réglage comportent un organe moteur et un organe récepteur apte à être entraíné par l'organe moteur au moyen d'une liaison par complémentarité de forme, l'un des organes moteur et récepteur étant déformable de façon à interrompre la liaison lorsqu'il est soumis à une sollicitation d'intensité supérieure à une intensité prédéterminée.
- the locking element is slidably movable between the two positions;
- the locking element is arranged to be directly actuated from one to the other of the two positions by a user;
- the blocking element extends inside a body of the pipette
- the pipette is arranged so that the blocking element is able to transmit a control movement to a member of the adjustment means in the active position, and is unfit for this transmission in the inactive position;
- the pipette is arranged in such a way that the locking element is able to transmit a movement from one to the other of two members of the adjustment means other than the locking element in the active position and is unfit for this transmission by inactive position;
- the movement is a rotation;
- the adjustment means comprise two members arranged to be interconnected when the locking element is in the active position and to be disengaged from one another when the locking element is in the inactive position;
- the pipette comprises two adjustment control members;
- the pipette includes a sample control knob forming a regulating control member;
- the pipette comprises means for returning the blocking element in the inactive position;
- the pipette comprises means for holding the locking element in the active position against the return means;
- the pipette is arranged so that the blocking element is able to pass from the active position to the inactive position with crossing a hard point, and conversely, and
- the adjustment means comprise a motor member and a receiver member adapted to be driven by the motor member by means of a complementary fit connection, one of the motor and receiver members being deformable so as to interrupt the connection when it is subjected to a solicitation of intensity greater than a predetermined intensity.
D'autres caractéristiques et avantages de l'invention apparaítront encore dans la description suivante d'un mode préféré de réalisation et d'une variante donnés à titre d'exemples non limitatifs. Aux dessins annexés :
- la figure 1 est une vue partielle en coupe axiale d'une pipette selon un mode préféré de réalisation de l'invention;
- la figure 2 est une vue en perspective d'une partie du mécanisme de réglage de la pipette de la figure 1 ;
- la figure 3 est une vue à plus grande échelle du mécanisme de la figure 2 ;
- la figure 4 est une vue en section axiale du mécanisme de la figure 2 ;
- la figure 5 est une vue en perspective d'une sous-partie du mécanisme de la figure 2 ;
- la figure 6 est une vue en élévation de la sous-partie de la figure 5;
- la figure 7 est une vue en perspective du crabot et de l'entraíneur du mécanisme de la figure 4 ;
- les figures 8 à 11 sont quatre vues partielles en coupe axiale montrant différentes étapes de la coopération du bouton de réglage et du coupleur du mécanisme de la figure 4 ;
- la figure 12 est une vue en coupe transversale de la sous-partie de la figure 6 suivant le plan XII-XII;
- la figure 13 est une vue en coupe éclatée de certains éléments de la figure 12 ;
- la figure 14 est une vue en coupe de la vis de réglage seule;
- les figures 15 à 18 illustrent différentes étapes de la coopération des éléments de la figure 12 ; et
- la figure 19 est une vue analogue à la figure 12 montrant une variante de réalisation de l'invention.
- Figure 1 is a partial axial sectional view of a pipette according to a preferred embodiment of the invention;
- Figure 2 is a perspective view of a portion of the pipette adjustment mechanism of Figure 1;
- Figure 3 is an enlarged view of the mechanism of Figure 2;
- Figure 4 is an axial sectional view of the mechanism of Figure 2;
- Figure 5 is a perspective view of a subpart of the mechanism of Figure 2;
- Figure 6 is an elevational view of the subpart of Figure 5;
- Figure 7 is a perspective view of the clutch and the driver of the mechanism of Figure 4;
- Figures 8 to 11 are four partial views in axial section showing different stages of the cooperation of the adjusting knob and the coupler of the mechanism of Figure 4;
- Figure 12 is a cross-sectional view of the subpart of Figure 6 along the plane XII-XII;
- Figure 13 is an exploded sectional view of some elements of Figure 12;
- Figure 14 is a sectional view of the adjusting screw alone;
- Figures 15 to 18 illustrate different steps of the cooperation of the elements of Figure 12; and
- Figure 19 is a view similar to Figure 12 showing an alternative embodiment of the invention.
La pipette de prélèvement selon le présent mode de réalisation de l'invention est du même type que celle du document FR-2 696 110. On se référera donc à ce document pour certains détails de la pipette déjà connus de ce document. On ne décrira ici en détail que certains aspects du mécanisme de réglage du volume.The sampling pipette according to this mode of embodiment of the invention is of the same type as of document FR-2 696 110. It will therefore be referred to document for some details of the pipette already known from this document. We will describe here in detail only certain aspects of the volume adjustment mechanism.
La pipette 2 comprend classiquement un corps 2
servant de poignée à saisir par la main de
l'utilisateur. La pipette comporte un piston non
illustré mobile à coulissement suivant un axe
longitudinal 10 de la pipette dans une cavité
inférieure de la pipette afin d'aspirer dans celle-ci
un volume de liquide à prélever ou de l'expulser hors
de cette cavité. Le déplacement du piston est commandé
notamment au moyen d'une tige de commande 4 d'axe 10
reliée en partie inférieure au piston par des pièces
d'un type connu et non illustrées. Cette tige 4 est
surmontée à son extrémité supérieure par un bouton
poussoir 6 rigidement fixé à la tige, que l'utilisateur
peut actionner avec le pouce de la main tenant la
pipette. Ainsi le piston s'abaisse et remonte en
fonction du même mouvement du bouton. La pipette
comporte un ressort de rappel apte à replacer le piston
et la tige en partie haute à la fin de leur course vers
le bas pour l'expulsion du liquide, et un ressort de
purge ajoutant son effet à celui du précédent ressort
lorsque la course du piston se poursuit vers le bas
pour une course de purge.The
Le volume à pipeter durant une course normale
complète du piston, hors course de purge, peut être
réglé au moyen d'un bouton de réglage 8 en forme de
bague et du bouton-poussoir 6. Ces deux boutons sont
montés à rotation autour de l'axe longitudinal 10 de la
pipette. Une rotation de l'un ou l'autre de ces boutons
provoque la rotation d'une vis de réglage 5 coaxiale à
la tige 4 autour de son axe 10. La façon dont la
rotation de la vis 5 entraíne la variation du volume à
pipeter est connue et ne sera pas décrite. On va
maintenant décrire en détail la partie supérieure du
mécanisme de réglage.The volume to be pipetted during a normal race
complete piston, out of purge stroke, can be
adjusted by means of an
Toutes les pièces qui vont maintenant être
décrites ont l'axe 10 pour axe de symétrie, sauf
indication contraire.All the pieces that will now be
described have
En référence aux figures 1 à 4, la pipette
comporte un coupleur 12 monté à coulissement sur la
tige 4 mais fixe en rotation par rapport à celle-ci. A
cette fin, le coupleur présente un orifice supérieur
central présentant trois pattes 14 radiales s'engageant
dans trois gorges longitudinales 16 de la tige 4. Cet
orifice est formé par une rondelle supérieure 18 du
coupleur. Le coupleur comporte trois bras 20 s'étendant
vers le bas parallèlement à l'axe 10 à partir de la
rondelle 18. Chaque bras 20 est globalement aplati
suivant la direction radiale à l'axe 10 et présente sur
sa face 22 opposée à l'axe un relief 24 allongé suivant
la direction circonférentielle à l'axe 10.With reference to FIGS. 1 to 4, the pipette
comprises a
Le bouton de réglage 8 est mobile à coulissement
suivant l'axe 10 et à rotation autour de cet axe. Il
présente une forme essentiellement cylindrique d'axe
10. La face externe 26 de ce bouton est accessible à
l'utilisateur pour sa manoeuvre à travers des fenêtres
du corps. Elle comporte à cette fin des reliefs de
préhension. Près de son bord circulaire supérieur, le
bouton 8 comporte trois fourches 30 s'étendant en
saillie radiale en direction de l'axe. Ces fourches
présentent une forme femelle en « U » ouverte en
direction de l'axe, de forme complémentaire au profil
des bras 20 et recevant ceux-ci respectivement.The
Il découle de cet agencement que le bouton 8 est
fixé en rotation au coupleur 12 mais n'y est pas fixé
en coulissement. Le bouton 8 peut occuper d'une part
une position basse, ou position inactive, ou position
verrouillée, et d'autre part une position haute ou
active ou déverrouillée. Ces deux positions sont
indépendantes de la position angulaire du bouton 8
autour de l'axe. Le bouton passe de l'une à l'autre
position par coulissement suivant l'axe. Le coupleur 12
comporte un ressort annulaire 26 d'axe 10 sollicitant
radialement les bras 20 sur leur face interne pour
tendre à les éloigner radialement de l'axe.It follows from this arrangement that
En position basse, comme illustré aux figures 1-4
et 8, les bras 20 sont reçus dans les fourches mais pas
les reliefs 24. Il en est de même en position haute,
comme illustré à la figure 11. Au cours du mouvement de
passage de l'une à l'autre position, illustré aux
figures 8 à 11, les reliefs 24 passent dans les
fourches et provoquent la flexion temporaire des bras
20 en direction radiale. Ce passage produit un clic
sonore et constitue un point dur lors de la manoeuvre
qui manifestent pour l'utilisateur le changement de
position haute ou basse. De plus, les reliefs 24
maintiennent le bouton en position haute à l'encontre
du ressort de rappel, sauf action contraire de
l'utilisateur.In the low position, as shown in Figures 1-4
and 8, the
En référence aux figures 1, 4 et 7, la pipette
comporte un crabot 32 de forme générale cylindrique
présentant une nervure périphérique annulaire externe
34 à mi-hauteur environ. Le bouton 8 comporte deux
pièces cylindriques 8a et 8b inférieure et supérieure
emmanchées à force extérieurement sur le crabot 32 et
en appui axial sur la nervure 34. Le bouton 8 est
rigidement fixé au crabot. Le crabot présente sur sa
face externe, illustrée en détail sur la figure 7, des
reliefs coopérant avec des reliefs complémentaires du
bouton pour assurer ces liaisons rigides. Le crabot 32
comporte une denture 36 s'étendant près de son bord
supérieur, en saillie radiale de sa face interne en
direction de l'axe.With reference to FIGS. 1, 4 and 7, the pipette
has a clutch 32 of generally cylindrical shape
having an outer annular
La pipette comporte un entraíneur 38 présentant
une partie supérieure 40 de forme cylindrique munie de
plusieurs dents 42, par exemple au nombre de deux,
s'étendant près de son bord supérieur, en saillie
radiale de sa face externe en direction opposée à
l'axe. Ces deux dents sont aptes à venir en prise avec
la denture 36 du crabot lorsqu'elles s'étendent à la
même hauteur que celle-ci le long de l'axe 10. The pipette comprises a
L'entraíneur 38 peut être rendu mobile par rapport
à la vis de réglage 5. Il s'étend directement en regard
de celle-ci radialement. Contrairement à la vis de
réglage 5 qui est mobile suivant un mouvement
hélicoïdal autour de l'axe 10, l'entraíneur 38 est fixe
à coulissement suivant l'axe 10 par rapport au corps de
la pipette. Il est bloqué à cette fin en partie
supérieure par une entretoise 44 et en partie
inférieure par une pièce 46 illustrées à la figure 1.The
En référence notamment aux figures 5, 6 et 12,
l'entraíneur 38 comporte deux pattes principales 48 et
deux pattes secondaires 50 s'étendant parallèlement à
l'axe 10 vers le bas à partir de la partie supérieure
40. Les pattes secondaires 50 ont une forme en secteur
de cylindre d'axe 10. Elles sont alternées autour de
l'axe avec les pattes principales 48. Les pattes
principales 48 ont une face externe cylindrique et
présentent une face interne plane en saillie radiale de
laquelle s'étend une nervure 52 profilée parallèlement
à l'axe 10 et à section rectangulaire. L'entraíneur 38
comporte un ressort 54 encerclant extérieurement les
quatre pattes 48, 50 et logé dans une encoche externe
de celles-ci. Le ressort tend à rapprocher les pattes
radialement de l'axe.With particular reference to FIGS. 5, 6 and 12,
the
La vis de réglage 5 est creuse et traversée
longitudinalement par la tige de commande 4. Ces deux
pièces sont totalement indépendantes dans leur
mouvement relatif. La vis de réglage 5 a une forme
générale circulaire de révolution. Toutefois, plus
précisément, elle présente deux méplats 56 parallèles
l'un à l'autre et à l'axe 10 et opposés de part et
d'autre de cet axe. Ces méplats s'étendent sur une
portion médiane 58 de la vis s'étendant au-dessus d'une
portion inférieure filetée 60 de la vis servant au
réglage du volume. Ces méplats 56 sont joints l'un à
l'autre par des arcs de cercle 61. La vis de réglage
présente en outre deux ergots longitudinaux 62
parallèles à l'axe 10, s'étendant au bord des méplats
respectifs de façon à présenter une butée lorsqu'on
parcourt circonférentiellement la face externe de la
vis 5 à partir des méplats, mais aussi de façon à
présenter un arc de cercle ne formant pas une butée à
partir des zones cylindriques 61.The adjusting
Les deux ergots 62 ne sont pas symétriques l'un de
l'autre par rapport à l'axe 10 mais le sont par rapport
à un plan médian de la vis parallèle aux deux méplats.
De plus, les deux ergots 62 ne s'étendent pas
exactement en coïncidence en ce qui concerne leur
position le long de l'axe 10. Ils se chevauchent sur un
certain tronçon. Mais l'un des ergots s'étend plus haut
que l'autre alors que ce dernier s'étend vers le bas
davantage que le premier. Aussi, les deux ergots sont-ils
en chevauchement partiel le long de l'axe 10. La
position longitudinale du deuxième ergot, normalement
caché sur la figure 6, a toutefois été indiquée par le
trait 56.The two lugs 62 are not symmetrical one of
the other relative to
L'entraíneur 38 peut être couplé à la vis 5 en
rotation, ou désaccouplé de celle-ci.The
Lorsqu'il est couplé, comme sur les figures 12 et
15, l'entraíneur est situé à un niveau de la vis sur
lequel se chevauchent les deux ergots 62. Les pattes
secondaires 48 sont en appui sur les zones cylindriques
61 dont elles épousent la forme. Elles réalisent avec
celles-ci un contact surface contre surface. Les
nervures 52 sont en appui radial sur les méplats 56 et
en butée sur les ergots 62 respectifs. Le ressort 54
maintient les quatre pattes en appui sur la vis 5 et
notamment maintient la prise des nervures sur les
ergots. Par conséquent, un mouvement à rotation de
l'entraíneur 38 peut être transmis à la vis de réglage
5. Comme l'entraíneur est fixe à coulissement le long
de l'axe à la différence de la vis 5, cette rotation
produit le coulissement de la vis le long de l'axe, la
vis ayant un mouvement hélicoïdal. Les deux pièces sont
ainsi couplées à rotation autour de l'axe au moyen de
forces de friction et surtout au moyen des ergots et
nervures. La transmission du couple a donc lieu même en
présence d'un fort couple résistant.When coupled, as in Figures 12 and
15, the coach is located at a level of the screw on
which overlap the two
Les ergots 62 sont positionnés de sorte qu'au
voisinage de chaque position de fin de course haute et
basse de la vis de réglage 5, l'ergot qui assure la
transmission du mouvement en direction de cette butée
s'interrompt, comme illustré sur les figures 14 à 18.
Dès lors, sur toute la plage de mouvement restant à
parcourir jusqu'à atteindre la position de butée, la
transmission du couple ne se fait plus que grâce aux
forces de friction des pattes sur la vis. Dans ces
conditions, cette transmission n'a lieu que si
l'intensité des forces de liaison, et donc l'intensité
du couple résistant, est inférieure à une valeur
prédéterminée fonction du ressort 54. Cette
transmission a néanmoins lieu, de sorte que
l'utilisateur peut continuer à manoeuvrer (indirectement
comme on le verra plus loin) l'entraíneur 38 pour
entraíner la vis 5. Dès que la vis 5 arrive en fin de
course de réglage, le couple résistant devient
infiniment grand et interrompt la liaison par les
forces de friction. Malgré l'effet de rappel du ressort
54, les pattes principales 48 s'écartent alors pour
quitter les méplats et arriver sur les zones 61 pour
suivre la forme de la vis et l'entraíneur 38 tourne
seul. La vis de réglage 5 n'est donc pratiquement plus
sollicitée et reste immobile. Le filet 60 de la vis 5
est donc protégé à l'égard des sollicitations
excessives.The
Si l'utilisateur veut actionner la vis 5 dans
l'autre sens à partir de cette position, il lui suffit
d'actionner l'entraíneur 38 dans l'autre sens. Avant
moins d'un demi-tour, l'une des nervures 52 rencontre
l'autre ergot 62 et les deux pièces sont à nouveau
liées à rotation dans l'autre sens. Le même
fonctionnement a lieu au voisinage de l'autre extrémité
de la course de réglage.If the user wants to operate the
On va maintenant décrire le fonctionnement du
bouton de réglage 8.We will now describe the operation of the
La position basse, inactive, verrouillée, du
bouton est illustrée aux figures 1, 3 et 4. Les bras 20
sont en prise avec le bouton 8. La tige 4 est donc
solidaire en rotation du bouton 8. Dans cette position,
les dents 36 du crabot sont hors de prise avec les
dents 42 de l'entraíneur 38. Aucun mouvement du bouton
8 n'entraíne donc en rotation l'entraíneur 38 ou la vis
5. Cette position basse du bouton 8 inactive donc les
moyens de réglage. Le volume à pipeter ne peut donc pas
être modifié volontairement ou involontairement. Les
mentions « verrouillé » ou « locked » inscrites sur la
face externe 26 du bouton 8 apparaissent dans la
fenêtre à destination de l'utilisateur. Un ressort de
rappel 60 illustré à la figure 1 prenant appui
axialement vers le haut sur le coupleur 12 et vers le
bas sur le bouton 8 sollicite ce dernier pour le
maintenir dans cette position basse.The low, inactive, locked position of
button is illustrated in Figures 1, 3 and 4. The
Si l'utilisateur souhaite régler le volume, il
fait coulisser le bouton 8 vers le haut à l'encontre du
ressort 60 de sorte que les fourches 30 franchissant
les reliefs 24 produisent un clic et un point dur. Le
bouton est alors dans la position supérieure, active,
déverrouillée. Il est maintenu dans cette position par
les reliefs 24, sauf action contraire de l'utilisateur.
Dans cette position, les dents 36 du crabot sont en
prise avec les dents 42 de l'entraíneur 38. Une
sollicitation directe du bouton 8 ou du bouton 6 à
rotation exercée par l'utilisateur est donc transmise
par les dents 36, 42 à l'entraíneur 38, puis à la vis
de réglage 5 dans la mesure où celle-ci n'est pas déjà
en fin de course pour le sens de réglage souhaité.
Lorsque le volume de prélèvement souhaité est réglé,
l'utilisateur fait à nouveau coulisser le bouton 8 dans
la position basse pour empêcher un déréglage
intempestif.If the user wants to adjust the volume, he or she
slide the
On remarque, dans la pipette qui vient d'être
décrite, que le serrage de l'entraíneur 38 sur la vis 5
et donc leur embrayage ou débrayage se font
automatiquement et non par l'action directe de
l'utilisateur sur ces pièces. De plus, l'utilisateur
n'actionne jamais directement la vis de réglage 5.We notice, in the pipette that has just been
described, that the tightening of the
On pourra prévoir que des deux éléments 5, 38,
celui qui est déformable pour interrompre leur liaison
est la vis 5. It can be expected that two
On a illustré à la figure 19 une variante de réalisation dans laquelle les éléments analogues ont des références numériques augmentées de 100. La tige 104 n'a pas été illustrée.FIG. 19 illustrates a variant of realization in which analogous elements have numerical references increased by 100. The stem 104 has not been illustrated.
Dans cette variante, les nervures 152 ont un
profil en « V » à pointe arrondie. Les méplats 156 sont
remplacés par des rainures 156 à profil en « V » de
même angle que celui des nervures pour permettre
l'entraínement de la vis 105 par l'entraíneur 138. Au
voisinage des positions de butée, les rainures
respectives s'élargissent en accentuant l'inclinaison
de l'une de leurs deux faces. Cette face forme une
rampe. La pipette est agencée de sorte que, lorsque la
position de fin de course est atteinte, la force de
serrage du ressort est insuffisante pour maintenir les
nervures 152 dans les rainures 156. La rampe provoque
alors la sortie des nervures hors des rainures et
l'écartement des pattes principales 148, de sorte que
l'entraíneur n'entraíne plus la vis et continue à
tourner seul.In this variant, the
La pipette pourra comprendre des moyens
électroniques d'affichage (par exemple à cristaux
liquides) d'un paramètre relatif au fonctionnement de
la pipette. Par exemple, ces moyens pourront indiquer
en permanence l'état verrouillé ou déverrouillé du
bouton 8.The pipette may include means
electronic displays (eg crystal
of a parameter relating to the operation of
the pipette. For example, these means may indicate
permanently locked or unlocked state of
Claims (13)
- Sampling pipette comprising means (6, 12, 8, 38, 5) for adjusting a volume of liquid to be sampled, comprising at least one adjustment control member, the pipette comprising a blocking element (8) able to move between an inactive position in which it renders the adjusting means unable to adjust and an active position in which it renders the adjusting means able to adjust, the blocking element being the adjustment control member, characterized in that the pipette is arranged in such a way that the or each adjustment control member can move while remaining in the inactive position.
- Pipette according to Claim 1, characterized in that the blocking element (8) can move in sliding between the two positions.
- Pipette according to Claim 1 or 2, characterized in that the blocking element (8) extends inside a body of the pipette.
- Pipette according to any one of Claims 1 to 3, characterized in that it is arranged in such a way that the blocking element (8) is able to transmit an adjusting movement to a member (38) of the adjusting means in the active position, and is unable to transmit in this way in the inactive position.
- Pipette according to any one of Claims 1 to 4, characterized in that it is arranged in such a way that the blocking element (8) is able to transmit a movement from one (12) to the other (38) of two members of the adjusting means other than the blocking element in the active position, and is unable to transmit in this way in the inactive position.
- Pipette according to either one of Claims 4 and 5, characterized in that the movement is a rotation.
- Pipette according to any one of claims 1 to 6, characterized in that the adjusting means comprise two members (8, 38) arranged to mesh together when the blocking element (8) is in an active position and to be disengaged from one another when the blocking element is in an inactive position.
- Pipette according to any one of claims 1 to 7, characterized in that the pipette has two adjustment control members (6, 8).
- Pipette according to any one of claims 1 to 8, characterized in that it comprises a sampling control knob (6) forming an adjustment control member.
- Pipette according to any one of claims 1 to 9, characterized in that it comprises return means (60) for returning the blocking element (8) to the inactive position.
- Pipette according to Claim 10, characterized in that it comprises means (24) for holding the blocking element (8) in the active position against the action of the return means (60).
- Pipette according to any one of Claims 1 to 11, characterized in that it is arranged in such a way that the blocking element is able to move from the active position to the inactive position passing through a hard point.
- Pipette according to any one of Claims 1 to 12, characterized in that the adjusting means comprise a drive member (38) and a receiving member (5) able to be driven by the drive member at least by means of a connection through complementing shapes, one (38) of the drive and receiving members being deformable in such a way as to break the connection when subjected to stress of an intensity greater than a predetermined intensity.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK01921520T DK1268067T3 (en) | 2001-04-09 | 2001-04-09 | Liquid withdrawal pipette provided with means for controlling the withdrawal volume |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0004473A FR2807343B1 (en) | 2000-04-07 | 2000-04-07 | COLLECTION PIPETTE PROVIDED WITH MEANS FOR ADJUSTING THE VOLUME TO BE COLLECTED |
FR0004473 | 2000-04-07 | ||
PCT/FR2001/001068 WO2001076748A1 (en) | 2000-04-07 | 2001-04-09 | Pipette provided with sampled volume adjusting means |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1268067A1 EP1268067A1 (en) | 2003-01-02 |
EP1268067B1 true EP1268067B1 (en) | 2004-06-30 |
Family
ID=8848995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01921520A Expired - Lifetime EP1268067B1 (en) | 2000-04-07 | 2001-04-09 | Pipette provided with sampling volume adjusting means |
Country Status (15)
Country | Link |
---|---|
US (1) | US6959616B2 (en) |
EP (1) | EP1268067B1 (en) |
JP (1) | JP4728554B2 (en) |
KR (1) | KR100687591B1 (en) |
CN (2) | CN1182921C (en) |
AT (1) | ATE270150T1 (en) |
AU (2) | AU2001248498B2 (en) |
CA (1) | CA2404717C (en) |
DE (1) | DE60104099T2 (en) |
ES (1) | ES2221894T3 (en) |
FR (1) | FR2807343B1 (en) |
MX (1) | MXPA02009882A (en) |
PT (1) | PT1268067E (en) |
RU (1) | RU2274489C2 (en) |
WO (1) | WO2001076748A1 (en) |
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US5792424A (en) * | 1996-03-05 | 1998-08-11 | Rainin Instrument Co., Inc. | Manual pipette with delayed-action home position latch |
FI961649A0 (en) * | 1996-04-15 | 1996-04-15 | Labsystems Oy | Spaerrpipett |
US5983733A (en) * | 1996-11-15 | 1999-11-16 | Hamilton Company | Manual pipette |
US5958343A (en) * | 1997-12-29 | 1999-09-28 | Astle; Thomas W. | Small volume pipettor |
US6295880B1 (en) | 1999-12-08 | 2001-10-02 | Warren E. Gilson | Adjustable pipette |
US6532837B1 (en) * | 2000-02-03 | 2003-03-18 | Rainin Instrument, Llc | Pipette device with tip ejector utilizing stored energy |
FR2807341B1 (en) * | 2000-04-07 | 2002-07-12 | Gilson Sa | PIPETTE FOR COLLECTING LIQUID SAMPLES WITH REMOVABLE EJECTOR |
FR2807558B1 (en) | 2000-04-07 | 2004-04-02 | Gilson Sa | PIPETTE FOR SAMPLING PROVIDED WITH MEANS FOR DISPLAYING A PARAMETER OF THE PIPETTE |
FR2807339B1 (en) | 2000-04-07 | 2002-12-13 | Gilson Sa | PIPETTE FOR TAKING LIQUID SAMPLES WITH ADJUSTABLE EJECTOR |
FR2807340B1 (en) | 2000-04-07 | 2002-12-06 | Gilson Sa | PIPETTE FOR TAKING LIQUID SAMPLES WITH CONE EJECTOR MECHANISM |
FR2807343B1 (en) | 2000-04-07 | 2002-12-06 | Gilson Sa | COLLECTION PIPETTE PROVIDED WITH MEANS FOR ADJUSTING THE VOLUME TO BE COLLECTED |
FR2807345B1 (en) | 2000-04-07 | 2002-07-12 | Gilson Sa | SIMPLIFIED DISASSEMBLY PIPETTE |
FR2807342B1 (en) | 2000-04-07 | 2002-07-12 | Gilson Sa | CONCEAL EJECTOR PIPETTE |
FIU20010274U0 (en) * | 2001-07-06 | 2001-07-06 | Biohit Oyj | The suction device |
US6532877B1 (en) * | 2002-01-22 | 2003-03-18 | Stanrail Corporation | Railroad car roof panel and skylight assembly |
-
2000
- 2000-04-07 FR FR0004473A patent/FR2807343B1/en not_active Expired - Fee Related
-
2001
- 2001-04-09 ES ES01921520T patent/ES2221894T3/en not_active Expired - Lifetime
- 2001-04-09 JP JP2001574257A patent/JP4728554B2/en not_active Expired - Fee Related
- 2001-04-09 DE DE60104099T patent/DE60104099T2/en not_active Expired - Lifetime
- 2001-04-09 AU AU2001248498A patent/AU2001248498B2/en not_active Ceased
- 2001-04-09 AU AU4849801A patent/AU4849801A/en active Pending
- 2001-04-09 WO PCT/FR2001/001068 patent/WO2001076748A1/en active IP Right Grant
- 2001-04-09 AT AT01921520T patent/ATE270150T1/en not_active IP Right Cessation
- 2001-04-09 KR KR1020027013413A patent/KR100687591B1/en not_active IP Right Cessation
- 2001-04-09 EP EP01921520A patent/EP1268067B1/en not_active Expired - Lifetime
- 2001-04-09 CN CNB018076157A patent/CN1182921C/en not_active Expired - Fee Related
- 2001-04-09 PT PT01921520T patent/PT1268067E/en unknown
- 2001-04-09 MX MXPA02009882A patent/MXPA02009882A/en active IP Right Grant
- 2001-04-09 US US10/240,428 patent/US6959616B2/en not_active Expired - Lifetime
- 2001-04-09 CA CA002404717A patent/CA2404717C/en not_active Expired - Fee Related
- 2001-04-09 RU RU2002126277/04A patent/RU2274489C2/en active
- 2001-04-09 CN CN2004100929300A patent/CN1607382B/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
MXPA02009882A (en) | 2004-05-05 |
CN1607382B (en) | 2013-03-27 |
FR2807343A1 (en) | 2001-10-12 |
JP2003530551A (en) | 2003-10-14 |
KR100687591B1 (en) | 2007-02-28 |
US20040035228A1 (en) | 2004-02-26 |
WO2001076748A1 (en) | 2001-10-18 |
AU4849801A (en) | 2001-10-23 |
RU2274489C2 (en) | 2006-04-20 |
ATE270150T1 (en) | 2004-07-15 |
US6959616B2 (en) | 2005-11-01 |
CN1422182A (en) | 2003-06-04 |
DE60104099T2 (en) | 2005-06-30 |
AU2001248498B2 (en) | 2005-06-16 |
CN1607382A (en) | 2005-04-20 |
CN1182921C (en) | 2005-01-05 |
CA2404717C (en) | 2009-11-10 |
KR20020088433A (en) | 2002-11-27 |
JP4728554B2 (en) | 2011-07-20 |
FR2807343B1 (en) | 2002-12-06 |
DE60104099D1 (en) | 2004-08-05 |
PT1268067E (en) | 2004-11-30 |
CA2404717A1 (en) | 2001-10-18 |
ES2221894T3 (en) | 2005-01-16 |
EP1268067A1 (en) | 2003-01-02 |
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