EP1255502B1 - Elements chirurgicaux maxillo-faciaux avec motifs de repetition microgeometriques ordonnes - Google Patents

Elements chirurgicaux maxillo-faciaux avec motifs de repetition microgeometriques ordonnes Download PDF

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Publication number
EP1255502B1
EP1255502B1 EP01908781.6A EP01908781A EP1255502B1 EP 1255502 B1 EP1255502 B1 EP 1255502B1 EP 01908781 A EP01908781 A EP 01908781A EP 1255502 B1 EP1255502 B1 EP 1255502B1
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EP
European Patent Office
Prior art keywords
pattern
recited
grooves
implant
bone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP01908781.6A
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German (de)
English (en)
Other versions
EP1255502A2 (fr
EP1255502A4 (fr
Inventor
John Ricci
Harold Alexander
Charles Di Naiman
Bruce L. Hollander
Ingo Kozak
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Evollution IP Holdings Inc
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Evollution IP Holdings Inc
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Application filed by Evollution IP Holdings Inc filed Critical Evollution IP Holdings Inc
Priority to EP12157708.4A priority Critical patent/EP2921129B1/fr
Publication of EP1255502A2 publication Critical patent/EP1255502A2/fr
Publication of EP1255502A4 publication Critical patent/EP1255502A4/fr
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A—HUMAN NECESSITIES
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    • A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
    • A61C8/0034—Long implant, e.g. zygomatic implant
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    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0026—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in surface structures
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    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
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    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
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    • A61F2310/00598—Coating or prosthesis-covering structure made of compounds based on metal oxides or hydroxides
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
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    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses

Definitions

  • the present disclosure relates to the provision of ordered repeating micro-geometric patterns to bone and tissue interface zones of dental implants, to effect enhanced adhesion to soft tissue and osseointegration of an implant to bone.
  • Substrates containing grooves of different configurations and sizes have been shown to have orientating effects on fibroblasts and substrates containing grooves of varying depth have been shown to have different degrees of effect on individual cell orientation establishing that grooved surfaces can modulate cell orientation in vitro and can cause oriented cell and tissue growth in vivo.
  • fibrous tissue forms strong interdigitations with relatively large grooves in the range of about 140 ⁇ m and can result in an effective barrier against soft tissue downgrowth perpendicular to the grooves. It has also been shown that smaller grooves on the order of about 3-22 ⁇ m were more effective in the contact guidance of individual cells. D.M. Brunette, et al. Development, supra; P. Clark et al, supra.
  • the current methods used to texture the surfaces of dental implant elements typically employ sand, glass bead and alumina grit blasting techniques, and acid etching techniques, of the implant surface.
  • compressed air is generally used to drive a blasting medium onto the implant surface at a high velocity to deform and, in some instances, remove portions of the implant surface.
  • the surface texture obtained depends upon the size, shape and hardness of the implant material and on the velocity at which the blasting medium is driven onto the implant surface.
  • the most common surfaces produced by sand or glass bead blasting are matte or satinfinish, while alumina grit blasting produces a random roughened surface.
  • etching techniques a pattern or mask is placed upon that surface of the implant desired not to be texturized.
  • the exposed parts are then typically treated with an acid that corrodes the exposed surface of the implant whereupon the acid treated surface is washed or neutralized with an appropriate solvent and the pattern or mask is removed.
  • Illustrative of the sand or glass bead blasting technique is the method disclosed in U.S. Pat. No. 5,057,208 to H.R. Sherry, et al wherein the implant surface is shot blasted with metal shot followed by glass bead blasting and then electropolishing.
  • an acid etching technique is the method disclosed in U.S. Pat. No. 4,778.469 to R.Y. Lin, et al wherein an acid soluble (e.g. aluminum or zinc) space occupier is used.
  • the space occupier contains the pattern to be transferred to the implant surface and is placed on the desired portion of the implant surface that is to be texturized. The space occupier is pressed into the implant surface and is then removed by treating it with acid.
  • U.S. Patent No. 4,752,294 (1988) to Lundgren refers to tissue ingrowth channels and openings having a dimension of about 30 microns. Accordingly, the dimension of interest to Lundgren is well in excess of the maximum dimension (25 microns) of concern in the present disclosure. Further, the teaching of Lundgrin is fundamentally that of a guide or element, of substantially three-dimensional character, for facilitating directed tissue regeneration. The present disclosure relates only to surface textures and does not address tissue regeneration.
  • U.S. Patent No. 4,553.272 (1985) to Mears relates, as in Van Recum above, to the development of porous implants having pore sizes in a range of 25 to 400 microns, that is, a minimum range which is well in excess of the maximum range applicable to the ordered microgeometric repetitive surface patterns taught herein. Also, in view of the large dimension of the channels taught by Mears, no relationship exists or is suggested between cell size, structure size, and cellular control resultant thereof.
  • U.S. Patent No. 5,004,475 (1991) to Vermeire relates to a hip prosthesis having channels or grooves which, similarly, to Mears, are intended to promote tissue ingrowth but which do not correlate between surface microgeometry, cell size, and cell growth. Further Vermeire does not teach any preferred structure or dimension for the channels or grooves thereof.
  • Patents such as U.S. Patent No. 5,094,618 (1992) to Sullivan and 5,316,478 (1994) to Chalifoux teach the use of threaded dental post for endodontic use in association with dental restorations and improved securement between the restoration and a surviving tooth portion.
  • Such references employ substantially random projections of a dimension much greater than that contemplated by the present disclosure, however, primarily differ from the in instant disclosure from the lack of teaching of ordered, repetitive, surface patterns within the applicable range in order to obtain advantageous characteristic of growth of colonies of cell at the interface between a maxillofacial bone and/or tissue and a dental implant and/or abutment element.
  • Bone tissue is the rigid supporting tissue constituting the principal component of almost all adult vertebrate skeletal structures. It exists in either dense or spongy form, known respectively as compact and cancellous bone.
  • the typical bone cell size is of the order of about 10,000 nm, that is 10 microns.
  • Bone tissue consists of a chemical mixture of inorganic salts (65 to 70 percent) and various organic substances (30 to 35 percent) and is both hard and elastic. Its hardness is derived from inorganic constituents, principally calcium phosphate and calcium carbonate, with small amounts of fluorides, sulfates, and chlorides; its elasticity is derived from such organic substances as collagen, elastic cellular material, and fats.
  • Internal tubular structures called Haversian canals contain nerve tissues and blood vessels that provide bones with organic nourishment. Surrounding these canals is a somewhat porous tissue composed of thin plates, known as lamellae, and usually containing cavities filled with a network of connective tissue called marrow or myeloid tissue.
  • Bone marrow accounts for from 2 to 5 percent of the body weight of a person and consists of tissue of two types. Yellow bone marrow is made up principally of fat, and red bone marrow is tissue in which red and white blood cells and blood platelets originate.
  • the external portions of bones, enclosing all the components mentioned above, include the compact and hardest of all bone tissue, which is in turn generally sheathed by a vascular, fibrous membrane known as the periosteum.
  • implants of this disclosure comprise a plurality of separate zones of textured surface, each zone containing a different repetitive microgeometric design or pattern which is presented and exposed to the particular cell type for development of its unique colony growth.
  • These different repetitive microgeometric textured design surfaces are intended to:
  • the implants of the disclosure can be provided from suitable and acceptable materials that are commercially available such as cast or wrought cobalt and chrome alloys, various grades of commercial titanium, titanium alloys, stainless steel alloys, thermoplastic resins such as polyethyletherketone, polyphenylene sulfide, ceramics, alumina, as well as combinations thereof.
  • a surface consisting of 1 2 - p groove and ridges has been shown to increase the RBM (rat bone marrow) to RTF (rat tendon fibroblast) cell colony growth ratio to encourage bone cell growth over fibrous tissue growth.
  • RBM rat bone marrow
  • RTF rat tendon fibroblast
  • the ratio of bone to soft tissue colony area increase, on a given surface is an important parameter in surface selection.
  • the ratio indicates the relative stimulation or inhibition of cell growth on these surfaces. Theoretically, this ratio would be significant to provide advantage for growth of one or another cell type on a surface, with high ratios favoring bone cell growth and low ratios favoring fibrous tissue growth. Based on these ratios, a 2-micron indentation or groove provided a 32.8% decrease in bone/soft tissue growth, providing a significant advantage in soft cell tissue growth.
  • the surface could be used to increase fibrous tissue cell growth; it can also be used to significantly orient growth of these cells.
  • a 4-micron indentation or groove surface provided a similar ratio, but it is based on lower overall growth rates. Therefore, if non-oriented fibrous cell growth is required, a flat control surface provides an inherent advantage to RTF tissue cells at a ratio of bone to soft tissue cell growth of approximately 0.6. This effect has been observed in vivo where smooth surfaces have been shown to favor formation of thick fibrous tissue capsule formation as compared to textured surfaces of the same composition, which show less fibrous capsule formation and more extensive osseointegration.
  • the surface having the highest ratio of bone to soft tissue cell growth is the 12- ⁇ m/micron indentation or groove substrate.
  • the basis of the ratio is the fact that this surface inhibits soft tissue colony growth by 53.1 % relative to controls. This is close to the maximal suppression of soft tissue cell growth seen on such microgeometrics. The same surface, however, does not maximally suppress bone cell growth (46.3% suppression relative to controls). The differential suppression results in a 14.4% increase in bone/soft tissue growth relative to the control ratio. Where both cell types are present and compete for growth, this provides a significant advantage to bone colony growth. Bone cells grown on this surface also exhibits greatly enhanced directional growth in the x-axis. Such an in vivo surface favors bone over soft tissue growth and can be used to conduct directional bone growth.
  • the textured substrates were further studied to determine the preferable substrates and their structure for control of cell growth.
  • the study was conducted to determine the effect of a range of grooves on the control of cell growth.
  • the experimental surfaces were observed to cause oriented cell attachment and migration, resulting in elongated colony growth, which was accelerated in the x-direction (parallel to the axis of surface microgeometry) and inhibited in the y-direction (perpendicular to the axis of surface microgeometry).
  • the cells appeared to be "channelled” in the x-direction, as compared with control culture where outgrowing cells move randomly on flat surfaces.
  • the most efficient "channelling” was observed on the 6- ⁇ m and 8 ⁇ m surfaces. On these surfaces, both hard and soft cell types were observed to attach and orient within the grooves. This resulted in enhanced x-axis growth and almost no y-axis growth by both cell types on these surfaces.
  • a dental implant system which includes at least an implant element and, in a given application, an abutment element, may be selectably surfaced in the fashion illustrated in Figs. 1 thru 6 which show a variety of patterns which may comprise ordered microgeometric, repetitive surface patterns, and which may be applied to materials inclusive of titanium, stainless steel, plastics, ceramics, biocompatible glass and combinations thereof which materials may be coated with coatings inclusive hydroxyapatite, RBM roughening, titanium, plasma sprayed, calcium sulfate, biocompatible glass, collagen, growth factor compounds, and combination thereof. More particularly, with reference to Fig.
  • the subject ordered microgeometric repetitive patterns may take the form of a multiplicity of alternating grooves 10 and ridges12 in which each respective ridge and groove displays a width between about 6.0 to about 25 microns and a depth in a range between about 2 to about 25 microns.
  • an infinite repeating pattern of co-parallel linear ridges and grooves having substantially equal width defines a micro textured surface of an implant or substrate as contemplated by the instant disclosure.
  • a surface in which alternating ridges 14 and grooves 16 increase y-axis in width with reference to a transverse axis relative to the axis of said ridges and grooves. Accordingly, with reference to types of tissues with which a transition of tissue type or gradient of tissue density exists, a textured surface of the type of Fig. 2 may be employed.
  • ridges 18 take the form of projections while grooves 20 take the form of recesses to thereby define a checkerboard configuration.
  • ridges and grooves alternate with reference to both a x and y-axes of a given surface.
  • Fig. 4 differs from that of Fig. 3 in that ridges 22 thereof form a bi-axial linear pattern. Similarly, grooves 24 of the embodiment of Fig. 4 define a x-y matrix formed of recesses that may assume a number of geometrics.
  • Fig. 5 is shown embodiment of the disclosure in which circular depressions 26 define grooves or depressions while the areas therebetween, namely, spaces 28 define ridges or projections.
  • alternating ridges and grooves, " as used herein, encompasses a variety of microtexturized geometric patterns in which the ridges and grooves thereof while alternating relative to each other may themselves comprise any one of a variety of geometries inclusive of channels, rectangles, parallelograms, squares, circles and ovals.
  • FIG. 6 there is shown a grid like arrangement in which grooves 30 define an xy matrix which is etched into a surface 32 such that surface 32, when viewed relative to etched grooves 30, comprises ridges.
  • the width (or diameter) of a given groove need not correspond to that of its respective ridge, providing such widths fall within the above-referenced range of about 2 to 25 microns with a depth in a range of about 2 to about 25 microns.
  • a micro-geometric repetitive pattern within the scope of the present disclosure may define a guide for preferential promotion of the rate, orientation and directionality of growth of colonies of cells of maxillofacial bone or tissue without requirement that the width of a ridge be equal to that of a groove in that it is, essentially, the groove of the microtexturized surface that defines the guide for preferential promotion of growth of colonies of cells.
  • FIG. 7 thru 14 there is shown diagrammatic cross-sections which may be employed in association with the microgeometric textured configurations above described with reference to Figs. 1 thru 6 .
  • the views of Figs, 7 thru 14 illustrate the range of geometries which may be defined within the yz plane of the surface patterns.
  • Figs. 7 thru 9 show variations in ridge width a, ridge and groove height b, and groove width c.
  • ridge height will equal groove depth.
  • Parameter d is the sum of ridge and groove width.
  • Fig. 7 The right side of Fig. 7 indicates that y-axis surfaces need not be linear.
  • Figs. 10 and 11 show that the walls of the ridges and/or grooves may be yz sloped either inwardly or outwardly relative to the z-axis.
  • Figs. 12 and 13 show that the transition from a y-axis ridge surface to a groove surface need not be a sharp one but, rather, may be curved.
  • Fig. 14 is shown a cross-sectional view of a pattern in which all yz surfaces are sinusoidal. In such embodiment, the potential for "bridging" between lines of cell colony growth is maximized since an abrupt delineation between ridges and grooves is not present.
  • Figs. 15 thru 19 Shown in Figs. 15 thru 19 are further xy surface patterns which are programmable through the use of processes selected from the process group consisting of laser etching, acid etching, mechanical etching and photolithography. More particularly, Fig. 15 comprises a radiating pattern. Fig. 16 a concentric circular pattern, Fig. 17 a radiating fan pattern, Fig. 18 a radiating/concentric pattern, and Fig. 19 a radiating pattern with an intersecting polar pattern. It is, therefrom, to be appreciated that an ordered microgeometric repetitive surface pattern may, within the scope of the disclosure, assume a wide variety of unidirectional linear, bi-axial linear, radial, radial and polar, nonlinear, and differential linear or polar patterns.
  • a simple cylindrical implant element 40 of the present dental implant system in which both a platform section 42 and an anchor section 44 thereof are provided with a unidirectional linear repetitive surface pattern of the type of Fig. 1 above taken in combination with any of the cross sectional geometries of Figs. 7 thru 14 above.
  • a multiplicity of alternating ridges and grooves is applied to the entire lateral surface of implant 40 along an axis which is co-axial with the axis of surgical insertion of the implant into a maxo-facial bone or tissue.
  • Fig. 21 is shown an upper portion of a buttress thread implant 46 which has been surgically inserted into bone 48.
  • the anchor section has not been microtexturized while platform section 50 thereof has been provided with a first ordered microgeometric repetitive surface pattern as to a distal section 52 thereof while a proximal portion 54 has been provided with a second ordered geometric pattern more suitable for purpose of tissue (as opposed to bone) adhesion or interface.
  • Such a second ordered pattern exhibits a width of about 2 to about 25 microns and a depth in a range of about 2 to about 25 microns in that it has been determined that tissue, such as gum tissue, is more amenable to preferential promotion of rate, orientation and directionality of growth of colonies of cells if the width of grooves is somewhat smaller than that above discussed with reference to bone adhesion and interface.
  • a further buttress thread implant 100 which has been surgically inserted within bone 48.
  • the entire lateral surface of the anchor of the buttress thread implant has been furnished with the same first ordered repetitive surface 52 above described with reference to Fig. 21 .
  • proximal region 154 has been provided with a surface more suitable to tissue adhesion interface, namely, said second ordered pattern, while lower region 152 has been provided with the same pattern as anchor surface 53.
  • a gripping surface 60 used for purposes of surgical insertion and for complemental receipt of an abutment element of a dental implant system.
  • Fig. 23 comprises an enlarged view of a bone adhesion interface 162 which exists between bone 48 and the first ordered microgeometric repetitive of the anchor 53 of the implant of 100. Also shown therein are lower and upper regions 152 and 154 of platform section 150 of the implant as well as an interface 165 of said upper region 154 with gum tissue 164. Further shown is adhesion interfaces 163 between bone 48 and lower region 152 of platform 150. Therefrom may be appreciated the effect of the inventive microgeometric repetitive surface patterns in the formation of bone and tissue adhesion interfaces, that is, the effect of which is to strengthen bone and tissue in the regions immediately surrounding a dental implant element.
  • Micro-geometric patterns of this type may be formed by various methods, including, without limitation, laser etching, acid etching, mechanical etching, and photo-lithography.
  • Fig. 24 is similar to the views of Figs. 22 and 23 , but for the use of a textured cylindrical anchor 244, as opposed to a buttress thread anchor section, of a dental implant 200.
  • gingival epithelium 66 above gum tissue 164 also referred to as the connective tissue, between the epithelium and the cortical bone 48.
  • abutment 270 secured upon implant projection 268 of a dental implant system, that has been provided with collars 254 having a microtexturized regions 266 to effect gum and epithelium tissue adhesion interfaces thereto.
  • a collar 253 of implant 200 has been provided with a microtexturized surface particularly adapted for bone adhesion interface 265. It may, accordingly, from the view of Fig. 24 , be appreciated that in a given application as many as five different microtexturized surfaces may be employed to maximize bone and tissue adhesion to one or another portion of an implant element and/or of an abutment element of a dental implant system. As such, different patterns of tissue or bone interface and adhesion, that is, differing forms of promotion of rate, orientation and directionality of growth of contacting colonies of cells will be achieved with reference to differing micro-textured surfaces of the implant material. Such interfaces are indicated by numerals 262 (implant anchor to bone interface), 265 (implant collar to bone interface), 266 (collar to gum) 272.
  • an implant 300 may be used as a means of surgical support of a maxillofacial bone 302 by securement thereof to a bone 304 of the sinus complex.
  • Such implant is of value in the area of reconstructive surgery and in dental procedures in which the cortical bone lacks sufficient strength or stability to otherwise receive and hold an implant element.
  • the upper and lower ends of the implant 300 will be provided with microtexturized surfaces as above described.
  • Figs. 26 thru 31 are shown micrographs of the inventive microgeometric surfaces at magnifications ranging from 600 to 1700.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Dentistry (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Ceramic Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Dental Prosthetics (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)

Claims (15)

  1. Système d'implant dentaire comprenant un élément d'implant (40, 46, 100, 200) destiné à une insertion par voie chirurgicale dans un os et un tissu maxillo-faciaux d'un patient, ledit élément d'implant ayant une section de collier proximale (42, 50, 150, 250) et une section de type ancrage distale (44, 52, 53, 244), ledit élément d'implant étant configuré pour la réception complémentaire d'un élément de point d'appui d'un pont, et ledit élément d'implant étant configuré de telle sorte que, dès réception d'un élément de point d'appui d'un pont, la région proximale supérieure de ladite section de collier proximale soit contiguë audit élément de point d'appui d'un pont, l'intégralité de la surface latérale de ladite section de collier proximale (42, 50, 150, 250) ayant un premier motif en surface micro-géométrique ordonné répétitif sous forme d'une multiplicité de crêtes et rainures alternées, chacune ayant une largeur établie dans une plage d'environ 2 à environ 25 micromètres, et une profondeur établie dans une plage d'environ 2 à environ 25 micromètres, au moyen desquelles lesdits motifs micro-géométriques répétitifs définissent un guide pour la promotion préférentielle de la vitesse, de l'orientation et de la direction de la croissance des colonies de cellules dudit os ou tissu maxillo-facial, qui sont en contact avec lesdits motifs en surface.
  2. Système d'implant dentaire selon la revendication 1, dans lequel la surface latérale de ladite section de type ancrage distale (44, 53, 244) dudit élément d'implant comprend aussi ledit premier motif micro-géométrique répétitif sur celle-ci.
  3. Système d'implant dentaire selon la revendication 1, dans lequel la surface latérale d'une région supérieure (54, 154, 254) de ladite section de collier proximale (50, 150, 250) comprend un deuxième motif micro-géométrique ordonné de crêtes et rainures dans une plage de largeur entre environ 2 et environ 25 micromètres, et une profondeur dans une plage d'environ 2 à 25 micromètres, ladite région supérieure de ladite section de collier proximale définissant une interface d'adhérence au tissu mou (165, 266), et dans lequel la surface latérale d'une région inférieure (52, 152, 253) de ladite section proximale comprend ledit premier motif en surface de crêtes et rainures alternées, la surface latérale de ladite région inférieure constituant une interface d'adhérence au tissu osseux (163, 265).
  4. Système d'implant dentaire selon la revendication 1, comprenant en outre un élément de point d'appui d'un pont proportionné pour l'engagement complémentaire avec ledit élément d'implant, la surface latérale dudit élément de point d'appui d'un pont comprenant une zone d'adhérence tissulaire définie par un motif répétitif micro-géométrique ordonné sous forme d'une multiplicité de crêtes et rainures alternées ayant des largeurs établies dans une plage entre environ 2 et environ 25 micromètres, et une profondeur établie dans une plage d'environ 2 à 25 micromètres.
  5. Système d'implant dentaire selon la revendication 4, dans lequel les matériaux de base dudit élément de point d'appui d'un pont sont choisis dans le groupe comprenant les matériaux de titane commercialement pur, d'alliages de titane, d'acier inoxydable, de matières plastiques, de céramique, de verre biocompatible et des combinaisons de ceux-ci.
  6. Système d'implant dentaire selon la revendication 1, dans lequel les matériaux de base dudit élément d'implant sont choisis dans le groupe comprenant les matériaux de titane et d'alliages de celui-ci, d'acier inoxydable, de céramique, de verre biocompatible et des combinaisons de ceux-ci.
  7. Système d'implant dentaire selon la revendication 1, dans lequel ledit motif micro-géométrique répétitif de crêtes et rainures comprend l'application sur les surfaces dudit élément d'implant dans des orientations qui, relativement à un axe longitudinal dudit système d'implant, sont choisies dans le groupe comprenant les orientations verticale, horizontale, diagonale, radiale, circonférentielle, et concentrique.
  8. Système d'implant dentaire selon la revendication 7, dans lequel une surface dudit élément d'implant comprend un revêtement choisi dans le groupe de surfaces consistant en l'hydroxyapatite, la rugosification dans un milieu de soufflage résorbable, le titane, un revêtement par projection plasma, le sulfate de calcium, le verre biocompatible, le collagène, des composés de facteurs de croissance, et des combinaisons de ceux-ci.
  9. Système d'implant dentaire selon la revendication 1, dans lequel ledit motif de crêtes et rainures définit des formes géométriques sensiblement parallèles.
  10. Système d'implant dentaire selon la revendication 9, dans lequel ledit motif est de type grille.
  11. Système d'implant dentaire selon la revendication 1, dans lequel ledit motif de crêtes et rainures définit une forme géométrique radiale.
  12. Système d'implant dentaire selon la revendication 1, dans lequel ledit motif de crêtes et rainures définit des formes géométriques polaires.
  13. Système selon la revendication 11, dans lequel ledit motif comprend en outre des formes géométriques polaires.
  14. Système d'implant dentaire selon la revendication 6, dans lequel ledit motif micro-géométrique répétitif est généré par gravure laser, mordançage à l'acide, gravure mécanique, ou photolithographie.
  15. Système selon la revendication 1, dans lequel ledit élément d'implant présente un profil longitudinal radial choisi dans le groupe de formes géométriques comprenant une forme de type vis, une vis conique, une forme cylindrique, une forme cylindrique conique, un filetage trapézoïdal, et un filetage à butée inverse.
EP01908781.6A 2000-02-08 2001-02-01 Elements chirurgicaux maxillo-faciaux avec motifs de repetition microgeometriques ordonnes Expired - Lifetime EP1255502B1 (fr)

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US500038 1995-07-10
US09/500,038 US6419491B1 (en) 1993-11-02 2000-02-08 Dental implant system with repeating microgeometric surface patterns
PCT/US2001/003313 WO2001058374A2 (fr) 2000-02-08 2001-02-01 Elements chirurgicaux maxillo-faciaux avec motifs de repetition microgeometriques ordonnes

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WO2001058374A2 (fr) 2001-08-16
EP2921129B1 (fr) 2018-06-27
HK1215368A1 (zh) 2016-08-26
WO2001058374A3 (fr) 2002-01-17
ES2564458T3 (es) 2016-03-22
ES2682306T3 (es) 2018-09-19
EP2921129A1 (fr) 2015-09-23
US6419491B1 (en) 2002-07-16
EP1255502A2 (fr) 2002-11-13
EP1255502A4 (fr) 2006-07-26
TR201810436T4 (tr) 2018-08-27
AU2001236614A1 (en) 2001-08-20

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