EP1239866A4 - Induzierung von zellulärer immunantwort auf her2/neu mit hilfe von peptid- und neukleinsäurezubereitungen - Google Patents
Induzierung von zellulärer immunantwort auf her2/neu mit hilfe von peptid- und neukleinsäurezubereitungenInfo
- Publication number
- EP1239866A4 EP1239866A4 EP00984214A EP00984214A EP1239866A4 EP 1239866 A4 EP1239866 A4 EP 1239866A4 EP 00984214 A EP00984214 A EP 00984214A EP 00984214 A EP00984214 A EP 00984214A EP 1239866 A4 EP1239866 A4 EP 1239866A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- neu
- her2
- peptide
- nucleic acid
- immune responses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 101150029707 ERBB2 gene Proteins 0.000 title 1
- 230000001413 cellular effect Effects 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
- A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/605—MHC molecules or ligands thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05008363A EP1568373A3 (de) | 1999-12-10 | 2000-12-11 | Induzierung von zellulärer Immunantwort auf HER2/neu mit Hilfe von Peptid- und Nukleinsäurezubereitungen |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45829999A | 1999-12-10 | 1999-12-10 | |
US458299 | 1999-12-10 | ||
PCT/US2000/033591 WO2001041787A1 (en) | 1999-12-10 | 2000-12-11 | INDUCING CELLULAR IMMUNE RESPONSES TO HER2/neu USING PEPTIDE AND NUCLEIC ACID COMPOSITIONS |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP05008363A Division EP1568373A3 (de) | 1999-12-10 | 2000-12-11 | Induzierung von zellulärer Immunantwort auf HER2/neu mit Hilfe von Peptid- und Nukleinsäurezubereitungen |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1239866A1 EP1239866A1 (de) | 2002-09-18 |
EP1239866A4 true EP1239866A4 (de) | 2005-02-09 |
Family
ID=23820228
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00984214A Withdrawn EP1239866A4 (de) | 1999-12-10 | 2000-12-11 | Induzierung von zellulärer immunantwort auf her2/neu mit hilfe von peptid- und neukleinsäurezubereitungen |
EP05008363A Withdrawn EP1568373A3 (de) | 1999-12-10 | 2000-12-11 | Induzierung von zellulärer Immunantwort auf HER2/neu mit Hilfe von Peptid- und Nukleinsäurezubereitungen |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP05008363A Withdrawn EP1568373A3 (de) | 1999-12-10 | 2000-12-11 | Induzierung von zellulärer Immunantwort auf HER2/neu mit Hilfe von Peptid- und Nukleinsäurezubereitungen |
Country Status (5)
Country | Link |
---|---|
EP (2) | EP1239866A4 (de) |
JP (1) | JP2003530083A (de) |
AU (1) | AU2087401A (de) |
CA (1) | CA2393738A1 (de) |
WO (1) | WO2001041787A1 (de) |
Families Citing this family (98)
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---|---|---|---|---|
JP2005515192A (ja) | 2001-11-29 | 2005-05-26 | ダンドリット バイオテック アクティーゼルスカブ | ヒト又は動物において免疫応答を誘導するための医薬組成物 |
FR2837837B1 (fr) * | 2002-03-28 | 2006-09-29 | Roussy Inst Gustave | Epitopes peptidiques communs a des antigenes d'une meme famille multigenique |
AU2003292127A1 (en) * | 2002-11-26 | 2004-06-18 | Antarus Lifescience Gmbh | Method for the generation of antibodies against a desired antigen using preselected animals for immunization |
EP1903056A3 (de) | 2002-12-10 | 2008-05-07 | Idm Pharma, Inc. | HLA-A1, -A2, -A3, -A24, -B7 and -B44 bindende Peptide die Tumorassoziiert-Antigen Epitopen enthalten, und Zusammensetzungen davon |
CA2514288C (en) * | 2003-03-05 | 2015-07-07 | Dendreon Corporation | Compositions and methods employing alternative reading frame polypeptides for the treatment of cancer and infectious disease |
AU2004232971A1 (en) | 2003-04-18 | 2004-11-04 | Idm Pharma Inc. | HLA-A2 tumor associated antigen peptides and compositions |
JPWO2005007694A1 (ja) * | 2003-07-16 | 2007-09-20 | 株式会社グリーンペプタイド | HER2/neuペプチドおよびその治療上の用途 |
EP1682159A4 (de) | 2003-10-16 | 2010-07-21 | Stephen John Ralph | Immunomodulierende zusammensetzungen und ihre verwendungen |
SG149815A1 (en) | 2003-11-06 | 2009-02-27 | Seattle Genetics Inc | Monomethylvaline compounds capable of conjugation to ligands |
US20080171058A1 (en) * | 2003-11-13 | 2008-07-17 | Polly Gregor | Compositions and Methods For Synergistic Induction of Antitumor Immunity |
MXPA06014065A (es) | 2004-06-01 | 2007-01-31 | Genentech Inc | Conjugados de droga-anticuerpo y metodos. |
CN101065151B (zh) | 2004-09-23 | 2014-12-10 | 健泰科生物技术公司 | 半胱氨酸改造的抗体和偶联物 |
US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
JP4961706B2 (ja) * | 2004-09-29 | 2012-06-27 | 東レ株式会社 | Hlaクラスii拘束性新規癌抗原ペプチド |
CN101370513B (zh) * | 2005-12-23 | 2013-04-03 | 瓦克松生物技术公司 | 由肿瘤抗原衍生的优化隐蔽性肽组成的免疫原性多肽及其用途 |
US7972602B2 (en) * | 2006-08-11 | 2011-07-05 | Dendreon Corporation | Promiscuous HER-2/Neu CD4 T cell epitopes |
US20100310640A1 (en) * | 2007-11-01 | 2010-12-09 | Knutson Keith L | Hla-dr binding peptides and their uses |
JP2010006705A (ja) * | 2008-06-13 | 2010-01-14 | Atlas Antibodies Ab | Her2サブセット |
US9249187B2 (en) | 2009-01-28 | 2016-02-02 | Epimmune Inc. | Pan-DR binding polypeptides and uses thereof |
IN2012DN03025A (de) | 2009-09-09 | 2015-07-31 | Ct Se Llc | |
GB201004551D0 (en) | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
EA024730B1 (ru) | 2010-04-15 | 2016-10-31 | Медимьюн Лимитед | Пирролбензодиазепиновые соединения, их конъюгаты, фармацевтические композиции, содержащие указанные конъюгаты, и применение указанных конъюгатов |
KR101839163B1 (ko) | 2010-06-08 | 2018-03-15 | 제넨테크, 인크. | 시스테인 조작된 항체 및 접합체 |
WO2012074757A1 (en) | 2010-11-17 | 2012-06-07 | Genentech, Inc. | Alaninyl maytansinol antibody conjugates |
AU2011338281A1 (en) | 2010-12-08 | 2013-07-11 | Expression Pathology, Inc. | Truncated Her2 SRM/MRM assay |
EP2655401B1 (de) * | 2010-12-20 | 2016-03-09 | The Regents of the University of Michigan | Hemmer der bindeinteraktion des epidermalen wachstumsfaktor-rezeptor-wärmeschock-proteins 90 |
CA2833212C (en) | 2011-05-12 | 2020-06-09 | Genentech, Inc. | Multiple reaction monitoring lc-ms/ms method to detect therapeutic antibodies in animal samples using framework signature peptides |
EP2755677B1 (de) * | 2011-09-15 | 2020-11-04 | Medigene AG | Anti-her2-impfstoff auf der basis von multimeren strukturen aus aav |
KR101877598B1 (ko) | 2011-10-14 | 2018-07-11 | 메디뮨 리미티드 | 피롤로벤조디아제핀 및 그의 컨주게이트 |
AU2013221309B2 (en) * | 2012-02-17 | 2017-03-30 | Mayo Foundation For Medical Education And Research | Methods and materials for generating CD8+ T cells having the ability to recognize cancer cells expressing a HER2/neu polypeptide |
WO2013130093A1 (en) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarkers for treatment with anti-tubulin chemotherapeutic compounds |
LT2839860T (lt) | 2012-10-12 | 2019-07-10 | Medimmune Limited | Pirolobenzodiazepinai ir jų konjugatai |
HUE042731T2 (hu) | 2012-10-12 | 2019-07-29 | Adc Therapeutics Sa | Pirrolobenzodiazepin-antitest konjugátumok |
ES2680153T3 (es) | 2012-10-12 | 2018-09-04 | Adc Therapeutics Sa | Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas |
TR201815418T4 (tr) | 2012-10-12 | 2018-11-21 | Adc Therapeutics Sa | Pirrolobenzodiazepin -anti-psma antikor konjugatları. |
US10695433B2 (en) | 2012-10-12 | 2020-06-30 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
EP2906296B1 (de) | 2012-10-12 | 2018-03-21 | ADC Therapeutics SA | Pyrrolobenzodiazepin-antikörper-konjugate |
EP2906251B1 (de) | 2012-10-12 | 2017-09-27 | ADC Therapeutics SA | Pyrrolobenzodiazepin-anti-cd22-antikörperkonjugate |
US9567340B2 (en) | 2012-12-21 | 2017-02-14 | Medimmune Limited | Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases |
EP2935268B2 (de) | 2012-12-21 | 2021-02-17 | MedImmune Limited | Pyrrolobenzodiazepine und konjugate davon |
RU2014102939A (ru) * | 2013-02-05 | 2015-08-10 | Нитто Денко Корпорейшн | Вакцинная композиция для чрескожного введения |
RU2014102941A (ru) * | 2013-02-05 | 2015-08-10 | Нитто Денко Корпорейшн | Вакцинная композиция для введения через слизистую оболочку |
CA2905181C (en) | 2013-03-13 | 2020-06-02 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof for providing targeted therapy |
KR102066318B1 (ko) | 2013-03-13 | 2020-01-14 | 메디뮨 리미티드 | 피롤로벤조디아제핀 및 그의 컨쥬게이트 |
US9821074B2 (en) | 2013-03-13 | 2017-11-21 | Genentech, Inc. | Pyrrolobenzodiazepines and conjugates thereof |
TWI636792B (zh) | 2013-08-12 | 2018-10-01 | 建南德克公司 | 1-(氯甲基)-2,3-二氫-1h-苯并[e]吲哚二聚體抗體-藥物結合物化合物及使用與治療方法 |
WO2015052535A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
WO2015052532A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
WO2015052534A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
JP6671292B2 (ja) | 2013-12-16 | 2020-03-25 | ジェネンテック, インコーポレイテッド | ペプチド模倣化合物及びその抗体−薬物コンジュゲート |
CN105828840B (zh) | 2013-12-16 | 2020-08-04 | 基因泰克公司 | 1-(氯甲基)-2,3-二氢-1H-苯并[e]吲哚二聚体抗体-药物缀合物化合物及使用和治疗方法 |
CN107106700B (zh) | 2013-12-16 | 2020-10-30 | 基因泰克公司 | 肽模拟化合物及其抗体-药物缀合物 |
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WO2016037644A1 (en) | 2014-09-10 | 2016-03-17 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
EP3191521A2 (de) | 2014-09-12 | 2017-07-19 | F. Hoffmann-La Roche AG | Cystein-manipulierte antikörper und konjugate |
CN106714844B (zh) | 2014-09-12 | 2022-08-05 | 基因泰克公司 | 蒽环类二硫化物中间体、抗体-药物缀合物和方法 |
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GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
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MA43345A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation |
MA43354A (fr) | 2015-10-16 | 2018-08-22 | Genentech Inc | Conjugués médicamenteux à pont disulfure encombré |
MA45326A (fr) | 2015-10-20 | 2018-08-29 | Genentech Inc | Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation |
GB201520550D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
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US10537576B2 (en) | 2015-12-09 | 2020-01-21 | Expression Pathology, Inc. | Methods for treating Her2-positive breast cancer |
GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
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CN108700598A (zh) | 2016-03-25 | 2018-10-23 | 豪夫迈·罗氏有限公司 | 多路总抗体和抗体缀合的药物量化测定法 |
MA44605A (fr) * | 2016-04-06 | 2019-02-13 | Immatics Biotechnologies Gmbh | Nouveaux peptides et combinaison de peptides pour une utilisation dans l'immunothérapie contre la leucémie myéloïde aiguë (lma) et d'autres cancers |
GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
PL3458101T3 (pl) | 2016-05-20 | 2021-05-31 | F. Hoffmann-La Roche Ag | Koniugaty PROTAC-przeciwciało i sposoby ich stosowania |
EP3465221B1 (de) | 2016-05-27 | 2020-07-22 | H. Hoffnabb-La Roche Ag | Bioanalytisches verfahren zur charakterisierung von ortsspezifischen antikörper-wirkstoff-konjugaten |
JP7043425B2 (ja) | 2016-06-06 | 2022-03-29 | ジェネンテック, インコーポレイテッド | シルベストロール抗体-薬物コンジュゲート及び使用方法 |
EP3496763A1 (de) | 2016-08-11 | 2019-06-19 | Genentech, Inc. | Pyrrolobenzodiazepin-prodrugs und antikörperkonjugate davon |
JP7050770B2 (ja) | 2016-10-05 | 2022-04-08 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 抗体薬物コンジュゲートの調製方法 |
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EP3612537B1 (de) | 2017-04-18 | 2022-07-13 | Medimmune Limited | Pyrrolobenzodiazepinkonjugate |
WO2018193102A1 (en) | 2017-04-20 | 2018-10-25 | Adc Therapeutics Sa | Combination therapy with an anti-axl antibody-drug conjugate |
UA127900C2 (uk) | 2017-06-14 | 2024-02-07 | Ейдісі Терапьютікс Са | Схема дозування для введення adc до cd19 |
MX2020001880A (es) | 2017-08-18 | 2021-07-06 | Medimmune Ltd | Conjugados de pirrolobenzodiazepina. |
WO2019060398A1 (en) | 2017-09-20 | 2019-03-28 | Ph Pharma Co., Ltd. | ANALOGUES OF THAILANSTATINE |
GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
EP3870235A1 (de) | 2018-10-24 | 2021-09-01 | F. Hoffmann-La Roche AG | Konjugierte chemische abbauauslöser und verwendungsverfahren |
CN113227119A (zh) | 2018-12-10 | 2021-08-06 | 基因泰克公司 | 用于与含Fc的蛋白质进行位点特异性缀合的光交联肽 |
GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
DE102019114735A1 (de) * | 2019-06-02 | 2020-12-03 | PMCR GmbH | HLA-Tumorantigenpeptiden der Klasse I und II zur Behandlung von Mamma-/Brustkarzinomen |
GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
FR3119325B1 (fr) | 2021-01-29 | 2023-08-11 | Renault Jean Yves | Compositions liposomales orales |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994003205A1 (en) * | 1992-08-07 | 1994-02-17 | Cytel Corporation | Hla binding peptides and their uses |
WO1999045954A1 (en) * | 1998-03-13 | 1999-09-16 | Epimmune, Inc. | Hla-binding peptides and their uses |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5801005A (en) * | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
US5783567A (en) * | 1997-01-22 | 1998-07-21 | Pangaea Pharmaceuticals, Inc. | Microparticles for delivery of nucleic acid |
EP1189624A4 (de) * | 1999-06-29 | 2005-02-23 | Epimmune Inc | Hla-bindende peptide und deren verwendung |
-
2000
- 2000-12-11 CA CA002393738A patent/CA2393738A1/en not_active Abandoned
- 2000-12-11 EP EP00984214A patent/EP1239866A4/de not_active Withdrawn
- 2000-12-11 EP EP05008363A patent/EP1568373A3/de not_active Withdrawn
- 2000-12-11 AU AU20874/01A patent/AU2087401A/en not_active Abandoned
- 2000-12-11 WO PCT/US2000/033591 patent/WO2001041787A1/en not_active Application Discontinuation
- 2000-12-11 JP JP2001543131A patent/JP2003530083A/ja active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994003205A1 (en) * | 1992-08-07 | 1994-02-17 | Cytel Corporation | Hla binding peptides and their uses |
WO1999045954A1 (en) * | 1998-03-13 | 1999-09-16 | Epimmune, Inc. | Hla-binding peptides and their uses |
Non-Patent Citations (3)
Title |
---|
FISK BRYAN ET AL: "Identification of an Immunodominant Peptide of HER-2/neu Protooncogene Recognized by Ovarian Tumor-specific Cytotoxic T Lymphocyte Lines", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 181, no. 6, 1995, pages 2109 - 2117, XP009030958, ISSN: 0022-1007 * |
KONO KOJI ET AL: "Identification of HER2/neu-derived peptide epitopes recognized by gastric cancer-specific cytotoxic T lymphocytes", INTERNATIONAL JOURNAL OF CANCER, vol. 78, no. 2, 5 October 1998 (1998-10-05), pages 202 - 208, XP002280379, ISSN: 0020-7136 * |
See also references of WO0141787A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2001041787A1 (en) | 2001-06-14 |
JP2003530083A (ja) | 2003-10-14 |
CA2393738A1 (en) | 2001-06-14 |
EP1568373A2 (de) | 2005-08-31 |
EP1568373A3 (de) | 2005-12-21 |
EP1239866A1 (de) | 2002-09-18 |
AU2087401A (en) | 2001-06-18 |
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