EP1159070A1 - Appareil permettant en son sein le transfert de liquides par capillarite - Google Patents
Appareil permettant en son sein le transfert de liquides par capillariteInfo
- Publication number
- EP1159070A1 EP1159070A1 EP00910911A EP00910911A EP1159070A1 EP 1159070 A1 EP1159070 A1 EP 1159070A1 EP 00910911 A EP00910911 A EP 00910911A EP 00910911 A EP00910911 A EP 00910911A EP 1159070 A1 EP1159070 A1 EP 1159070A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- groove
- partition
- sample
- compartments
- deep groove
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
- B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/089—Virtual walls for guiding liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
Definitions
- the present invention relates to an apparatus which comprises within it compartments delimited by a partition, creating a space for the oriented movement and independently of at least one liquid sample. When there are at least two different liquid samples, it is possible to move them, make them converge and make them react together.
- Document GB-A-2,261,284 therefore proposes a device for transferring liquids to carry out diagnostic tests. This device uses channels made of porous material.
- the capillary function is used due to the use of a porous material. This requires the insertion of this porous material and also to provide an impermeable material between two channels of porous material containing different liquids. This technique is therefore quite expensive to implement.
- US-A-5,842,787 relates to microfluidic systems which incorporate channels of variable dimensions. These channels have essentially depths which can vary. However, these variations are also associated with the width of these channels. Thus the greater the depth of a channel, the narrower its width, and vice versa.
- the proposed apparatus solves all of the problems raised by proposing a structure which uses capillarity to allow the movement of liquids while minimizing the phenomena of retention. This allows perfectly efficient guidance even in the presence of a free space, which does not provide delimitation of the transferred liquid.
- the present invention relates to an apparatus comprising at least one flat surface at the level of which compartments are present and delimited by a partition, the compartments creating a space which allows the displacement of at least one liquid sample independently and , when there are at least two liquid samples, their independent displacement and their bringing together to make them react together, characterized in that the compartments consist of at least two different types of grooves:
- each deep groove has a dimension which does not involve capillarity.
- at least one surface groove is adjacent to a deep groove.
- At least one deep groove is adjacent to a surface groove.
- a deep groove is positioned between two surface grooves.
- the deep groove has a free end, and the two surface grooves meet at this free end to create a reaction zone.
- the reaction zone is at a distance from the partition or the partitioning film which involves capillarity.
- the reaction zone is at a distance from the partition or the partitioning film which does not involve capillarity.
- Figure 1 shows an elevational view of the face of the device having the compartment according to the invention.
- FIG. 2 represents a partial cross-sectional view along A-A of FIG. 1.
- Figure 3 shows a view identical to Figure 2 in which a liquid sample is present.
- Figure 4 shows a view identical to Figures 2 and 3 in which two different liquid samples are present.
- Figure 5 shows a sectional view identical to Figure 2, but of a second embodiment containing a liquid sample.
- Figure 6 shows a sectional view identical to Figure 2, but of a third embodiment of the present invention, in which a liquid sample is present.
- the present invention relates to an apparatus 1 well shown in all of Figures 2 to 6 in partial sectional view according to three different embodiments.
- Such an apparatus 1 can be used for the analysis of one or more different liquid samples in which one seeks to identify one or more analytes, according to all the simple or complex analysis processes involving one or more different reagents according to the nature chemical, physical or biological of the analyte (s) sought.
- the technical principles defined below are not limited to a particular analyte, the only condition being that the analyte is distributed in the sample to be analyzed in suspension or in solution.
- the analysis process implemented can be carried out, in homogeneous or heterogeneous or mixed form.
- ligand any biological species such as, for example, an antigen, an antigen fragment, a peptide, an antibody, an antibody fragment, a hapten, a nucleic acid, a nucleic acid fragment, a hormone, a vitamin.
- An example of the application of analytical techniques concerns immunoassays, whatever their format, by direct analysis or by competition.
- Another example of application relates to the detection and / or quantification of nucleic acids comprising all the operations necessary for this detection and / or this quantification from any sample containing the target nucleic acids.
- the device 1 is in fact made up of a card whose two upper and lower faces are parallel to each other. Well heard the horizontal position is absolutely not mandatory, it is possible to use this card vertically or tilted.
- the two faces are flat but the upper face is the most advantageous for the present invention.
- the upper flat surface 2 of the device 1 has cavities which create compartments 3.
- the compartments are partitioned with respect to the flush surfaces of the surface 2 by means of a partition or partitioning film 4.
- This compartment 3, thus isolated, is in fact made up of different shapes.
- This FIG. 2 corresponds to the view in partial section along AA of FIG. 1.
- the two surface grooves 16 are parallel to each other all along the deep groove 6.
- the deep groove 6 has a free end 7 where the two surface grooves 16 meet in order to create a reaction zone 8.
- first liquid sample 5 at one of the surface grooves 16. This is the case in FIG. 3. It is also possible to isolate in addition a second liquid sample 15 at the level of the another surface groove 16. This is the case in FIG. 4. In fact, so that the liquids 5 and 15 remain in position at the level of the surface tongues 16 and do not mix, it is necessary that the distance separating the bottom of the surface tongue 16 relative to the partitioning film 4 is sufficiently weak to involve the capillary force.
- the adequate distance between the film 4 and the groove 16 to have an optimal capillary force is between 50 and 800 micrometers ( ⁇ m), and preferably between 300 and 500 ⁇ m.
- the distance between the film 4 and the groove 16 is chosen to be 400 ⁇ m.
- This dimension is in fact characteristic of the liquids 5 and / or 15 which are used in the apparatus 1 in relation to the nature of the materials used in the apparatus. Depending on the viscosity, density, wettability or surface tension of liquids and depending on the hydrophilic or hydrophobic nature of the materials used, as for example the partitioning film or the card, it will be necessary to possibly vary this distance.
- the distance separating the film 4 from the bottom of the deep groove 6 is very large so that no capillary force allows the retention of liquid 5 or 15 at this level. It is of course obvious that it is necessary that, at the level of the width of this deep groove, there is no possibility of involving capillarity.
- the nature of the flexible film may vary depending on the nature of the analysis card and of the fluids tested, in particular for compatibility reasons.
- a TPX (polymethylethylpentene) or BOPP (bi-oriented polypropylene) polymer film makes it possible to carry out biological tests.
- the fixing of these films can be carried out by gluing (coating of glue such as for example silicone glues on the film) or by welding.
- An example of adhesive BOPP is provided by the company BioMérieux Inc (St Louis, MO, USA) under the reference 022004-2184.
- the analysis card is obtained by machining a technical plastic material such as impact polystyrene reference R540E from the company GOODFELLOW, compatible with the treated liquids.
- the card could be obtained by precision molding, but all other manufacturing methods and in particular those used in semiconductor techniques such as those described in patent application WO-A-97/02357 are usable for the manufacture of the analysis card.
- FIG. 5 it is essentially a construction opposite to the first embodiment of the figures. 1 to 4.
- the surface groove 16 is located in the center and is surrounded by two deep grooves 6. The liquid sample 5 is then only in contact with the bottom of the surface groove 16.
- FIG. 6 it is possible according to FIG. 6 to have only a single surface groove 16 and a single deep groove 6.
- all cases are possible and conceivable.
- the introduction of liquids 5 and / or 15 can be carried out by means of valve systems, pumps and / or channels as described in the patent applications filed today by the applicant under the following titles:
- the movement of liquids 5 and 15 is carried out in different ways. For example, we can generate vibrations; the card 1 can be positioned in a substantially vertical position, in which the liquids have their movement which is facilitated by gravity; you can use centrifugal force.
- Pumping systems can be incorporated inside or outside the device, such as, for example, diaphragm pumps (US-A-5,277,556), piezoelectric peristaltic pumps (US-A-5, 126,022), ferrofluid transport systems, electric and hydrodynamic pumps (Richter et al., Sensors and Actuators, 29, pi 59- 165, 1991). It is also possible to use the combination of at least two of these techniques.
Landscapes
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- External Artificial Organs (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
Description
Claims
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9903034 | 1999-03-09 | ||
FR9903034A FR2790684B1 (fr) | 1999-03-09 | 1999-03-09 | Appareil permettant en son sein le transfert de liquides par capillarite |
PCT/FR2000/000581 WO2000053321A1 (fr) | 1999-03-09 | 2000-03-09 | Appareil permettant en son sein le transfert de liquides par capillarite |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1159070A1 true EP1159070A1 (fr) | 2001-12-05 |
EP1159070B1 EP1159070B1 (fr) | 2003-12-17 |
Family
ID=9543085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00910911A Expired - Lifetime EP1159070B1 (fr) | 1999-03-09 | 2000-03-09 | Appareil permettant en son sein le transfert de liquides par capillarite |
Country Status (10)
Country | Link |
---|---|
US (1) | US7169353B1 (fr) |
EP (1) | EP1159070B1 (fr) |
JP (1) | JP4360454B2 (fr) |
AT (1) | ATE256499T1 (fr) |
AU (1) | AU761808B2 (fr) |
CA (1) | CA2362412C (fr) |
DE (1) | DE60007285T2 (fr) |
ES (1) | ES2212990T3 (fr) |
FR (1) | FR2790684B1 (fr) |
WO (1) | WO2000053321A1 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6406672B1 (en) | 2000-01-28 | 2002-06-18 | Roche Diagnostics | Plasma retention structure providing internal flow |
JP4123275B2 (ja) * | 2004-02-06 | 2008-07-23 | 日本電気株式会社 | 制御構造、分離装置およびグラディエント形成装置ならびにそれらを用いるマイクロチップ |
WO2005083390A1 (fr) * | 2004-02-20 | 2005-09-09 | Research Foundation Of The State University Of New York | Procede et dispositif servant à manipuler des liquides dans des systemes microfluidiques |
DE102005048236A1 (de) * | 2005-10-07 | 2007-04-12 | Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg | Vorrichtung und Verfahren zur Bestimmung der Volumenanteile der Phasen in einer Suspension |
US8834813B2 (en) * | 2007-07-23 | 2014-09-16 | Nanoentek, Inc. | Chip for analyzing fluids |
KR100900511B1 (ko) * | 2007-07-23 | 2009-06-03 | 주식회사 디지탈바이오테크놀러지 | 유체분석용 칩 |
KR100878229B1 (ko) * | 2007-11-22 | 2009-01-12 | 주식회사 디지탈바이오테크놀러지 | 유체분석용 칩 |
US9289763B2 (en) * | 2012-07-23 | 2016-03-22 | Tasso, Inc. | Methods, systems, and devices relating to open microfluidic channels |
JP2014097485A (ja) * | 2012-10-18 | 2014-05-29 | Enplas Corp | 液体取扱装置 |
Family Cites Families (38)
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US3925166A (en) | 1974-09-06 | 1975-12-09 | Us Health | Automated system for the determination of bacterial antibiotic susceptibilities |
JPS52105354A (en) * | 1976-02-28 | 1977-09-03 | Hisaka Works Ltd | Condenser |
US4260687A (en) | 1976-09-07 | 1981-04-07 | Warner-Lambert Company | Diagnostic device |
US4318994A (en) | 1979-08-30 | 1982-03-09 | Mcdonnell Douglas Corporation | Enterobacteriaceae species biochemical test card |
EP0075605B1 (fr) * | 1981-09-25 | 1987-01-21 | Winfried Dr. med. Stöcker | Dispositif pour analyses photométriques |
EP0192794B1 (fr) | 1985-02-27 | 1988-06-22 | Horiba, Ltd. | Récipient pour liquides pour appareils d'analyse |
US4676274A (en) * | 1985-02-28 | 1987-06-30 | Brown James F | Capillary flow control |
US4756884A (en) * | 1985-08-05 | 1988-07-12 | Biotrack, Inc. | Capillary flow device |
US4761381A (en) | 1985-09-18 | 1988-08-02 | Miles Inc. | Volume metering capillary gap device for applying a liquid sample onto a reactive surface |
FR2592170B1 (fr) | 1985-12-20 | 1988-02-05 | Guigan Jean | Procede et dispositif pour delivrer une quantite predeterminee de plasma a partir d'un echantillon de sang en vue d'analyses. |
US4812294A (en) | 1986-02-28 | 1989-03-14 | Automated Diagnostic Systems, Inc. | Specimen processing system |
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US4892708A (en) | 1987-07-01 | 1990-01-09 | Miles Inc. | Fluid separation and processing device |
US5472671A (en) * | 1989-04-26 | 1995-12-05 | Nilsson; Sven-Erik | Cuvette |
US5286454A (en) * | 1989-04-26 | 1994-02-15 | Nilsson Sven Erik | Cuvette |
US5242606A (en) * | 1990-06-04 | 1993-09-07 | Abaxis, Incorporated | Sample metering port for analytical rotor having overflow chamber |
US5230866A (en) | 1991-03-01 | 1993-07-27 | Biotrack, Inc. | Capillary stop-flow junction having improved stability against accidental fluid flow |
CA2062027C (fr) * | 1991-03-04 | 1998-05-19 | William Aldrich | Systeme de controle du liquide pour cartouches de diagnostic utilisees dans des instruments d'analyse |
ATA166091A (de) * | 1991-08-23 | 1996-02-15 | Faigle Heinz Kg | Füllkörper |
WO1993019827A1 (fr) | 1992-04-02 | 1993-10-14 | Abaxis, Inc. | Rotor d'analyse comportant une chambre de melange de colorants |
US5288463A (en) | 1992-10-23 | 1994-02-22 | Eastman Kodak Company | Positive flow control in an unvented container |
WO1994026414A1 (fr) | 1993-05-17 | 1994-11-24 | Syntex (U.S.A.) Inc. | Recipient de reaction pour essai par liaison specifique et procede d'utilisation |
CA2143365A1 (fr) | 1994-03-14 | 1995-09-15 | Hugh V. Cottingham | Methode et appareil pour l'amplification de l'acide nucleique |
US5595712A (en) * | 1994-07-25 | 1997-01-21 | E. I. Du Pont De Nemours And Company | Chemical mixing and reaction apparatus |
IL115327A (en) | 1994-10-07 | 2000-08-13 | Bayer Ag | Diaphragm pump |
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JP4912517B2 (ja) | 1996-04-03 | 2012-04-11 | アプライド バイオシステムズ リミテッド ライアビリティー カンパニー | 複数の分析物の検出のためのデバイスおよび方法 |
US6001307A (en) | 1996-04-26 | 1999-12-14 | Kyoto Daiichi Kagaku Co., Ltd. | Device for analyzing a sample |
FR2749663B1 (fr) | 1996-06-07 | 1998-07-31 | Bio Merieux | Carte d'analyse a usage unique comprenant un conduit d'ecoul ement de liquides |
US6136212A (en) | 1996-08-12 | 2000-10-24 | The Regents Of The University Of Michigan | Polymer-based micromachining for microfluidic devices |
DE19648695C2 (de) * | 1996-11-25 | 1999-07-22 | Abb Patent Gmbh | Vorrichtung zur automatischen und kontinuierlichen Analyse von Flüssigkeitsproben |
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US6090251A (en) * | 1997-06-06 | 2000-07-18 | Caliper Technologies, Inc. | Microfabricated structures for facilitating fluid introduction into microfluidic devices |
DE19827754C1 (de) * | 1998-06-23 | 2000-02-10 | Graffinity Pharm Design Gmbh | Einrichtung für eine nahezu gleichzeitige Synthese einer Vielzahl von Proben |
DE29907804U1 (de) * | 1998-04-30 | 1999-10-07 | Graffinity Pharmaceutical Design GmbH, 69120 Heidelberg | Vorrichtung für den Transport von Flüssigkeiten entlang vorgegebener Leitwege |
US6171870B1 (en) * | 1998-08-06 | 2001-01-09 | Spectral Diagnostics, Inc. | Analytical test device and method for use in medical diagnoses |
EP1230544B1 (fr) * | 1999-06-18 | 2004-07-28 | Gamera Bioscience Corporation | Dispositifs et methodes permettant d'effectuer des analyses homogenes miniatures |
-
1999
- 1999-03-09 FR FR9903034A patent/FR2790684B1/fr not_active Expired - Fee Related
-
2000
- 2000-03-09 AU AU32953/00A patent/AU761808B2/en not_active Ceased
- 2000-03-09 ES ES00910911T patent/ES2212990T3/es not_active Expired - Lifetime
- 2000-03-09 WO PCT/FR2000/000581 patent/WO2000053321A1/fr active IP Right Grant
- 2000-03-09 AT AT00910911T patent/ATE256499T1/de not_active IP Right Cessation
- 2000-03-09 CA CA002362412A patent/CA2362412C/fr not_active Expired - Fee Related
- 2000-03-09 DE DE60007285T patent/DE60007285T2/de not_active Expired - Lifetime
- 2000-03-09 US US09/936,077 patent/US7169353B1/en not_active Expired - Fee Related
- 2000-03-09 EP EP00910911A patent/EP1159070B1/fr not_active Expired - Lifetime
- 2000-03-09 JP JP2000603804A patent/JP4360454B2/ja not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
---|
See references of WO0053321A1 * |
Also Published As
Publication number | Publication date |
---|---|
US7169353B1 (en) | 2007-01-30 |
AU3295300A (en) | 2000-09-28 |
FR2790684A1 (fr) | 2000-09-15 |
ATE256499T1 (de) | 2004-01-15 |
DE60007285T2 (de) | 2004-09-02 |
EP1159070B1 (fr) | 2003-12-17 |
JP2002538482A (ja) | 2002-11-12 |
DE60007285D1 (de) | 2004-01-29 |
CA2362412A1 (fr) | 2000-09-14 |
FR2790684B1 (fr) | 2001-05-11 |
CA2362412C (fr) | 2008-08-26 |
ES2212990T3 (es) | 2004-08-16 |
JP4360454B2 (ja) | 2009-11-11 |
AU761808B2 (en) | 2003-06-12 |
WO2000053321A1 (fr) | 2000-09-14 |
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