EP1158955B1 - Zusammensetzung zur behandlung von hypersensitiven zähnen enthaltend zinnfluorid - Google Patents

Zusammensetzung zur behandlung von hypersensitiven zähnen enthaltend zinnfluorid Download PDF

Info

Publication number
EP1158955B1
EP1158955B1 EP00907871A EP00907871A EP1158955B1 EP 1158955 B1 EP1158955 B1 EP 1158955B1 EP 00907871 A EP00907871 A EP 00907871A EP 00907871 A EP00907871 A EP 00907871A EP 1158955 B1 EP1158955 B1 EP 1158955B1
Authority
EP
European Patent Office
Prior art keywords
composition
desensitizing agent
desensitizing
weight
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP00907871A
Other languages
English (en)
French (fr)
Other versions
EP1158955A1 (de
Inventor
Gregory P. Dodd
Kenneth J. Markowitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Block Drug Co Inc
Original Assignee
Block Drug Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Block Drug Co Inc filed Critical Block Drug Co Inc
Publication of EP1158955A1 publication Critical patent/EP1158955A1/de
Application granted granted Critical
Publication of EP1158955B1 publication Critical patent/EP1158955B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the dental composition according to the invention is preferably in the form of a gel or paste dentifrice, but can also be in the form of a pre-rinse or rinse mouthwash concentrate.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (9)

  1. Wasserfreie Dentalzusammensetzung zur Behandlung von überempfindlichen Zähnen, umfassend ein erstes desensibilisierendes Mittel, das SnF2 ist, in einer Menge von 0,1 bis 2 Gew.% der Zusammensetzung und ein zweites desensibilisierendes Mittel, das ein Polyelektrolyt ist, der eine anionische funktionelle Gruppe enthält, in einer Menge von 0,1 bis 20 Gew.% der Zusammensetzung, worin das erste desensibilisierende Mittel und das zweite desensibilisierende Mittel direkt in der Zusammensetzung kombiniert sind ohne die Notwendigkeit zur Trennung der ersten und zweiten desensibilisierenden Mittel bis zur Behandlung der überempfindlichen Zähne.
  2. Zusammensetzung gemäß Anspruch 1, worin das zweite desensibilisierende Mittel Polyacrylsäure ist.
  3. Zusammensetzung gemäß Anspruch 2, worin das zweite desensibilisierende Mittel eine vernetzte Polyacrylsäure ist.
  4. Zusammensetzung gemäß einem der Ansprüche 1 bis 3, die ferner ein wasserfreies Feuchthaltmittel, das aus der Gruppe ausgewählt ist, die aus Glycerin, Sorbit und anderen essbaren mehrwertigen Alkoholen wie Polyethylenglykol besteht, in einer Menge von 15 bis 98 Gew.% der Zusammensetzung umfasst.
  5. Zusammensetzung gemäß Anspruch 4 in Form eines Gel- oder Pasten-Zahnputzmittels.
  6. Zusammensetzung gemäß Anspruch 5 in Form eines Vorspülungs- oder Spülungs-Mundwaschzahnputzmittels.
  7. Verwendung einer wasserfreien dentalen Zusammensetzung, die ein erstes desensibilisierendes Mittel, das SnF2 ist, in einer Menge von 0,1 bis 2 Gew.% der Zusammensetzung und ein zweites desensibilisierendes Mittel, das ein Polyelektrolyt ist, der eine anionische funktionelle Gruppe enthält, in einer Menge von 0,1 bis ca. 20 Gew.% der Zusammensetzung umfasst, in der Herstellung einer Dentalzusammensetzung, worin das erste desensibilisierende Mittel und das zweite desensibilisierende Mittel direkt in der Zusammensetzung ohne die Notwendigkeit zur Trennung der ersten und zweiten desensibilisierenden Mittel bis zur Behandlung der überempfindlichen Zähne kombiniert werden.
  8. Verwendung gemäß Anspruch 7, worin das zweite desensibilisierende Mittel Polyacrylsäure ist.
  9. Verwendung gemäß Anspruch 8, worin das zweite desensibilisierende Mittel vernetzte Polyacrylsäure ist.
EP00907871A 1999-03-10 2000-03-10 Zusammensetzung zur behandlung von hypersensitiven zähnen enthaltend zinnfluorid Expired - Lifetime EP1158955B1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12361199P 1999-03-10 1999-03-10
US123611P 1999-03-10
US512526 2000-02-24
US09/512,526 US6592853B2 (en) 1999-03-10 2000-02-24 Dentin desensitizer containing stannous fluoride
PCT/GB2000/000875 WO2000053155A1 (en) 1999-03-10 2000-03-10 Compositions containing stannous fluoride for the treatment of hypersensitive teeth

Publications (2)

Publication Number Publication Date
EP1158955A1 EP1158955A1 (de) 2001-12-05
EP1158955B1 true EP1158955B1 (de) 2003-09-17

Family

ID=26821717

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00907871A Expired - Lifetime EP1158955B1 (de) 1999-03-10 2000-03-10 Zusammensetzung zur behandlung von hypersensitiven zähnen enthaltend zinnfluorid

Country Status (19)

Country Link
US (1) US6592853B2 (de)
EP (1) EP1158955B1 (de)
JP (1) JP4828025B2 (de)
KR (1) KR20010108340A (de)
CN (1) CN1348354A (de)
AT (1) ATE249809T1 (de)
AU (1) AU2933300A (de)
BR (1) BR0008865A (de)
CA (1) CA2364187A1 (de)
CZ (1) CZ20013250A3 (de)
DE (1) DE60005307T2 (de)
ES (1) ES2206198T3 (de)
HK (1) HK1039573A1 (de)
HU (1) HUP0201294A2 (de)
MX (1) MXPA01009102A (de)
NZ (1) NZ514086A (de)
PL (1) PL351897A1 (de)
RU (1) RU2001127431A (de)
WO (1) WO2000053155A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635676B2 (en) * 1999-04-28 2003-10-21 Regents Of The University Of Michigan Non-toxic antimicrobial compositions and methods of use
US7655252B2 (en) 1999-04-28 2010-02-02 The Regents Of The University Of Michigan Antimicrobial nanoemulsion compositions and methods
JP2010209109A (ja) * 2001-06-25 2010-09-24 Regents Of The Univ Of Michigan 抗微生物ナノエマルジョンの組成物および方法
US20040086467A1 (en) * 2001-10-10 2004-05-06 Frederick Curro Dental compositions for hypersensitive teeth
EP1501441A1 (de) * 2002-05-08 2005-02-02 Dentsply International, Inc. Spritzenendstück mit kappe
CN1917852A (zh) * 2003-12-19 2007-02-21 诺瓦敏科技公司 使用含有生物活性玻璃的洁牙剂预防或减少蚀斑和/或龈炎的组合物及方法
US20070054243A1 (en) * 2005-09-07 2007-03-08 Jurgen Schemmer Method and apparatus for treating dentin sensitivity
US20080107612A1 (en) * 2006-09-07 2008-05-08 Simonton Thomas C Anti-caries dental material
US8747872B2 (en) 2007-05-02 2014-06-10 The Regents Of The University Of Michigan Nanoemulsion therapeutic compositions and methods of using the same
EP2376089B1 (de) 2008-11-17 2018-03-14 The Regents of the University of Michigan Krebsvakzine-zusammensetzungen und anwendungsverfahren dafür
EP2281544A1 (de) * 2009-07-27 2011-02-09 The Procter & Gamble Company Mundpflegezusammensetzungen mit Zinn, Kalium und Monofluorphosphat
EP2281543A1 (de) 2009-07-27 2011-02-09 The Procter & Gamble Company Mundpflegezusammensetzungen mit Zinn- und Kaliumsalze
US9572907B2 (en) * 2010-10-01 2017-02-21 Covidien Lp Implantable polymeric films
WO2014186742A2 (en) * 2013-05-17 2014-11-20 Acupac Packaging, Inc. Anhydrous hydrogel composition
US11033096B2 (en) 2017-12-12 2021-06-15 Colgate-Palmolive Company Oral care refill head and oral care kit including the same

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3863006A (en) 1973-01-29 1975-01-28 Milton Hodosh Method for desensitizing teeth
US4296096A (en) * 1979-07-05 1981-10-20 Colgate-Palmolive Company High viscosity dentifrice
US4418057A (en) * 1983-02-09 1983-11-29 Scherer Laboratories, Inc. Method of forming stable dental gel of stannous fluoride
US4533544A (en) * 1984-03-26 1985-08-06 Scherer Laboratories, Inc. Method of forming stable dental gel of stannous fluoride
US4701319A (en) * 1984-09-14 1987-10-20 The Procter & Gamble Company Toothpaste compositions
US4661341A (en) 1984-10-30 1987-04-28 The Procter & Gamble Company Oral compositions
US4842847A (en) * 1987-12-21 1989-06-27 The B. F. Goodrich Company Dental calculus inhibiting compositions
US4892725A (en) * 1988-05-09 1990-01-09 The B. F. Goodrich Company Tartar inhibition on teeth
US5017363A (en) 1989-11-15 1991-05-21 Gillette Canada, Inc. Stabilized stannous fluoride toothpaste
AU648040B2 (en) * 1989-11-15 1994-04-14 Gillette Canada Inc. Stabilized stannous fluoride compositions for oral care
JPH03200719A (ja) * 1989-12-27 1991-09-02 Lion Corp 口腔用組成物
US5270031A (en) * 1991-12-20 1993-12-14 Block Drug Company Inc. Dentinal desensitizing compositions
EP0675707A1 (de) * 1993-05-28 1995-10-11 HAWE NEOS DENTAL Dr. H. V. WEISSENFLUH AG Zinnfluorid-präparat für die zahnpflege
US5690912A (en) * 1994-04-25 1997-11-25 Colgate Palmolive Company SnF2 gel of improved stand-up and efficacy in the treatment of dentine hypersensitivity
US5674474A (en) * 1994-04-25 1997-10-07 Colgate Palmolive Company SNF 2 gel of improved stand-up and stability
US5843409A (en) * 1994-08-08 1998-12-01 Colgate Palmolive Company Two component dentifrice for the treatment of dentinal hypersensitivity
US5716600A (en) * 1995-11-14 1998-02-10 Professional Dental Technologies, Inc. Stable stannous fluoride toothpaste compositions
US5871715A (en) * 1997-02-28 1999-02-16 Gillette Canada Inc. Stannous fluoride gel with improved stand-up
US5932192A (en) 1997-04-23 1999-08-03 Colgate-Palmolive Company Lower astringent two component stannous and potassium salt containing dentifrice
US6365134B1 (en) * 1999-07-07 2002-04-02 Scientific Pharmaceuticals, Inc. Process and composition for high efficacy teeth whitening
US6284030B1 (en) * 1999-09-29 2001-09-04 Scientific Pharmaceuticals, Inc Saliva cured one component dental formulations

Also Published As

Publication number Publication date
RU2001127431A (ru) 2003-06-27
BR0008865A (pt) 2002-01-02
PL351897A1 (en) 2003-06-30
DE60005307T2 (de) 2004-07-15
KR20010108340A (ko) 2001-12-07
HK1039573A1 (zh) 2002-05-03
JP2002538192A (ja) 2002-11-12
NZ514086A (en) 2001-09-28
EP1158955A1 (de) 2001-12-05
CA2364187A1 (en) 2000-09-14
CN1348354A (zh) 2002-05-08
WO2000053155A1 (en) 2000-09-14
AU2933300A (en) 2000-09-28
CZ20013250A3 (cs) 2002-01-16
DE60005307D1 (de) 2003-10-23
US6592853B2 (en) 2003-07-15
ES2206198T3 (es) 2004-05-16
JP4828025B2 (ja) 2011-11-30
MXPA01009102A (es) 2003-07-14
US20020098155A1 (en) 2002-07-25
HUP0201294A2 (en) 2002-08-28
ATE249809T1 (de) 2003-10-15

Similar Documents

Publication Publication Date Title
US8562954B2 (en) Dental compositions with sensitivity relief
RU2718064C2 (ru) Композиции для ухода за полостью рта, содержащие комплексы цинк-аминокислота-галогенид
US7182937B2 (en) Anhydrous dentrifice formulations for the delivery of incompatible ingredients
EP0696450B1 (de) Zweikomponenten Zahnpflegemittel zur Behandlung von Dentinhyperempfindlichkeit
US4130636A (en) Dentifrice
EP2925285B1 (de) Mundpflegezusammensetzung
US3932606A (en) Dentifrice
EP1158955B1 (de) Zusammensetzung zur behandlung von hypersensitiven zähnen enthaltend zinnfluorid
RU2719365C1 (ru) Композиции для ухода за полостью рта
US20130209376A1 (en) Oral care compositions
EP0242977B1 (de) Mundhygienemittel
US11253449B2 (en) Oral care compositions
RU2092153C1 (ru) Композиция для реминерализации деминерализованной части зубов
AU2012200659A1 (en) Dental compositions with sensitivity relief

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20010906

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI PAYMENT 20010905

17Q First examination report despatched

Effective date: 20020118

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Extension state: SI

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CH

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030917

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030917

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030917

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030917

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030917

Ref country code: LI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20030917

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REF Corresponds to:

Ref document number: 60005307

Country of ref document: DE

Date of ref document: 20031023

Kind code of ref document: P

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20031217

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20031217

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20031217

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20031226

NLV1 Nl: lapsed or annulled due to failure to fulfill the requirements of art. 29p and 29m of the patents act
PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20040310

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20040310

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20040331

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2206198

Country of ref document: ES

Kind code of ref document: T3

ET Fr: translation filed
PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20040618

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1039573

Country of ref document: HK

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 16

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20160315

Year of fee payment: 17

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 18

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 19

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20170331

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170331

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20190215

Year of fee payment: 20

Ref country code: IT

Payment date: 20190319

Year of fee payment: 20

Ref country code: GB

Payment date: 20190227

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20190220

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20190401

Year of fee payment: 20

REG Reference to a national code

Ref country code: DE

Ref legal event code: R071

Ref document number: 60005307

Country of ref document: DE

REG Reference to a national code

Ref country code: GB

Ref legal event code: PE20

Expiry date: 20200309

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20200309

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20220127

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20200311