EP1146072B1 - Particules sphérique oxydiques, leur préparation et utilisation - Google Patents
Particules sphérique oxydiques, leur préparation et utilisation Download PDFInfo
- Publication number
- EP1146072B1 EP1146072B1 EP01109140A EP01109140A EP1146072B1 EP 1146072 B1 EP1146072 B1 EP 1146072B1 EP 01109140 A EP01109140 A EP 01109140A EP 01109140 A EP01109140 A EP 01109140A EP 1146072 B1 EP1146072 B1 EP 1146072B1
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- lanthanides
- spherical
- particles according
- compounds
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/011—Nanostructured additives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/014—Additives containing two or more different additives of the same subgroup in C08K
Definitions
- the invention relates to spherical oxide particles having a first oxidic compound selected from titanium, zirconium, aluminum, yttrium and silicon and at least one further oxide of lanthanides, a process for their preparation and their use as a filler in the medical field.
- Inorganic particles are used as fillers in a very versatile way to improve the properties of plastics. Above all, mechanical properties such as strength, modulus of elasticity and hardness are significantly improved by fillers. For many applications, a narrow particle size distribution and a spherical shape of the particles have proved to be advantageous, which could already be achieved for various inorganic elements.
- the particles can fulfill different applications simultaneously as fillers.
- Important criteria which particles are to fulfill as fillers are narrow size distribution, freedom from agglomerates, spherical form and, if appropriate, surface functionalization, radiopacity and, for medical applications, the possibility of containing the particles or the particles provided with the particles, e.g. detected by magnetic resonance imaging.
- the spherical particles after the DE 196 43 781 A1 Although have sufficient radiopacity for many applications, but have the disadvantage that they or the corresponding products can be detected only poorly by magnetic resonance imaging. This is particularly unfavorable for applications in the medical field, as no harmless and non-destructive diagnostics of the composite is possible.
- spherical oxide particles which consist of a first oxide compound selected from titanium, zirconium, aluminum, yttrium and silicon and at least one further oxide of the lanthanides.
- the great advantage of the novel spherical oxide particles is that their size is arbitrarily adjustable (5 to 10,000 nm) and the lanthanides contained therein have large magnetic moments. The reason is that lanthanides have relatively large magnetic moments due to their unpaired (f) electrons. When used in magnetic resonance imaging, the paramagnetic lanthanides act as relaxation accelerators because their large permanent magnetic moments favor the setting of the magnetic moments of the environment in the applied magnetic field.
- the combination of the selected metal oxides in particular the combination of oxides of the lanthanides with, for example, silicon oxide, gives particles which, in terms of properties, have the same properties as those used in the US Pat DE 196 43 781 A1 are comparable, and that at the same time the lanthanides contained therein have large magnetic moments, which are for non-destructive detection under the action of a magnetic field of great advantage.
- the first oxidic compound is used in a proportion of 20 to 95% by weight, particularly preferably 60 to 95% by weight, and the second oxidic compound in an amount of 80 to 5% by weight or 40 to 5% by weight are included.
- the spherical particles can be constructed in different ways.
- a preferred embodiment proposes that the particles have an onion-shell-like structure and the first oxide compound or an oxide of the lanthanides forms the core.
- the first oxide preferably forms the core.
- SiO 2 is particularly preferred for the first oxides because of its favorable price.
- the core can be in such a Case have a size of 20 to 500 nm. At least one shell is then applied to this core, wherein the thickness of the shell is preferably in the range of 10 to 50 nm. This results in the core / shell model particles with a total size of the particles from 30 to 600 nm. The standard deviation is ⁇ 15%.
- a second possibility of constructing the particles according to the invention is that there is a homogeneous distribution of the metal oxides, ie the first oxide and at least one further oxide of the lanthanides ( Fig. 2 ).
- the particles of the invention may also be porous.
- the above-described particles may also be provided with a surface modification.
- the surface modification can be obtained by partial or complete hydrolytic condensation of one or more hydrolytically condensable compounds of silicon and optionally other elements selected from boron, aluminum, phosphorus, tin, lead, transition metals, lanthanides and actinides, and / or the above precondensates derived, if appropriate, in the presence of a catalyst and / or a solvent by the action of water or moisture.
- the Si compounds used allow a large variability in the targeted influence on the properties.
- they may have the mechanical properties, e.g. influence the impact resistance of the composite.
- the functional groups e.g., polymerizable double bonds present in a relatively large number ensure good incorporation of the filler into the resin or composite.
- water glass solutions can be used.
- the invention further relates to a process for the preparation of the particles according to the invention as claimed in claims 11 to 14.
- the preparation of these particles can be done in and of themselves by means of the known sol-gel method. All known processes, such as e.g. the Stöber process or the emulsion or aerosol method can be used.
- At least one metal - as a fillable hydrated oxide - is emulsified in dissolved form or in the form of a sol in the aqueous phase and using an emulsifier in an organic liquid.
- the precipitation of the oxide hydride or other oxide hydrates in the emulsified water droplets is effected by dissolving at least one compound selected from quaternary ammonium, phosphonium and other onium compounds and salts of long chain organic acids before and during or after formation of the emulsion, the compound in question either already is present in the OH or H form or is generated in situ, after which the water is removed by distillation.
- small particles can be embedded in larger particles whose matrix consists of the same or a different oxide, so as to obtain a composite structure of the particles.
- Such a construction can also be achieved when smaller particles grow up to large ones.
- Particles with a homogeneous distribution of different Oxides in the respective particles can be obtained by the joint hydrolysis and condensation of various metal oxide precursors (eg metal alkoxides, alkyl carbonyls).
- various metal oxide precursors eg metal alkoxides, alkyl carbonyls.
- spherical particles are to be produced in a kind of core-shell structure, then it is possible to apply one or more shells of metal oxides and / or metal oxide mixtures to spherical metal oxide particles.
- This is done by e.g. to a nucleus of an oxide of a lanthanoide by hydrolytic condensation of one or more hydrolytically condensable compounds of the elements titanium, zirconium, aluminum, yttrium and / or silicon and / or precondensates derived from the abovementioned compounds, optionally in the presence of a catalyst and / or a solvent by the action of water or moisture, the corresponding oxide will be. Accordingly, it is possible to proceed if the core is an oxide of titanium, zirconium, aluminum, yttrium and / or silicon.
- Silicon tetraethoxysilane, methyltrimethoxysilane, 3-methacryloxypropyltrimethoxysilane, 3-aminopropyltrimethoxysilane, dimethyldiethoxysilane, trimethylmethoxysilane, 3-chloropropyltrichlorosilane, trichlorosilane.
- Aluminum aluminum secondary butoxide, aluminum acetylacetonate, aluminum chloride, basic aluminum 2-hexanoate, aluminum hydroxide, aluminum isopropoxide.
- Titanium bis (cyclopentadienyl) titanium dichloride, cyclopentadienyl titanium trichloride, titanium (IV) n-butoxide, titanium (III) chloride, titanium (IV) chloride, titanium (IV) ethoxide, tetrakis (dimethylamino) titanium, titanium diisopropoxy bisacetylacetonate, titanium (IV) allyl acetoacetate triisopropoxide , Titanium (IV) oxide bis (pentanedionate).
- Yttrium tris (cyclopentadienyl) yttrium, yttrium (III) acetate, yttrium (III) acetylacetonate, yttrium (III) 2-ethylhexanoate, yttrium (III) chloride, yttrium (III) carbonate, yttrium (III) isopropoxide, yttrium (III ) oxalate, yttria-isopropylate.
- Zirconium bis (cyclopentadienyl) zirconium dichloride, bis (cyclopentadienyl) zirconium hydrochloride (Schwartz reagent), cyclopentadienylzirconium trichloride, zirconium (IV) carbonate, zirconium (IV) chloride, zirconium (IV) acetylacetonate, zirconium (IV) n-propoxide, zirconyl-2 ethylhexanoate.
- cerium (IV) t-butoxide cerium (IV) tetramethylheptanedionate, cerium (III) -2-ethylhexanoate, cerium (III) 2,4-pentanedionate, cerium (III) oxalate, dysprosium (III) acetylacetonate, Dysprosium (III) acetate, dysprosium (III) isopropoxide, erbium (III) acetate, erbium (III) methoxyethoxide, erbium (III) acetylacetonate, tris (cyclopentanedienyl) erbium, erbium (III) oxalate, europium (III) methacrylate, europium ( III) acetylacetonate, europium (III) theonyltrifluoroacetonate, gadolinium (III) acetylacetonate, ga
- hydrolytically condensable lanthanoid compounds such as hydrolytically condensable compounds of the elements titanium, zirconium, aluminum, yttrium and / or silicon or derived from the above compounds precondensates optionally in the presence of a catalyst and / or a solvent subjected to hydrolytic condensation by the action of water or moisture.
- the particles of the invention are particularly suitable as a filler in the medical field, which allows a safe and non-destructive diagnosis. Further possible applications are the use in optical, electrical or electro-optical components, as radiopaque carriers for medical applications, as contrast agents, as catalysts or as NMR and tracer reagents. In principle, therefore, the particles according to the invention are applicable in any polymer matrices.
- FIGS. 1 to 3 show schematically greatly simplified the structure of particles of the invention.
- FIG. 4 shows the magnetic moments of the lanthanoid ions M 3+ . It can be seen that by incorporating such oxdic compounds corresponding magnetic moments can be realized, so that then can be done in the particle in its application a very easy identification, for example by means of NMR.
- FIG. 5 shows very impressively the uniformity of the particles produced by the method according to the invention.
- FIG. 6 documents the narrow particle size distribution obtained in the particles according to the invention.
- DRIFTS diffuse reflection infrared Fourier transform spectroscopy
- the X-ray opacities of the lanthanide-containing particles described in Examples 1 to 4 are more than twice as high as those of pure SiO 2 particles.
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Composite Materials (AREA)
- General Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oxygen, Ozone, And Oxides In General (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Silicon Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Compositions Of Oxide Ceramics (AREA)
Claims (15)
- Particules oxydantes sphériques présentant une taille particulaire de 5 à 10 000 nm contenant 0,1 à 99,9 % en poids d'un premier composé oxydant choisi parmi le titane, le zirconium, l'aluminium, l'yttrium et le silicium, et au moins un autre oxyde d'éléments de la série des lanthanides.
- Particules sphériques selon la revendication 1, caractérisées en ce qu'elles contiennent 20 à 95 % en poids du premier composé oxydant et 80 à 5 % en poids d'oxydes de lanthanides.
- Particules sphériques selon la revendication 2, caractérisées en ce qu'elles contiennent 60 à 95 % en poids du premier composé oxydant et 40 à 5 % en poids d'oxydes de lanthanides.
- Particules sphériques selon au moins l'une quelconque des revendications 1 à 3, caractérisées en ce que les particules possèdent une structure en pelure d'oignon, et en ce que le premier composé oxydant, ou un oxyde de lanthanides, forme le noyau.
- Particules sphériques selon au moins l'une quelconque des revendications 1 à 3, caractérisées en ce que les oxydes métalliques sont répartis de manière homogène.
- Particules sphériques selon au moins l'une quelconque des revendications 1 à 3, caractérisées en ce que les particules constituées d'un ou de plusieurs oxydes métalliques sont intégrées à une matrice constituée d'un ou de plusieurs oxydes métalliques.
- Particules sphériques selon au moins l'une quelconque des revendications 1 à 6, caractérisées en ce qu'elles présentent une modification de surface que l'on a obtenue par condensation hydrolytique partielle ou complète d'un ou de plusieurs composés condensables par hydrolyse constitués de silicium et, éventuellement, d'autres éléments du groupe comprenant le bore, l'aluminium, le phosphore; l'étain, le plomb, les métaux de transition, les lanthanides et les actinides, et/ou de précondensats dérivés des composés précités, éventuellement, en présence d'un catalyseur et/ou d'un solvant et en faisant réagir de l'eau ou de l'humidité.
- Particules sphériques selon au moins l'une quelconque des revendications 1 à 7, caractérisées en ce qu'elles présentent une taille particulaire de 20 à 500 nm.
- Particules sphériques selon au moins l'une quelconque des revendications 1 à 8, caractérisées en ce que l'écart type de la taille particulaire est inférieur à 15 %.
- Particules sphériques selon au moins l'une quelconque des revendications 1 à 9, caractérisées en ce que le premier oxyde est un oxyde de silicium.
- Procédé de fabrication de particules sphériques selon au moins l'une quelconque des revendications 1 à 10, caractérisé en ce que l'on applique sur des particules sphériques d'oxydes métalliques choisis parmi les composés oxydants de titane, de zirconium, d'aluminium, d'yttrium et/ou de silicium, une ou plusieurs pellicules d'oxydes métalliques et/ou de mélanges d'oxydes métalliques, respectivement, en effectuant la condensation hydrolytique d'un ou de plusieurs composés condensables par hydrolyse et/ou de précondensats dérivés des composés précités, éventuellement, en présence d'un catalyseur et/ou d'un solvant et en faisant réagir de l'eau ou de l'humidité.
- Procédé selon la revendication 11, caractérisé en ce que l'on applique sur des particules d'oxydes métalliques choisis parmi les composés oxydants de lanthanides, une ou plusieurs pellicules d'oxydes métalliques et/ou de mélanges d'oxydes métalliques, respectivement, en effectuant la condensation hydrolytique de composés condensables par hydrolyse constitués des éléments titane, zirconium, aluminium, yttrium et/ou silicium, et/ou de précondensats dérivés des composés précités, éventuellement, en présence d'un catalyseur et/ou d'un solvant et en faisant réagir de l'eau ou de l'humidité.
- Procédé selon l'une quelconque des revendications 11 à 12, caractérisé en ce que l'on soumet un mélange de composés condensables par hydrolyse choisis parmi le titane, le zirconium, l'aluminium, l'yttrium et/ou le silicium, à une condensation hydrolytique avec au moins un autre composé condensable par hydrolyse constitué d'éléments de la série des lanthanides et/ou de précondensats dérivés des composés précités, éventuellement, en présence d'un catalyseur et/ou d'un solvant et en faisant réagir de l'eau ou de l'humidité.
- Procédé selon au moins l'une quelconque des revendications 11 à 13, caractérisé en ce que l'on soumet les particules obtenues à une modification de surface en réalisant la condensation, à la surface des particules, d'un ou de plusieurs composés modifiés sous forme organique, condensables par hydrolyse et constitués des éléments Sn, Si, B, Al, P, Pb, de métaux de transition, de lanthanides et d'actinides, et/ou de précondensats dérivés des composés précités, éventuellement en présence d'un catalyseur et/ou d'un solvant, en faisant réagir de l'eau ou de l'humidité.
- Utilisation des particules sphériques oxydantes selon l'une quelconque des revendications 1 à 10, comme matériau de charge dans le domaine médical, par exemple, comme agent de charge dentaire opaque aux rayons X, comme support opaque aux rayons X pour des applications médicales, comme agent de contraste, comme catalyseur, comme réactif de RMN et comme réactif de marquage et pour un usage dans des composants optiques, électriques ou électrooptiques.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10018405 | 2000-04-13 | ||
DE10018405A DE10018405B4 (de) | 2000-04-13 | 2000-04-13 | Sphärische oxidische Partikel und deren Verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1146072A1 EP1146072A1 (fr) | 2001-10-17 |
EP1146072B1 true EP1146072B1 (fr) | 2008-09-24 |
Family
ID=7638655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01109140A Expired - Lifetime EP1146072B1 (fr) | 2000-04-13 | 2001-04-12 | Particules sphérique oxydiques, leur préparation et utilisation |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1146072B1 (fr) |
AT (1) | ATE409204T1 (fr) |
DE (2) | DE10018405B4 (fr) |
DK (1) | DK1146072T3 (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10317067A1 (de) * | 2003-04-14 | 2004-11-11 | Degussa Ag | Domänen in einer Metalloxid-Matrix |
DE102005018059A1 (de) | 2003-10-24 | 2006-10-26 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zum Verbrücken von Hydroxy- oder Carbonsäuregruppen enthaltenden, organisch polymerisierbaren Silanen oder Silanharzeinheiten, sowie Produkte dieses Verfahrens |
DE102005018351B4 (de) | 2005-04-20 | 2008-05-29 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verwendung widerstandsfähiger, langlebiger Komposite im Dentalbereich |
DE102005019600A1 (de) | 2005-04-27 | 2006-11-09 | Ivoclar Vivadent Ag | Oberflächenmodifizierte Füllstoffe |
EP2080503B1 (fr) | 2008-01-18 | 2011-09-14 | Ivoclar Vivadent AG | Matériaux dentaires dotés d'agents de remplissage à surface fonctionnalisée |
DE102009012698A1 (de) | 2009-03-11 | 2010-09-16 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Partikel mit einer lumineszierenden anorganischen Schale, Verfahren zur Beschichtung von Partikeln sowie deren Verwendung |
EP2527321A1 (fr) | 2011-05-27 | 2012-11-28 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Liaisons polymérisables dotées d'esters de (méth)acryloyl et de groupes sulfonate ou sulfate ainsi que leur utilisation |
EP2714653B1 (fr) | 2011-05-27 | 2017-05-03 | Fraunhofer Gesellschaft zur Förderung der angewandten Forschung E.V. | Composés comprenant des radicaux (méth)acrylate et des groupes sulfonate ou sulfate, polymères et condensats à partir de ceux-ci et utilisation des polymères et des condensats |
DE102011050672B4 (de) | 2011-05-27 | 2020-06-25 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Kieselsäure(hetero)polykondensate mit (Meth)acrylresten und entweder Sulfonat- oder Sulfatgruppen, für deren Herstellung geeignete Silane sowie Verfahren zum Herstellen der Kondensate und der Silane |
DE102011054440A1 (de) | 2011-10-12 | 2013-04-18 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Kieselsäurepolykondensate mit cyclischen olefinhaltigen Strukturen, Verfahren zu deren Herstellung sowie deren Verwendung |
DE102012202005A1 (de) | 2011-10-12 | 2013-04-18 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Gefüllte und ungefüllte, organisch modifizierte, gegebenenfalls organisch vernetzte Kieselsäure(hetero)polysilikate als Dentalmaterialien für die "Chairside"-Behandlung |
DE102012104139A1 (de) | 2012-05-11 | 2013-11-14 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verwendung eines ungefüllten oder mit Füllstoff gefüllten, organisch modifizierten Kieselsäure(hetero)polykondensats in medizinischen und nichtmedizinischen Verfahren zum Verändern der Oberfläche eines Körpers aus einem bereits ausgehärteten, ungefüllten oder mit Füllstoff gefüllten Kieselsäure(hetero)polykondensat, insbesondere für die zahnmedizinische "Chairside"-Behandlung |
US20150139913A1 (en) * | 2012-06-04 | 2015-05-21 | Migrata U.K. Limited | Medical use of particles of titanium and/or titanium oxide |
DE102013108594A1 (de) | 2013-08-08 | 2015-02-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Silane und Kieselsäure(hetero)polykondensate mit über Kupplungsgruppen angebundenen Aromaten, die sich als oder für Matrixsysteme mit hoher Transluzenz und guter Mechanik eignen |
DE102014115751B4 (de) | 2014-10-29 | 2020-08-27 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Mit aromatischen Resten und mit Hydroxygruppen substituierte Silane und Kieselsäure(hetero)polykondensate sowie Derivate davon, die sich als solche oder als Komposite für (Matrix-)Systeme mit hoher Transluzenz und guter Mechanik eignen |
DE102015114397A1 (de) | 2015-08-28 | 2017-03-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Misch- und Formverfahren für gefüllte Duromere aus organisch vernetzbaren Kompositmassen, insbesondere für dentale Zwecke |
DE102018117631A1 (de) | 2018-07-20 | 2020-01-23 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Innovatives Materialsystem und Verfahren zur Fertigung von patientenindividuellen Komfort-Ohrpassstücken für die Hörakustik-, Audio und Gehörschutzbranche |
DE102018117617A1 (de) | 2018-07-20 | 2020-01-23 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Herstellung von Formkörpern aus einem anorganisch-organischen Hybridpolymer mit hoher Auflösung mittels 3D-Druck, Formkörper mit hohen Biegefestigkeiten und E-Moduln und deren Anwendung für dentale Zwecke |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3927224A (en) * | 1971-12-15 | 1975-12-16 | Owens Illinois Inc | Luminescent and/or photoconductive materials |
DE3421157A1 (de) * | 1984-06-07 | 1985-12-12 | Ernst Leitz Wetzlar Gmbh, 6330 Wetzlar | Verbundwerkstoff auf kunststoffbasis fuer prothetische zwecke |
DE19500634C1 (de) * | 1995-01-11 | 1996-08-29 | Fraunhofer Ges Forschung | Fluoreszierende Materialien |
EP0747034B1 (fr) * | 1995-06-08 | 2001-08-16 | Vita Zahnfabrik H. Rauter GmbH & Co. KG | Mélange de poudres pour la préparation d'une pâte de matériau opaque |
DE19643781C2 (de) * | 1996-10-29 | 2000-01-27 | Fraunhofer Ges Forschung | Sphärische Partikel auf der Basis von Metalloxiden, Verfahren zu deren Herstellung und deren Verwendung |
-
2000
- 2000-04-13 DE DE10018405A patent/DE10018405B4/de not_active Expired - Fee Related
-
2001
- 2001-04-12 EP EP01109140A patent/EP1146072B1/fr not_active Expired - Lifetime
- 2001-04-12 AT AT01109140T patent/ATE409204T1/de active
- 2001-04-12 DK DK01109140T patent/DK1146072T3/da active
- 2001-04-12 DE DE50114342T patent/DE50114342D1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1146072A1 (fr) | 2001-10-17 |
DE50114342D1 (de) | 2008-11-06 |
DE10018405B4 (de) | 2004-07-08 |
DK1146072T3 (da) | 2008-12-08 |
DE10018405A1 (de) | 2001-10-25 |
ATE409204T1 (de) | 2008-10-15 |
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