EP1140171A4 - METHODS AND PRODUCTS FOR REGULATING THE COMPLEMENT ACTIVATION ASSOCIATED WITH THE LECTIN COMPLEMENT SYSTEM - Google Patents

METHODS AND PRODUCTS FOR REGULATING THE COMPLEMENT ACTIVATION ASSOCIATED WITH THE LECTIN COMPLEMENT SYSTEM

Info

Publication number
EP1140171A4
EP1140171A4 EP99967362A EP99967362A EP1140171A4 EP 1140171 A4 EP1140171 A4 EP 1140171A4 EP 99967362 A EP99967362 A EP 99967362A EP 99967362 A EP99967362 A EP 99967362A EP 1140171 A4 EP1140171 A4 EP 1140171A4
Authority
EP
European Patent Office
Prior art keywords
products
methods
pathway associated
complement
regulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99967362A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1140171A1 (en
Inventor
Gregory L Stahl
Charles D Collard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham and Womens Hospital Inc
Original Assignee
Brigham and Womens Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham and Womens Hospital Inc filed Critical Brigham and Womens Hospital Inc
Publication of EP1140171A1 publication Critical patent/EP1140171A1/en
Publication of EP1140171A4 publication Critical patent/EP1140171A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP99967362A 1998-12-15 1999-12-15 METHODS AND PRODUCTS FOR REGULATING THE COMPLEMENT ACTIVATION ASSOCIATED WITH THE LECTIN COMPLEMENT SYSTEM Withdrawn EP1140171A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11239098P 1998-12-15 1998-12-15
PCT/US1999/029919 WO2000035483A1 (en) 1998-12-15 1999-12-15 Methods and products for regulating lectin complement pathway associated complement activation
US112390P 2008-11-07

Publications (2)

Publication Number Publication Date
EP1140171A1 EP1140171A1 (en) 2001-10-10
EP1140171A4 true EP1140171A4 (en) 2002-03-13

Family

ID=22343639

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99967362A Withdrawn EP1140171A4 (en) 1998-12-15 1999-12-15 METHODS AND PRODUCTS FOR REGULATING THE COMPLEMENT ACTIVATION ASSOCIATED WITH THE LECTIN COMPLEMENT SYSTEM

Country Status (4)

Country Link
EP (1) EP1140171A4 (ja)
JP (1) JP2002532079A (ja)
CA (1) CA2347734A1 (ja)
WO (1) WO2000035483A1 (ja)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6969601B2 (en) 1997-04-03 2005-11-29 Jensenius Jens Chr MASP-2, a complement-fixing enzyme, and uses for it
US7273925B1 (en) 1998-12-15 2007-09-25 Brigham And Women's Hospital, Inc. Methods and products for regulating lectin complement pathway associated complement activation
WO2001012212A1 (en) * 1999-08-13 2001-02-22 The Brigham And Women's Hospital, Inc. Inhibitors of the lectin complement pathway (lcp) and their use
NZ523900A (en) * 2000-07-13 2004-02-27 Jens Christian Jensenius Isolation and characterisation of a mannan-binding lectin (MBL) associated serine protease (MASP-2) and uses thereof to treat infections
EP1186299A1 (en) * 2000-09-12 2002-03-13 Universitair Medisch Centrum Utrecht The diagnosis, prevention, and/or succesful treatment of atherosclerosis, infectious diseases, and disturbances in the immune system
AU2004216176B2 (en) * 2003-02-21 2008-04-03 Genentech, Inc. Methods for preventing and treating tissue damage associated with ischemia-reperfusion injury
CN1798769A (zh) 2003-05-12 2006-07-05 内蒂穆恩公司 抗masp－2抗体
US7919094B2 (en) 2004-06-10 2011-04-05 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
GB0412966D0 (en) 2004-06-10 2004-07-14 Univ Leicester Genetically modified non-human mammals and cells
US8840893B2 (en) 2004-06-10 2014-09-23 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
US8524453B2 (en) 2006-02-10 2013-09-03 The Brigham And Woman's Hospital, Inc. Lectin complement pathway assays and related compositions and methods
NZ576195A (en) 2006-10-10 2012-04-27 Az Univ Amsterdam Complement inhibition for improved nerve regeneration
RU2600876C2 (ru) 2009-10-16 2016-10-27 Омерос Корпорейшен Способ лечения диссеминированного внутрисосудистого свертывания крови путем ингибирования masp-2 зависимой активации комплемента
US9315585B2 (en) 2010-06-19 2016-04-19 Memorial Sloan Kettering Cancer Center Anti-GD2 antibodies
US9644035B2 (en) 2011-04-08 2017-05-09 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
EP3287142B1 (en) 2011-04-08 2021-08-04 University Of Leicester Methods for treating conditions associated with masp-2 dependent complement activation
CA3131223C (en) 2011-05-04 2024-01-30 Omeros Corporation Compositions for inhibiting masp-2 dependent complement activation
CA2903576C (en) 2013-03-15 2021-06-08 Nai-Kong V. Cheung High affinity anti-gd2 antibodies
CN108588033B (zh) * 2018-04-24 2021-09-24 富恩生物技术（成都）有限公司 杂交瘤细胞株、cd31单克隆抗体、制备方法及应用
CN115120705A (zh) * 2022-07-07 2022-09-30 新乡医学院 甘露聚糖结合凝集素在抑制细胞衰老方面的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001519A1 (en) * 1987-08-20 1989-02-23 Children's Hospital Corporation Human mannose binding protein
WO1991006010A1 (en) * 1989-10-11 1991-05-02 Institute Of Child Health Diagnostic procedure
JPH06121695A (ja) * 1992-10-13 1994-05-06 Fuji Yakuhin Kogyo Kk 抗ヒトマンノース結合蛋白モノクローナル抗体およびその利用
JPH07238100A (ja) * 1994-02-25 1995-09-12 Sumitomo Electric Ind Ltd ヒトのｍａｓｐに対するモノクローナル抗体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270199A (en) 1987-08-20 1993-12-14 The Children's Medical Center Corporation Human mannose-binding protein
DE3927723A1 (de) * 1989-01-26 1990-08-02 Ulrich Prof Dr Speck N - acetylglucosamin zur buccalen anwendung
WO1993018775A1 (en) * 1992-03-19 1993-09-30 The University Of British Columbia Method and composition for suppression of side effects of anti-inflammatory drugs
US5998173A (en) * 1996-02-20 1999-12-07 The University Of Bristish Columbia Process for producing N-acetyl-D-glucosamine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001519A1 (en) * 1987-08-20 1989-02-23 Children's Hospital Corporation Human mannose binding protein
WO1991006010A1 (en) * 1989-10-11 1991-05-02 Institute Of Child Health Diagnostic procedure
JPH06121695A (ja) * 1992-10-13 1994-05-06 Fuji Yakuhin Kogyo Kk 抗ヒトマンノース結合蛋白モノクローナル抗体およびその利用
JPH07238100A (ja) * 1994-02-25 1995-09-12 Sumitomo Electric Ind Ltd ヒトのｍａｓｐに対するモノクローナル抗体

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
CHAKA W ET AL: "Induction of TNF-alpha in human peripheral blood mononuclear cells by the mannoprotein of cryptococcus neoformans involves human mannose binding protein", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 159, 1997, pages 2979 - 2985, XP002145899, ISSN: 0022-1767 *
COLLARD C D ET AL: "ENDOTHELIAL REOXYGENATION ACTIVATES THE LECTIN COMPLEMENT PATHWAY: INHIBITION WITH ANTI-HUMAN MANNOSE BINDING LECTIN(MBL) THERAPY", MOLECULAR PHARMACOLOGY, BALTIMORE, MD, US, vol. 36, no. 4/5, March 1999 (1999-03-01), pages 278, XP000944464, ISSN: 0026-895X *
COLLARD C D ET AL: "REOXYGENATION OF HYPOXIC HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS (HUVECS) ACTIVATES THE LECTIN COMPLEMENT PATHWAY (LCP)", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD, US, vol. 12, no. 4, 17 March 1998 (1998-03-17), pages A29, XP000944437, ISSN: 0892-6638 *
ENDO M ET AL: "GLOMERULA DEPOSITION OF MANNOSE-BINDING LECTIN (MBL) INDICATES A NOVEL MECHANISM OF COMPLEMENT ACTIVATION IN IGA NEPHROPATHY", NEPHROLOGY DIALYSIS TRANSPLANTATION, OXFORD UNIVERSITY PRESS, GB, vol. 13, no. 8, 1998, pages 1984 - 1990, XP000874166, ISSN: 0931-0509 *
LHOTTA K ET AL: "GLOMERULAR DEPOSITION OF MANNOSE-BINDING LECTIN IN HUMAN GLOMERULONEPHRITIS", NEPHROLOGY DIALYSIS TRANSPLANTATION, OXFORD UNIVERSITY PRESS, GB, vol. 14, no. 4, April 1999 (1999-04-01), pages 881 - 886, XP000944395, ISSN: 0931-0509 *
PATENT ABSTRACTS OF JAPAN vol. 018, no. 410 (C - 1232) 2 August 1994 (1994-08-02) *
PATENT ABSTRACTS OF JAPAN vol. 1996, no. 01 31 January 1996 (1996-01-31) *
See also references of WO0035483A1 *
TENNER A J ET AL: "MANNOSE BINDING PROTEIN (MBP) ENHANCES MONONUCLEAR PHAGOCYTE FUNCTION VIA A RECEPTOR THAT CONTAINS THE 126,00 MR COMPONENT OF THE C1Q RECEPTOR", IMMUNITY, CELL PRESS, US, vol. 3, no. 4, 1 October 1995 (1995-10-01), pages 485 - 493, XP002058774, ISSN: 1074-7613 *
TERAI I ET AL: "ALPHA2-MACROGLOBULIN BINDS TO AND INHIBITS MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASE", INTERNATIONAL IMMUNOLOGY, OXFORD UNIVERSITY PRESS, GB, vol. 7, no. 10, October 1995 (1995-10-01), pages 1579 - 1584, XP001034131, ISSN: 0953-8178 *

Also Published As

Publication number Publication date
JP2002532079A (ja) 2002-10-02
WO2000035483A1 (en) 2000-06-22
CA2347734A1 (en) 2000-06-22
EP1140171A1 (en) 2001-10-10

Similar Documents

Publication Publication Date Title
EP1140171A4 (en) METHODS AND PRODUCTS FOR REGULATING THE COMPLEMENT ACTIVATION ASSOCIATED WITH THE LECTIN COMPLEMENT SYSTEM
IL137963A0 (en) Compositions and methods for regulating lymphocyte activation
GB2348808B (en) Methods and compositions for desensitisation
PL347164A1 (en) Verifiable holographic article
HU9900636D0 (en) Confectionery product and process
SG74616A1 (en) Hinge and method
GB9715293D0 (en) Monitor and/or overload means
IL138207A0 (en) Methods and devices for modulating the immune response
GB9615405D0 (en) Chocolate products
GB2354009B (en) Process for de-chlorinating and de-fouling oil
EP1055980A4 (en) ELECTRONIC DEVICE AND CONTROL METHOD THEREFOR
PL332631A1 (en) Spray-crystallised products and associated methods
GB9902300D0 (en) Holography apparatus, method and product
IL120554A0 (en) Kombucha products and processes for the preparation thereof
AU2752399A (en) Method for continuous casting and device for carrying out the method
HK1036273A1 (en) Pyridine derivative and pharmaceutical containing the same
PL343432A1 (en) Methods and devices for modulating the immune response
ZA98795B (en) Selection method and products resulting therefrom
HK1005644A2 (en) An anti-counterfeit product
ZA981366B (en) Sheathed continuously cast products
AU7764798A (en) Product and method for providing glutamine
AU3142499A (en) Device and method for preparing food portions
AU6010998A (en) Method and device for the continuous cooking of pulp
TW306166U (en) Rootstalk product slicer and shredder
GB9823959D0 (en) Shaped food products

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20010613

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 20020124

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 7A 61K 39/395 A, 7C 12N 5/06 B, 7C 12N 5/16 B, 7G 01N 33/50 B

17Q First examination report despatched

Effective date: 20020912

17Q First examination report despatched

Effective date: 20020912

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20080529