EP1135152A1 - Pharmazeutische zusammensetzung die cyclosporin in einem fettträger enthält - Google Patents
Pharmazeutische zusammensetzung die cyclosporin in einem fettträger enthältInfo
- Publication number
- EP1135152A1 EP1135152A1 EP99963798A EP99963798A EP1135152A1 EP 1135152 A1 EP1135152 A1 EP 1135152A1 EP 99963798 A EP99963798 A EP 99963798A EP 99963798 A EP99963798 A EP 99963798A EP 1135152 A1 EP1135152 A1 EP 1135152A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- pharmaceutical composition
- cyclosporin
- lipids
- monoglycerides
- cyclosporine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Definitions
- Neoral ® , Neoral ® or Sandimmune ® from the gastro-intestinal tract is, however, incomplete and variable and it is recommended that transplant patients taking the soft gelatin capsules or the oral solution over a period of time are monitored .at repeated intervals for cyclosporine blood levels to avoid toxicity due to high levels, and possible organ rejection due to low absorption, respectively.
- the pharmaceutical composition of the invention can also contain conventional additives and excipients, such as antiseptic agents, preservatives, thickening agents, pigments, flavouring and the like, in combinations as needed.
- a formulation in accordance with WO 95/20945 was prepared by mixing the following ingredients I- g-rfidi-e-n-t -k-b-y weig-ht-
- PC phosphatidylcholine, from Lucas Meyer SL, h-GL and h-PE were obtained from Ontario LipidTeknik AB .
- Soy bean oil is a long-chain C16-C20 triglyceride, CPL ® - Soybean oil from Ontario LipidTeknik AB .
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9804192 | 1998-12-03 | ||
SE9804192A SE9804192D0 (sv) | 1998-12-03 | 1998-12-03 | New formulation |
PCT/SE1999/002259 WO2000032219A1 (en) | 1998-12-03 | 1999-12-03 | A pharmaceutical composition comprising cyclosporin in a lipid carrier |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1135152A1 true EP1135152A1 (de) | 2001-09-26 |
Family
ID=20413540
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99963798A Withdrawn EP1135152A1 (de) | 1998-12-03 | 1999-12-03 | Pharmazeutische zusammensetzung die cyclosporin in einem fettträger enthält |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1135152A1 (de) |
JP (1) | JP2002531412A (de) |
AU (1) | AU764413B2 (de) |
CA (1) | CA2352388A1 (de) |
HU (1) | HUP0105399A3 (de) |
NO (1) | NO20012736D0 (de) |
NZ (1) | NZ512194A (de) |
PL (1) | PL348062A1 (de) |
SE (1) | SE9804192D0 (de) |
WO (1) | WO2000032219A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0200475D0 (sv) * | 2002-02-15 | 2002-02-15 | Ltp Lipid Technologies Provide | Oral farmaceutisk beredning |
US20050058671A1 (en) * | 2003-05-09 | 2005-03-17 | Bedding Peter M.J. | Dietary supplement and method for treating digestive system-related disorders |
SE0303135D0 (sv) * | 2003-11-25 | 2003-11-25 | Lipocore Holding Ab | Controlled food effect composition |
SE0401942D0 (sv) * | 2004-07-28 | 2004-07-28 | Lipopeptide Ab | New antimicrobial peptide complexes |
AU2006240551A1 (en) * | 2005-04-28 | 2006-11-02 | Dsm Ip Assets B.V. | Pharmaceutical dosage forms comprising a lipid phase |
WO2012144943A1 (en) * | 2011-04-18 | 2012-10-26 | Lipidor Ab | Liquid carrier for oral delivery of a pharmacologically active agent |
JP6334151B2 (ja) * | 2012-12-25 | 2018-05-30 | ポーラ化成工業株式会社 | 逆ベシクル組成物 |
JP6242582B2 (ja) * | 2013-04-01 | 2017-12-06 | ポーラ化成工業株式会社 | 逆ベシクル組成物の製造方法 |
JP6242581B2 (ja) * | 2013-04-01 | 2017-12-06 | ポーラ化成工業株式会社 | 逆ベシクル組成物の製造方法 |
WO2014103742A1 (ja) * | 2012-12-25 | 2014-07-03 | ポーラ化成工業株式会社 | 逆ベシクル組成物及びその製造方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR0148748B1 (ko) * | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
US5529785A (en) * | 1993-05-12 | 1996-06-25 | Dietl; Hans | Pharmaceutical preparation containing cyclosporin(s) for oral administration and process for producing same |
AU691250B2 (en) * | 1994-02-04 | 1998-05-14 | Lipocore Holding Ab | Lipophilic carrier preparations |
MY129435A (en) * | 1994-10-26 | 2007-04-30 | Novartis Ag | Pharmaceutical microemulsion preconcentrates |
IT1289939B1 (it) * | 1997-02-20 | 1998-10-19 | Angelini Ricerche Spa | Composizione farmaceutica acquosa comprendente un principio attivo altamente insolubile in acqua |
US6063762A (en) * | 1997-12-05 | 2000-05-16 | Chong Kun Dang Corp. | Cyclosporin-containing microemulsion preconcentrate composition |
-
1998
- 1998-12-03 SE SE9804192A patent/SE9804192D0/xx unknown
-
1999
- 1999-12-03 PL PL99348062A patent/PL348062A1/xx not_active Application Discontinuation
- 1999-12-03 WO PCT/SE1999/002259 patent/WO2000032219A1/en not_active Application Discontinuation
- 1999-12-03 JP JP2000584910A patent/JP2002531412A/ja active Pending
- 1999-12-03 NZ NZ512194A patent/NZ512194A/xx unknown
- 1999-12-03 AU AU20167/00A patent/AU764413B2/en not_active Ceased
- 1999-12-03 CA CA002352388A patent/CA2352388A1/en not_active Abandoned
- 1999-12-03 HU HU0105399A patent/HUP0105399A3/hu unknown
- 1999-12-03 EP EP99963798A patent/EP1135152A1/de not_active Withdrawn
-
2001
- 2001-06-01 NO NO20012736A patent/NO20012736D0/no not_active Application Discontinuation
Non-Patent Citations (1)
Title |
---|
See references of WO0032219A1 * |
Also Published As
Publication number | Publication date |
---|---|
HUP0105399A2 (en) | 2002-06-29 |
WO2000032219A1 (en) | 2000-06-08 |
AU2016700A (en) | 2000-06-19 |
CA2352388A1 (en) | 2000-06-08 |
JP2002531412A (ja) | 2002-09-24 |
AU764413B2 (en) | 2003-08-21 |
PL348062A1 (en) | 2002-05-06 |
HUP0105399A3 (en) | 2005-06-28 |
NO20012736L (no) | 2001-06-01 |
NO20012736D0 (no) | 2001-06-01 |
SE9804192D0 (sv) | 1998-12-03 |
NZ512194A (en) | 2002-09-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20010522 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
AX | Request for extension of the european patent |
Free format text: AL;LT;LV;MK;RO;SI |
|
17Q | First examination report despatched |
Effective date: 20031014 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20040427 |