NZ512194A - A pharmaceutical composition comprising cyclosporin in a lipid carrier - Google Patents

A pharmaceutical composition comprising cyclosporin in a lipid carrier

Info

Publication number
NZ512194A
NZ512194A NZ512194A NZ51219499A NZ512194A NZ 512194 A NZ512194 A NZ 512194A NZ 512194 A NZ512194 A NZ 512194A NZ 51219499 A NZ51219499 A NZ 51219499A NZ 512194 A NZ512194 A NZ 512194A
Authority
NZ
New Zealand
Prior art keywords
cyclosporin
pharmaceutical composition
lipid carrier
composition
lipids
Prior art date
Application number
NZ512194A
Inventor
Bengt Herslof
Peter Kaufmann
Carl-Gunnar Kroon
Original Assignee
Lipocore Holding Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipocore Holding Ab filed Critical Lipocore Holding Ab
Publication of NZ512194A publication Critical patent/NZ512194A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

A pharmaceutical composition comprising a cyclosporin as an active substance in a lipid carrier, which carrier comprises membrane lipids in combination with monoglycerides and optionally non-polar lipids, which composition is characterized in being liquid at room temperature and containing 0.5-25 % cyclosporin, 10-45 % membrane lipids, 10-55 % monoglycerides and 0-45 % non-polar lipids. The composition is bioequivalent to a commercial drug containing in addition to cyclosporin and additives also toxic emulsifiers and ethanol.
NZ512194A 1998-12-03 1999-12-03 A pharmaceutical composition comprising cyclosporin in a lipid carrier NZ512194A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9804192A SE9804192D0 (en) 1998-12-03 1998-12-03 New formulation
PCT/SE1999/002259 WO2000032219A1 (en) 1998-12-03 1999-12-03 A pharmaceutical composition comprising cyclosporin in a lipid carrier

Publications (1)

Publication Number Publication Date
NZ512194A true NZ512194A (en) 2002-09-27

Family

ID=20413540

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ512194A NZ512194A (en) 1998-12-03 1999-12-03 A pharmaceutical composition comprising cyclosporin in a lipid carrier

Country Status (10)

Country Link
EP (1) EP1135152A1 (en)
JP (1) JP2002531412A (en)
AU (1) AU764413B2 (en)
CA (1) CA2352388A1 (en)
HU (1) HUP0105399A3 (en)
NO (1) NO20012736D0 (en)
NZ (1) NZ512194A (en)
PL (1) PL348062A1 (en)
SE (1) SE9804192D0 (en)
WO (1) WO2000032219A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0200475D0 (en) * 2002-02-15 2002-02-15 Ltp Lipid Technologies Provide Oral pharmaceutical preparation
US20050058671A1 (en) * 2003-05-09 2005-03-17 Bedding Peter M.J. Dietary supplement and method for treating digestive system-related disorders
SE0303135D0 (en) * 2003-11-25 2003-11-25 Lipocore Holding Ab Controlled food effect composition
SE0401942D0 (en) * 2004-07-28 2004-07-28 Lipopeptide Ab New antimicrobial peptide complexes
JP2008539230A (en) * 2005-04-28 2008-11-13 ガレニカ テクノロジー アンチエボラグ Pharmaceutical dosage forms containing a lipid phase
EP2699267A4 (en) * 2011-04-18 2014-11-12 Lipidor Ab Liquid carrier for oral delivery of a pharmacologically active agent
WO2014103742A1 (en) * 2012-12-25 2014-07-03 ポーラ化成工業株式会社 Reverse vesicle composition and method for producing same
JP6242582B2 (en) * 2013-04-01 2017-12-06 ポーラ化成工業株式会社 Method for producing reverse vesicle composition
JP6242581B2 (en) * 2013-04-01 2017-12-06 ポーラ化成工業株式会社 Method for producing reverse vesicle composition
JP6334151B2 (en) * 2012-12-25 2018-05-30 ポーラ化成工業株式会社 Reverse vesicle composition

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0148748B1 (en) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 A multiphase cyclosporin composition
US5529785A (en) * 1993-05-12 1996-06-25 Dietl; Hans Pharmaceutical preparation containing cyclosporin(s) for oral administration and process for producing same
JP3203359B2 (en) * 1994-02-04 2001-08-27 リポコーア・ホールディング・アクチエボラーグ Lipophilic carrier formulation
IL115742A (en) * 1994-10-26 2000-06-01 Novartis Ag Pharmaceutical compositions comprising a difficultly soluble active agent a hydrophilic phase a lipophilic phase and a surfactant
IT1289939B1 (en) * 1997-02-20 1998-10-19 Angelini Ricerche Spa AQUEOUS PHARMACEUTICAL COMPOSITION INCLUDING A HIGHLY WATER INSOLUBLE ACTIVE SUBSTANCE
US6063762A (en) * 1997-12-05 2000-05-16 Chong Kun Dang Corp. Cyclosporin-containing microemulsion preconcentrate composition

Also Published As

Publication number Publication date
HUP0105399A3 (en) 2005-06-28
AU764413B2 (en) 2003-08-21
SE9804192D0 (en) 1998-12-03
WO2000032219A1 (en) 2000-06-08
PL348062A1 (en) 2002-05-06
NO20012736L (en) 2001-06-01
JP2002531412A (en) 2002-09-24
EP1135152A1 (en) 2001-09-26
HUP0105399A2 (en) 2002-06-29
AU2016700A (en) 2000-06-19
CA2352388A1 (en) 2000-06-08
NO20012736D0 (en) 2001-06-01

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Legal Events

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PSEA Patent sealed
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